A novel ion channel formed by interaction of TRPML3 with TRPV5.

TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore forming domains of TRPML and TRPV5/TRPV6 channels have similarities that indicate possible functional interactions between these TRP channel subfamilies. Here we show that TRPML3 and TRPV5 associate to form a novel heteromeric ion channel. This novel conductance is detectable under conditions that do not activate either TRPML3 or TRPV5. It has pharmacological similarity with TRPML3 and requires functional TRPML3 as well as functional TRPV5. Single channel analyses revealed that TRPML3 and TRPV5 heteromers have different features than the respective homomers, and furthermore, that they occur in potentially distinct stoichiometric configurations. Based on overlapping expression of TRPML3 and TRPV5 in the kidney and the inner ear, we propose that TRPML3 and TRPV5 heteromers could have a biological function in these organs

Weight loss and competition weight in Ultimate Fighting Championship (UFC) athletes

Previous research has demonstrated that professional mixed martial arts (MMA) athletes employ a variety of weight manipulation strategies to compete at given weight classes. Although there is much literature demonstrating weight manipulation methods, minimal research exists analyzing how much weight MMA athletes lose prior to the official weigh-in. Moreover, there is minimal research examining how much weight professional MMA athletes gain between the official weigh-in and competition. Therefore, the purpose of the current study was to analyze weight loss/regain in professional MMA athletes. Data collected from 616 professional MMA athletes (31.1 ± 4.0 yrs. ; 177.1 ± 4.7 cm) competing for the Ultimate Fighting Championship (UFC) between 2020 and 2022 were used for the study. The athlete’s weight was obtained 72 h, 48 h, and 24 h prior to the official weigh-in, at the official weigh-in, and prior to competition. Random effects analysis was utilized to compare weight at a variety of time points between different weight classes. All statistics were analyzed, and significance was set at p ≤ 0.05. There is a significant (p ≤ 0.05) difference between weight classes and time points in professional MMA. MMA athletes decrease body weight significantly prior to the official weigh-in. MMA athletes increase body weight significantly between official weigh-in and competition. Based on these data, it appears that MMA athletes average a weight loss of nearly 7 % within 72 h prior to the official weigh-in. The data also suggest that athletes gain nearly 10 % of total weight between the official weigh-in and competition

Building a patient safety toolkit for use in general practice

Despite 340 000 000 primary care consultations annually in the UK, most of the literature on patient safety has focused on hospital-based services. To improve safety in primary care settings, we must know what methods, tools and indicators are available to measure and monitor patient safety. In collaboration with patient safety experts at the University of Dundee, we were able to identify a number of existing tools, and many of these were adopted for use in the Patient Safety Toolkit

Overcoming the barriers to implementing urban road user charging schemes

Urban road user charging offers the potential to achieve significant improvements in urban transport, but is notoriously difficult to implement. Cities need guidance on the range of factors to be considered in planning and implementing such schemes. This paper summarises the results of a 3 year programme which has collated evidence on the issues of most concern to cities. A state of the art report has provided evidence on 14 themes, ranging from objectives and design to implementation and evaluation. A set of 16 case studies has reviewed experience in design and implementation across Europe. The paper summarises their findings, provides references to more detailed information, presents the resulting policy recommendations to European, national and local government, and outlines the areas in which further research is needed

MOST Spacebased Photometry of the Transiting Exoplanet System HD 189733: Precise Timing Measurements for Transits Across an Active Star

We have measured transit times for HD 189733b passing in front of its bright (V = 7.67) chromospherically active and spotted parent star. Nearly continuous broadband optical photometry of this system was obtained with the MOST (Microvariability & Oscillations of STars) space telescope during 21 days in August 2006, monitoring 10 consecutive transits. We have used these data to search for deviations from a constant orbital period which can indicate the presence of additional planets in the system that are as yet undetected by Doppler searches. There are no transit timing variations above the level of ${\pm}45$ s, ruling out super-Earths (of masses 1 - 4 M_{\earth}) in the 1:2 and 2:3 inner resonances and planets of 20 M_{\earth} in the 2:1 outer resonance of the known planet. We also discuss complications in measuring transit times for a planet that transits an active star with large star spots, and how the transits can help constrain and test spot models. This has implications for the large number of such systems expected to be discovered by the CoRoT and Kepler missions.Comment: 26 pages, 7 figures, accepted to Ap

MOST Spacebased Photometry of the Transiting Exoplanet System HD 209458: Transit Timing to Search for Additional Planets

We report on the measurement of transit times for the HD 209458 planetary system from photometry obtained with the MOST (Microvariability & Oscillations of STars) space telescope. Deviations from a constant orbital period can indicate the presence of additional planets in the system that are yet undetected, potentially with masses approaching an Earth mass. The MOST data sets of HD 209458 from 2004 and 2005 represent unprecedented time coverage with nearly continuous observations spanning 14 and 43 days and monitoring 3 transits and 12 consecutive transits, respectively. The transit times we obtain show no variations on three scales: (a) no long-term change in P since before 2004 at the 25 ms level, (b) no trend in transit timings during the 2005 run, and (c) no individual transit timing deviations above 80 sec level. Together with previously published transit times from Agol & Steffen (2007), this allows us to place limits on the presence of additional close-in planets in the system, in some cases down to below an Earth mass. This result, along with previous radial velocity work, now eliminates the possibility that a perturbing planet could be responsible for the additional heat source needed to explain HD 209458b's anomalous low density.Comment: 21 pages, 6 figures, accepted to the Ap

A Plan to Facilitate the Early Career Development of Minority Scholars in the Health Sciences

http://dx.doi.org/10.1080/1937191100374817

Hydrogeology of Stromboli volcano, Aeolian Islands (Italy) from the interpretation of resistivity tomograms, self-potential, soil temperature and soil CO2 concentration measurements

International audienceTo gain a better insight of the hydrogeology and the location of the main tectonic faults of Stromboli volcano in Italy, we collected electrical resistivity measurements, soil CO2 concentrations, temperature and self-potential measurements along two profiles. These two profiles started at the village of Ginostra in the southwest part of the island. The first profile (4.8 km in length) ended up at the village of Scari in the north east part of the volcano and the second one (3.5 km in length) at Forgia Vecchia beach, in the eastern part of the island. These data were used to provide insights regarding the position of shallow aquifers and the extension of the hydrothermal system. This large-scale study is complemented by two high-resolution studies, one at the Pizzo area (near the active vents) and one at Rina Grande where flank collapse areas can be observed. The Pizzo corresponds to one of the main degassing structure of the hydrothermal system. The main degassing area is localized along a higher permeability area corresponding to the head of the gliding plane of the Rina Grande sector collapse. We found that the self-potential data reveal the position of an aquifer above the villages of Scari and San Vincenzo. We provide an estimate of the depth of this aquifer from these data. The lateral extension of the hydrothermal system (resistivity ∼15-60 ohm m) is broader than anticipated extending in the direction of the villages of Scari and San Vincenzo (in agreement with temperature data recorded in shallow wells). The lateral extension of the hydrothermal system reaches the lower third of the Rina Grande sector collapse area in the eastern part of the island. The hydrothermal body in this area is blocked by an old collapse boundary. This position of the hydrothermal body is consistent with low values of the magnetization (<2.5 A m−1) from previously published work. The presence of the hydrothermal body below Rina Grande raises questions about the mechanical stability of this flank of the edifice

Deuteron Electroweak Disintegration

We study the deuteron electrodisintegration with inclusion of the neutral currents focusing on the helicity asymmetry of the exclusive cross section in coplanar geometry. We stress that a measurement of this asymmetry in the quasi elastic region is of interest for an experimental determination of the weak form factors of the nucleon, allowing one to obtain the parity violating electron neutron asymmetry. Numerically, we consider the reaction at low momentum transfer and discuss the sensitivity of the helicity asymmetry to the strangeness radius and magnetic moment. The problems coming from the finite angular acceptance of the spectrometers are also considered.Comment: 30 pages, Latex, 7 eps figures, submitted to Phys.Rev.C e-mail: [email protected] , [email protected]