Antigen-specific immune reactions to ischemic stroke

Brain proteins are detected in the cerebrospinal fluid (CSF) and blood of stroke patients and their concentration is related to the extent of brain damage. Antibodies against brain antigens develop after stroke, suggesting a humoral immune response to the brain injury. Furthermore, induced immune tolerance is beneficial in animal models of cerebral ischemia. The presence of circulating T cells sensitized against brain antigens, and antigen presenting cells (APCs) carrying brain antigens in draining lymphoid tissue of stroke patients support the notion that stroke might induce antigen-specific immune responses. After stroke, brain proteins that are normally hidden from the periphery, inflammatory mediators, and danger signals can exit the brain through several efflux routes. They can reach the blood after leaking out of the damaged blood-brain barrier (BBB) or following the drainage of interstitial fluid to the dural venous sinus, or reach the cervical lymph nodes through the nasal lymphatics following CSF drainage along the arachnoid sheaths of nerves across the nasal submucosa. The route and mode of access of brain antigens to lymphoid tissue could influence the type of response. Central and peripheral tolerance prevents autoimmunity, but the actual mechanisms of tolerance to brain antigens released into the periphery in the presence of inflammation, danger signals, and APCs, are not fully characterized. Stroke does not systematically trigger autoimmunity, but under certain circumstances, such as pronounced systemic inflammation or infection, autoreactive T cells could escape the tolerance controls. Further investigation is needed to elucidate whether antigen-specific immune events could underlie neurological complications impairing recovery from stroke

Lepton flavor changing higgs boson decays in some extensions of the Standard Model

We present our results for the one-loop contributions to the Higgs boson flavor-changing decays h → μτ in two extensions of the Standard Model: the Little Higgs Model with T-parity and the Two Higgs Doublet Model with a fourth generation of fermions. In both cases we find that the respective branching ratio BR(h → μτ) is of order 10−4 – 10−6. In the case of the 4G2HDM, the one-loop radiative correction is of the same order of magnitude as the tree level branching ratio. We find that in both models the branching ratios for the decay modes h → eτ, eμ are even more suppressed

Lepton flavor changing higgs boson decays in a two higgs doublet model with a fourth generation of fermions

We analyze the flavor changing decay h → μt in the framework of a two Higgs doublet model with a fourth generation of fermions (4G2HDM) which couples only to the heavy scalar doublet. We find that the respective branching ratio at one-loop level can reach values as high as 10-4-10-6 for masses of 300 GeV-1 TeV for the heavy leptons in the fourth family and the new heavy Higgs bosons. These radiative corrections are of the same order of magnitude as the tree level prediction of the 4G2HDM

Design of an Automated Machine that Projects Ultraviolet Rays for the Safety of Food Products for Supermarkets

Abstract—This research presents the design and control of a machine for use in shopping centers and markets, which has been designed using mechatronic systems and artificial intelligence. In this research, a control is established for each moment of use, thus being more autonomous and efficient. The development of the project shows that the action of a reconnaissance camera with artificial intelligence before the disinfection chamber and mechanized pivoting arms at the outlet improves the autonomy of the machine. Also, a control panel was added that regulates the selection and control process in case of inconveniences; In addition, the type C UV disinfection chamber is covered with ABS polymer to prevent the rays from going outside. From the above, the mechatronic system implemented will improve the quality and disinfection time of the products in supermarkets

Design of an automatic system of an accelerated biogas biodigester for rural areas in Peru

This research presents the design and control of a biodigester with mechatronic systems for control and a closed systemof controlled compression to reduce the times in the generation of biogas. The development of the project shows that the application of level sensors, electro valves, and exhaust ducts are feasible in each tank through a control panel in order to monitor each process. Theacceleration stage to obtain biogas consists of a closed system type cylinder-piston, to perform a controlled compression reducing fermentation times, additionally it was considered that the drive of this cylinder is mechanical type due to the limited access of electrical energy in rural areas. The control and design of the proposed system will provide multiple improvements in homes in rural Peruvian areas that require solutions based on better use of natural resources with the waste generated by livestock, use of energy reducing pollution to their environment, creating access to energy generation, and the possibility of reducing diseases due to the consumption of polluting fuels during the preparation of their food

Design of a mechatronic assistant in the treatment of cognitive abilities using musical stimuli for people with dementia

This research presents the design and control of a mechatronic assistant for the treatment with music therapy in dementia patients, in emphasis on Alzheimer’s disease, through control software im- plemented in a mechatronic system. The development of research shows that the proposed mechatronic system detects and records the behavior of brain waves, through communication in order to perform some corrective action against a possible unwanted unfore- seen response during therapy. This communication can be in real time by communicating via Bluetooth through an application to a family member or patient manager and regulates the musical style according to the type of brain wave that best effects the patient with dementia and additionally, with a cloud record for further analysis of the improvement and progress of the patient. With this, the implemented mechatronic assistant will improve the well-being and quality of life of dementia patients

Design of an automated system for the production of chicha de Jora

This research presents the design and control of the fermentation, boiling, and straining process of chicha de Jora with mechatronic systems. In this work, process control is developed in the 2 tanks to monitor the procedure to optimize the resources and time of the elaboration. The development of the project shows that the application of 2 solenoid valves and sensors such as level and temperature sensors are feasible for better control of the boiling process. A mixer was also added to the first tank to ensure that the essence of the inputs remains in the liquid. In addition, it is possible to visualize an optimal operation of the system, including PLC programming as it makes the operation more autonomous, managing to accelerate the fermentation process and to be adequate according to the degree of alcohol required. The value obtained from the motor to drive the 6-blade mixer is 17,384 watts taking as a parameter the viscosity, the power number, and the appropriate rotation speed. The implemented control will help to accelerate the process of obtaining chicha de Jora and to monitor the degree of alcohol produced in the fermentation process

Intratracheal dopamine attenuates pulmonary edema and improves survival after ventilator-induced lung injury in rats

Journal Article; Research Support, Non-U.S. Gov't;INTRODUCTION Clearance of alveolar oedema depends on active transport of sodium across the alveolar-epithelial barrier. beta-Adrenergic agonists increase clearance of pulmonary oedema, but it has not been established whether beta-agonist stimulation achieves sufficient oedema clearance to improve survival in animals. The objective of this study was to determine whether the increased pulmonary oedema clearance produced by intratracheal dopamine improves the survival of rats after mechanical ventilation with high tidal volume (HVT). METHODS This was a randomized, controlled, experimental study. One hundred and thirty-two Wistar-Kyoto rats, weighing 250 to 300 g, were anaesthetized and cannulated via endotracheal tube. Pulmonary oedema was induced by endotracheal instillation of saline solution and mechanical ventilation with HVT. Two types of experiment were carried out. The first was an analysis of pulmonary oedema conducted in six groups of 10 rats ventilated with low (8 ml/kg) or high (25 ml/kg) tidal volume for 30 or 60 minutes with or without intratracheally instilled dopamine. At the end of the experiment the animals were exsanguinated and pulmonary oedema analysis performed. The second experiment was a survival analysis, which was conducted in two groups of 36 animals ventilated with HVT for 60 minutes with or without intratracheal dopamine; survival of the animals was monitored for up to 7 days after extubation. RESULTS In animals ventilated at HVT with or without intratracheal dopamine, oxygen saturation deteriorated over time and was significantly higher at 30 minutes than at 60 minutes. After 60 minutes, a lower wet weight/dry weight ratio was observed in rats ventilated with HVT and instilled with dopamine than in rats ventilated with HVT without dopamine (3.9 +/- 0.27 versus 4.9 +/- 0.29; P = 0.014). Survival was significantly (P = 0.013) higher in animals receiving intratracheal dopamine and ventilated with HVT, especially at 15 minutes after extubation, when 11 of the 36 animals in the HVT group had died as compared with only one out of the 36 animals in the HVT plus dopamine group. CONCLUSION Intratracheal dopamine instillation increased pulmonary oedema clearance in rats ventilated with HVT, and this greater clearance was associated with improved survival.This work was supported in part by RED GIRA (G03/063) and FIBAO Research Foundation.Ye

LOS ESTILOS DE APRENDIZAJE DESDE EL MODELO V.A.K. Y LA RESOLUCION DE PROBLEMAS DE GEOMETRIA PLANA EN LOS ESTUDIANTES DEL TERCER GRADO DE SECUNDARIA DE LA INSTITUCIÓN EDUCATIVA COLEGIO EXPERIMENTAL DE APLICACIÓN UNE DEL DISTRITO LURIGANCHO-CHOSICA 2016

El objetivo de este trabajo de investigación es dar cuenta de los aspectos más significativos de la influencia de los estilos de aprendizaje en el aprendizaje significativo en el área de Matemática, en los estudiantes del 3ero grado, sección C, del colegio de aplicación de la UNE, Ugel 06, distrito de Lurigancho -2016. El objetivo general del trabajo de examen es decidir genuinamente cómo los estilos de aprendizaje impactan el aprendizaje crítico en el espacio de las Matemáticas, de los estudiantes de tercer grado, área C. El enfoque utilizado fue una prueba con una configuración de semi-prueba dado que hubo intercesión del científico en la variable dependiente, mediante la utilización de estilos de aprendizaje. El Universo estuvo conformado por 154 estudiantes suplentes de tercer grado de Educación Secundaria correspondientes al quinto segmento de este grado y el ejemplo está compuesto por 60 estudiantes de tercer grado, segmento An y C. El procedimiento para la recolección de datos fue la revisión y el instrumento fue la prueba de información, que se aplicó a los 60 suplentes de tercer grado, segmento An y C, en el espacio de Matemáticas.The objective of this research work is to account for the most significant aspects of the influence of learning styles on meaningful learning in the area of ​​Mathematics, in students of the 3rd grade, section C, of ​​the UNE application college. , Ugel 06, district of Lurigancho -2016. The general objective of the exam work is to genuinely decide how learning styles impact critical learning in the space of Mathematics, of third grade students, area C. The approach used was a test with a given semi-test configuration. that there was intercession of the scientist in the dependent variable, through the use of learning styles. The Universe was made up of 154 substitute students from the third grade of Secondary Education corresponding to the fifth segment of this grade and the example is made up of 60 students from the third grade, segment An and C. The procedure for data collection was the review and The instrument was the information test, which was applied to the 60 substitutes of third grade, segment An and C, in the Mathematics space

LOS ESTILOS DE APRENDIZAJE DESDE EL MODELO V.A.K. Y LA RESOLUCION DE PROBLEMAS DE GEOMETRIA PLANA EN LOS ESTUDIANTES DEL TERCER GRADO DE SECUNDARIA DE LA INSTITUCIÓN EDUCATIVA COLEGIO EXPERIMENTAL DE APLICACIÓN UNE DEL DISTRITO LURIGANCHO-CHOSICA 2016

El objetivo de este trabajo de investigación fue este trabajo da cuenta de los aspectos más significativos de la influencia de los estilos de aprendizaje en el aprendizaje significativo en el área de Matemática, en los estudiantes del 3ero grado, sección C, del colegio de aplicación de la UNE, Ugel 06, distrito de Lurigancho -2016. El objetivo general del trabajo de examen es decidir genuinamente cómo los estilos de aprendizaje impactan el aprendizaje crítico en el espacio de las Matemáticas, de los estudiantes de tercer grado, área C. El enfoque utilizado fue una prueba con una configuración de semi-prueba dado que hubo intercesión del científico en la variable dependiente, mediante la utilización de estilos de aprendizaje. El Universo estuvo conformado por 154 estudiantes suplentes de tercer grado de Educación Secundaria correspondientes al quinto segmento de este grado y el ejemplo está compuesto por 60 estudiantes de tercer grado, segmento An y C. El procedimiento para la recolección de datos fue la revisión y el instrumento fue la prueba de información, que se aplicó a los 60 suplentes de tercer grado, segmento An y C, en el espacio de Matemáticas Palabras claves: Resolución, aprendizaje, matemática y estilos de aprendizaje.The objective of this research work was this work gives an account of the most significant aspects of the influence of learning styles on meaningful learning in the area of ​​Mathematics, in students of the 3rd grade, section C, of ​​the application school of UNE, Ugel 06, district of Lurigancho -2016. The general objective of the examination paper is to genuinely decide How learning styles impact critical learning in the learning space Mathematics, of third grade students, area C. The approach used was a test with a semi-test configuration given that there was intercession of the scientist in the dependent variable, through the use of learning styles. The universe was made up of 154 substitute students from the third grade of Secondary Education corresponding to the fifth segment of this degree and the example is made up of 60 third grade students, segment An and C. The procedure for collecting data was the review and the instrument was the information test, which was applied to 60 third grade substitutes, segment An and C, in the Mathematics space Keywords: Resolution, learning, mathematics and learning styles