Bifurcation gaps in asymmetric and high-dimensional hypercycles

Hypercycles are catalytic systems with cyclic architecture. These systems have been suggested to play a key role in the maintenance and increase of information in prebiotic replicators. It is known that for a large enough number of hypercycle species (n>4 the coexistence of all hypercycle members is governed by a stable periodic orbit. Previous research has characterized saddle-node (s-n) bifurcations involving abrupt transitions from stable hypercycles to extinction of all hypercycle members, or, alternatively, involving the outcompetition of the hypercycle by so-called mutant sequences or parasites. Recently, the presence of a bifurcation gap between a s-n bifurcation of periodic orbits and a s-n of fixed points has been described for symmetric five-member hypercycles. This gap was found between the value of the replication quality factor Q from which the periodic orbit vanishes (QPO)and the value where two unstable (nonzero) equilibrium points collide (QSS). Here, we explore the persistence of this gap considering asymmetries in replication rates in five-member hypercycles as well as considering symmetric, larger hypercycles. Our results indicate that both the asymmetry in Malthusian replication constants and the increase in hypercycle members enlarge the size of this gap. The implications of this phenomenon are discussed in the context of delayed transitions associated to the so-called saddle remnants. Read More: https://www.worldscientific.com/doi/abs/10.1142/S021812741830001X Read More: https://www.worldscientific.com/doi/abs/10.1142/S021812741830001XPeer ReviewedPreprin

Individual differences in control of language interference in late bilinguals are mainly related to general executive abilities

Background: Recent research based on comparisons between bilinguals and monolinguals postulates that bilingualism enhances cognitive control functions, because the parallel activation of languages necessitates control of interference. In a novel approach we investigated two groups of bilinguals, distinguished by their susceptibility to cross-language interference, asking whether bilinguals with strong language control abilities ('non-switchers") have an advantage in executive functions (inhibition of irrelevant information, problem solving, planning efficiency, generative fluency and self-monitoring) compared to those bilinguals showing weaker language control abilities ('switchers"). Methods: 29 late bilinguals (21 women) were evaluated using various cognitive control neuropsychological tests [e.g., Tower of Hanoi, Ruff Figural Fluency Task, Divided Attention, Go/noGo] tapping executive functions as well as four subtests of the Wechsler Adult Intelligence Scale. The analysis involved t-tests (two independent samples). Non-switchers (n = 16) were distinguished from switchers (n = 13) by their performance observed in a bilingual picture-naming task. Results: The non-switcher group demonstrated a better performance on the Tower of Hanoi and Ruff Figural Fluency task, faster reaction time in a Go/noGo and Divided Attention task, and produced significantly fewer errors in the Tower of Hanoi, Go/noGo, and Divided Attention tasks when compared to the switchers. Non-switchers performed significantly better on two verbal subtests of the Wechsler Adult Intelligence Scale (Information and Similarity), but not on the Performance subtests (Picture Completion, Block Design). Conclusions: The present results suggest that bilinguals with stronger language control have indeed a cognitive advantage in the administered tests involving executive functions, in particular inhibition, self-monitoring, problem solving, and generative fluency, and in two of the intelligence tests. What remains unclear is the direction of the relationship between executive functions and language control abilities

Determinantes push e pull do prêmio de risco-país para economias emergentes: uma avaliação econométrica

This article aims to identify the main determinants of the country risk premiums CDS 5 Years and EMBI+ for eight emerging economies. Econometric estimations relied on autoregressive GMM (time series) and GMM-DIFF (panel data). The analysis period is 2003-2019 and depends on the country and the data availability (monthly and quarterly data). We have tested push (exogenous) and pull (country-specifics) regressors. The empirical results have shown that some push factors have significant effects, which indicates that the global financial and trade cycles play an essential role in determining emerging country risk premiums. However, those economies may mitigate global influences through some internal macroeconomic policies. In our models, the international reserves stock growth rate was the primary statistically significant pull variable, highlighting the importance of external sound accounts for emerging countries.Este artigo tem como objetivo identificar os principais determinantes dos prêmios de risco-país CDS 5 Anos e EMBI+ de uma amostra de oito economias emergentes. As estimativas econométricas basearam-se em modelos GMM autorregressivos (séries temporais) e GMM-DIFF (dados em painel). O período de análise, a depender do país e da disponibilidade de dados, é de 2003 a 2019 (dados mensais e trimestrais). Foram testadas variáveis explicativas do tipo push (exógenas) e do tipo pull (específicas dos países). Os resultados empíricos demonstraram que alguns fatores push têm efeitos significantes, o que indica que os ciclos financeiros e comerciais globais têm importante papel para a determinação dos prêmios de risco-país emergentes. Todavia, essas economias podem mitigar influências globais através de políticas macroeconômicas internas. A principal variável do tipo pull foi a taxa de crescimento do estoque de reservas internacionais, o que destaca a importância de sólidas contas externas para as economias emergentes

Loneliness among surgical patients - measuring levels of loneliness using De Jong Gierveld Loneliness Scale and Revised UCLA Loneliness Scale

Objective: Loneliness is a state that most people will experience during their lifetime. In order to raise awareness of loneliness and its complexity, we attempted to measure the span of loneliness among the surgical patients hospitalized in the Department of Surgery in the 4th Military Teaching Hospital in Wroclaw.  The aim of this study was to establish correlations between loneliness, measured using and four other variables: age, gender, nutritional state and quality of life of surveyed patients. Material and methods: A total of 100 patients in the Surgery Department in the 4 th Military Teaching Hospital in Wroclaw, Poland, were enrolled.  The Mini-Nutritional Assessment (MNA) questionnaire was used to assess their nutritional status; the World Health Organization Quality of Life Scale (WHO-QoL-BREF) was used to assess their quality of life; the De Jong Gierveld Loneliness Scale (DJGLS) and Revised UCLA Loneliness Scale (R-UCLA) were used to assess their loneliness level. Results:The WHO-QoL-BREF showed that patients’ quality of life (QoL) self-perception was between average and good, health self-perception was average as well. Lowest score of QoL was found in the physical domain whereas the highest was found in the social domain. The MNA showed that 8% of the study group was malnourished, 49% at risk of malnutrition and 43% displayed a normal nutritional status. 49% of the study group experience loneliness during study by DJGLS. A significant positive correlation between loneliness status and QoL was observed in physical health self-perception (r=0,226, p=0,024). Negative correlation was found between loneliness and QoL in psychological, social and environmental domains (p<0,001).   Conclusions: Loneliness has a significant negative impact on the quality of life.Sex, age and nutritional status can not be predictors of patient’s loneliness. More than half of patients were in a disturbing nutrition state. &nbsp

Management of Motion and Anatomical Variations in Charged Particle Therapy:Past, Present, and Into the Future

The major aim of radiation therapy is to provide curative or palliative treatment to cancerous malignancies while minimizing damage to healthy tissues. Charged particle radiotherapy utilizing carbon ions or protons is uniquely suited for this task due to its ability to achieve highly conformal dose distributions around the tumor volume. For these treatment modalities, uncertainties in the localization of patient anatomy due to inter- and intra-fractional motion present a heightened risk of undesired dose delivery. A diverse range of mitigation strategies have been developed and clinically implemented in various disease sites to monitor and correct for patient motion, but much work remains. This review provides an overview of current clinical practices for inter and intra-fractional motion management in charged particle therapy, including motion control, current imaging and motion tracking modalities, as well as treatment planning and delivery techniques. We also cover progress to date on emerging technologies including particle-based radiography imaging, novel treatment delivery methods such as tumor tracking and FLASH, and artificial intelligence and discuss their potential impact towards improving or increasing the challenge of motion mitigation in charged particle therapy

Effects of hydrostatic pressure on the magnetism and martensitic transition of Ni-Mn-In magnetic superelastic alloys

We report magnetization and differential thermal analysis measurements as a function of pressure accross the martensitic transition in magnetically superelastic Ni-Mn-In alloys. It is found that the properties of the martensitic transformation are significantly affected by the application of pressure. All transition temperatures shift to higher values with increasing pressure. The largest rate of temperature shift with pressure has been found for Ni$_{50}$Mn$_{34}$In$_{16}$ as a consequence of its small entropy change at the transition. Such a strong pressure dependence of the transition temperature opens up the possibility of inducing the martensitic transition by applying relatively low hydrostatic pressures.Comment: 3 pages, 3 figures. Accepted for publication in Applied Physics Letter

Self-Assessment of Individual Differences in Language Switching

Language switching is omnipresent in bilingual individuals. In fact, the ability to switch languages (code switching) is a very fast, efficient, and flexible process that seems to be a fundamental aspect of bilingual language processing. In this study, we aimed to characterize psychometrically self-perceived individual differences in language switching and to create a reliable measure of this behavioral pattern by introducing a bilingual switching questionnaire. As a working hypothesis based on the previous literature about code switching, we decomposed language switching into four constructs: (i) L1 switching tendencies (the tendency to switch to L1; L1-switch); (ii) L2 switching tendencies (L2-switch); (iii) contextual switch, which indexes the frequency of switches usually triggered by a particular situation, topic, or environment; and (iv) unintended switch, which measures the lack of intention and awareness of the language switches. A total of 582 Spanish–Catalan bilingual university students were studied. Twelve items were selected (three for each construct). The correlation matrix was factor-analyzed using minimum rank factor analysis followed by oblique direct oblimin rotation. The overall proportion of common variance explained by the four extracted factors was 0.86. Finally, to assess the external validity of the individual differences scored with the new questionnaire, we evaluated the correlations between these measures and several psychometric (language proficiency) and behavioral measures related to cognitive and attentional control. The present study highlights the importance of evaluating individual differences in language switching using self-assessment instruments when studying the interface between cognitive control and bilingualism

Phonetic Skills and Verbal Memory Capacity Predict Phonetic-based Word Learning: An Event-related Potential Study

The learning of new words is a challenge that accompanies human beings throughout the entire life span. Although the main electrophysiological markers of word learning have already been described, little is known about the performance-dependent neural machinery underlying this exceptional human faculty. Furthermore, it is currently unknown how word learning abilities are related to verbal memory capacity, auditory attention functions, phonetic discrimination skills, and musicality. Accordingly, we used EEG and examined 40 individuals, who were assigned to two groups (low [LPs] and high performers [HPs]) based on a median split of word learning performance, while they completed a phonetic-based word learning task. Furthermore, we collected behavioral data during an attentive listening and a phonetic discrimination task with the same stimuli to address relationships between auditory attention and phonetic discrimination skills, word learning performance, and musicality. The phonetic-based word learning task, which also included a nonlearning control condition, was sensitive enough to segregate learning-specific and unspecific N200/N400 manifestations along the anterior-posterior topographical axis. Notably, HPs exhibited enhanced verbal memory capacity and we also revealed a performance-dependent spatial N400 pattern, with maximal amplitudes at posterior electrodes in HPs and central maxima in LPs. Furthermore, phonetic-based word learning performance correlated with verbal memory capacity and phonetic discrimination skills, whereas the latter was related to musicality. This experimental approach clearly highlights the multifaceted dimensions of phonetic-based word learning and is helpful to disentangle learning-specific and unspecific ERPs

Economic Beliefs and Party Preference

VIII Congreso Iberoamericano de Nutrición. ¿Nutrición basada en la videncia o en la evidencia

Factors associated with mechanical ventilation longer than 24 h after liver transplantation in patients at risk for bleeding

Background: This risk analysis aimed to explore all modifiable factors associated with prolonged mechanical ventilation (lasting > 24 h) after liver transplantation, based on prospectively collected data from a clinical trial.Methods: We evaluated 306 candidates. Ninety-three patients were excluded for low risk for transfusion (preoperative haemoglobin > 130 g.l(-1)), and 31 patients were excluded for anticoagulation therapy, bleeding disorders, familial polyneuropathy, or emergency status. Risk factors were initially identified with a log-binomial regression model. Relative risk was then calculated and adjusted for age, sex, and disease severity (Model for End-Stage Liver Disease [MELD] score).Results: Early tracheal extubation was performed in 149 patients (84.7%), and 27 patients (15.3%) required prolonged mechanical ventilation. Reoperations were required for 6.04% of the early extubated patients and 44% of patients who underwent prolonged ventilation (p = 0.001). A MELD score > 23 was the main risk factor for prolonged ventilation. Once modifiable risk factors were adjusted for MELD score, sex, and age, three factors were significantly associated with prolonged ventilation: tranexamic acid (p = 0.007) and red blood cell (p = 0.001) infusion and the occurrence of postreperfusion syndrome (p = 0.004). The median (IQR) ICU stay was 3 (2-4) days in the early extubation group vs. 5 (3-10) days in the prolonged ventilation group (p = 0.001). The median hospital stay was also significantly shorter after early extubation, at 14 (10-24) days, vs. 25 (14-55) days in the prolonged ventilation group (p = 0.001). Eight patients in the early-extubation group (5.52%) were readmitted to the ICU, nearly all for reoperations, with no between-group differences in ICU readmissions (prolonged ventilation group, 3.7%).Conclusion: We conclude that bleeding and postreperfusion syndrome are the main modifiable factors associated with prolonged mechanical ventilation and length of ICU stay, suggesting that trials should explore vasopressor support strategies and other interventions prior to graft reperfusion that might prevent potential fibrinolysis