Twin shaping filter technique for signals compensation in CZT detectors grown by the vertical bridgman method

CdTe/CdZnTe is a consolidated material to realize detectors for a large variety of applications, such as medical, industrial, and space research. An Italian collaboration, involving the CNR/IMEM and INAF/IASF institutes, was born some years ago with the aim to develop a national capability to produce CZT detectors starting from the material growth to the final detection device. Some important features of these detectors (pulse height, energy resolution, photopeak efficiency) are affected by the charge collection efficiency: the low mobility of the charge carriers (particularly the holes) and trapping/detrapping phenomena can degrade the CdTe/CZT detectors response, depending on the distance between the charge formation position and the collecting electrodes. Several efforts have been made to improve the detection efficiency as well as the energy resolution, using both the optimization of the electrode geometry (drift strip technique, coplanar-grid, small pixel effect) and pulse height compensation methods to overcome the hole trapping problem. We have studied a bi-parametric method that uses a twin pulse shaping active filter to analyze the same signal: one slow, which is proportional to the energy of the photon, and one fast, which depends on the position of the interaction with respect to the collecting electrode. The experimental results obtained with the application of this bi-parametric technique on planar CZT detectors of good quality grown by the Vertical Bridgman method at CNR/IMEM are presented as a function of the bias voltage, photon energy and shaping time pairs

Surgical Brain Metastases: Management and Outcome Related to Prognostic Indexes: A Critical Review of a Ten-Year Series

Brain metastasis are the most common neoplastic lesions of the nervous system. Many cancer patients are diagnosed on the basis of a first clinical presentation of cancer on the basis of a single or multiple brain lesions. Brain metastases are manifestations of primary disease progression and often determine a poor prognosis. Not all patients with a brain metastases undergo surgery: many are submitted to alternative or palliative treatments. Management of patients with brain metastases is still controversial, and many studies have been developed to determine which is the best therapy. Furthermore, management of patients operated for a brain metastasis is often difficult. Chemotherapy, stereotactic radiosurgery, panencephalic radiation therapy, and surgery, in combination or alone, are the means most commonly used. We report our experience in the management of a ten-year series of surgical brain metastasis and discuss our results in the preoperative and postoperative management of this complex condition

Signal compensation in CZT detectors grown by the Vertical Bridgman method using a twin-shaping filter technique

CdTe/CZT is now a material consolidated for the detectors realization operating at room temperature, which find a large variety of applications in astrophysics, medical imaging and security. An Italian collaboration, involving the CNR/IMEM and INAF/IASF institutes, was born several years ago with the aim to develop a national capability to produce CZT detectors starting from the material growth to the final detection device. The collection efficiency of the charge carriers affects some important features of these detectors, such as the pulse height, energy resolution, photopeak efficiency. In fact the low mobility of the charge carriers (particularly the holes) and trapping/detrapping phenomena can degrade the CdTe/CZT detector response, depending on the distance between the charge formation position and the collecting electrodes. Two kinds of techniques can be used to improve both the collection efficiency and the energy resolution, based on the optimization of the electrode geometry and/or signal compensation methods. We have implemented a biparametric method that uses a twin pulse shaping active filter to analyze the same signal from the detector: one “slow”, which is proportional to the energy of the incident photon, and one “fast”, which depends on the position of the interaction with respect to the collecting electrode. We present this biparametric technique applied on planar CZT detectors grown by the Vertical Bridgman method at CNR/IMEM (Parma), the experimental results obtained as a function of the bias voltage, photon energy, shaping time pairs and the compensated spectra

From EHR to EDC - The Experience at the Policlinico Hospital in Milan.

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Twin-Shaping Filter Technique Applied to CZT Detectors

CdTe/CdZnTe is an attractive and consolidated material with which to realize detectors with good efficiency and energy resolution, operating at room temperature for a large variety of applications such as astrophysics, medical imaging and security. However, this type of material suffers from the low mobility of the charge carriers (particularly the holes), which are trapped and so degrade the detector response in terms of charge collection efficiency, energy resolution and photopeak efficiency. The response of a planar CdTe/CdZnTe detector, which depends on the distance between the charge formation position and the collecting electrodes, can be improved by using two kinds of techniques, based on the optimization of the electrode geometry and/or signal compensation methods. We are studying the feasibility and the reliability of a biparametric method that uses a twin pulse shaping active filter to analyze each signal from the detector twice: one “Slow”, which is proportional to the energy of the incident photon, and one “Fast”, which depends on the position of the interaction with respect to the collecting electrode. In this paper we describe the bi-parametric technique applied to planar CdZnTe detectors grown by CNR/IMEM and to Spectrometer Grade detectors. We report the experimental results in terms of energy resolution, peak-to valley ratio and photopeak efficiency, as well as the compensated spectra obtained as a function of the bias voltage, photon energy and shaping time pairs. We also report the results obtained by using a CdZnTe drift strip detector. Furthermore, this technique could be implemented in an array of detectors, whose front-end electronics is composed of ASICs, where the shaping time can be selected for each channel, like the RENA-3 IC (NOVA R&D)

Focussing crystals for use in broad band hard X/soft gamma-ray Laue lenses

Hard X-/soft gamma-ray astronomy is a crucial window for the study of the most energetic and violent events in the Universe. To fulfil the scientific requirements in this regime, a new generation of telescopes with a broad operational band extending from tens up to several hundreds of keV and exploiting unprecedented sensitivity (50-100 times better that current instruments) is required. We report on diffractive bent crystals made of Gallium Arsenide (GaAs) that are suitable for the construction of high sensitivity X-/gamma-ray Laue lens space telescopes. Laue lenses, made of sets of diffractive crystals working in transmission, offer one possibility, albeit technically challenging, to build a new generation of focusing telescopes that can extend the energy band far beyond the 80 keV limit for current multilayer concentrators. In particular, we present the results obtained from the characterization of crystals that will be used to realise a broad band Laue demonstrator. They have been studied in terms of focusing capability and diffraction efficiency by using a flat X-ray panel imager and an HPGe spectrometer as focal plane detectors. The GaAs tiles, bent via a surface lapping procedure, have been developed at the IMEM/CNR in Parma (Italy) in the framework of the LAUE project funded by the Italian Space Agency. The main goal of the project was to build a broad band Laue lens demonstrator for hard X-/soft gamma-rays (80-300 keV

High performance 3D CZT spectro-imager for BNCT-SPECT: preliminary characterization

The National Institute of Nuclear Physics (INFN) is supporting the 3CaTS project with the aim of developing a new Single Photon Emission Computed Tomography (SPECT) system for real time 10 B therapeutic dose monitoring in the binary experimental hadron therapy called Boron Neutron Capture Therapy (BNCT). BNCT is a highly selective tumour treatment based on the neutron capture reaction 10 B(n,α) 7 Li. The secondary particles have a high LET with ranges in tissues of the order of 10 μm (thus less than the mean cell diameter of few tens μm). Targeting the 10 B delivery towards cancer, the released energy lethally damages only the malignant cells sparing the normal tissues, thus enabling a cell-level selective treatment. To properly exploit this selectivity it is mandatory to know the 10 B spatial distribution inside patients body during neutron irradiation. This can be achieved by detecting the 478 keV γ ray emitted in the 94% of 10 B capture reactions by a SPECT system. A 3D CZT drift strip detector with a sensitive volume of 20x20x5 mm 3 was developed, able to perform high-resolution X-ray and γ ray spectroscopic imaging (10-1000 keV). The detector signals are analysed by a custom digital multi-channel electronics, based on two pipelined fast and slow analysis, able to perform multi-parameter analysis and fine temporal coincidences (<; 20 ns). Energy resolution of 3.3% (4 keV) and 2% (13 keV) FWHM was measured, with uncollimated sources and no corrections, at 122 keV and 662 keV, respectively

Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics

The Italian Consensus Position Statement on Diagnosis, Treatment and Prevention of Obesity in Children and Adolescents integrates and updates the previous guidelines to deliver an evidence based approach to the disease. The following areas were reviewed: (1) obesity definition and causes of secondary obesity; (2) physical and psychosocial comorbidities; (3) treatment and care settings; (4) prevention.The main novelties deriving from the Italian experience lie in the definition, screening of the cardiometabolic and hepatic risk factors and the endorsement of a staged approach to treatment. The evidence based efficacy of behavioral intervention versus pharmacological or surgical treatments is reported. Lastly, the prevention by promoting healthful diet, physical activity, sleep pattern, and environment is strongly recommended since the intrauterine phase

How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March-April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p &lt; 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p &lt; 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p &lt; 0.0001) or urgent (20.4% vs. 38.5%; p &lt; 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p &lt; 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon-patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice

Vegetation history of Lago Battaglia (Eastern Gargano coast, Apulia Italy) during the middle-Late Holocene

A pollen and charcoal record from Gargano (southern Italy) provides new information on the vegetation history and environmental change in southern Italy during the middle to late Holocene. The chronological framework is provided by six AMS radiocarbon dates carried out on plant macroremains. Pollen diagrams record a Mediterranean vegetation along the coastland and a stable mixed oak forest at higher elevations between ca. 5900 and 4200 cal b.p. A sharp and dramatic fall of tree pollen concentrations and a change in fire frequencies occurred from approximately 4200 cal b.p. suggesting a climate change towards drier conditions. This event is coherent with regional and extra-regional palaeoclimatic records that suggest that a mid-Holocene dry period was experienced in southern Italy, southern Spain, and perhaps further afield. Human impact on vegetation seems to have occurred since about 2700 cal b.