What is in a radio loud NLS1?

A fraction of Narrow Line Seyfert 1 galaxies (NLS1) are hosted by galaxies that present a disturbed morphology, in some cases hinting for merger processes, that are putative sources of gas replenishment. We have been investigating the poorly studied population of radio loud NLS1 (RL-NLS1) showing a flat radio spectrum, assumed to be the manifestation of the presence of a radio jet. In some of the objects the infrared emission is well fitted by a combination of an AGN component and an "active" host galaxy component like M82, the estimate SFR being in the LIRG/ULIRG range (10-500 Msun/year). In order to better characterize that component, we have been investigating the sub-millimeter/millimeter emission of the sources using APEX. Here we present the results concerning a pilot sample of 2 representative objects.Comment: 5 pages, published on Proceedings of Science - volume "Revisiting narrow-line Seyfert 1 galaxies and their place in the Universe

Investigation of dissimilar metal welds by energy-resolved neutron imaging

A nondestructive study of the internal structure and compositional gradient of dissimilar metal-alloy welds through energy-resolved neutron imaging is described in this paper. The ability of neutrons to penetrate thick metal objects (up to several cm) provides a unique possibility to examine samples which are opaque to other conventional techniques. The presence of Bragg edges in the measured neutron transmission spectra can be used to characterize the internal residual strain within the samples and some microstructural features, e.g. texture within the grains, while neutron resonance absorption provides the possibility to map the degree of uniformity in mixing of the participating alloys and intermetallic formation within the welds. In addition, voids and other defects can be revealed by the variation of neutron attenuation across the samples. This paper demonstrates the potential of neutron energy-resolved imaging to measure all these characteristics simultaneously in a single experiment with sub-mm spatial resolution. Two dissimilar alloy welds are used in this study: Al autogenously laser welded to steel, and Ti gas metal arc welded (GMAW) to stainless steel using Cu as a filler alloy. The cold metal transfer variant of the GMAW process was used in joining the Ti to the stainless steel in order to minimize the heat input. The distributions of the lattice parameter and texture variation in these welds as well as the presence of voids and defects in the melt region are mapped across the welds. The depth of the thermal front in the Al–steel weld is clearly resolved and could be used to optimize the welding process. A highly textured structure is revealed in the Ti to stainless steel joint where copper was used as a filler wire. The limited diffusion of Ti into the weld region is also verified by the resonance absorption

Passive nonlinear pulse shaping in normally dispersive fiber systems

We propose a novel approach to characterize the parabolically-shaped pulses that can be generated from more conventional pulses via nonlinear propagation in cascaded sections of commercially available normally dispersive (ND) fibers. The impact of the initial pulse chirp on the passive pulse reshaping is examined. We furthermore demonstrate that the combination of pulse pre-chirping and propagation in a single ND fiber yields a simple, passive method for generating various temporal waveforms of practical interest

Pengaruh Biaya Kualitas terhadap Laba Bersih Perusahaan (Studi Kasus pada PT. Pindad (Persero)

This study aimed to get a picture of the quality costs incurred by the company, Net Income has been achieved and how much influence the cost of the quality of the Net Income that has been achieved by PT. PINDAD (Persero). In this study, there are two variables: the cost of quality (X) and the Corporate Net Income (Y). Quality costs consist of costs of prevention and appraisal costs. In this study the authors used an explanatory research methods, the research to explain the causal relationship between variables through hypothesis testing, so in this study collected data taken from company documents in the form of quantitative data. The design was correlational research design that aims to discover whether there is any relationship between variables and, if so, how close relationship as well as the means or not the relationship. The population in this study is the cost of quality and earnings quality issued by PT. PINDAD (Persero) in the Division of Wrought and Cast for a wide range of commercial and non-commercial products. The sampling technique used is the technique of Non-Probability Sampling through purposive sampling form, thus obtained 38 samples which are orders product orders Impeller Material 125 JB 2002 to 2009. The technique of collecting data through field studies (interviews, observations), and the research literature . Based on the data that has been obtained, the next writer process these data using Pearson Product Moment (PPM) and the coefficient determinant (KP). Of processing the data obtained correlation coefficient of quality costs to net income of the value of r = 0.883. Interpretation of the value of the correlation coefficient in the high category / very strong and positive, meaning that the cost of quality with net income are high relationship / very strong and the direction of the relationship is positive. If the cost of quality, the greater the greater the net profit achieved and vice versa if the smaller the cost of quality then the smaller the net profit achieved. While the magnitude of the effect on net income of quality costs or the coefficient determinant is equal to 78.0% and the remaining 22.0% is influenced by other factors

Doubling of optical signals using triangular pulses

We propose a novel technique of doubling optical pulses in both frequency and time domains based on a combination of cross-phase modulation induced by a triangular pump pulse in a nonlinear Kerr medium and subsequent propagation in a dispersive medium

spongeScan: A web for detecting microRNA binding elements in lncRNA sequences.

Non-coding RNA transcripts such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are important genetic regulators. However, the functions of many of these transcripts are still not clearly understood. Recently, it has become apparent that there is significant crosstalk between miRNAs and lncRNAs and that this creates competition for binding between the miRNA, a lncRNA and other regulatory targets. Indeed, various competitive endogenous RNAs (ceRNAs) have already been identified where a lncRNA acts by sequestering miRNAs. This implies the down-regulation in the interaction of the miRNAs with their mRNA targets, what has been called a sponge effect. Multiple approaches exist for the prediction of miRNA targets in mRNAs. However, few methods exist for the prediction of miRNA response elements (MREs) in lncRNAs acting as ceRNAs (sponges). Here, we present spongeScan (http://spongescan.rc.ufl.edu), a graphical web tool to compute and visualize putative MREs in lncRNAs, along with different measures to assess their likely behavior as ceRNAs

Efecto de las heladas sobre la capacidad germinativa de bellotas de encina

Un aspecto clave para lograr la regeneración de dehesas y montes bajos, los sistemas más extensos de aprovechamiento de la encina en España, son las características fisiológicas de la bellota. Se analizó la capacidad germinativa de bellotas procedentes de 15 encinas (familias) en dehesa y 15 familias en monte bajo de la misma finca, tras someterlas en laboratorio a heladas de distinta intensidad (-3ºC, -6ºC, -9ºC, -12ºC, -15ºC). Las bellotas procedentes de dehesa tuvieron una capacidad germinativa menor y con mayor variabilidad entre familias, aunque heladas incluso moderadas (-6ºC) afectaron en mayor medida a la germinación de las bellotas de montes bajos, si bien la reducción fue ya generalizada (60% en todas las familias); tras la exposición a -12ºC o inferior, la germinación fue residual en todos los casos. Se concluye que bajas temperaturas son un factor limitante para la regeneración de la encina en el interior de la península Ibérica

Real-World Health Care Outcomes and Costs Among Patients With Juvenile Idiopathic Arthritis in Spain

Direct cost; Family impact; Juvenile arthritisCost directe; Impacte familiar; Artritis juvenilCoste directo; Impacto familiar; Artritis juvenilBackground: Juvenile idiopathic arthritis (JIA) is the most frequent chronic rheumatic disease in children. If inflammation is not adequately treated, joint damage, long-term disability, and active disease during adulthood can occur. Identifying and implementing early and adequate therapy are critical for improving clinical outcomes. The burden of JIA on affected children, their families, and the healthcare system in Spain has not been adequately assessed. The greatest contribution to direct costs is medication, but other expenses contribute to the consumption of resources, negatively impacting healthcare cost and the economic conditions of affected families. Objective: To assess the direct healthcare, indirect resource utilization, and associated cost of moderate-to-severe JIA in children in routine clinical practice in Spain. Methods: Children were enrolled in this 24-month observational, multicentric, cross-sectional, retrospective study (N = 107) if they had been treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs), had participated in a previous study (ITACA), and continued to be followed up at pediatric rheumatology units at 3 tertiary Spanish hospitals. Direct costs included medication, specialist and primary care visits, hospitalizations, emergency visits or consultations, surgeries, physiotherapy, and tests. Indirect costs included hospital travel expenses and loss of caregiver working hours. Unitary costs were obtained from official sources (€, 2020). Results: Overall, children had inactive disease/low disease activity according to JADAS-71 score and very low functional disability as measured by Childhood Health Assessment Questionnaire score. Up to 94.4% of children received treatment, mainly with bDMARDs as monotherapy (84.5%). Among anti-TNFα treatments, adalimumab (47.4%) and etanercept (40.2%) were used in similar proportions. Annual mean (SD) total JIA cost was €7516.40 (€5627.30). Average cost of pharmacological treatment was €3021.80 (€3956.20), mainly due to biologic therapy €2789.00 (€3399.80). Direct annual cost (excluding treatments) was €3654.60 (€3899.00). Indirect JIA cost per family was €747.20 (€1452.80). Conclusion: JIA causes significant costs to the Spanish healthcare system and affected families. Public costs are partly due to the high cost of biologic treatments, which nevertheless remain an effective long-term treatment, maintaining inactive disease/low disease activity state; a very low functional disability score; and a good quality of life

Pengaruh Biaya Kualitas Terhadap Laba Bersih Perusahaan (Studi Kasus Pada PT. Pindad (Persero)

This study aimed to get a picture of the quality costs incurred by the company, Net Income has been achieved and how much influence the cost of the quality of the Net Income that has been achieved by PT. PINDAD (Persero). In this study, there are two variables: the cost of quality (X) and the Corporate Net Income (Y). Quality costs consist of costs of prevention and appraisal costs.�������������� In this study the authors used an explanatory research methods, the research to explain the causal relationship between variables through hypothesis testing, so in this study collected data taken from company documents in the form of quantitative data. The design was correlational research design that aims to discover whether there is any relationship between variables and, if so, how close relationship as well as the means or not the relationship.�������������� The population in this study is the cost of quality and earnings quality issued by PT. PINDAD (Persero) in the Division of Wrought and Cast for a wide range of commercial and non-commercial products. The sampling technique used is the technique of Non-Probability Sampling through purposive sampling form, thus obtained 38 samples which are orders product orders Impeller Material 125 JB 2002 to 2009. The technique of collecting data through field studies (interviews, observations), and the research literature . Based on the data that has been obtained, the next writer process these data using Pearson Product Moment (PPM) and the coefficient determinant (KP).�������������� Of processing the data obtained correlation coefficient of quality costs to net income of the value of r = 0.883. Interpretation of the value of the correlation coefficient in the high category / very strong and positive, meaning that the cost of quality with net income are high relationship / very strong and the direction of the relationship is positive. If the cost of quality, the greater the greater the net profit achieved and vice versa if the smaller the cost of quality then the smaller the net profit achieved. While the magnitude of the effect on net income of quality costs or the coefficient determinant is equal to 78.0% and the remaining 22.0% is influenced by other factors.�Keywords: quality costs; net profi

Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: a systematic review and meta-analysis

Background: Hypertension and proteinuria are critically involved in the progression of chronic kidney disease. Despite treatment with renin angiotensin system inhibition, kidney function declines in many patients. Aldosterone excess is a risk factor for progression of kidney disease. Hyperkalaemia is a concern with the use of mineralocorticoid receptor antagonists. We aimed to determine whether the renal protective benefits of mineralocorticoid antagonists outweigh the risk of hyperkalaemia associated with this treatment in patients with chronic kidney disease. Methods: We conducted a meta-analysis investigating renoprotective effects and risk of hyperkalaemia in trials of mineralocorticoid receptor antagonists in chronic kidney disease. Trials were identified from MEDLINE (1966–2014), EMBASE (1947–2014) and the Cochrane Clinical Trials Database. Unpublished summary data were obtained from investigators. We included randomised controlled trials, and the first period of randomised cross over trials lasting ≥4 weeks in adults. Results: Nineteen trials (21 study groups, 1 646 patients) were included. In random effects meta-analysis, addition of mineralocorticoid receptor antagonists to renin angiotensin system inhibition resulted in a reduction from baseline in systolic blood pressure (−5.7 [−9.0, −2.3] mmHg), diastolic blood pressure (−1.7 [−3.4, −0.1] mmHg) and glomerular filtration rate (−3.2 [−5.4, −1.0] mL/min/1.73 m2). Mineralocorticoid receptor antagonism reduced weighted mean protein/albumin excretion by 38.7 % but with a threefold higher relative risk of withdrawing from the trial due to hyperkalaemia (3.21, [1.19, 8.71]). Death, cardiovascular events and hard renal end points were not reported in sufficient numbers to analyse. Conclusions: Mineralocorticoid receptor antagonism reduces blood pressure and urinary protein/albumin excretion with a quantifiable risk of hyperkalaemia above predefined study upper limit