Executive Summary: Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of Americaa

These guidelines are intended for use by infectious disease specialists, orthopedists, and other healthcare professionals who care for patients with prosthetic joint infection (PJI). They include evidence-based and opinion-based recommendations for the diagnosis and management of patients with PJI treated with debridement and retention of the prosthesis, resection arthroplasty with or without subsequent staged reimplantation, 1-stage reimplantation, and amputatio

Bone and joint infections in adults: a comprehensive classification proposal

Ten currently available classifications were tested for their ability to describe a continuous cohort of 300 adult patients affected by bone and joint infections. Each classification only focused, on the average, on 1.3\u2009\ub1\u20090.4 features of a single clinical condition (osteomyelitis, implant-related infections, or septic arthritis), being able to classify 34.8\u2009\ub1\u200924.7% of the patients, while a comprehensive classification system could describe all the patients considered in the study. RESULT AND CONCLUSION: A comprehensive classification system permits more accurate classification of bone and joint infections in adults than any single classification available and may serve for didactic, scientific, and clinical purposes

Oral versus intravenous antibiotics for bone and joint infection

BACKGROUND The management of complex orthopedic infections usually includes a prolonged course of intravenous antibiotic agents. We investigated whether oral antibiotic therapy is noninferior to intravenous antibiotic therapy for this indication. METHODS We enrolled adults who were being treated for bone or joint infection at 26 U.K. centers. Within 7 days after surgery (or, if the infection was being managed without surgery, within 7 days after the start of antibiotic treatment), participants were randomly assigned to receive either intravenous or oral antibiotics to complete the first 6 weeks of therapy. Follow-on oral antibiotics were permitted in both groups. The primary end point was definitive treatment failure within 1 year after randomization. In the analysis of the risk of the primary end point, the noninferiority margin was 7.5 percentage points. RESULTS Among the 1054 participants (527 in each group), end-point data were available for 1015 (96.3%). Treatment failure occurred in 74 of 506 participants (14.6%) in the intravenous group and 67 of 509 participants (13.2%) in the oral group. Missing end-point data (39 participants, 3.7%) were imputed. The intention-to-treat analysis showed a difference in the risk of definitive treatment failure (oral group vs. intravenous group) of −1.4 percentage points (90% confidence interval [CI], −4.9 to 2.2; 95% CI, −5.6 to 2.9), indicating noninferiority. Complete-case, per-protocol, and sensitivity analyses supported this result. The between-group difference in the incidence of serious adverse events was not significant (146 of 527 participants [27.7%] in the intravenous group and 138 of 527 [26.2%] in the oral group; P=0.58). Catheter complications, analyzed as a secondary end point, were more common in the intravenous group (9.4% vs. 1.0%). CONCLUSIONS Oral antibiotic therapy was noninferior to intravenous antibiotic therapy when used during the first 6 weeks for complex orthopedic infection, as assessed by treatment failure at 1 year. (Funded by the National Institute for Health Research; OVIVA Current Controlled Trials number, ISRCTN91566927. opens in new tab.

“Tool Clinics” – Embracing multiple perspectives in privacy research and privacy-sensitive design

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'Tool clinic' as a technique for interdisciplinary research and dialogue in ICT design: The case of privacy and user control in online social networks

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Choice Architecture for Human-Computer Interaction

© 2014 A. Jameson, B. Berendt, S. Gabrielli, F. Cena, C. Gena, F. Vernero, and K. Reinecke. People in human-computer interaction have learned a great deal about how to persuade and influence users of computing technology. They have much less well-founded knowledge about how to help users choose for themselves. It's time to correct this imbalance. A first step is to organize the vast amount of relevant knowledge that has been built up in psychology and related fields in terms of two comprehensive but easy-to-remember models: The Aspect model answers the question "How do people make choices?" by describing six choice patterns that choosers apply alternately or in combination, based on Attributes, Social influence, Policies, Experience, Consequences, and Trial and error. The Arcade model answers the question "How can we help people make better choices?" by describing six general high-level strategies for supporting choice: Access information and experience, Represent the choice situation, Combine and compute, Advise about processing, Design the domain, and Evaluate on behalf of the chooser. These strategies can be implemented with straightforward interaction design, but for each one there are also specifically relevant technologies. Combining these two models, we can understand virtually all existing and possible approaches to choice support as the application of one or more of the Arcade strategies to one or more of the Aspect choice patterns. After introducing the idea of choice architecture for humancomputer interaction and the key ideas of the Aspect and Arcade models, we discuss each of the Aspect patterns in detail and show how the high-level Arcade strategies can be applied to it to yield specific tactics. We then apply the two models in the domains of online communities and privacy. Most of our examples concern choices about the use of computing technology, but the models are equally applicable to everyday choices made with the help of computing technology.status: publishe

Lack of Association between Toll-Like Receptor 2 Polymorphisms and Susceptibility to Severe Disease Caused by Staphylococcus aureus

To investigate a putative link between genetically determined variations in Toll-like receptor 2 (TLR2) and the occurrence of severe Staphylococcus aureus infection, the functional Arg753Gln single-nucleotide polymorphism and the GT repeat microsatellite in the TLR2 gene were examined in a large case-control study. No associations with disease or mortality attributable to these features were found