La tensión ocular y la rigidez escleral en el preoperatorio y postoperatorio de la intervención de desprendimiento de retina : su valor diagnóstico y pronóstico

Tesis Univ. Complutense.Depto. de Inmunología, Oftalmología y ORLFac. de MedicinaTRUEProQuestpu

La tensión ocular y la rigidez escleral en el preoperatorio y postoperatorio de la intervención de desprendimiento de retina : su valor diagnóstico y pronóstico

Tesis Univ. Complutense.Depto. de Inmunología, Oftalmología y ORLFac. de MedicinaTRUEProQuestpu

Ethical implications of information and communication technologies in the context of development : a theological evaluation of current development strategies

Thesis advisor: Thomas MassaroThis thesis does not intend to diminish the incontestable contribution of technology in combating poverty and underdevelopment. On the contrary, this thesis is an expression of optimism when it comes to the use of technology in bringing some measure of welfare to those deprived of adequate conditions of life. At the same time, this thesis is a reflection on the meaning of those bold words: technology, welfare and condition of life. We tend to put them together very easily and cavalierly, but the link may be less than fully evident, especially if we do not have a clear idea of what conditions of life we are promoting and pursuing.Thesis (STL) — Boston College, 2011.Submitted to: Boston College. School of Theology and Ministry.Discipline: Sacred Theology

The genus Cotoneaster (Rosaceae) in NW Africa

Abstract Romo A. & Boratyński A.: The genus Cotoneaste

Incidencia del conocimiento de la normativa tributaria sobre servicios digitales prestados por sujetos no domiciliados en la gestión del cumplimiento tributario de la empresa Cóndor Perú S.A.C. en el año 2015

La presente investigación tiene como objetivo determinar la manera en que el conocimiento de la normativa tributaria sobre servicios digitales prestados por sujetos no domiciliados incide en la gestión del cumplimiento tributario de la empresa Cóndor Perú S.A.C. en el año 2015, a efecto de reducir las contingencias de carácter tributario y planificar un cumplimiento tributario eficiente. Con relación a la metodología empleada, se utilizó el diseño no experimental – descriptivo, el método empleado fue el analítico-deductivo. El tipo de investigación fue mixto, puesto que comprendió el uso de fuentes bibliográficas y documentación contable, así como actividades de recolección de datos en campo. Así también, se emplearon técnicas para la recopilación de información, los cuales se llevaron a cabo mediante la revisión de documentación contable y la aplicación de un cuestionario al personal contable y financiero. Los resultados obtenidos mostraron que un 60.50% de las respuestas marcadas por el personal del área contable y finanzas fueron incorrectas, lo cual incide de manera negativa en la gestión del cumplimiento tributario de la empresa. De ese modo, la persona al no contar con los elementos técnicos y normativos necesarios sería incapaz de prevenir o evitar contingencias que deben ser atendida con capacitaciones internas y diseño de planes de acción ante fiscalizaciones.Trabajo de suficiencia profesionalCampus Lima Centr

Control automático de tiempo de precalentamiento en ajuste de interruptores termomagnéticos

T3-2020Se exponen los diferentes mecanismos para la realización de este nuevo sistema, para lo cual fue necesario el desarrollo de una aplicación que permite realizar de forma autónoma la verificación y certificación de las conexiones de los cables planos flexibles.Maestrí

Computational Exploration of Lexical Development in Down Syndrome

Research on lexical development in Down syndrome (DS) has emphasized a dissociation between language comprehension and production abilities, with production of words being relatively more impaired than comprehension. Current theories stress the role of associative learning on lexical development. However, there have been no attempts to explain the atypical lexical development in DS based on atypical associative learning. The long-term potentiation (LTP) and long-term depression (LTD) of synapses, underlying associative learning, are altered in DS. Here we present a neural network model that instantiates notions from neurophysiological studies to account for the disparities between lexical comprehension and production in DS. Our simulations show that an atypical LTP/LTD balance affects comprehension and production differently in an associative model of lexical development

Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

[EN]Oxidative stress is related to ageing and degenerative diseases, including cancer. However, a moderate amount of reactive oxygen species (ROS) is required for the regulation of cellular signalling and gene expression. A low level of ROS is important for maintaining quiescence and the differentiation potential of haematopoietic stem cells (HSCs), whereas the level of ROS increases during haematopoietic differentiation; thus, suggesting the importance of redox signalling in haematopoiesis. Here, we will analyse the importance of ROS for haematopoiesis and include evidence showing that cells from leukaemia patients live under oxidative stress. The potential sources of ROS will be described. Finally, the level of oxidative stress in leukaemic cells can also be harnessed for therapeutic purposes. In this regard, the reliance of front-line anti-leukaemia chemotherapeutics on increased levels of ROS for their mechanism of action, as well as the active search for novel compounds that modulate the redox state of leukaemic cells, will be analysed

From altered synaptic plasticity to atypical learning:a computational model of Down syndrome

Learning and memory rely on the adaptation of synaptic connections. Research on the neurophysiology of Down syndrome has characterized an atypical pattern of synaptic plasticity with limited long-term potentiation (LTP) and increased long-term depression (LTD). Here we present a neurocomputational model that instantiates this LTP/LTD imbalance to explore its impact on tasks of associative learning. In Study 1, we ran a series of computational simulations to analyze the learning of simple and overlapping stimulus associations in a model of Down syndrome compared with a model of typical development. Learning in the Down syndrome model was slower and more susceptible to interference effects. We found that interference effects could be overcome with dedicated stimulation schedules. In Study 2, we ran a second set of simulations and an empirical study with participants with Down syndrome and typically developing children to test the predictions of our model. The model adequately predicted the performance of the human participants in a serial reaction time task, an implicit learning task that relies on associative learning mechanisms. Critically, typical and atypical behavior was explained by the interactions between neural plasticity constraints and the stimulation schedule. Our model provides a mechanistic account of learning impairments based on these interactions, and a causal link between atypical synaptic plasticity and associative learning