Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P =. 043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.Fundação para a Ciência e Tecnologia, Portugal (POCI/SAU-ESP/61080/ 2004 and fellowship to A.C., contract SFRH/BD/11837/2003); CAPES (Brazilian government) (grant to A.P); and the Fungal Research Trust, United Kingdom

An Interactive Biobjective Method for Solving a Waste Collection Problem

The aim of this paper is to propose a framework in order to solve the real-world waste collection problem in a city of southern Spain modeled as an Asymmetric Vehicle Routing Problem (AVRP) with side constraints and several variations. In this problem, not only are vehicle capacity and temporal constraints considered but multiple trips are also allowed. Furthermore, two objectives will be considered: the minimization of the total distance and the balance of the working day. Finally, in order to select a single solution among all efficient (or nondominated) solutions, an interactive method is designed using reference points

Integrated Value Model for Sustainable Assessment of Modular Residential Towers: Case Study: Ten Degrees Croydon and Apex House in London

Modular construction can become sustainable by making all aspects of the design and construction process more effective during all phases. This paper aims to develop and use a sustainability assessment model for modular residential buildings in two case studies. This research uses the Integrated Value Model for Sustainable Assessment (MIVES), which is a multi-criteria decision-making model for sustainability assessment. This model considers all aspects of sustainability, environmental, economic and social, and helps stakeholders make decisions. Few previous studies have assessed all these aspects in full and MIVES make this assessment possible. For assessment purposes, two modular buildings have been chosen, namely “Ten Degrees Croydon” as the tallest high-rise modular residential building in the world and “Apex House” as the second tallest modular building in the world, both in London. These residential towers were assessed using MIVES, demonstrating a very satisfactory sustainability index in all the above aspects

Sustainability Assessment of Residential Skyscrapers Based on Multi-criteria Decision-making Method: 9 Dubai Case Studies

Residential skyscrapers play a vital role in all aspects of sustainable developments as an integral component of the built environment. The need for tall buildings first arose in Chicago in the late 19th century while today more and more skyscrapers are built to accommodate many occupants in the small available land plots of the world’s megacities. In this paper, after reviewing previous studies, a series of effective indicators are prioritized so that a method for analysing the sustainability performance of residential skyscraper buildings relating to the three dimensions of sustainability is presented. Residential skyscrapers should be designed to respond to all different requirements during their life cycle. Inclusion of economic, social and environmental dimensions of sustainable development in the initial design results in a higher quality of life in residential skyscraper buildings. The method used in this paper is the Integrated Value Model for Sustainable Assessment (MIVES) - a multi18 criteria decision-making method for assessing sustainability. In this regard, nine residential skyscrapers as case studies have been evaluated in Dubai. Based on the multi-criteria approach used in this paper, the analysed residential skyscrapers in Dubai have a sustainability performance in range of 0.29 < SI < 0.62

VEZF1 elements mediate protection from DNA methylation

There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states. Chromatin insulator or barrier elements are key components of these processes as they can establish boundaries between chromatin states. The ability of elements such as the paradigm &#946;-globin HS4 insulator to block the range of enhancers or the spread of repressive histone modifications is well established. Here we have addressed the hypothesis that a barrier element in vertebrates should be capable of defending a gene from silencing by DNA methylation. Using an established stable reporter gene system, we find that HS4 acts specifically to protect a gene promoter from de novo DNA methylation. Notably, protection from methylation can occur in the absence of histone acetylation or transcription. There is a division of labor at HS4; the sequences that mediate protection from methylation are separable from those that mediate CTCF-dependent enhancer blocking and USF-dependent histone modification recruitment. The zinc finger protein VEZF1 was purified as the factor that specifically interacts with the methylation protection elements. VEZF1 is a candidate CpG island protection factor as the G-rich sequences bound by VEZF1 are frequently found at CpG island promoters. Indeed, we show that VEZF1 elements are sufficient to mediate demethylation and protection of the APRT CpG island promoter from DNA methylation. We propose that many barrier elements in vertebrates will prevent DNA methylation in addition to blocking the propagation of repressive histone modifications, as either process is sufficient to direct the establishment of an epigenetically stable silent chromatin stat

Pion and proton showers in the CALICE scintillator-steel analogue hadron calorimeter

Showers produced by positive hadrons in the highly granular CALICE scintillator-steel analogue hadron calorimeter were studied. The experimental data were collected at CERN and FNAL for single particles with initial momenta from 10 to 80 GeV/c. The calorimeter response and resolution and spatial characteristics of shower development for proton- and pion-induced showers for test beam data and simulations using Geant4 version 9.6 are compared.Comment: 26 pages, 16 figures, JINST style, changes in the author list, typos corrected, new section added, figures regrouped. Accepted for publication in JINS

The Politics of Social Inclusion: Bridging Knowledge and Policies Towards Social Change

This volume looks at concepts and processes of social exclusion and social inclusion. It traces a number of discourses, all of them routed in a relational power analysis, examining them in the context of the UN Agenda for Sustainable Development 2030 with its commitment to "leave no one behind." The book combines analysis that is fundamentally critical of the rhetoric of social inclusion in academic and UN discourse with narratives of social exclusion processes and social inclusion contestation, based on ethnographic field research findings in La Paz, Kingston, Port-au-Prince, Kampala, Beijing, Chongqing, Mumbai, Delhi, and villages in Northern India. As a result, it contributes to revealing the politics of social inclusion, offering policy proposals towards overcoming exclusions.Comparative Research Programme on Poverty (CROP) at the University of Bergen.publishedVersio