Morphological changes in kidney glomeruli of rats with chronic toxic hepatitis and its correction with lisinopril, L-arginine-L-glutamate and their combination

The article presents structural changes of glomerular component of kidneys in rats with chronic toxic hepatitis (CTH) and the results of its correction with lisinopril and L-arginine L-glutamate. The influence of ACE inhibitors or angiotensin-blockers (AT) II on RAS chains is known to result in positive therapeutic effect. Addition of lisinopril to complex therapy has positively affected not only the clinical manifestations of the disease but also the functional status of kidneys, primarily due to the influence on filtration processes. Considering the significance of RAS activation in the development of hepatorenal syndrome, the aim of the work was to study the influence of ACE inhibitors (lisinopril) on kidney morphological structure during modeling of CTH, to compare its effect with hepatoprotector L-Glutargin-L-glutamate as well as to evaluate structural changes in kidney glomeruli after combined use of those drugs. The experimental study was conducted on 60 white laboratory immature rats, with initial body weight of 50-70g. CTH was modeled by intragastric administration of CCl4 oil solution in a dose of 0.1 ml / 100 g of the body weight twice a week for eight weeks. Drug correction was performed by introduction of lisinopril (in a dose of 20 mg / kg) and L-arginine-L-glutamate (in a dose of 30 mg / kg). The study revealed pronounced morphological changes in kidney glomeruli (destruction of glomerular vessels and cells) in CTH. The use of corrective factors in the experiment made it possible to decrease the severity of pathological changes. The use of lisinopril resulted in restoration of glomerular structure. After administration of L-arginine-L-glutamate, decrease of degenerative changes in kidney glomeruli was detected. Combined use of both chemical compounds mutually potentiated their action and was accompanied by membrane-stabilizing effect and intensification of aforementioned restoration processes in structural components of nephron glomeruli. Thus, it was established that after 90 days of experimentally modeled CTH, pronounced morphological changes in kidney glomeruli (destruction of vessels and glomerular cells) occurred

The Usage of a System on a Chip for the Synthesis of Radar

Most developers who work with DSP tasks face the problem of lack of computing resources for implementing hardware solutions for image processing or synthesis. One way to accelerate computing is to use specialized hardware that has significant computing resources

FPGA use for digital signal processing

This article considers the possibility of increasing the performance of digital signal processing (DSP) using parallel computing techniques. The features of using FPGAs are given. The advantages of using FPGA to DSP processors are compared

Формирование покрытий смешанными оксидами алюминия и марганца на сплаве АЛ25

Features of plasma electrolytic oxidation of the AL25 cast complex-alloyed aluminum alloy are discussed. It has been shown that a variation in the nature and concentration ratio of the electrolyte components provides the formation of mixed-oxide coatings containing the materials of the basic matrix and the dopant. An increase in the coating thickness and the manganese oxide content in the coating is achieved by the homogenization of the treated surface owing to the simultaneous formation of oxides and the removal of alloying components of the alloy from the surface layers. Current density intervals that provide a uniform distribution of elements in the coating and a high efficiency of the Faraday and thermochemical reactions are determined. It is found that the stoichiometric oxygen index in MnOx oxides is x = 1.71–1.87. Testing of the synthesized oxide systems in the model oxidation of carbon (II) oxide to CO₂ shows that the ignition and complete conversion temperatures are at the level of values characteristic of platinum catalysts.Рассмотрены особенности плазменно-электролитического оксидирования литейного сложнолегированного сплава алюминия АЛ25. Показано, что варьирование природы и соотношения концентраций компонентов электролита позволяет формировать покрытия смешанными оксидами, в состав которых входит материал основной матрицы и допанта. Повышение толщины покрытия и содержания в нем оксида марганца достигается гомогенизацией обрабатываемой поверхности за счет одновременного формирования оксидов и удаления легирующих компонентов сплава из поверхностных слоев. Установлены интервалы плотности тока, обеспечивающие равномерное распределение элементов в покрытии и высокую эффективность фарадеевских и термохимических реакций. Показано, что стехиометрический индекс по кислороду в оксидах MnOx составляет x = 1,71–1,87. Тестирование синтезированных оксидных систем в модельной реакции окисления оксида углерода (II) до CO₂ показало, что температура зажигания и полной конверсии находится на уровне платиновых катализаторов

Відносини США та Китаю на сучасному етапі (торговельно-економічний аспект) (USA-China relations at the current stage (trade-economic aspect)

У статті висвітлено сучасні економічно-торговельні відносини США та Китаю. Досліджено історичний процес формування відносин між двома могутніми державами. Розглянуто наслідки торгової війни для світової економіки. (The article examines the current economic and trade relation between the USA and China. Investigated the historical process of forming relations between two powerful states. Considered the consequences of the trade war for the world economy.

Disinfection of Surfaces Contaminated with SARS-CoV-2 Coronavirus by UV Radiation of Low-Pressure Mercury-Vapour Lamp

The aim of the work was to determine the effective ultraviolet (UV) doses required for the disinfection of surfaces contaminated with the SARS-CoV-2 coronavirus using a low-pressure mercury lamp. Materials and methods. To carry out prompt disinfection of surfaces, a specially designed source of UV radiation with a power of 7.5 W at a wavelength of 254 nm in the form of a portable flashlight was employed, which has a high efficiency of UV radiation output and the possibility of long-term autonomous operation from a compact battery. In the studies, a suspension culture of the SARS-CoV-2 coronavirus with biological activity of 5.3∙106 PFU/ml was used. The objects of testing were plastic Petri dishes (disposable) and office paper (grade C, density 80 g/m2 ). Results and discussion. Doses of UV radiation that provide disinfection of surfaces contaminated with the COVID-19 pathogen with an efficiency of 99.0 % (paper) to 99.95 % (plastic) have been determined. The results obtained make it possible to recommend a portable UV irradiator for use in the practice of preventive measures to combat the spread of the disease caused by the SARS-CoV-2 coronavirus

Correction: Reusable snorkel masks adapted as particulate respirators

ntroduction During viral pandemics, filtering facepiece (FFP) masks together with eye protection form the essential components of personal protective equipment (PPE) for healthcare workers. There remain concerns regarding insufficient global supply and imperfect protection offered by currently available PPE strategies. A range of full-face snorkel masks were adapted to accept high grade medical respiratory filters using bespoke-designed 3D-printed connectors. We compared the protection offered by the snorkel to that of standard PPE using a placebo-controlled respirator filtering test as well as a fluorescent droplet deposition experiment. Out of the 56 subjects tested, 42 (75%) passed filtering testing with the snorkel mask compared to 31 (55%) with a FFP3 respirator mask (p = 0.003). Amongst the 43 subjects who were not excluded following a placebo control, 85% passed filtering testing with the snorkel versus to 68% with a FFP3 mask (p = 0.008). Following front and lateral spray of fluorescence liquid particles, the snorkel mask also provided superior protection against droplet deposition within the subject’s face, when compared to a standard PPE combination of FFP3 masks and eye protection (3.19x108 versus 6.81x108 fluorescence units, p<0.001). The 3D printable adaptors are available for free download online at https://www.ImperialHackspace.com/COVID-19-Snorkel-Respirator-Project/. Conclusion Full-face snorkel masks adapted as particulate respirators performed better than a standard PPE combination of FFP3 mask and eye protection against aerosol inhalation and droplet deposition. This adaptation is therefore a promising PPE solution for healthcare workers during highly contagious viral outbreaks

TECHNOLOGY FOR DEVELOPMENT OF ELECTRONIC TEXTBOOK ON HANDICRAFTS METHODOLOGY

The main approaches to defining the concept of electronic textbook have been analyzed in the article. The main advantages of electronic textbooks in the context of future teachers’ training have been outlined. They are interactivity, feedback provision, availability of navigation and search engine. The author has presented and characterized the main stages in the technology of development of an electronic textbook on Handicraft and Technology Training Methodology: determination of its role and significance in the process of mastering the discipline; justification of its structure; outline of the stages of its development in accordance with the defined structure. The characteristic feature of the developed electronic textbook is availability of macro- and microstructure. Macrostructure is viewed as a sequence of components of the electronic textbook that are manifested in its content; microstructure is considered to be an internal pattern of each component of macrostructure