An On-line BIST RAM Architecture with Self Repair Capabilities

The emerging field of self-repair computing is expected to have a major impact on deployable systems for space missions and defense applications, where high reliability, availability, and serviceability are needed. In this context, RAM (random access memories) are among the most critical components. This paper proposes a built-in self-repair (BISR) approach for RAM cores. The proposed design, introducing minimal and technology-dependent overheads, can detect and repair a wide range of memory faults including: stuck-at, coupling, and address faults. The test and repair capabilities are used on-line, and are completely transparent to the external user, who can use the memory without any change in the memory-access protocol. Using a fault-injection environment that can emulate the occurrence of faults inside the module, the effectiveness of the proposed architecture in terms of both fault detection and repairing capability was verified. Memories of various sizes have been considered to evaluate the area-overhead introduced by this proposed architectur

Online and Offline BIST in IP-Core Design

This article presents an online and offline built-in self-test architecture implemented as an SRAM intellectual-property core for telecommunication applications. The architecture combines fault-latency reduction, code-based fault detection, and architecture-based fault avoidance to meet reliability constraint

Lynda Bruce : Espaces intimes = Lynda Bruce : Intimate Spaces

Includes a brief commentary on Bruce's paintings

C3C^{3} : A Command-line Catalogue Cross-matching tool for modern astrophysical survey data

In the current data-driven science era, it is needed that data analysis techniques has to quickly evolve to face with data whose dimensions has increased up to the Petabyte scale. In particular, being modern astrophysics based on multi-wavelength data organized into large catalogues, it is crucial that the astronomical catalog cross-matching methods, strongly dependant from the catalogues size, must ensure efficiency, reliability and scalability. Furthermore, multi-band data are archived and reduced in different ways, so that the resulting catalogues may differ each other in formats, resolution, data structure, etc, thus requiring the highest generality of cross-matching features. We present $C^{3}$ (Command-line Catalogue Cross-match), a multi-platform application designed to efficiently cross-match massive catalogues from modern surveys. Conceived as a stand-alone command-line process or a module within generic data reduction/analysis pipeline, it provides the maximum flexibility, in terms of portability, configuration, coordinates and cross-matching types, ensuring high performance capabilities by using a multi-core parallel processing paradigm and a sky partitioning algorithm.Comment: 6 pages, 4 figures, proceedings of the IAU-325 symposium on Astroinformatics, Cambridge University pres

Molecular Mechanism of DNA Topoisomerase I-Dependent rDNA Silencing: Sir2p Recruitment at Ribosomal Genes

Saccharomyces cerevisiae sir2Δ or top1Δ mutants exhibit similar phenotypes involving ribosomal DNA, including (i) loss of transcriptional silencing, resulting in non-coding RNA hyperproduction from cryptic RNA polymerase II promoters; (ii) alterations in recombination; and (iii) a general increase in histone acetylation. Given the distinct enzymatic activities of Sir2 and Top1 proteins, a histone deacetylase and a DNA topoisomerase, respectively, we investigated whether genetic and/or physical interactions between the two proteins could explain the shared ribosomal RNA genes (rDNA) phenotypes. We employed an approach of complementing top1Δ cells with yeast, human, truncated, and chimeric yeast/human TOP1 constructs and of assessing the extent of non-coding RNA silencing and histone H4K16 deacetylation. Our findings demonstrate that residues 115–125 within the yeast Top1p N-terminal domain are required for the complementation of the top1Δ rDNA phenotypes. In chromatin immunoprecipitation and co-immunoprecipitation experiments, we further demonstrate the physical interaction between Top1p and Sir2p. Our genetic and biochemical studies support a model whereby Top1p recruits Sir2p to the rDNA and clarifies a structural role of DNA topoisomerase I in the epigenetic regulation of rDNA, independent of its known catalytic activity

Microwave-assisted FeCl3-catalysed production of glucose from giant reed and cardoon cellulose fraction and its fermentation to new generation oil by oleaginous yeasts

The replacement of fossil fuels and materials with biofuels and bioproducts is a crucial current global goal. Biorefining of lignocellulosic biomass generates pentose and hexose sugars which can be converted into several added-value bio-based compounds. Among biofuels, biodiesel is one of the most promising renewable energy sources since it does not require new technology and engines for its use. Traditional biodiesel is produced on the industrial scale starting from vegetable oils obtained from oleaginous crops, such as palm oil, rapeseed oil and sunflower oil. However, most of the oleaginous plant species are food crops, determining the ethical debate on the right use of these renewable resources and the competition between the energy industry and food chain. An innovative and promising solution is represented by single cell oil (SCO) produced from oleaginous yeasts. This new generation oil, if obtained from low or negative value industrial waste, represents a promising platform chemical for the production of biodiesel, biosurfactants, animal feed and biobased plastics [1]. This study investigated the microwave-assisted FeCl3-catalysed hydrolysis of giant reed (Arundo donax L.) and defatted cardoon (Cynara cardunculus L.) cellulose fractions to give glucose. Giant reed is a promising energy crops able to grow on marginal lands, while cardoon stalks are the crop residue in the production of vegetable oil. A preliminary acid pretreatment was adopted for giant reed [2], while steam-explosion pretreatment was performed on cardoon [3], both allowing a significant removal of xylan fractions. Under different reactions conditions, the microwave-assisted FeCl3-catalysed hydrolysis converted the two pretreated feedstocks into glucose-rich hydrolysates which were employed as fermentation medium for the production of SCO by the oleaginous yeast Lipomyces starkeyi DSM 70296. For giant reed, the low production of furanic compounds enabled the direct fermentation of undetoxified hydrolysates, while for cardoon the furfural removal was necessary before the fermentation step. After hydrolysis, for both hydrolysates the fermentation provided promising lipid yields (~14 wt%) and oil content (~25 wt%). Figure 1 shows the process layout of the implemented third-generation biorefinery scheme. The SCO appears a valid candidate for the production of new generation biodiesel with good oxidative stability and cold flow properties. Moreover, it resulted very similar to palm and rapeseed oils, usually employed as a renewable source for the production of traditional biodiesel

Machine learning based data mining for Milky Way filamentary structures reconstruction

We present an innovative method called FilExSeC (Filaments Extraction, Selection and Classification), a data mining tool developed to investigate the possibility to refine and optimize the shape reconstruction of filamentary structures detected with a consolidated method based on the flux derivative analysis, through the column-density maps computed from Herschel infrared Galactic Plane Survey (Hi-GAL) observations of the Galactic plane. The present methodology is based on a feature extraction module followed by a machine learning model (Random Forest) dedicated to select features and to classify the pixels of the input images. From tests on both simulations and real observations the method appears reliable and robust with respect to the variability of shape and distribution of filaments. In the cases of highly defined filament structures, the presented method is able to bridge the gaps among the detected fragments, thus improving their shape reconstruction. From a preliminary "a posteriori" analysis of derived filament physical parameters, the method appears potentially able to add a sufficient contribution to complete and refine the filament reconstruction.Comment: Proceeding of WIRN 2015 Conference, May 20-22, Vietri sul Mare, Salerno, Italy. Published in Smart Innovation, Systems and Technology, Springer, ISSN 2190-3018, 9 pages, 4 figure

Spider surgical system versus multiport laparoscopic surgery. Performance comparison on a surgical simulator

BACKGROUND: The rising interest towards minimally invasive surgery has led to the introduction of laparo-endoscopic single site (LESS) surgery as the natural evolution of conventional multiport laparoscopy. However, this new surgical approach is hampered with peculiar technical difficulties. The SPIDER surgical system has been developed in the attempt to overcome some of these challenges. Our study aimed to compare standard laparoscopy and SPIDER technical performance on a surgical simulator, using standardized tasks from the Fundamentals of Laparoscopic Surgery (FLS). METHODS: Twenty participants were divided into two groups based on their surgical laparoscopic experience: 10 PGY1 residents were included in the inexperienced group and 10 laparoscopists in the experienced group. Participants performed the FLS pegboard transfers task and pattern cutting task on a laparoscopic box trainer. Objective task scores and subjective questionnaire rating scales were used to compare conventional laparoscopy and SPIDER surgical system. RESULTS: Both groups performed significantly better in the FLS scores on the standard laparoscopic simulator compared to the SPIDER. Inexperienced group: Task 1 scores (median 252.5 vs. 228.5; p = 0.007); Task 2 scores (median 270.5 vs. 219.0; p = 0.005). Experienced group: Task 1 scores (median 411.5 vs. 309.5; p = 0.005); Task 2 scores (median 418.0 vs. 331.5; p = 0.007). Same aspects were highlighted for the subjective evaluations, except for the inexperienced surgeons who found both devices equivalent in terms of ease of use only in the peg transfer task. CONCLUSIONS: Even though the SPIDER is an innovative and promising device, our study proved that it is more challenging than conventional laparoscopy in a population with different degrees of surgical experience. We presume that a possible way to overcome such challenges could be the development of tailored training programs through simulation methods. This may represent an effective way to deliver training, achieve mastery and skills and prepare surgeons for their future clinical experience

Erythropoietin: Recent Developments in the Treatment of Spinal Cord Injury

Erythropoietin (EPO), originally identified for its critical function in regulating production and survival of erythrocytes, is a member of the type 1 cytokine superfamily. Recent studies have shown that EPO has cytoprotective effects in a wide variety of cells and tissues. Here is presented the analysis of EPO effects on spinal cord injury (SCI), considering both animal experiments concerning to mechanisms of neurodegeneration in SCI and EPO as a neuroprotective agent, and some evidences coming from ongoing clinical trials. The evidences underling that EPO could be a promising therapeutic agent in a variety of neurological insults, including trauma, are mounting. In particular, it is highlighted that administration of EPO or other recently generated EPO analogues such as asialo-EPO and carbamylated-EPO demonstrate interesting preclinical and clinical characteristics, rendering the evaluation of these tissue-protective agents imperative in human clinical trials. Moreover the demonstration of rhEPO and its analogues' broad neuroprotective effects in animal models of cord lesion and in human trial like stroke, should encourage scientists and clinicians to design clinical trials assessing the efficacy of these pharmacological compounds on SCI