A Fast Quasi-Conformal Mapping Preconditioner for Electromagnetic Integral Equations

Boundary Element Methods (BEMs) are efficient strategies to numerically solve electromagnetic radiation and scattering problems. Unfortunately, however, classical BEM formulations suffer from ill-conditioning when the frequency is low, or the discretization density is high. In the past, several remedies have been presented for these ill-conditioning problems including preconditioners based on Calderón identities, hierarchical bases, and current decompositions. While effective, these strategies however require ad-hoc procedures including mesh-refinements, new basis function definitions, and adapted fast methods that, if not implemented properly, can become computationally cumbersome

On a Frequency-Stabilized Single Current Inverse Source Formulation

Several strategies are available for solving the inverse source problem in electromagnetics. Among them, many have been focusing in retrieving Love currents by solving, after regularization, for Love’s electric and magnetic currents. In this work we present a dual-element discretization, analysis, and stabilization of an inverse source formulation providing Love data by solving for only one current. This results in substantial savings and allows for an effective quasi-Helmholtz projector stabilization of the resulting operator. Theoretical considerations are complemented by numerical tests showing effectiveness and efficiency of the newly proposed method

On preconditioning electromagnetic integral equations in the high frequency regime via helmholtz operators and quasi-helmholtz projectors

Fast and accurate resolution of electromagnetic problems via the boundary element method (BEM) is oftentimes challenged by conditioning issues occurring in three distinct regimes: (i) when the frequency decreases and the discretization density remains constant, (ii) when the frequency is kept constant while the discretization is refined and (iii) when the frequency increases along with the discretization density. While satisfactory remedies to the problems arising in regimes (i) and (ii), respectively based on Helmholtz decompositions and Calderon-like techniques have been presented, the last regime is still challenging. In fact, this last regime is plagued by both spurious resonances and ill-conditioning, the former can be tackled via combined field strategies and is not the topic of this work. In this contribution new symmetric scalar and vectorial electric type formulations that remain well-conditioned in all of the aforementioned regimes and that do not require barycentric discretization of the dense electromagnetic potential operators are presented along with a spherical harmonics analysis illustrating their key properties

On a Low-Frequency and Contrast Stabilized Full-Wave Volume Integral Equation Solver for Lossy Media

In this article, we present a new regularized electric flux volume integral equation (D-VIE) for modeling high-contrast conductive dielectric objects in a broad frequency range. This new formulation is particularly suitable for modeling biological tissues at low frequencies, as it is required by brain epileptogenic area imaging, but also at higher ones, as it is required by several applications, including, but not limited to, deep brain stimulation (DBS). When modeling inhomogeneous objects with high complex permittivities at low frequencies, the traditional D-VIE is ill-conditioned and suffers from numerical instabilities that result in slower convergence and less accurate solutions. In this work, we address these shortcomings by leveraging a new set of volume quasi-Helmholtz projectors. Their scaling by the material permittivity matrix allows for the rebalancing of the equation when applied to inhomogeneous scatterers and, thereby, makes the proposed method accurate and stable even for high complex permittivity objects until arbitrarily low frequencies. Numerical results, canonical and realistic, corroborate the theory and confirm the stability and the accuracy of this new method both in the quasi-static regime and at higher frequencies

Magnetic and Combined Field Integral Equations Based on the Quasi-Helmholtz Projectors

Boundary integral equation methods for analyzing electromagnetic scattering phenomena typically suffer from several of the following shortcomings: 1) ill-conditioning when the frequency is low; 2) ill-conditioning when the discretization density is high; 3) ill-conditioning when the structure contains global loops (which are computationally expensive to detect); 4) incorrect solution at low frequencies due to a loss of significant digits; and 5) the presence of spurious resonances. In this article, quasi-Helmholtz projectors are leveraged to obtain magnetic field integral equation (MFIE) that is immune to drawbacks 1)-4). Moreover, when this new MFIE is combined with a regularized electric field integral equation (EFIE), a new quasi-Helmholtz projector-combined field integral equation (CFIE) is obtained that also is immune to 5). The numerical results corroborate the theory and show the practical impact of the newly proposed formulations

Closure of a gastrocutaneous fistula by a tulip-bundle technique

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Smoking as a cofactor for causation of chronic pancreatitis: a meta-analysis.

OBJECTIVES: To assess the evidence for tobacco smoking as a risk factor for the causation of chronic pancreatitis. METHODS: We performed a meta-analysis with random-effects models to estimate pooled relative risks (RRs) of chronic pancreatitis for current, former, and ever smokers, in comparison to never smokers. We also performed dose-response, heterogeneity, publication bias, and sensitivity analyses. RESULTS: Ten case-control studies and 2 cohort studies that evaluated, overall, 1705 patients with chronic pancreatitis satisfied the inclusion criteria. When contrasted to never smokers, the pooled risk estimates for current smokers was 2.8 (95% confidence interval [CI], 1.8-4.2) overall and 2.5 (95% CI, 1.3-4.6) when data were adjusted for alcohol consumption. A dose-response effect of tobacco use on the risk was ascertained: the RR for subjects smoking less than 1 pack per day was 2.4 (95% CI, 0.9-6.6) and increased to 3.3 (95% CI, 1.4-7.9) in those smoking 1 or more packs per day. The risk diminished significantly after smoking cessation, as the RR estimate for former smokers dropped to a value of 1.4 (95% CI, 1.1-1.9). CONCLUSIONS: Tobacco smoking may enhance the risk of developing chronic pancreatitis. Recommendation for smoking cessation, besides alcohol abstinence, should be incorporated in the management of patients with chronic pancreatitis

Retreatment with pegylated interferon plus ribavirin of chronic hepatitis C non-responders to interferon plus ribavirin: A meta-analysis.

BACKGROUND/AIMS: Efficacy of retreatment with pegylated interferon (PEG-IFN) plus ribavirin of non-responders to standard or pegylated IFN plus ribavirin has been assessed in various studies, but sustained virologic response (SVR) rates are variable and factors influencing efficacy and tolerability still remain incompletely defined. We aimed to focus on SVR rates and to identify factors influencing them in this meta-analysis. METHODS: MEDLINE as well as a manual search were used. Studies were included if they were controlled or uncontrolled trials, if they had been published as full-length papers and if they included non-responders to standard or pegylated IFN and ribavirin therapy. Fourteen trials were included in the meta-analysis. Data on study populations, interventions, and outcomes were extracted from trials using a random-effects model. Primary outcome was the SVR rate. RESULTS: The pooled estimate of SVR rate was 16.3% (95% Confidence Interval - 95% CI, 8.3-29.6%). There was a significant heterogeneity among studies (p<0.0001). Heterogeneity was less apparent in studies that included fewer patients with cirrhosis or overweight. By meta-regression, higher SVR rate was observed in trials with a lower prevalence of subjects with genotype 1 infection and with fewer overweight patients. The use of a 24-week retreatment stopping rule did not affect SVR rate. CONCLUSIONS: The overall modest efficacy argues against an indiscriminate retreatment with PEG-IFN and ribavirin of all non-responders. Restricting retreatment to non-overweight patients or to those with genotype 2 or 3 infection, using a 24-week retreatment stopping rule, would optimize the potential benefit with a scarce likelihood of missing a curative response

A New Refinement-Free Preconditioner for the Symmetric Formulation in Electroencephalography

Widely employed for the accurate solution of the electroencephalography forward problem, the symmetric formulation gives rise to a first kind, ill-conditioned operator illsuited for complex modelling scenarios. This work presents a novel preconditioning strategy based on an accurate spectral analysis of the operators involved which, differently from other Calderón-based approaches, does not necessitate the barycentric refinement of the primal mesh (i.e., no dual matrix is required). The discretization of the new formulation gives rise to a well-conditioned, symmetric, positive-definite system matrix, which can be efficiently solved via fast iterative techniques. Numerical results for both canonical and realistic head models validate the effectiveness of the proposed formulation