Wireless Transmission of GPS Values for UAVas Navigation using 802.15.4b LAN Standard Protocol (ZIGBEE)

In the last few years UAVs systems have become relevant for many military applications including non military security work such as surveillance of pipelines. An autonomous UAVis often preferred for those missions that are dull, dirty or dangerous for manned aircraft. It has the ability to hover and it has free band GPS direction and tilt sensors for smooth navigation. There is no person on board to control the aircraft. Due to the advancement in satellite receiver tracking systems, an integrated system employing latest tracking techniques using satellite Receiver in the form of GPS is integrated with this vehicle. The data of GPS is transferred to the vehicle wirelessly with the help of Zigbee transceiver module. The GPS has made navigation systems practical for a number of land-vehicle navigation applications. In this paper we have devised an algorithm and hardware implementation scheme to transfer the GPS values from the PAV to the ground station wirelessly to control its aerial navigation

Wireless Transmission of GPS Values for UAV’s Navigation using 802.15.4b LAN Standard Protocol (ZIGBEE)

In the last few years UAVs systems have become relevant for many military applications including non military security work such as surveillance of pipelines. An autonomous UAVis often preferred for those missions that are dull, dirty or dangerous for manned aircraft. It has the ability to hover and it has free band GPS direction and tilt sensors for smooth navigation. There is no person on board to control the aircraft. Due to the advancement in satellite receiver tracking systems, an integrated system employing latest tracking techniques using satellite Receiver in the form of GPS is integrated with this vehicle. The data of GPS is transferred to the vehicle wirelessly with the help of Zigbee transceiver module. The GPS has made navigation systems practical for a number of land-vehicle navigation applications. In this paper we have devised an algorithm and hardware implementation scheme to transfer the GPS values from the PAV to the ground station wirelessly to control its aerial navigation

Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function

In addition to their antibiotic activities, azithromycin (AZM) exhibits anti-inflammatory effects in various respiratory diseases. One of the potent anti-inflammatory mechanisms is through inhibition of CD4+ helper T (Th) cell effector function. However, their impact on specific Th subset is obscure. Herein, we demonstrate the cellular basis of phenotypic and functional alterations associated with Th subsets following AZM treatment in vitro. Using well-characterized Th subset specific chemokine receptors, we report significant suppression of T cell receptor (TCR)-stimulated hyperactivated CCR4+CXCR3+ (Th0) expansion compared to CCR4-CXCR3+ (Th1-like) and CCR4+CXCR3- (Th2-like) cells. Interestingly, this effect was associated with diminished cell proliferation. Furthermore, AZM significantly inhibited the inflammatory cytokines IFN-γ and IL-4 production, CCR4 and CXCR3 receptor expression, and viability of Th0, Th1-like, and Th2-like subsets. Our findings suggest that AZM differentially affects TCR-activated Th subsets phenotype and function, and CCR4 and CXCR3 downregulation and suppressed Th0 subset expansion could potentially influence their trafficking and differentiation into cytokine-producing effector cells

Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression

Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent years has further established diagnostic as well as prognostic importance of CXCR4 signaling. CXCR4 and SDF-1 are routinely reported to be elevated in tumors, distant metastases, which correlates with poor survival of patients. These findings have kindled interest in the mechanisms that regulate CXCR4/SDF-1 expression. Of note, there is a particular interest in the epigenetic regulation of CXCR4 signaling that may be responsible for upregulated CXCR4 in primary as well as metastatic cancers. This review first lists the clinical evidence supporting CXCR4 signaling as putative cancer diagnostic and/or prognostic biomarker, followed by a discussion on reported epigenetic mechanisms that affect CXCR4 expression. These mechanisms include regulation by non-coding RNAs, such as, microRNAs, long non-coding RNAs and circular RNAs. Additionally, we also discuss the regulation of CXCR4 expression through methylation and acetylation. Better understanding and appreciation of epigenetic regulation of CXCR4 signaling can invariably lead to identification of novel therapeutic targets as well as therapies to regulate this oncogenic signaling.Open Access funding for this article has been provided by the Qatar National Library

Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity

Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is upregulated in asthma and correlates with disease severity. The gene expression of IL-19 was significantly higher in lung tissue from patients with severe and mild/moderate asthma compared to healthy controls. IL-19 protein level, however, was significantly higher in the blood and saliva of patients with severe asthma compared to mild/ moderate subgroups as measured by ELISA assay. IL-19 protein level was not affected by corticosteroid treatment in plasma. Our data provide insights into the potential use of IL-19 as a saliva marker for asthma severity and a potential therapeutic target

Reported Male Circumcision Practices in a Muslim-Majority Setting

Introduction. Male circumcision is a recommended practice in Muslim tradition. It is important to ensure that this procedure is performed as safely as possible in these communities. Methods. Five hundred adult men and women with at least one male child less than 18 years were interviewed in Karachi, Pakistan, regarding details of their child’s circumcision. The survey focused on actual and perceived delays in circumcision and perceptions about appropriate age and reasons and benefits and complications of the procedure. Circumcisions done after two months of age were defined as delayed. Results. Religious requirement was the primary reason for circumcision in 92.6% of children. However, 89.6% of respondents were of the opinion that circumcision had medical benefits as well. Half of the children (54.1%) had delayed circumcision (range 2.5 months to 13 years), even though 81.2% of parents were of the opinion that circumcisions should be done within 60 days of birth. Facility-delivered babies had less delay in circumcisions (49.1%) as compared to home-delivered babies (60.5%). Conclusion. Understanding the perceptions and practices around male circumcision can help guide national strategies for designing and implementing safe circumcision programs in Muslim-majority settings, with the potential to benefit an annual birth cohort of 20–25 million boys worldwide

Impementasi Supervisi Pendidikan dalam Meningkatkan Proses Pembelajaran di Ibtidaiyah Swasta Aisyiyah Wil. SUMUT

Supervisi di sekolah dilaksanakan oleh kepala sekolah yang bertindak sebagai supervisor, maka ia harus mampu melakukan berbagai pengawasan dan pengendalian untuk meningkatkan kinerja guru. Pengawasan dan pengendalian merupakan tindakan preventiv untuk mencegah agar guru tidak melakukan penyimpangan dan lebih berhatihati dalam melaksanakan pekerjaannya sebagai pendidik. Oleh karena itu, penelitian ini mengungkap kegiatan supervisi yang dilakukan oleh Kepala sekolah Ibtidaiyah Swasta Aisyiyah Wil. Sumut terhadap kinerja guru. Adapun hasil dari penelitian ini adalah:1). Fokus kegiatan supervisi yang dilakukan kepala sekolah dapat diidentifikasikan ke dalam dua hal yaitu; kegiatan supervisi yang menyangkut administrasi guru dan kegiatan proses belajar mengajar, 2). Kegiatan supervisi sangat membantu bagi guru dalam memecahkan masalah-masalah pendidikan yang dihadapi guru pada saat melakukan pembelajaran, serta dapat memberikan motivasi bagi guru agar selalu meningkatkan pengetahuan untuk menjadi guru yang professional dalam melaksanakan pembelajaran, 3). Hambatan kepala sekolah dalam supervisi adalah tumpang tindih kegiatan dan keterbatasan dana operasional

Energy Saving through Efficient BOG Prediction and Impact of Static Boil-off-Rate in Full Containment-Type LNG Storage Tank

Boil-off gas (BOG) from a liquefied natural gas (LNG) storage tank depends on the amount of heat leakage however, its assessment often relies on the static value of the boil-off rate (BOR) suggested by the LNG tank vendors that over/under predicts BOG generation. Thus, the impact of static BOR on BOG predictions is investigated and the results suggest that BOR is a strong function of liquid level in a tank. Total heat leakage in a tank practically remains constant, nonetheless the unequal distribution of heat in vapor and liquid gives variation in BOR. Assigning the total tank heat leak to the liquid is inappropriate since a part of heat increases vapor temperature. At the lower liquid level, BOG is under-predicted and at a higher level, it is over-predicted using static BOR. Simulation results show that BOR varies from 0.012 wt% per day for an 80% tank fill to 0.12 wt% per day at 10% tank fill