Ohio\u27s Home-Rule Amendment: Why Ohio\u27s General Assembly Creating Regional Governments would Combat the Regional Race to the Bottom under Current Home-Rule Principles

This Note argues that Ohio’s home-rule principles foster a regional “race to the bottom and proposes that the Ohio General Assembly pass legislation creating regional governments to combat the absence of coordination among regional localities

Ohio\u27s Home-Rule Amendment: Why Ohio\u27s General Assembly Creating Regional Governments would Combat the Regional Race to the Bottom under Current Home-Rule Principles

This Note argues that Ohio’s home-rule principles foster a regional “race to the bottom and proposes that the Ohio General Assembly pass legislation creating regional governments to combat the absence of coordination among regional localities

Implementación de la Transformada Discreta Wavelet en un sistema embebido para el análisis de registros electronistagmográficos

En el presente trabajo se describe el diseño y desarrollo de un sistema embebido basado en un microcontrolador de 32 bits, cuyo objetivo es determinar si la patología vertiginosa que sufre un paciente se debe al Sistema Nervioso Central (SNC) o al aparato vestibular. El software desarrollado para efectuar el análisis implementa la Transformada Discreta Wavelet (DWT), a fin de poder determinar la energía de los detalles de registros electronistagmográficos. Los resultados fueron comparados con los obtenidos con el software Matlab 7.0 instalado en una computadora personal. Se observo que los valores relativos de energías fueran similares, con la ventaja de tener un sistema fácilmente portable. La importancia de este desarrollo radica en que el método tradicional para efectuar este diagnóstico está basado en la observación de los registros en papel por parte de un especialista experimentado.Centro de Técnicas Analógico-Digitale

MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors.

MYC is dysregulated in \u3e50% of cancers, but direct targeting of MYC has been clinically unsuccessful. Targeting downstream MYC effector pathways represents an attractive alternative. MYC regulates alternative mRNA splicing, but the mechanistic links between MYC and the splicing machinery in cancer remain underexplored. Here, we identify a network of co-expressed splicing factors (SF-modules) in MYC-active breast tumors. Of these, one is a pan-cancer SF-module correlating with MYC activity across 33 tumor types. In mammary cell models, MYC activation leads to co-upregulation of pan-cancer module SFs and to changes in \u3e4,000 splicing events. In breast cancer organoids, co-overexpression of the pan-cancer SF-module induces MYC-regulated splicing events and increases organoid size and invasiveness, while knockdown decreases organoid size. Finally, we uncover a MYC-activity pan-cancer splicing signature correlating with survival across tumor types. Our findings provide insight into the mechanisms of MYC-regulated splicing and for the development of therapeutics for MYC-driven tumors

Determinación de la densidad de potencia irradiada por estaciones bases GSM 1900 mediante la transformada discreta wavelet

Para conocer el nivel de energía electromagnética o específicamente la densidad de potencia que irradian distintas fuentes de emisión de radio frecuencia, y determinar si cumplen con la normativa vigente, se efectúan mediciones con distintas técnicas tanto en banda angosta como en banda ancha. Muchas señales de interés como las de telefónía móvil poseen características no estacionarias o transitorias como derivas, tendencias y cambios abruptos; siendo éstas a menudo la parte más importante de la señal. Nuestra línea de trabajo analiza diferentes tipos de modulación (tanto analógica como digital) para determinar la densidad de potencia irradiada por diferentes emisores individualmente y simultáneamente. El interés se centra en las emisiones de una Estación Base de Telefonía Móvil basada en el estándar GSM (Glogal System for Mobile Communication) 1900, empleando la Transformada Discreta Wavelet (TDW). La Transformada Discreta Wavelet resulta ser una aproximación más flexible que la Transformada Discreta de Fourier, para determinar con mayor exactitud el tiempo y la frecuencia por medio de la variación del tamaño de las ventanas. El análisis de la señal adquirida empleando la TDW nos permite determinar tiempo, frecuencia y niveles de energía en dicho ancho de banda.Eje: Procesamiento de señales y sistemas en tiempo realRed de Universidades con Carreras en Informática (RedUNCI

Establishing the measurement properties of the Residential Environment Impact Scale (Version 4.0)

Michele Harrison - ORCID: 0000-0001-6088-2998 https://orcid.org/0000-0001-6088-2998Kirsty Forsyth - ORCID: 0000-0002-6732-1699 https://orcid.org/0000-0002-6732-1699Linda Irvine Fitzpatrick - ORCID: 0000-0002-9599-8015 https://orcid.org/0000-0002-9599-8015Background Developed as an environment assessment informed by the Model of Human Occupation, the Residential Environment Impact Survey considered the physical, social and activity features of the environment, evaluating the impact of the environment on resident’s quality of life. Clinicians reported that the Residential Environment Impact Survey was a useful tool; however, it had not been structured to be a measurement tool and did not have established psychometric properties. Aims/objectives This study examines the psychometric properties of the restructured Residential Environment Impact Scale Version 4.0 (REIS), which measures the level of environment support provided to residents. Material and methods The REIS was completed across residential sites for people with complex mental health needs. A many facets Rasch analysis was conducted to establish the reliability and validity of the REIS. Results The REIS demonstrated reasonable psychometric properties, with items demonstrating internal scale validity and scale items following an expected pattern of increasingly challenging environment support. Conclusions and significance Initial evidence suggests that the REIS provides a valid and reliable measure of environment support, providing a detailed assessment of how physical, social and activity elements of the environment support or inhibit participation and can be applied across a range of living environments.https://doi.org/10.1080/11038128.2022.2143891aheadofprintaheadofprin

Splicing alterations in healthy aging and disease.

Alternative RNA splicing is a key step in gene expression that allows generation of numerous messenger RNA transcripts encoding proteins of varied functions from the same gene. It is thus a rich source of proteomic and functional diversity. Alterations in alternative RNA splicing are observed both during healthy aging and in a number of human diseases, several of which display premature aging phenotypes or increased incidence with age. Age-associated splicing alterations include differential splicing of genes associated with hallmarks of aging, as well as changes in the levels of core spliceosomal genes and regulatory splicing factors. Here, we review the current known links between alternative RNA splicing, its regulators, healthy biological aging, and diseases associated with aging or aging-like phenotypes. This article is categorized under: RNA in Disease and Development \u3e RNA in Disease RNA Processing \u3e Splicing Regulation/Alternative Splicing