Primary leiomyosarcoma of the pancreas: report of a case treated by local excision and review of the literature

First described by Ross in 1951, primary pancreatic leiomyosarcoma is a rare mesenchymal tumour of the pancreas, with nonspecific clinical and radiological features and a poor prognosis, if unresectable

Forma mentis networks map how nursing and engineering students enhance their mindsets about innovation and health during professional growth

Reconstructing a "forma mentis", a mindset, and its changes, means capturing how individuals perceive topics, trends and experiences over time. To this aim we use forma mentis networks (FMNs), which enable direct, microscopic access to how individuals conceptually perceive knowledge and sentiment around a topic, providing richer contextual information than machine learning. FMNs build cognitive representations of stances through psycholinguistic tools like conceptual associations from semantic memory (free associations, i.e., one concept eliciting another) and affect norms (valence, i.e., how attractive a concept is). We test FMNs by investigating how Norwegian nursing and engineering students perceived innovation and health before and after a 2-month research project in e-health. We built and analysed FMNs by six individuals, based on 75 cues about innovation and health, and leading to 1,000 associations between 730 concepts. We repeated this procedure before and after the project. When investigating changes over time, individual FMNs highlighted drastic improvements in all students' stances towards "teamwork", "collaboration", "engineering" and "future", indicating the acquisition and strengthening of a positive belief about innovation. Nursing students improved their perception of "robots" and "technology" and related them to the future of nursing. A group-level analysis related these changes to the emergence, during the project, of conceptual associations about openness towards multidisciplinary collaboration, and a positive, leadershiporiented group dynamics. The whole group identified "mathematics" and "coding" as highly relevant concepts after the project. When investigating persistent associations, characterising the core of students' mindsets, network distance entropy and closeness identified as pivotal in the students' mindsets concepts related to "personal well-being", "professional growth" and "teamwork". This result aligns with and extends previous studies reporting the relevance of teamwork and personal well-being for Norwegian healthcare professionals, also within the novel e-health sector. Our analysis indicates that forma mentis networks are powerful proxies for detecting individual- and grouplevel mindset changes due to professional growth. FMNs open new scenarios for datainformed, multidisciplinary interventions aimed at professional training in innovation.publishedVersio

Bacchanalia : celebrar el pasado, hacerlo presente, proyectar el futuro

Bacchanalia es un proyecto-puente que combina música y poesía clásica y que pretende llevar a los oídos de la postmodernidad los clásicos grecolatinos. Con notas e instrumentos contemporáneos, Bacchanalia quiere hacer revivir, renovar y remodelar aquellos textos que nunca han conocido atardecer, demostrando que su pervivencia y su popularidad se debe a lo genuino de los temas que tratan. Dos mil años y más de historia no han modificado la esencia del hombre; sin embargo, en este tiempo, los clásicos se han estigmatizado bajo un aparente estereotipo de elitismo y erudición. Con una voz y una guitarra, un violín, un bouzouki, un contrabajo y unas percusiones cinco músicos, reconocidos a nivel nacional e internacional, buscan lograr el mismo pathos que en su momento consiguió el anónimo cantor con su parca lira. Aquí presentaremos el proyecto, en particular su faceta pedagógica, la página web oficial con sus diferentes apartados y canales de difusión (redes sociales y web) y una propuesta de guía pedagógica que estamos elaborando bajo la supervisión de la Dra. Gemma Puigvert del Departament de Ciències de l'Antiguitat i l'Edat Mitjana de la UAB

Unpacking the Meanings of a ‘Normal Life’ Among Lesbian, Gay, Bisexual and Transgender Eastern European Migrants in Scotland

This article explores the experiences of lesbian, gay, bisexual and transgender (LGBT) migrants from Central and Eastern Europe and the Former Soviet Union in Scotland. Drawing on interviews with 50 migrants, the article focuses on the experiences and aspirations which they articulate as being part of ‘a normal life’, and analyses them within broader conceptual understandings of security and ‘normality’. We first examine how normality is equated with an improved economic position in Scotland, and look at the ways in which this engenders feelings of emotional security and well-being. We then explore how more positive experiences around sexuality and gender identity are key to a sense of emotional security – i.e. of feeling accepted as ‘normal’, being visible as an LGBT person but ‘blending in’ rather than standing out because of it. Finally we look at the ways in which the institutional framework in Scotland, in particular the presence of LGBT-affirmative legislation, is seen by participants to have a normalising effect within society, leading to a broader sense of inclusion and equality – found, again, to directly impact upon participants’ own feelings of security and emotional well-being. The article engages with literatures on migration and sexuality and provides an original contribution to both: through its focus upon sexuality, which remains unexplored in debates on ‘normality’ and migration in the UK; and by bringing a migration perspective to the debates in sexuality studies around the normalising effect of the law across Europe. By bringing these two perspectives together, we reveal the inter-relationship between sexuality and other key spheres of our participants’ lives in order to better understand their experiences of migration and settlement

Testosterone-induced effects on lipids and inflammation

Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention has been paid to the possible involvement of gonadal hormones, especially in recent years. In particular, testosterone, the main androgen, is thought to play a beneficial, protective role in the body. Other important elements to be related to pain, inflammation, and hormones are lipids, heterogenic molecules whose altered metabolism is often accompanied by the release of interleukins, and lipid-derived proinflammatory mediators. Here we report data on interactions often not considered in chronic pain mechanisms

Dramatic play as a means to explore and support preschool children’s thinking about thermal insulation

Research in young children’s ideas, representations, and pre-conceptions about the natural and technical world has a long history. Most of the studies in the field have used individual, semi-structured interviews as a methodological technique to generate and collect empirical data. However, less is known about how tracing procedures can come in line and be incorporated into everyday educational reality in early childhood settings in a way that reflects young children’s interests and needs. The present study uses dramatic play to trace young children’s thinking in science and advance their science learning experiences. The study focuses on a science concept young children are familiar with in everyday life though has not been thoroughly studied in the literature yet: thermal insulation. Empirical data from 6 preschoolers in Greece are presented. Qualitative data were collected through recordings of children’s dialogues, children’s drawings, field notes from the early childhood teachers, and photographs. The findings revealed that during their dramatic play children a) developed basic argumentation to express their thinking about the phenomenon; b) related the phenomenon with the thermal condition and changes in temperature; c) identified materials and objects with insulating properties and distinguish them from others with non-insulating properties, and d) came to the conclusion that the use of amplified insulation materials can lead to better insulation results. The outcomes of the study add to the research methodology in early childhood science education and inform practice providing a pedagogical framework that balances between play-based pedagogies and advanced learning outcomes in science for young learners

A munkahelyi mentálhigiéné generációs jellemzői : generációs különbségek a munkahelyi stressz, megküzdési stratégiák, szervezeti elkötelezettség, szervezeti elégedettség, és jól-lét függvényében

A cikk alapjául szolgáló kutatásban a szerző célja volt a munkahelyi mentálhigiénének azon vonatkozásait feltárni, hogy a munkaerőpiacon ma jelen lévő négy generáció – Baby Boom, X, Y, Z – vonatkozásában megismerje az egyes ge- nerációk mentálhigiénés sajátosságait, a munkahelyi stressz és a munkafüggőség függvényében, illetve a szervezeti elkötelezettség, szervezeti elégedettség, jól-lét tekintetében, és feltérképezze a különböző generációkra jellemző megküzdési stratégiákat. Hipotézisei egy kivételével részben, avagy egészben igazolódtak. A kutatás eredményei alátámasztják, hogy vannak kimutatható, ka- rakterisztikus generációs jellegzetességek a munkahelyi mentálhigiéné kutatott aspektusainak függvényében. Nélkülözhetetlen az életkor-tudatos, életkorbarát HR politika bevezetése a modern 21. századi szervezeteknél

Minor mutations in HIV protease at baseline and appearance of primary mutation 90M in patients for whom their first protease-inhibitor ntiretroviral regimens failed

The association between minor mutations in human immunodeficiency virus (HIV) protease at baseline and development of common primary mutation 90M at virological failure (conferring some resistance to all protease inhibitors [PIs]) was evaluated in 93 previously drug-naive patients experiencing failure of their first PI-based antiretroviral regimens. In logistic regression analysis, the probability of accumulating a new 90M mutation at virological failure was associated with the presence at baseline of minor mutation 36I (naturally occurring in ∼25% of HIV clade B and in >80% of HIV non-clade-B viruses) (adjusted odds ratio, 13.5 [95% confidence interval, 1.89–95.6]; P=.009) and, possibly, of 10I/V. This suggests a potential role for the presence of 36I at baseline in predicting the appearance of 90M at virological failure