Development of Portable Air Conditioning System Using Peltier and Seebeck Effect

The society bustle factor in this day and age, most people want to find equipment that is often used in everyday life in a small and light weight design. The purpose of this project is to develop portable air conditioning system without using any gas. The system used thermoelectric heat pump as main device for producing cool air known as Peltier Effect. The generating system theoretically can recycle the heat loss to produce additional electricity for other usage. The efficacy of this system tested using two types of experimental using Peltier and Seebeck Effect. Both experimental are conducted using 3 specific volumes; 1) 1000cm3; 2) 4000cm3; and 3) 9000cm3. As a result, temperature for heating and cooling systems achieve around 16 – 40 degree Celcius (oC) while the voltage generated around 12V in 30 minutes

Particle Swarm Optimization (PSO) for Simulating Robot Movement on Two-Dimensional Space Based on Odor Sensing

Nowadays, researches in robotic field have grown increasingly. There are several types of research categories in the field of robotic. Recently, one of the famous research works recently was odor sensing. Within the technology that grows rapidly, this topic has become an interest among researchers. An odor sensing is not only applied in the medical field, but it has also been widely used in the industry. The gradient of concentration of an odor is measured by diluting some amount to reach the threshold of an odor. This paper focused on the implementation of the Particle Swarm Optimization (PSO) method based on odor sensing in two (2) dimensional space. However, it only discusses and focuses on applying in ideal condition. An ideal condition here means that there is no disturbance included in this simulation. The main idea of this paper was to observe how the particle agents make the movement based on concentration by applying the PSO method. The real sensor cannot be implemented in this simulation because the value of concentration is measured due to the distance from the particles agent to the goal of agents. Higher gradient concentration is shown at the shorter distance to the goal. The contributions in this paper are mainly to create an algorithms model by using Particle Swarm Optimization (PSO) to calculate the paths of movement of mobile robot until they reach the goals (source of odor) with respect to the concepts of odor sensing

Graphical User Interface (GUI) Controlled Mobile Robot

The advanced design and development of robotic technology in producing multi task are increasingly. In this paper presents about designing and developing mobile robot model that can be controlled using Graphical User Interface (GUI) via wireless protocol. This paper focuses on the control mobile robot by using the GUI as navigation control and the user can get a view an image and real time video on visual basic software. To address the problem of sired based control, XBee wireless communication circuit was used in mobile robot through a computer command. The development of this mobile robot consists of a chassis, a graphical user interface (GUI), XBee module, DC gear motor, camera, track wheels and microcontroller type PIC18F4550. Differential driving method using L298 circuit was used to control movement of the robot. In mechanical design, the wheel track has been used instead of conventional wheels to enable the robot to travel through different types of surfaces or rough terrain. In addition, wireless cameras was attached to the robot as a system of monitoring function. Finally, the robot will be designed to control wireless remote control that can control robots. Wireless remote control allows the user of an environment that is unsafe or dangerous device and evades wires or cables interfere with the movement of the robot

Consumers’ purchasing decision towards food products of small and medium enterprises

The gross domestic product (GDP) of Malaysia has continuously increased from year to year. All industry sectors are responsible for contributing to Malaysia’s GDP, including the food and beverage (F&B) industry. The sales within the Malaysian F&B retail industry were forecast to grow yearly. This study is to examine Malaysian consumers’ acceptance of F&B products of small and medium enterprises (SMEs). In depth, this study also tries to investigate whether consumers use experience when making a decision to buy SMEs’ F&B products in the hypermarket. Results from structural equation modeling shows that consumers are barely aware of the existence of SMEs’ F&B products and prefer to buy establish brands’ products in the hypermarket. Hence, we suggest SMEs be more prominent in marketing their products. This action will influence consumer decisions in choosing SMEs brands over established brands’ products

Embracing Monogenic Parkinson's Disease: The MJFF Global Genetic PD Cohort

Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is limited. Objective: The objectives are to (1) establish an international cohort of affected and unaffected individuals with PD-linked variants; (2) provide harmonized and quality-controlled clinical characterization data for each included individual; and (3) further promote collaboration of researchers in the field of monogenic PD. Methods: We conducted a worldwide, systematic online survey to collect individual-level data on individuals with PD-linked variants in SNCA, LRRK2, VPS35, PRKN, PINK1, DJ-1, as well as selected pathogenic and risk variants in GBA and corresponding demographic, clinical, and genetic data. All registered cases underwent thorough quality checks, and pathogenicity scoring of the variants and genotype–phenotype relationships were analyzed. Results: We collected 3888 variant carriers for our analyses, reported by 92 centers (42 countries) worldwide. Of the included individuals, 3185 had a diagnosis of PD (ie, 1306 LRRK2, 115 SNCA, 23 VPS35, 429 PRKN, 75 PINK1, 13 DJ-1, and 1224 GBA) and 703 were unaffected (ie, 328 LRRK2, 32 SNCA, 3 VPS35, 1 PRKN, 1 PINK1, and 338 GBA). In total, we identified 269 different pathogenic variants; 1322 individuals in our cohort (34%) were indicated as not previously published. Conclusions: Within the MJFF Global Genetic PD Study Group, we (1) established the largest international cohort of affected and unaffected individuals carrying PD-linked variants; (2) provide harmonized and quality-controlled clinical and genetic data for each included individual; (3) promote collaboration in the field of genetic PD with a view toward clinical and genetic stratification of patients for gene-targeted clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

Using global team science to identify genetic parkinson's disease worldwide.

No abstract available

Mutations in Wnt2 Alter Presynaptic Motor Neuron Morphology and Presynaptic Protein Localization at the Drosophila Neuromuscular Junction

Wnt proteins are secreted proteins involved in a number of developmental processes including neural development and synaptogenesis. We sought to determine the role of the Drosophila Wnt7b ortholog, Wnt2, using the neuromuscular junction (NMJ). Mutations in wnt2 produce an increase in the number of presynaptic branches and a reduction in immunolabeling of the active zone proteins, Bruchpilot and synaptobrevin, at the NMJ. There was no change, however, in immunolabeling for the presynaptic proteins cysteine-string protein (CSP) and synaptotagmin, nor the postsynaptic proteins GluRIIA and DLG at the NMJ. Consistent with the presynaptic defects, wnt2 mutants exhibit approximately a 50% reduction in evoked excitatory junctional currents. Rescue, RNAi, and tissue-specific qRT-PCR experiments indicate that Wnt2 is expressed by the postsynaptic cell where it may serve as a retrograde signal that regulates presynaptic morphology and the localization of presynaptic proteins

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

\ua9 2023, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations