Perspective of buried oxide thickness variation on triple metal-gate (TMG) recessed-S/D FD-SOI MOSFET

Recently, Fully-Depleted Silicon on Insulator (FD-SOI) MOSFETs have been accepted as a favourable technology beyond nanometer nodes, and the technique of Recessed-Source/Drain (Re-S/D) has made it more immune in regards of various performance factors. However, the proper selection of Buried-Oxide (BOX) thickness is one of the major challenges in the design of FD-SOI based MOS devices in order to suppress the drain electric penetrations across the BOX interface efficiently. In this work, the effect of BOX thickness on the performance of TMG Re-S/D FD-SOI MOSFET has been presented at 60 nm gate length. The perspective of BOX thickness variation has been analysed on the basis of its surface potential profile and the extraction of the threshold voltage by performing two-dimensional numerical simulations. Moreover, to verify the short channel immunity, the impact of gate length scaling has also been discussed. It is found that the device attains two step-up potential profile with suppressed short channel effects. The outcomes reveal that the Drain Induced Barrier Lowering (DIBL) values are lower among conventional SOI MOSFETs. The device has been designed and simulated by using 2D numerical ATLAS Silvaco TCAD simulator

PREVENTION OF ARSHAS WITH REFERENCE TO LIFESTYLE CHANGES: SCOPE IN AYURVEDA

Arshas or hemorrhoid is quite a common problem observed both in men and women. It can be a recurrent and painful intrusion in life. Even young people who are in good shape can get Arshas. The incidence of Arshas is increasing day by day due to the influence of western food habits, diet which contains very less amount of soluble fibre, inappropriate diet regimen and Vegadharana (suppression of natural urge to defecate) which causes constipation. Other factors which trigger Arshas are improper toilet habits, sedentary work style or strenuous work, prolonged periods of standing or sitting, prolonged travelling on two wheelers and overweight. Its incidence increases as age advances, and at least 50% of people over the age of 50 years have some degree of hemorrhoidal symptoms. Therefore, simple lifestyle changes can effectively reduce the recurrence of this common and painful condition. There is a wide spread description of etiological factors and pathogenesis of Arshas in Ayurvedic literatures as well as surgical textbooks. The measures of prevention such as implementing various Pathyapathyas with respect to Ahara and Vihara (diet regimen and simple life style changes) have great importance in the present day scenario. By understanding the Nidana and samprapti the various preventive measures can be interpreted rightly and implemented so that it will prevent the disease Arshas. Therefore the need for the understanding of the Pathyapathya of Arshas along with certain life style changes becomes valuable for the common man as well as the physicians in the preventive and the curative aspects of the disease. There by, we can prevent occurrence and recurrence of Arshas

Psychiatric comorbidity in substance abusing population in Garhwal hills of Uttarakhand

Background: Psychiatric morbidity occurs more frequently in patients with substance abuse than in the general population. Routine evaluation and treatment of psychiatric morbidity can be helpful in improving care of substance abusing population but such data are relatively meager from developing countries.Methods: This study was conducted in the Out-patient facility of the Department of Psychiatry, Veer Chandra Singh Garhwali Government Institute of Medical Science & Research, Srinagar (Uttarakhand), starting from 23 September 2015. One hundred consecutive treatment seeking subjects fulfilling international classification of diseases and related health problems, 10th Revision (ICD-10), criteria for mental and behavioral disorders due to psychoactive substance use were included in the study. All the participants were required to sign an informed consent approved by the institutional ethical committee before being enrolled in the study. All the subjects included in the study were administered a semi-structured Proforma to elicit the clinical and socio-demographic variables.  Results: One hundred patients consisting of 95 men (95%) and 05 women (05%) were included. The average age of the sample was 39.68 years (SD=11.97). As for the socio-demographic variables other than age, 87% of the patients were married, 62% patients were living in nuclear families and 66% belonged to the rural areas. 79% patients were educated up to high school and above and only 06% were illiterate. 36 % of the subjects screened positive for psychiatric morbidity. Psychiatric morbidity was significant higher in unmarried people with less education (primary or less) and those living in nuclear families.  Conclusions: Psychiatric comorbidity was found in 36% of the study subjects

Information Security Behavioral Model: Towards Employees’ Knowledge and Attitude

Information Security has become a significant concern for today’s organizations. The internal security threats acts as the most curtail type of security threat within an organization. These internal security threats are a result of poor conduct of security behavior by the employees within an organization. If not deal properly, it may hamper the auditing of organization. Auditing plays an important role in the business environment. Before conducting auditing it is essential to examine the behavioral aspect of the employees. The objective of this paper is to take out this internal threat that acts as a security slack, out of an organization by using a well-structured approach to develop a security behavior model. To validate the proposed model a survey method is used. The survey method measures the knowledge and attitude of an individual employee towards information security to analyze the behavioral security aspect of the employee’s. Statistical Analysis of the result of survey indicates that the employees’ knowledge and his attitude towards information security derive his behavior towards achieving ultimate organizational goal and thus validates the proposed security model

Analysis of labor induction in a tertiary care hospital

Background: Induction of labour (IOL) is a very common labour room procedure. Although labor is a natural physiological process, deliberate intervention in the form of induction may be required in many instances. It is needed in almost 20% of pregnant women for a variety of indications. The objective is to evaluate indications, different methods, and feto-maternal outcome of induced labour in tertiary care hospital.Methods: This was a retrospective study of IOL conducted in the department of obstetrics and gynecology, Shri Guru Ram Rai institute of medical and health sciences, Dehradun, Uttarakhand. Women who underwent IOL beyond 28 weeks gestation with single cephalic presentation with no contraindication for vaginal birth were included in the study. Statistical analysis was done with Microsoft excel.Results: A total of 1532 women delivered in the hospital during the study period. Among them, 498 women were induced (32.5%). Most common method of induction was misoprostol (40.36%) followed by prostaglandin E2 gel (26.90%).  Out of 498 inductions, 377 women delivered vaginally making success of induction around 75.70%. Among them, 335 women had normal delivery (67.26%) and 42 women required instrumental delivery (8.4%) and 121 women underwent lower segment caesarean section (LSCS) (24.29%).Conclusions: Elective inductions of labor in properly selected indications at optimized timings aid in achieving a favorable maternal and fetal outcome. Methods of inductions, timing and intrapartum monitoring plays an important role in influencing obstetric outcome

Systematic Review of Primary Hyperparathyroidism in India: The Past, Present, and the Future Trends

Primary hyperparathyroidism (PHPT) has become an asymptomatic disease in the Western world with the introduction of routine calcium screening. However, the same phenomenon is not observed in India. We have now systematically reviewed the status of PHPT in India. While there is a paucity of literature on PHPT from India when compared to Western countries, some information can be gleaned upon. Most patients present with symptomatic disease whereas very few are screen-detected cases (bone disease 77%, renal disease 36%, and 5.6% asymptomatic). Mean calcium, parathyroid hormone (PTH), and alkaline phosphate levels are high while Vitamin D levels are low. The average parathyroid gland weight is large and the majority being parathyroid adenomas (89.1%). Hungry bone syndrome (HBS) is common in the postoperative period. The disease-related mortality rate is 7.4%, recurrence 4.16%, and persistent disease 2.17%. We suggest that dedicated efforts are needed to pick up asymptomatic disease in India by methods like incorporating calcium estimation in the routine health check-up programs

Knowledge, attitude and belief about contraception in post-partum and post abortal women in a tertiary care centre

Background: In this modern era where women have achieved the highest positions in politics, corporate world and conquered the moon, on the other side she is still fighting for her right, i.e. health. For this the women should become economically independent. The concept of waiting for a son preference by the society should be discouraged. Postpartum and post abortal period are very crucial for a women especially for many of those belonging to the villages as this may be the only time she comes in contact with a health personnel. Hence counseling should be given to all patients at this time.Methods: We conducted a cross-sectional study in the department of obstetrics and gynecology of sir Sunder Lal hospital between August 2013 to October 2013. 230 post-partum and post abortal women were interrogated and counseled about various methods of contraception. Awareness about emergency contraception pill and MTPill was also noted.Results: Only 69% had heard about various methods of contraception. IUCD and OCP were known to most patients. Most patients knew about contraception from television and doctors. After counseling 97% patients wanted contraception. Most patients opted for IUCD, Barrier method and DepoProvera. 20% patients knew about emergency contraception pill and 34.4% patients about MTPill.Conclusions: There is lack of awareness of contraception, emergency contraception and medical abortion in women under study. Regular counseling is a must to all post-partum and post abortal women. Information should be provided about various methods and patients should be given a choice to choose the method of contraception

Retinopathy of prematurity in preterm babies in a local medical college and hospital

Background: Retinopathy of prematurity is a multifactorial vasoproliferative retinal disease that increases in incidence with decreasing gestational age and is one of the leading causes of preventable childhood blindness in India. Advances in neonatology have led to dramatic increase in survival of preterm neonates and in turn, to the risk of developing ROP. Since most of the risk factors associated with ROP mentioned above arise in the neonatal intensive care unit (NICU) itself and most of them are avoidable, cautious monitoring of the risk factors, early screening, follow up and surgical intervention have been shown to reduce the incidence and improve the outcome of ROP.Methods: This was a prospective observational study conducted for a period of 2 years. A total of 151 infants admitted in NICU /SNCU who satisfied the inclusion criteria were enrolled in this study. Initial and follow up screening was conducted in three phases the results were documented in proforma after ethical clearance.Results: Comparison of risk factors between eyes with and without ROP was done using Chi-square test. A p-value of<0.05 was considered to be statistically significant. Incidence of ROP in centre is found to be 33.8%. Among maternal risk factors, multiple gestation and PROM/PPROM is found to be significant in the development of ROP from this study. However, mode of delivery and gestational hypertension, were found to be not significant in ROP. Among neonatal risk factors, low birth weight, lower gestational age, prolonged oxygen exposure, blood transfusion, mechanical ventilation, sepsis, phototherapy was found to be significant in this study.Conclusions: ROP, being an emerging cause for potentially blinding visual disability, needs to be diagnosed early. Due to the advancements in neonatology and better survival of preterm babies, timely screening, regular follow up, early detection and intervention is mandatory. A multidisciplinary approach is required in diagnosis and treatment of the disease. Proper counselling and motivation for parents of preterm and low birth weight babies for regular follow up is also essential

Electrocardiographic abnormalities with quinine and artesunate combinations in comparison to quinine or artesunate alone in severe falciparum malaria

Background: In Multi drug resistant falciparum malaria anti-malarial combinations are frequently used i.e. Quinine and IV Artesunate. Quinine is associated with electrocardiographic disturbances. Artesunate in high dose produce QTC prolongation in animal models, so the electrocardiogram (ECG) is thoroughly studied.Methods: Severe falciparum malaria cases 15 to 60 years were randomly allocated into 3 treatment regimens i.e. Artesunate, Quinine alone and their combination. Electrocardiographic recordings were taken periodically in 3 groups and compared statistically.Results: The mean QTC interval is significantly prolonged in combination treatment group from 0.40+0.02 to 0.49+0.09 (P<0.05) ECG disturbance (44%). QTC prolongation was commonest (i.e. 27%) with electrolyte imbalance could produce life threatening cardiac arrhythmia (Polymorphic VT with Sr K+ 2.9). Artesunate alone was list prone (i.e. only 6%) Quinine though has comparatively more (i.e. 25%) but there is no life-threatening cardiac arrhythmia in artesunate and Quinine

Editorial: Pathogenesis, treatment, and future directions for rare T-cell leukemias

Mature T-cell leukemias represent rare, but increasingly recognized diseases of which, compared to their B-cell counterparts, comparatively little is established on their pathogenesis, diagnosis, and treatment. These leukemic post-thymic T-cell neoplasms range from the spectrum of chronic, sometimes debilitating disorders such as T-large granular lymphocytic leukemia (T-LGLL), and related leukemias such as NKLGLL, to more aggressive malignancies such as T- prolymphocytic leukemia (T-PLL). In this series, entitled ‘Pathogenesis, Treatment, and Future Directions for Rare T-cell Leukemias’ we review the current state of the science of these important T-cell neoplasms to inform on their treatment, diagnosis, and pathophysiology