Diseño y ejecución de un programa de prevención en violencia intrafamiliar y promoción de bienestar familiar en la comunidad de la localidad de Usaquén.

Cronograma de actividades, plan de acción, graficas, anexosEste proyecto consistió en desarrollar el diseño y ejecución de un programa de prevención en violencia intrafamiliar y promoción de bienestar familiar en la comunidad de la localidad de Usaquén, que capacitara a 213 adultos padres de familia de 6 casas vecinales de la localidad Usaquén y a 152 niños de edades entre los 3-5 años. el propósito fundamental es brindar a la comunidad herramientas conceptuales para el manejo de conflictos, la restitución de sus derechos y la prevención del abuso sexual en niños , bajo 3 ejes temáticos delimitados por los procesos psicosociales de ; Fortalecimiento comunitario, Relaciones de poder y restitución de derechos. Para la elaboración del programa se realizaron entrevistas a la comunidad acudiente a la comisaria primera de familia Usaquén y quienes fueron identificados como usuarios reincidentes en la solicitud del servicio de la institución con el objetivo de indagar información pertinente para la elaboración del árbol de problemas y objetivos con sus correspondientes estrategias a seguir, usuarios que para efectos de éste proyecto fueron denominados “consultante experto “. El resultado final es el diseño de un programa que utiliza metodología participativa con talleres desarrollados en base a los procesos psicosociales antes descritos.No registra

Two-Stage Stochastic Model to Invest in Distributed Generation Considering the Long-Term Uncertainties

yesThis paper used different risk management indicators applied to the investment optimization performed by consumers in Distributed Generation (DG). The objective function is the total cost incurred by the consumer including the energy and capacity payments, the savings, and the revenues from the installation of DG, alongside the operation and maintenance (O&M) and investment costs. Probability density function (PDF) was used to model the price volatility in the long-term. The mathematical model uses a two-stage stochastic approach: investment and operational stages. The investment decisions are included in the first stage and which do not change with the scenarios of the uncertainty. The operation variables are in the second stage and, therefore, take different values with every realization. Three risk indicators were used to assess the uncertainty risk: Value-at-Risk (VaR), Conditional Value-at-Risk (CVaR), and Expected Value (EV). The results showed the importance of migration from deterministic models to stochastic ones and, most importantly, the understanding of the ramifications of every risk indicator

Fifteen years controlling unwanted thoughts: A systematic review of the thought control ability questionnaire (TCAQ)

Thought control ability is a vulnerability factor implicated in the etiology and maintenance of emotional disorders. This manuscript aims to systematically review the use and psychometric performance of the Thought Control Ability Questionnaire (TCAQ), designed to assess people's ability to control unwanted thoughts. Three electronic databases were searched for papers administering the TCAQ published in indexed peer-reviewed journals. Data (participants characteristics, country, study design, etc.) were extracted from the results for qualitative synthesis. The TCAQ's content validity, dimensionality, internal consistency, test-retest reliability, convergent/divergent validity, floor/ceiling effects, and interpretability were summarized. Two reviewers independently screened articles and assessed quality taking COSMIN criteria into account. Finally, the review included 17 papers. The TCAQ has been administered to healthy individuals, students, and adult patients, in six languages from nine countries. We found that the TCAQ, and its shorter versions, demonstrate robust reliability and adequate content validity. Of interest is the TCAQ's capacity to predict performance in diverse experimental tasks focused on thought control. The TCAQ unidimensionality has been supported in exploratory and confirmatory factor analyses. Regarding construct validity, the TCAQ is significantly related to a wide range of psychopathological measures of anxiety, worry, depression, obsessive-compulsive symptoms, etc. However, as only a few of the included studies had a longitudinal design, we are unable to draw firm conclusions about the measure's temporal stability. Moreover, psychometric aspects such as factorial invariance across different samples have not been analyzed. Despite these limitations, based on available psychometric evidence we can recommend using the TCAQ for measuring perceived control of unwanted thoughts

Mejoramiento de la resistencia a la corrosión de las mezclas de hierro e itrio mediante pulvimetalurgia

It is manufactured by powder metallurgy a mixture of 0%, 1%, 3%, 5%, 7% by weight of Iron Ytrium Oxide, in order to establish the effect of the ceramic on the metal on exposure in stagnant 3.5% Sodium chloride solution at room temperature. The samples are tested for structural characterization obtained by X-ray diffraction (XRD), while the analysis of electrochemical properties has been carried through the study of polarization curves and electrochemical impedance spectroscopy. The characterization after the deterioration test was carried by XRD for the different mixtures, the corrosion products are identified with XRD. The results obtained include the mechanical alloy and the evidence of adding phases (Yttrium Iron Oxide) and (Yttrium Iron) as a result of the manufacturing process. The specimens had resistance to corrosion with respect to the increase of the ceramic in the metal due to the formation of the phases generated in the mixture. Nevertheless, the most adequate percentage has been determined at 5%, since this is the optimum quantity incorporated to the iron, capable of conferring it the properties of protection against corrosion.Se fabrica por vía Pulvimetalúrgica mezcla de 0%, 1%, 3%, 5%, 7% contenido en peso de Óxido de Itrio en Hierro Fe; con el fin de establecer la influencia del cerámico en el metal al ser expuesto en una solución con contenido de cloruro de sodio. Las probetas son sometidas a caracterización estructural obtenida mediante difracción de rayos X (DRX), mientras que el análisis de las propiedades electroquímicas se llevó a cabo mediante el estudio de las curvas de polarización y espectroscopia de impedancias electroquímica. La caracterización luego del ensayo de deterioro se realizó mediante DRX para las diferentes mezclas, los productos de corrosión se identificaron con DRX. A partir de los resultados se obtuvo la aleación mecánica y evidenciando nuevas fases (Óxido de itrio y hierro) y (Hierro de itrio) producto del proceso de la fabricación. Las muestras presentaron resistencia a la corrosión respecto al aumento del cerámico en el metal debido a la formación de las fases generadas por la mezcla, sin embargo, se determinó que el porcentaje más adecuado es el 5%, debido a que es la cantidad óptima incorporada al hierro, capaz de conferirle las propiedades de protección frente a la corrosión

Cost-Utility of Mindfulness-Based Stress Reduction for Fibromyalgia versus a Multicomponent Intervention and Usual Care: A 12-Month Randomized Controlled Trial (EUDAIMON Study)

Fibromyalgia (FM) is a prevalent, chronic, disabling, pain syndrome that implies high healthcare costs. Economic evaluations of potentially effective treatments for FM are needed. The aim of this study was to analyze the cost-utility of Mindfulness-Based Stress Reduction (MBSR) as an add-on to treatment-as-usual (TAU) for patients with FM compared to an adjuvant multicomponent intervention (FibroQoL) and to TAU. We performed an economic evaluation alongside a 12 month, randomized, controlled trial; data from 204 (68 per study arm) of the 225 patients (90.1%) were included in the cost-utility analyses, which were conducted both under the government and the public healthcare system perspectives. The main outcome measures were the EuroQol (EQ-5D-5L) for assessing Quality-Adjusted Life Years (QALYs) and improvements in health-related quality of life, and the Client Service Receipt Inventory (CSRI) for estimating direct and indirect costs. Incremental cost-effectiveness ratios (ICERs) were also calculated. Two sensitivity analyses (intention-to-treat, ITT, and per protocol, PPA) were conducted. The results indicated that MBSR achieved a significant reduction in costs compared to the other study arms (p < 0.05 in the completers sample), especially in terms of indirect costs and primary healthcare services. It also produced a significant incremental effect compared to TAU in the ITT sample (Delta QALYs = 0.053, p < 0.05, where QALYs represents quality-adjusted life years). Overall, our findings support the efficiency of MBSR over FibroQoL and TAU specifically within a Spanish public healthcare context

Respuesta de los circuitos nivel 1 ante cambios de tensión: consumo y pérdidas

This article presents a methodology that seeks to estimate the behavior of the demand of residential users and the losses in the network in face of the voltage changes of Level I '. Starting from the characterization of the consumption of household appliances, as a function of the service voltage, a general method is applied that allows to obtain a better approximation to the behavior of the load, compared to the models currently used.Este articulo presenta una metodología que busca estimar el comportamiento de la demanda delos usuarios residenciales y de las pérdidas en la redfrente a los cambios de tensión del Nivel I'.Partiendo de la caracterización del consumo de aparatos electrodomésticos, como una funciónde la tensión de servicio, se aplica un método general quepermite obtener una mejor aproximaciónal comportamiento de la carga, en comparación con los modelos actualmente utilizados

Locally-advanced primary neuroendocrine carcinoma of the breast : case report and review of the literature

Q4Q2Reporte de casoBackground Primary neuroendocrine carcinoma of the breast is a heterogeneous group of rare tumors with positive immunoreactivity to neuroendocrine markers in at least 50% of cells. Diagnosis also requires that other primary sites be ruled out and that the same tumor show histological evidence of a breast in situ component. Primary neuroendocrine carcinoma of the breast rarely presents as locally advanced disease and less frequently with such widespread metastatic disease as described herein. The review accompanying this case report is the first to provide an overview of all the cases of primary neuroendocrine carcinoma of the breast published in the literature and encompasses detailed information regarding epidemiology, histogenesis, clinical and histologic diagnosis criteria, classification, surgical and adjuvant treatment, as well as prognosis. We also provide recommendations for common clinical and histologic pitfalls associated with this tumor. Case presentation We describe a case of a 51-year-old Hispanic woman initially diagnosed with locally-advanced invasive ductal carcinoma that did not respond to neodjuvant treatment. After undergoing modified radical mastectomy the final surgical pathology showed evidence of alveolar-type primary neuroendocrine carcinoma of the breast. The patient was treated with cisplatin/etoposide followed by paclitaxel/carboplatinum. Thirteen months after surgery the patient is alive, but developed pulmonary, bone, and hepatic metastasis. Conclusion The breast in situ component of primary neuroendocrine carcinoma of the breast may prevail on a core biopsy samples increasing the probability of underdiagnosing this tumor preoperatively. Being aware of the existence of this disease allows for timely diagnosis and management. Optimal treatment requires simultaneous consideration of both the neuroendocrine and breast in situ tumor features

Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required

DeadEasy Mito-Glia: Automatic Counting of Mitotic Cells and Glial Cells in Drosophila

Cell number changes during normal development, and in disease (e.g., neurodegeneration, cancer). Many genes affect cell number, thus functional genetic analysis frequently requires analysis of cell number alterations upon loss of function mutations or in gain of function experiments. Drosophila is a most powerful model organism to investigate the function of genes involved in development or disease in vivo. Image processing and pattern recognition techniques can be used to extract information from microscopy images to quantify automatically distinct cellular features, but these methods are still not very extended in this model organism. Thus cellular quantification is often carried out manually, which is laborious, tedious, error prone or humanly unfeasible. Here, we present DeadEasy Mito-Glia, an image processing method to count automatically the number of mitotic cells labelled with anti-phospho-histone H3 and of glial cells labelled with anti-Repo in Drosophila embryos. This programme belongs to the DeadEasy suite of which we have previously developed versions to count apoptotic cells and neuronal nuclei. Having separate programmes is paramount for accuracy. DeadEasy Mito-Glia is very easy to use, fast, objective and very accurate when counting dividing cells and glial cells labelled with a nuclear marker. Although this method has been validated for Drosophila embryos, we provide an interactive window for biologists to easily extend its application to other nuclear markers and other sample types. DeadEasy MitoGlia is freely available as an ImageJ plug-in, it increases the repertoire of tools for in vivo genetic analysis, and it will be of interest to a broad community of developmental, cancer and neuro-biologists