Different evolutionary pathways underlie the morphology of wrist bones in hominoids

BACKGROUND The hominoid wrist has been a focus of numerous morphological analyses that aim to better understand long-standing questions about the evolution of human and hominoid hand use. However, these same analyses also suggest various scenarios of complex and mosaic patterns of morphological evolution within the wrist and potentially multiple instances of homoplasy that would benefit from require formal analysis within a phylogenetic context.We identify morphological features that principally characterize primate - and, in particular, hominoid (apes, including humans) - wrist evolution and reveal the rate, process and evolutionary timing of patterns of morphological change on individual branches of the primate tree of life. Linear morphological variables of five wrist bones - the scaphoid, lunate, triquetrum, capitate and hamate - are analyzed in a diverse sample of extant hominoids (12 species, 332 specimens), Old World (8 species, 43 specimens) and New World (4 species, 26 specimens) monkeys, fossil Miocene apes (8 species, 20 specimens) and Plio-Pleistocene hominins (8 species, 18 specimens). RESULT Results reveal a combination of parallel and synapomorphic morphology within haplorrhines, and especially within hominoids, across individual wrist bones. Similar morphology of some wrist bones reflects locomotor behaviour shared between clades (scaphoid, triquetrum and capitate) while others (lunate and hamate) indicate clade-specific synapomorphic morphology. Overall, hominoids show increased variation in wrist bone morphology compared with other primate clades, supporting previous analyses, and demonstrate several occurrences of parallel evolution, particularly between orangutans and hylobatids, and among hominines (extant African apes, humans and fossil hominins). CONCLUSIONS Our analyses indicate that different evolutionary processes can underlie the evolution of a single anatomical unit (the wrist) to produce diversity in functional and morphological adaptations across individual wrist bones. These results exemplify a degree of evolutionary and functional independence across different wrist bones, the potential evolvability of skeletal morphology, and help to contextualize the postcranial mosaicism observed in the hominin fossil record

Moral hazard and the demand for health services: A matching estimator approach

We estimate the impact of extra health insurance coverage beyond a National Health System on the demand for several health services. Traditionally, the literature has tried to deal with the endogeneity of the private (extra) insurance decision by finding instrumental variables. Since a priori instrumental variables are hard to find we take a different approach. We focus on the most common health insurance plan in Portugal, ADSE, which is given to all civil servants and their dependents. We argue that this insurance is exogenous, i.e., not correlated with the beneficiaries’ health status. This identifying assumption allows us to estimate the impact of having ADSE coverage on the demand for three different health services using a matching estimator technique. The health services used are number of visits, number of blood and urine tests, and the probability of visiting a dentist. Results show large positive effects of ADSE coverage for number of visits and tests among the young (18–30 years old) but only the latter is statistically significantly different from zero. The effects represent 21.8% and 30% of the average number of visits and tests for the young. On the contrary, we find no evidence of moral hazard on the probability of visiting a dentist.Publicad

Moral hazard and the demand for health services: a matching estimator approach

We estimate the impact of health insurance coverage beyond National Health Insurance on the demand for several health services. Traditionally, the literature has tried to deal with the endogeneity of the private (extra) insurance decision by finding instrumental variables. Since a priori instrumental variables are hard to find we take a different approach. We focus on the most common health insurance plan in Portugal, ADSE, which is given to all civil servants and their dependants. We argue this insurance is exogenous i.e. not correlated with beneficiaries’ health status. This identifying assumption allows us to estimate the impact of having ADSE coverage on three different health services using a matching estimator technique. The health services used are: number of visits, number of blood and urine tests, and the probability of visiting a dentist. Results show large positive effects of ADSE for number of visits and tests among the young (18 to 30 years old) but only the latter is statistically significantly different from zero. The effects represent 21.8 and 30% of the average number of visits and tests for the young. On the contrary, we find no evidence of moral hazard on the probability of visiting a dentist

MORAL HAZARD AND THE DEMAND FOR HEALTH SERVICES: A MATCHING ESTIMATOR APPROACH

In this paper we estimate the impact of health insurance coverage beyond National Health Insurance on the demand for several health services. Traditionally, the literature has tried to deal with the endogeneity of the private (extra) insurance decision by finding instrumental variables. It is hard to think, however, of any variable that a priori would be a good instrument and, therefore, we take a different approach. We concentrate on the most common health insurance plan in the Portuguese Health Survey, (ADSE), which is given to all civil servants and their dependants. We argue that this insurance is exogenous for most people i.e. not correlated with their health status. Under this identifying assumption we estimate the impact of having ADSE coverage on three different health services using a matching estimator technique. The measures of demand for health services are number of visits, number of blood and urine tests, and the probability of visiting a dentist. Preliminary results show large effects of ADSE for number of visits and tests among the young (18 to 30 years old) but only for tests are these effects statistically significantly different from zero. The magnitude of the effects represent 21.8 and 30 percent of the average number of visits and tests for the young. On the contrary we find no evidence of moral hazard on the probability of visiting a dentist. Finally, we argue that there is evidence of a positive cumulative effect of ADSE over the years.

Moral hazard and the demand for health services: A matching estimator approach.

We estimate the impact of extra health insurance coverage beyond a National Health System on the demand for several health services. Traditionally, the literature has tried to deal with the endogeneity of the private (extra) insurance decision by finding instrumental variables. Since a priori instrumental variables are hard to find we take a different approach. We focus on the most common health insurance plan in Portugal, ADSE, which is given to all civil servants and their dependents. We argue that this insurance is exogenous, i.e., not correlated with the beneficiaries’ health status. This identifying assumption allows us to estimate the impact of having ADSE coverage on the demand for three different health services using a matching estimator technique. The health services used are number of visits, number of blood and urine tests, and the probability of visiting a dentist. Results show large positive effects of ADSE coverage for number of visits and tests among the young (18–30 years old) but only the latter is statistically significantly different from zero. The effects represent 21.8% and 30% of the average number of visits and tests for the young. On the contrary, we find no evidence of moral hazard on the probability of visiting a dentist.Demand for health services; Matching estimator; Moral hazard; Portuguese health system;

Co-fermentation of onion and whey: a promising synbiotic combination

Juice from three different onion varieties was mixed with sweet whey and used as growth 18 substrate for four lactic acid bacteria strains, isolated from agri-food by-products, to 19 evaluate the possibility to exploit such substrates, known to be reach in bioactive 20 molecules, as fermented drinks for human consumption. Results show good growth 21 performance for Lactobacillus fabifermentans, L. plantarum and Streptococcus 22 macedonicus. On the contrary S. thermophilus did not grow in the mixture while S. 23 macedonicus did not develop in pure onion juice. After 48 h the overall sugar content 24 decreased significantly. In particular, glucose was not utilized while inulin was completely 25 preserved. Moreover, MS/MS analysis revealed the presence of the rare trisaccharide 26 lactosucrose. 27 In the light of these considerations, the formulation obtained may be considered a potential 28 synbiotic product with pleasant taste and beneficial effects for consumers and also an eco-29 friendly solution to convert an agro-food by-product into value added products

Espaço, lugar e local

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Characteristics of scholars who review for predatory and legitimate journals: linkage study of Cabells Scholarly Analytics and Publons data.

OBJECTIVES To describe and compare the characteristics of scholars who reviewed for predatory or legitimate journals in terms of their sociodemographic characteristics and reviewing and publishing behaviour. DESIGN Linkage of random samples of predatory journals and legitimate journals of the Cabells Scholarly Analytics' journal lists with the Publons database, employing the Jaro-Winkler string metric. Descriptive analysis of sociodemographic characteristics and reviewing and publishing behaviour of scholars for whom reviews were found in the Publons database. SETTING Peer review of journal articles. PARTICIPANTS Reviewers who submitted peer review reports to Publons. MEASUREMENTS Numbers of reviews for predatory journals and legitimate journals per reviewer. Academic age of reviewers, the total number of reviews, number of publications and number of reviews and publications per year. RESULTS Analyses included 183 743 unique reviews submitted to Publons by 19 598 reviewers. Six thousand and seventy-seven reviews were for 1160 predatory journals (3.31% of all reviews) and 177 666 reviews for 6403 legitimate journals (96.69%). Most scholars never submitted reviews for predatory journals (90.0% of all scholars); few scholars (7.6%) reviewed occasionally or rarely (1.9%) for predatory journals. Very few scholars submitted reviews predominantly or exclusively for predatory journals (0.26% and 0.35%, respectively). The latter groups of scholars were of younger academic age and had fewer publications and reviews than the first groups. Regions with the highest shares of predatory reviews were sub-Saharan Africa (21.8% reviews for predatory journals), Middle East and North Africa (13.9%) and South Asia (7.0%), followed by North America (2.1%), Latin America and the Caribbean (2.1%), Europe and Central Asia (1.9%) and East Asia and the Pacific (1.5%). CONCLUSION To tackle predatory journals, universities, funders and publishers need to consider the entire research workflow and educate reviewers on concepts of quality and legitimacy in scholarly publishing

Relation between clinical evaluation of deglutition and the computed tomography in acute ischemic stroke patients

Stroke is one of the main causes of permanent lesions in adults and can provoke global motor sequels, speech and language alterations, and swallowing. During the acute phase, the detection of aspiration risks is essential to prevent lung complications and to allow appropriate therapeutic interventions, making possible precocious oral feeding. In the literature, the correlations between the disturbance of the deglutition and the location of the lesion in patients with stroke are not specific. This way, the objective of the present study was to determine if correlation exists between the location of the vascular lesion and dysphagia in acute ischemic stroke patients. Bedside clinical evaluation of deglutition was made in 27 patients with acute ischemic stroke and the results were compared with the computed tomography findings. In the clinical evaluation, 48% patients were dysphagic and 52% had functional deglutition. In dysphagic patients, 84% had lesion in carotid territory, with 76% in the middle cerebral artery. In patients with functional deglutition, 57% had lesion in the middle cerebral artery and 22% in the posterior cerebral artery. In 50% of the patients with functional deglutition and in 46% of the dysphagics the lesion was in the left hemisphere. In conclusion, the hemispherical location is not associated with the presence or not of dysphagia, however most of the dysphagic patients presented alterations in the carotid territory, especially in the middle cerebral artery.O acidente vascular cerebral (AVC) é uma das principais causas de lesões permanentes em adultos, podendo provocar seqüelas motoras globais, alterações de fala, linguagem e deglutição. Durante a fase aguda, a detecção do risco de aspiração é fundamental para prevenir complicações pulmonares e permitir apropriadas intervenções terapêuticas, possibilitando alimentação por via oral precoce e segura. Na literatura, as correlações entre o distúrbio da deglutição e a localização da lesão em pacientes com AVC são inespecíficas. Desta forma, o objetivo do presente estudo foi determinar se existe correlação entre a localização das lesão vascular encefálica e a dificuldade de deglutição em pacientes com AVC isquêmico (AVCI). Foram incluídos 27 pacientes com AVCI que foram submetidos à avaliação clínica da deglutição no leito. Os resultados foram confrontados com resultados obtidos pela tomografia computadorizada do crânio, relacionados à localização das lesões. Na avaliação clínica, 48% dos pacientes apresentaram disfagia orofaríngea e 52% deglutição funcional. Em 84% dos pacientes disfágicos foram observadas alterações no território carotídeo, sendo 76% na artéria cerebral média (ACM). Nos pacientes com deglutição funcional 57% apresentaram alterações em ACM e 22% em artéria cerebral posterior. O hemisfério esquerdo foi afetado em 50% dos pacientes com deglutição funcional e em 46% dos disfágicos. Em conclusão, a localização hemisférica não está associada com a presença ou não de disfagia, porém a maioria dos pacientes disfágicos apresentou alterações no território carotídeo, notadamente na ACM.CEFACUSP FMRPUSP FMRP HCUNIFESP-EPM Instituto de Gerenciamento em Fonoaudiologia e DeglutiçãoUNIFESP, EPM, Instituto de Gerenciamento em Fonoaudiologia e DeglutiçãoSciEL