196 research outputs found
A Primary Prevention Clinical Risk Score Model for Patients With Brugada Syndrome (BRUGADA-RISK).
OBJECTIVES: The goal of this study was to develop a risk score model for patients with Brugada syndrome (BrS). BACKGROUND: Risk stratification in BrS is a significant challenge due to the low event rates and conflicting evidence. METHODS: A multicenter international cohort of patients with BrS and no previous cardiac arrest was used to evaluate the role of 16 proposed clinical or electrocardiogram (ECG) markers in predicting ventricular arrhythmias (VAs)/sudden cardiac death (SCD) during follow-up. Predictive markers were incorporated into a risk score model, and this model was validated by using out-of-sample cross-validation. RESULTS: A total of 1,110 patients with BrS from 16 centers in 8 countries were included (mean age 51.8 ± 13.6 years; 71.8% male). Median follow-up was 5.33 years; 114 patients had VA/SCD (10.3%) with an annual event rate of 1.5%. Of the 16 proposed risk factors, probable arrhythmia-related syncope (hazard ratio [HR]: 3.71; p < 0.001), spontaneous type 1 ECG (HR: 3.80; p < 0.001), early repolarization (HR: 3.42; p < 0.001), and a type 1 Brugada ECG pattern in peripheral leads (HR: 2.33; p < 0.001) were associated with a higher risk of VA/SCD. A risk score model incorporating these factors revealed a sensitivity of 71.2% (95% confidence interval: 61.5% to 84.6%) and a specificity of 80.2% (95% confidence interval: 75.7% to 82.3%) in predicting VA/SCD at 5 years. Calibration plots showed a mean prediction error of 1.2%. The model was effectively validated by using out-of-sample cross-validation according to country. CONCLUSIONS: This multicenter study identified 4 risk factors for VA/SCD in a primary prevention BrS population. A risk score model was generated to quantify risk of VA/SCD in BrS and inform implantable cardioverter-defibrillator prescription
Light scattering by lithium tantalate at room temperature
The room-temperature Raman spectra of LiTa03 for all symmetry phonons are investigated. We make a new assignment of the phonons, which agrees with the selection rules of a C3 symmetry instead of C3V, contrary to Kaminow and Johnston's previous work. The oblique phonon dispersions are obtained and tum out to be consistent with our phonon assignments. We obtain also the polariton dispersion curve and, from it, the lowftequency dielectric constant
Light scattering by lithium tantalate at room temperature
The room-temperature Raman spectra of LiTa03 for all symmetry phonons are investigated. We make a new assignment of the phonons, which agrees with the selection rules of a C3 symmetry instead of C3V, contrary to Kaminow and Johnston's previous work. The oblique phonon dispersions are obtained and tum out to be consistent with our phonon assignments. We obtain also the polariton dispersion curve and, from it, the lowftequency dielectric constant
The lower and middle Palaeolithic industries associated with the T4 terrace of the lower Tejo river (Central Portugal); archives of the earliest human occupation on western Iberia, during ca. 340 ka to 155 ka ago
Através dos registos geomorfológicos e sedimentares, os rios fornecem relevantes arquivos de
mudanças paleoambientais, nomeadamente paleoclimáticas e paleogeográficas. As sucessões
sedimentares melhor datadas são as mais importantes, com as idades numéricas dos respetivos dos
eventos sedimentares, de fósseis e de materiais arqueológicos, obtidas por uma variedade de técnicas.
Os arquivos fluviais do Quaternário fornecidos pelo rio Tejo em Portugal (Baixo Tejo) constituem um
importante repositório de dados para estudos da evolução da dinâmica sedimentar e da paisagem, bem
como da ocupação humana pré-histórica. O atual estado de conhecimentos resultantes das sucessivas
abordagens usando métodos da geomorfologia, litostratigrafia, arqueologia e datação numérica no
estudo do Terraço T4 do Baixo Tejo é aqui sintetizado. Este trabalho tem enfoque nos sítios com
indústrias do Paleolítico que foram encontradas no Terraço T4, o qual é constituído por uma unidade
basal de cascalheiras e uma unidade superior dominada por areias. Os mais antigos artefactos são de
rara ocorrência e foram encontrados na unidade de Cascalheiras Inferiores, apresentando formas bifaciais pouco elaboradas que podem ser atribuídas ao Acheulense, com uma idade provável de ca. 340 a 325 ka. Em contraste, os níveis estratigráficos inferiores e médios da unidade de Areias Superiores do T4 apresentam vários sítios arqueológicos que documentam fases sucessivas de um Acheulense evoluído, que foram datados de ca. 325 a 220 ka. Nos níveis estratigráficos dos depósitos do topo do T4 foram encontradas indústrias do Paleolítico Médio e datam, provavelmente, de ca. 165 a 155 ka.Because of their geomorphological and sedimentary records, rivers provide relevant archives of palaeoenvironmental change, namely palaeoclimatic and palaeogeographic. Well-dated long-term sedimentary successions sequences are of the most value, with the ages of sedimentary events, included fossils and archaeological materials provided by a range of numerical dating techniques. The Quaternary fluvial archives of the Tejo River in Portugal (the Lower Tejo) can provide important data for studies of landscape and sedimentary evolution, but also of the early human occupation. The present state of art achieved by using methods of geomorphology, lithostratigraphy, sedimentology, archaeology and absolute dating in the study of the Lower Tejo River T4 terrace is here summarized. The Lower Tejo has staircases that comprise a culminant sedimentary unit (the ancestral Tejo River, before the beginning of the fluvial incision stage) and six terraces (T1 to T6) located above the modern alluvial plain, with details as follows: T6 at +7-10 m (above river level), 64-32 ka, with Late Middle Palaeolithic (late Mousterian); T5 at +18-26 m, 136-75 ka, with Middle Palaeolithic industries and Mousterian knapping (Levallois); T4 at +34-48 m, similar to 340-155 ka, with Lower Palaeolithic (Early to Late Acheulian) to early Middle Palaeolithic; T3, T2 and T1 do not contain archaeological materials and only from the T3 (+43-78 m) and T1 (+84-164 m) finite absolute ages were obtained. The prehistoric human occupation of this area is of renewed interest because it contains evidence for an extensive Palaeolithic occupation. Related archaeological sites are present on both sides of the river, from the vicinity of the Spanish border (Vila Velha de Rodao; upstream) to the Lisboa area (near the river mouth). This work focuses on the Palaeolithic sites that were found on the T4 terrace, which is made of a basal Lower Gravels unit and an overlying Upper Sands unit. The oldest artefacts previously found in the Lower Gravels unit of the T4 terrace, display crude bifacial forms that can be attributed to the Acheulian, with a probable age of ca. 340 to 325 ka. In contrast, the lower and middle stratigraphic levels of the T4 Upper Sands unit has archaeological sites stratigraphically documenting successive phases of an evolved Acheulian, that were dated as ca. 325 to 220 ka. Notably, these Lower Paleolithic artisans were able to produce tools with different levels of sophistication, simply by applying different strategies. More elaborated reduction sequences were used in case of bifaces, and simpler reduction sequences to obtain cleavers. The differences observed in the lithic assemblages documented at each of these sites can be attributed to a certain degree to particular economic functionalities. But, simultaneously, taking into account the stratigraphic position of these sites and the global technological and typological characteristics of the most relevant tools types (bifaces, cleavers, side-scrapers) we are also impelled to consider the occurrence of local evolutionary chronological trends. In stratigraphic levels at the top deposits of T4, Middle Paleolithic industries have been found and probably date as ca. 165 to 155 ka. In the context of the human settlements of the Middle Pleistocene recognized on the terraces of the Tagus River in Portugal, most of the sites mentioned here in detail, contained in sedimentary deposits of the T4 Terrace and with a chronology of ca. 340 ka to ca. 220 ka, belong to the Lower Paleolithic. The data currently available seem to suggest the possibility of some variability in the lithic industries, if we consider sites with bifaces and hand axes, such as those of Monte Famaco and Vale do Forno (VF1 and VF8), with bifaces, but without axes as in Castelo Velho, to the sites of Fonte da Moita and Ribeira da Ponte da Pedra, where there are industries rich in fine pebbles and rare bifacial pieces. However, it should be pointed out that the specific reality of each of these sites is not comparable with the rest. In fact, this variability is further accentuated when the cave sites of the Almonda spring are introduced into the equation. The correlation of the already known results and the ones to be obtained in the future with the reality of other regions and with other contexts also already identified in the region, as is the case of the recent findings in karst cavities will not fail to enrich the discussion about the variability of the data known
Effects of Energy Cane (<i>Saccharum</i> spp.) Juice on Corn Ethanol (<i>Zea mays</i>) Fermentation Efficiency: Integration towards a More Sustainable Production
Despite being considered renewable, corn (Zea mays) ethanol still generates much debate over the use of fossil fuels in its production and is considered less sustainable than sugarcane (Saccharum spp.) ethanol. In Brazil, corn ethanol is starting to be produced in the Center-West and is expected to increase with the RenovaBio, a promising policy for biofuels adoption. In this context, energy cane (Saccharum spp.) is a biomass crop with high yields that can provide bagasse to supply the energy demand of the corn ethanol industry and provide juice with about 10% sugar content. However, the effects of introducing its juice in the production process are unknown. For these reasons, the objective of this study was to assess the effects of adding energy cane juice in corn ethanol production. Energy cane juice brings several advantages: (i) It provides sugars that can reduce by almost 50% the amount of corn and enzymes used, (ii) reduces the amount of water needed for ethanol production, and (iii) increases significantly the fermentation efficiency from 86.4% to 90.8% by providing minerals that support yeast growth. Therefore, energy cane can be integrated into the corn ethanol production process, making the fermentation more efficient and the production systems more sustainable
Wells and Geneva decision rules to predict pulmonary embolism: can we use them in Covid-19 patients?
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2021. For permissions please email: [email protected]. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)Pulmonary embolism (PE) is a recognized complication of SARS-COV2 infection due to hypercoagulability. Before the COVID era, the need for computed tomography pulmonary angiography (CTPA) to rule out PE was determined by clinical probability, based on Wells and Geneva scores, in association with D-dimer measurements. However, patients with SARS-COV2 infection have a pro-thrombotic and pro-inflammatory state which may compromise the usefulness of these algorithms to select patients for CTPA.info:eu-repo/semantics/publishedVersio
5 Propuestas para el dossier de pre-selección de la Candidatura de Córdoba 2016
Recopilación de las cinco propuestas que el Laboratorio de Urbanismo y Ordenación del Territorio de la Universidadd e Granada presentó al Concurso de preselección de propuestas para su incorporación al dossier de preselección de la candidatura Córdoba 2016 para ser Capital Cultural Europea. Se presentaron las siguientes propuestas:"Tres INTINERARIOS metroPOLITANOS y un PARQUE del GuadalQUIVIR", "Córdoba en Río", "Córdoba en proceso", "Marca-Ciudad", "Interferencias2016. A través del espejo", siendo "Córdoba en Río" seleccionada para su incorporación en el citado dossier
iBox-CRT : better response, less complicated, equally fast
Copyright © 2019 Oxford University PressIntroduction: The optimization of the left ventricle (LV) pacing site guided by the electrical delay increases CRT response rate (RR), however it’s necessary to develop technology that allows its universal use. Purpose: The aim is automatically, and operator-independent, access the conduction delay between the right ventricular (RV) stimulus and the LV available veins in order to select the LV pacing site. It is further intended to compare the total procedure and radiation times in relation to an historical control group.info:eu-repo/semantics/publishedVersio
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