Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis

Recently, we reported a novel role for KMO in the pathogenesis of acute pancreatitis (AP). A number of inhibitors of kynurenine 3-monooxygenase (KMO) have previously been described as potential treatments for neurodegenerative conditions and particularly for Huntington’s disease. However, the inhibitors reported to date have insufficient aqueous solubility relative to their cellular potency to be compatible with the intravenous (iv) dosing route required in AP. We have identified and optimized a novel series of high affinity KMO inhibitors with favorable physicochemical properties. The leading example is exquisitely selective, has low clearance in two species, prevents lung and kidney damage in a rat model of acute pancreatitis, and is progressing into preclinical development

Contribution a la synthese de la colchicine par voie photochimique

SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Quand l’homme se fait animal, deux cas de métamorphose chez Marie de France : Yonec et Bisclavret

En lisant des récits de métamorphose, le lecteur a rapidement l’impression de quitter la logique d’une nature dont les lois semblent comme violées par ces transformations extraordinaires. Au Moyen-Age, la métamorphose se situe au croisement de l’héritage gréco-latin, diffusé par la voie des traductions ovidiennes, et de l’héritage folklorique, constitué d’un ensemble de récits transmis par la tradition orale. Marie de France, qui, avec Yonec et Bisclavret, offre dans son recueil de Lais deux ..

PET metabolic imaging of time-dependent reorganization of olfactory cued fear memory networks in rats

International audienc

Rhine’s floods during roman antiquity. Geoarchaeology of the Oedenburg Gallo-Roman site (France).

International audienc