Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas

Background: The etiopathogenesis of prostate cancer (PC) is still not clear, but hormonal, genetic, and environmental factors are thought to play a role in the tumor pathogenesis. Astrocyte elevated gene-1(AEG-1) as a novel transmembrane protein is predominantly located in the perinuclear region and endoplasmic reticulum. It has been found that AEG-1 upregulation increases the invasive ability of glioma and prostate cancer. Basic fibroblast growth factor (bFGF), matrix metalloproteinase-9 (MMP-9), cyclooxygenases-2 (COX-2), and adenomatous polyposis coli (APC) are very important in tumor progression as well. Materials and Methods: This study included 97 radical prostatectomy specimens. IHC stains for bFGF, MMP-9, COX-2, APC, and AEG-1 were performed on the tissue microarray using standard procedures. For each patient, the age, Gleason score, tumor volume, lymphovascular invasion, lymph node metastasis, surgical margin, and the invasion of vesiculoseminalis areas were assessed. Analyses were performed using the statistical PASW (ver. 18). Results: Statistically significant positive relationships were found MMP-9 and COX-2 (r = 0.242 and P = 0.017), between MMP-9 and APC (r = 0.207 and P = 0.043), and between bFGF and AEG-1 (r = 0.295 and P = 0.004). However, the relationships between age and staining results and tumor volume and staining results were not found to be significant. Although a positive correlation was found between the Gleason score and tumor volume and the Gleason score and age (r = 0.415 and P = 0.0001; r = 0.246 and P = 0.015, respectively), we did not find a statistically significant relationship between other stains and other prognostic parameters (lymphovascular invasion, lymph node metastasis, surgical margin, or vesiculoseminalis invasion). Conclusion:The relationships we found between MMP-9 and COX-2, between MMP-9, and APC and between bFGF and AEG-1 as independent prognostic parameters could be helpful in the development of new therapeutic procedures.Keywords: Adenomatous polyposis coli, astrocyte elevated gene‑1, basic fibroblast growth factor, cyclooxygenases‑2, matrix metalloproteinase‑9, prognostic parameters, prostate adenocarcinomasNigerian Journal of Clinical Practice • Oct-Dec 2013 • Vol 16 • Issue

The effect of age and body mass index on plantar cutaneous sensation in healthy women

[Purpose] This study was conducted to examine the effects of age and body mass index on plantar cutaneous sensation in healthy women. [Subjects and Methods] Two hundred and three healthy female volunteers over the age of 20 were included in the study. The statistical analyses were performed by considering the age and body mass index values of the individuals. The individuals were divided according to their ages and body mass index values. Foot pain was measured with a visual analogue scale and plantar cutaneous sensation using Semmes-Weinstein monofilaments. [Results] Fifty-six (27.5%) of the participants had normal weights, 67 (33%) were overweight, and 80 (39%) were obese. Statistical analysis revealed that as age and body mass index values increased, plantar sensitivity decreased and the frequency and severity of pain increased. [Conclusion] It is possible that healthy women may experience a decrease in foot plantar sensation with increasing weight and age. If women do not have any health problems, proprioception and sensory training must be focused on in order to prevent balance and falling problems. © 2016 The Society of Physical Therapy Science. Published by IPEC Inc

Identifying relationships between kinesiophobia, functional level, mobility, and pain in older adults after surgery

Background: Further data on the causes of functional independence or disability after surgery are needed to explain the clinical decision-making process for older patients, their families, and policy-makers. There are a limited number of studies showing the relationship between kinesiophobia, functional status, pain and mobility in older adults after surgery. Aims: The study aims to investigate relationships among kinesiophobia, pain, mobility, and functional status in older adults after surgery. Methods: A comparative–descriptive and cross-sectional study. The research was conducted with 99 older adults in the general surgery clinic after surgery. A Visual Analogue Scale was used to evaluate pain levels, the Standardized Mini-Mental State Examination to evaluate mental function status, the Functional Independence Measure to assess functional independence in daily activities, the Rivermead Mobility Index to evaluate basic mobility in daily life, and the Tampa Scale for Kinesiophobia to assess fear of mobility. Results: Regression analysis revealed a significant negative correlation between social security and kinesiophobia, and also between functional level and type of anesthesia and mental status in older women (R2 = ? 0.185, p = 0.005; R2 = ? 0.167, p = 0.011 and p = 0.005, respectively). Discussion: In the literature, there are no standardized procedures during the evaluation and rehabilitation of older adults after abdominal or thoracic surgery, etc. operations. This study will contribute to the current literature by attracting interest in this field and increasing the evaluations performed. Conclusions: The study findings emphasize the importance of evaluating the functional, mobility, mental and kinesiophobic status of older adults after surgery in clinics, rehabilitation centers, or research. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.2-s2.0-8511847134

Kan gazı analiz cihazı ve direkt enzim atik ölçüm metodu ile elde edilen bikarbonat değerlerinin korelasyonu

Introduction: In this study, we investigated to whether there is a relationship between bicarbonate levels simultaneously measured with the mathematical calculation of blood gas analysis device derived pH and pCO2 and direct enzymatic method. Materials and methods: Arterial blood samples were taken from 90 patients hospitalized in the intensive care unit. Bicarbonate level was simultaneously measured in the ABL 800 blood gas analyzer with the method of mathematical calculation from the pH and pCO2 and in the Roche Diagnostics Cobas c501 with the enzymatic method. The results were compared. Results: Pearson correlation coefficient between the two measurements was r=0.944 showing a significant positive relationship. Also value of the ICC calculation which was 0.963 showed that there was a significant agreement between the two measurement methods (p=0.0001). None of the 90 values were not out of the agreement limits, as shown in Bland-Altman graphic. Conclusion: The present study showed that bicarbonate measurements with the blood gas analyzers which give quick results are reliable and acceptable when compared with the results of the direct enzymatic method. © TurkJBiochem.com

The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats

AYYILDIZ, Mustafa/0000-0002-6594-3080; Ankarali, Seyit/0000-0003-3752-0846; Yildirim, Mehmet/0000-0003-1798-5478WOS: 000293206400003PubMed: 21731075In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 mu g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 mu g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 mu g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 mu g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine.Committee for Scientific Research of Ondokuz Mayis UniversityOndokuz Mayis University [T235, T389]The authors would like to thank Prof Dr Yuksel Bek for the statistical analysis and Dr Leslie Scarth for help in polishing the English. This study was supported by the Committee for Scientific Research of Ondokuz Mayis University (Grant no: T235 and T389)

Clinicopathological profile of peritoneal tuberculosis and a new scoring model for predicting mortality: an international ID-IRI study

Existing literature about peritoneal tuberculosis (TBP) is relatively insufficient. The majority of reports are from a single center and do not assess predictive factors for mortality. In this international study, we investigated the clinicopathological characteristics of a large series of patients with TBP and determined the key features associated with mortality. TBP patients detected between 2010 and 2022 in 38 medical centers in 13 countries were included in this retrospective cohort. Participating physicians filled out an online questionnaire to report study data. In this study, 208 patients with TBP were included. Mean age of TBP cases was 41.4 ± 17.5 years. One hundred six patients (50.9%) were females. Nineteen patients (9.1%) had HIV infection, 45 (21.6%) had diabetes mellitus, 30 (14.4%) had chronic renal failure, 12 (5.7%) had cirrhosis, 7 (3.3%) had malignancy, and 21 (10.1%) had a history of immunosuppressive medication use. A total of 34 (16.3%) patients died and death was attributable to TBP in all cases. A pioneer mortality predicting model was established and HIV positivity, cirrhosis, abdominal pain, weakness, nausea and vomiting, ascites, isolation of Mycobacterium tuberculosis in peritoneal biopsy samples, TB relapse, advanced age, high serum creatinine and ALT levels, and decreased duration of isoniazid use were significantly related with mortality (p 0.05). This is the first international study on TBP and is the largest case series to date. We suggest that using the mortality predicting model will allow early identification of high-risk patients likely to die of TBP. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature

Kasık fıtığı tamirinde kırsal ve kentsel yerleşim yerine göre hastaların tutumları

Amaç: Kasık fıtığı onarımı en sık yapılan cerrahi uygulamalardan biridir. Bu çalışmanın amacı kırsal ve kentsel yerleşim yerlerinde yaşayan hastalar arasında tercih edilen anestezi yöntemi, hastaların karar verme sürecine katılımı ve hastanede yatma süresi açısından fark olup olmadığının değerlendirilmesidir. Gereç ve Yöntem: Kasım 2001- Nisan 2006 tarihleri arasında elektif kasık fıtığı onarımı uygulanan 206 hastaya ait veriler retrospektif olarak değerlendirildi. Karadeniz bölgesinde yerel bir hastanede kasık fıtığı nedeniyle ameliyat edilen hastalar ulaşım imkanlarına göre kırsal ve kentsel yerleşim yerinde yaşayanlar olarak 2 gruba ayrıldılar. Bu gruplar arasında tercih edilen anestezi yöntemi, hastanede ameliyat sonrası yatış süresi ve hastaların karar verme sürecine katılımı irdelendi. Aynı zamanda hastaların yaşı ve cinsiyetine göre bu parametreler açısından fark olup olmadığı irdelendi. Sonuç: Ameliyat sonrası hastanede ortalama yatış süresi kırsal alanda yaşayanlarda ve erkeklerde daha uzundur. Genç hastalar ve şehirliler, yaşlılar ve kırsal kesimde yaşayanlara göre seçilecek ameliyat ve anestezi yöntemi konusunda daha çok kendileri karar verme eğiliminde olmuşlardır.Purpose: Groin hernia repair is one of the commonest operations in surgical practice. The aim of this study was to find out if there is any difference between patients living in a rural area and those living in an urban area in terms of preferred type of anaesthesia, patients’ participation in decision making, and hospitalisation time. Methods: The records of patients that underwent an elective groin hernia repair between November 2001 and April 2006 were evaluated retrospectively. Preferred type of anaesthesia, hospitalisation time, and participation in the decision making were investigated in patients living in arural and an urban area, in the northern Black Sea region of Turkey. We also investigated whether the patient’s age and sex had any effect on these parameters. Results: A total of 206 patients underwent elective repair of groin hernia in a State Hospital. Mean postoperative time spent in hospital was significantly longer for patients living in the rural area than for those living in the urban area. The hospitalisation time was longer for male than for female patients. Local anaesthesia was the preferred type of anaesthesia for the elderly. Older patients and villagers mostly preferred the physician to make the final decision about their treatment and they had longer hospital stays. Conclusion: Mean hospitalisation time was longer for patients living in the rural area and for male patients than for female patients. Younger patients and city dwellers preferred to make their own decision about their treatment and they had shorter hospital stays

Haptic feedback enhances rhythmic motor control by reducing variability, not improving convergence rate

Stability and performance during rhythmic motor behaviors such as locomotion are critical for survival across taxa: falling down would bode well for neither cheetah nor gazelle. Little is known about how haptic feedback, particularly during discrete events such as the heel-strike event during walking, enhances rhythmic behavior. To determine the effect of haptic cues on rhythmic motor performance, we investigated a virtual paddle juggling behavior, analogous to bouncing a table tennis ball on a paddle. Here, we show that a force impulse to the hand at the moment of ball-paddle collision categorically improves performance over visual feedback alone, not by regulating the rate of convergence to steady state (e.g., via higher gain feedback or modifying the steady-state hand motion), but rather by reducing cycle-to-cycle variability. This suggests that the timing and state cues afforded by haptic feedback decrease the nervous system's uncertainty of the state of the ball to enable more accurate control but that the feedback gain itself is unaltered. This decrease in variability leads to a substantial increase in the mean first passage time, a measure of the long-term metastability of a stochastic dynamical system. Rhythmic tasks such as locomotion and juggling involve intermittent contact with the environment (i.e., hybrid transitions), and the timing of such transitions is generally easy to sense via haptic feedback. This timing information may improve metastability, equating to less frequent falls or other failures depending on the task