Aligning Sub-national Climate Actions for the new post-Paris Climate Regime

The rise of sub-national actors in global climate governance underscores the need for clear alignment between these efforts and their national counterparts. As these sub-national climate actions are filling gaps in mitigation, adaptation, and financing, among other functions, a critical question is how these efforts complement or overlap with national climate pledges. This consideration is particularly important in the context of the Paris Agreement’s mandate for fiveyear review cycles, where national governments will be asked to demonstrate progress towards climate mitigation goals and increase their ambition. In this paper, we argue that alignment – both vertically between multiple jurisdictions and horizontally with external networks and actors – is critical to clarifying climate actions between multiple levels of actors and to maximizing mitigation potential. We use nine case studies to demonstrate the varying degrees and modes of vertical integration between subnational and national climate actors. We find that the case studies embody different styles of vertical alignment, and exhibit significant variation in the degree and direction of vertical alignment within each of these modes. We also find that many case studies rely on horizontally- aligned international networks and coalitions to fill gaps in financial resources or technical support. As a proof of concept, we demonstrate that an additional 1 gigaton carbon dioxide equivalent (CO2e) in 2020 can be achieved in these nine case studies through stronger alignment that makes it possible to scale sub-national climate actions to the national level. These findings suggest there may be a missed opportunity to realize greater mitigation potential by fostering stronger vertical alignment, and enhancing coordination between horizontal networks of climate action and national governments

dataTEL - Datasets for Technology Enhanced Learning

The dataTEL white paper develop during the dataTEL workshop at the ARV2011. The workshop was motivated by the issue that very less educational datasets are publicly available in TEL, so that the outcomes of different TEL adaptive applications and recommender systems that support personalised learning are hardly comparable. In other domains like in e-commerce it is a common practise to use different datasets as benchmarks to evaluate recommender systems algorithms to make the results comparable (MovieLens, Book-Crossing, EachMovie dataset). So far, no universally valid knowledge exists in TEL on algorithm that can be successfully applied in a certain learning setting to personalise learning. Having a collection of datasets could be a first major step towards a theory of personalisation with in TEL that can be based on empirical experiments with verifiable and valid results. Therefore, the main objective of the dataTEL workshop was to explore suitable datasets for TEL with a specific focus on recommender and adaptive information systems that can take advantage of these datasets. In this context, new challenges emerge like unclear legal protection rights and privacy issues, suitable policies and formats to share data, required preprocessing procedures and rules to create sharable datasets, common evaluation criteria for recommender systems in TEL and how a dataset driven future in TEL could look like

STELLAR Alpine Rendez-Vous White Paper

Drachsler, H., Verbert, K., Sicilia, M. A., Wolpers, M., Manouselis, N., Vuorikari, R., Lindstaedt, S., & Fischer, F. (2011). dataTEL - Datasets for Technology Enhanced Learning. STELLAR Alpine Rendez-Vous White Paper. Alpine Rendez-Vous 2011 White paper collection, Nr. 13., France (2011) Accessible at: http://oa.stellarnet.eu/open-archive/browse?resource=6756_v1The dataTEL white paper develop during the dataTEL workshop at the ARV2011. The workshop was motivated by the issue that very less educational datasets are publicly available in TEL, so that the outcomes of different TEL adaptive applications and recommender systems that support personalised learning are hardly comparable. In other domains like in e-commerce it is a common practise to use different datasets as benchmarks to evaluate recommender systems algorithms to make the results comparable (MovieLens, Book-Crossing, EachMovie dataset). So far, no universally valid knowledge exists in TEL on algorithm that can be successfully applied in a certain learning setting to personalise learning. Having a collection of datasets could be a first major step towards a theory of personalisation within TEL that can be based on empirical experiments with verifiable and valid results. Therefore, the main objective of the dataTEL workshop was to explore suitable datasets for TEL with a specific focus on recommender and adaptive information systems that can take advantage of these datasets. In this context, new challenges emerge like unclear legal protection rights and privacy issues, suitable policies and formats to share data, required preprocessing procedures and rules to create sharable datasets, common evaluation criteria for recommender systems in TEL and how a dataset driven future in TEL could look like.dataTEL, NeLLL AlterEgo, STELLAR, MAVSE

Genomic analysis reveals Lactobacillus sanfranciscensis as stable element in traditional sourdoughs

Sourdough has played a significant role in human nutrition and culture for thousands of years and is still of eminent importance for human diet and the bakery industry. Lactobacillus sanfranciscensis is the predominant key bacterium in traditionally fermented sourdoughs

Identifikasi Jenis Mikroorganisme pada Tanaman Kurma di Kawasan Tangerang: Identification types of Microorganisms on Date palms roots in Tangerang Region

Dates palms (Phoenix dactylifera L.) are species of plants which can be found commonly in the Middle East. The fruits are occasionally found and consumed during Ramadhan. There are several factors which can affect the growth of the plant, mycorrhiza is one of the example. Mycorrhiza is a form of mutualistic symbiosis between the root of plants and fungus. This symbiosis is proven to be favorable for plants, as it can help the absorption of the nutrient, help the defensive mechanism against pathogens, and support the plant to cope with the water deficiency. Furthermore, the plants may also have an alternate form of mutualistic symbiosis with the bacteria called endophytic bacteria which involves in the transaction of nutrient and mineral. This study requires the isolation of microorganisms that can be found within the root of date palms. The isolation can be done with the usage of Potato Dextrose Agar (PDA) as the media. There were several microorganisms which can be found within the isolated plant’s root. Through identification based on its morphology characteristics, the microorganism that was found probably are Staphylococcus; Bacillus subtillis; Glomeromycota sp., and Glomaceae sp. Keywords: Bacteria, dates, Glomaceae sp., Glomeromycota sp., mycorhizz

Astro2020 Science White Paper: Triggered High-Priority Observations of Dynamic Solar System Phenomena

Unexpected dynamic phenomena have surprised solar system observers in the past and have led to important discoveries about solar system workings. Observations at the initial stages of these events provide crucial information on the physical processes at work. We advocate for long-term/permanent programs on ground-based and space-based telescopes of all sizes - including Extremely Large Telescopes (ELTs) - to conduct observations of high-priority dynamic phenomena, based on a predefined set of triggering conditions. These programs will ensure that the best initial dataset of the triggering event are taken; separate additional observing programs will be required to study the temporal evolution of these phenomena. While not a comprehensive list, the following are notional examples of phenomena that are rare, that cannot be anticipated, and that provide high-impact advances to our understandings of planetary processes. Examples include: new cryovolcanic eruptions or plumes on ocean worlds; impacts on Jupiter, Saturn, Uranus, or Neptune; extreme eruptions on Io; convective superstorms on Saturn, Uranus, or Neptune; collisions within the asteroid belt or other small-body populations; discovery of an interstellar object passing through our solar system (e.g. 'Oumuamua); and responses of planetary atmospheres to major solar flares or coronal mass ejections.Comment: Astro2020 white pape

CSF H3F3A K27M circulating tumor DNA copy number quantifies tumor growth and in vitro treatment response

https://deepblue.lib.umich.edu/bitstream/2027.42/145434/1/40478_2018_Article_580.pd

A Review of CRISPR Cas9 for SCA: Treatment Strategies and Could Target β-globin Gene and BCL11A Gene using CRISPR Cas9 Prevent the Patient from Sickle Cell Anemia?

BACKGROUND: Sickle cell anemia is a hereditary globin chain condition that leads to hemolysis and persistent organ damage. Chronic hemolytic anemia, severe acute and chronic pain, and end-organ destruction occur throughout the lifespan of sickle cell anemia. SCD is associated with a higher risk of mortality. Genome editing with CRISPR-associated regularly interspersed short palindromic repeats (CRISPR/Cas9) have therapeutic potential for sickle cell anemia thala. AIM: This research aimed to see if using CRISPR/Cas9 to target β-globin gene is an effective therapeutic and if it has a long-term effect on Sickle Cell Anemia. METHODS: The method used in this study summarizes the article by looking for keywords that have been determined in the title and abstract. The authors used official guidelines from Science Direct, PubMed, Google Scholar, and Journal Molecular Biology to select full-text articles published within the last decade, prioritizing searches within the past 10 years. RESULTS: CRISPR/Cas9-mediated genome editing in clinical trials contributes to α-globin gene deletion correcting β-thalassemia through balanced α- and β-globin ratios and inhibiting disease progression. CONCLUSION: HBB and BCL11A targeting by CRISPR/Cas9 deletion effectively inactivate BCL11A, a repressor of fetal hemoglobin production. However, further research is needed to determine its side effects and safety