What Can Open Access Do for Me? Personal Perspectives of KU Faculty

Four University of Kansas faculty presented as panelists during this event. Slides from their presentations are shared here

Improved Combination of Multiple Atmospheric GCM Ensembles for Seasonal Prediction

An improved Bayesian optimal weighting scheme is developed and used to combine six atmospheric general circulation model (GCM) seasonal hindcast ensembles. The approach is based on the prior belief that the forecast probabilities of tercile-category precipitation and near-surface temperature are equal to the climatological ones. The six GCMs are integrated over the 1950–97 period with observed monthly SST prescribed at the lower boundary, with 9–24 ensemble members. The weights of the individual models are determined by maximizing the log likelihood of the combination by season over the integration period. A key ingredient of the scheme is the climatological equal-odds forecast, which is included as one of the "models" in the multimodel combination. Simulation skill is quantified in terms of the cross-validated ranked probability skill score (RPSS) for the three-category probabilistic hindcasts. The individual GCM ensembles, simple poolings of three and six models, and the optimally combined multimodel ensemble are compared. The Bayesian optimal weighting scheme outperforms the pooled ensemble, which in turn outperforms the individual models. In the extratropics, its main benefit is to bring much of the large area of negative-precipitation RPSS values up to near-zero values. The skill of the optimal combination is almost always increased (in the large spatial averages considered) when the number of models in the combination is increased from three to six, regardless of which models are included in the three-model combination. Improvements are made to the original Bayesian scheme of Rajagopalan et al. by reducing the dimensionality of the numerical optimization, averaging across data subsamples, and including spatial smoothing of the likelihood function. These modifications are shown to yield increases in cross-validated RPSS skills. The revised scheme appears to be better suited to combining larger sets of models, and, in the future, it should be possible to include statistical models into the weighted ensemble without fundamental difficulty

Cross-time scales interactions and rainfall extreme events in southeastern South America for the austral summer. Part II: predictive skill

Potential and real predictive skill of the frequency of extreme rainfall in southeastern South America for the December–February season are evaluated in this paper, finding evidence indicating that mechanisms of climate variability at one time scale contribute to the predictability at another scale; that is, taking into account the interference of different potential sources of predictability at different time scales increases the predictive skill. Part I of this study suggested that a set of daily atmospheric circulation regimes, or weather types, was sensitive to these cross–time scale interferences, conducive to the occurrence of extreme rainfall events in the region, and could be used as a potential predictor. At seasonal scale, a combination of those weather types indeed tends to outperform all the other candidate predictors explored (i.e., sea surface temperature patterns, phases of the Madden–Julian oscillation, and combinations of both). Spatially averaged Kendall’s t improvements of 43% for the potential predictability and 23% for real-time predictions are attained with respect to standard models considering sea surface temperature fields alone. A new subseasonal-to-seasonal predictive methodology for extreme rainfall events is proposed based on probability forecasts of seasonal sequences of these weather types. The cross-validated real-time skill of the new probabilistic approach, as measured by the hit score and the Heidke skill score, is on the order of twice that associated with climatological values. The approach is designed to offer useful subseasonal-to-seasonal climate information to decision-makers interested not only in how many extreme events will happen in the season but also in how, when, and where those events will probably occur

The International Research Institute for Climate and Society: why, what and how

A climate-informed and climate-ready world is possible. Large investments are being made toward adaptation and resilience to climate change, but many of those investments are separated from the more immediate climate-related vulnerabilities and opportunities that society faces. Information is increasingly available that could be used to guide action; however, information alone is not sufficient. Research at the International Research Institute for Climate and Society (IRI) since 1996 has led to the identification of the several guiding principles to scope and address climate-related challenges to decision- and policy-makers at local-to-regional scale. These include climate-related information, such as assessment of the main vulnerabilities to climate variability and change in countries or regions, and the provision of climate information, products and tools to support decisions, including financial tools that are appropriate to the climate-related risk and that can mediate residual risk. The guiding principles also include identifying the technologies and practices that optimize results in coming years, demonstration of the usefulness of climate information to support climate-related decisions, training and capacity building, and partnerships for research and implementation. This essay introduces the evolution of the IRI and its work that is then elaborated through a series of articles that constitute a special issue of Earth Perspectives: Transdisciplinarity Enabled. The collection of articles provides insight into the science and process that lead to better climate-informed choices. Part of the collection of articles in the special issue covers specific stories of local-to-regional engagement with partners to address climate-related problems. Other articles represent how we do what we do, in particular highlighting the research, the climate forecast effort, and the IRI Data Library. Finally, there are two papers offered from partners that have long-time engagement with the IR

The International Research Institute for Climate and Society: why, what and how

A climate-informed and climate-ready world is possible. Large investments are being made toward adaptation and resilience to climate change, but many of those investments are separated from the more immediate climate-related vulnerabilities and opportunities that society faces. Information is increasingly available that could be used to guide action; however, information alone is not sufficient. Research at the International Research Institute for Climate and Society (IRI) since 1996 has led to the identification of the several guiding principles to scope and address climate-related challenges to decision- and policy-makers at local-to-regional scale. These include climate-related information, such as assessment of the main vulnerabilities to climate variability and change in countries or regions, and the provision of climate information, products and tools to support decisions, including financial tools that are appropriate to the climate-related risk and that can mediate residual risk. The guiding principles also include identifying the technologies and practices that optimize results in coming years, demonstration of the usefulness of climate information to support climate-related decisions, training and capacity building, and partnerships for research and implementation. This essay introduces the evolution of the IRI and its work that is then elaborated through a series of articles that constitute a special issue of Earth Perspectives: Transdisciplinarity Enabled. The collection of articles provides insight into the science and process that lead to better climate-informed choices. Part of the collection of articles in the special issue covers specific stories of local-to-regional engagement with partners to address climate-related problems. Other articles represent how we do what we do, in particular highlighting the research, the climate forecast effort, and the IRI Data Library. Finally, there are two papers offered from partners that have long-time engagement with the IR

Cross–Time Scale Interactions and Rainfall Extreme Events in Southeastern South America for the Austral Summer. Part I: Potential Predictors

The physical mechanisms and predictability associated with extreme daily rainfall in southeastern South America (SESA) are investigated for the December–February season in a two-part study. Through a k-mean analysis, this first paper identifies a robust set of daily circulation regimes that are used to link the frequency of rainfall extreme events with large-scale potential predictors at subseasonal-to-seasonal scales. This represents a basic set of daily circulation regimes related to the continental and oceanic phases of the South Atlantic convergence zone (SACZ) and wave train patterns superimposed on the Southern Hemisphere polar jet. Some of these recurrent synoptic circulation types are conducive to extreme rainfall events in the region through synoptic control of different mesoscale physical features and, at the same time, are influenced by climate phenomena that could be used as sources of potential predictability. Extremely high rainfall (as measured by the 95th and 99th percentiles) is associated with two of these weather types (WTs), which are characterized by moisture advection intrusions from lower latitudes and the Pacific Ocean; another three WTs, characterized by above-normal moisture advection toward lower latitudes or the Andes, are associated with dry days (days with no rain). The analysis permits the identification of several subseasonal-to-seasonal scale potential predictors that modulate the occurrence of circulation regimes conducive to extreme rainfall events in SESA. It is conjectured that a cross–time scale interaction between the different climate drivers improves the predictive skill of extreme precipitation in the region

On a possible new R^2 theory of supergravity

We consider a new MacDowell-Mansouri R^2-type of supergravity theory, an extension of conformal supergravity, based on the superalgebra Osp(1|8). Invariance under local symmetries with negative Weyl weight is achieved by imposing chirality-duality and double-duality constraints on curvatures, along with the usual constraint of vanishing supertorsion. An analysis of the remaining gauge symmetries shows that those with vanishing Weyl weight are invariances of the action at the linearized level. For the symmetries with positive Weyl weight we find that invariance of the action would require further modifications of the transformation rules. This conclusion is supported by a kinematical analysis of the closure of the gauge algebra.Comment: 52 pages, Late

Biological activity differences between TGF-β1 and TGF-β3 correlate with differences in the rigidity and arrangement of their component monomers

[Image: see text] TGF-β1, -β2, and -β3 are small, secreted signaling proteins. They share 71–80% sequence identity and signal through the same receptors, yet the isoform-specific null mice have distinctive phenotypes and are inviable. The replacement of the coding sequence of TGF-β1 with TGF-β3 and TGF-β3 with TGF-β1 led to only partial rescue of the mutant phenotypes, suggesting that intrinsic differences between them contribute to the requirement of each in vivo. Here, we investigated whether the previously reported differences in the flexibility of the interfacial helix and arrangement of monomers was responsible for the differences in activity by generating two chimeric proteins in which residues 54–75 in the homodimer interface were swapped. Structural analysis of these using NMR and functional analysis using a dermal fibroblast migration assay showed that swapping the interfacial region swapped both the conformational preferences and activity. Conformational and activity differences were also observed between TGF-β3 and a variant with four helix-stabilizing residues from TGF-β1, suggesting that the observed changes were due to increased helical stability and the altered conformation, as proposed. Surface plasmon resonance analysis showed that TGF-β1, TGF-β3, and variants bound the type II signaling receptor, TβRII, nearly identically, but had small differences in the dissociation rate constant for recruitment of the type I signaling receptor, TβRI. However, the latter did not correlate with conformational preference or activity. Hence, the difference in activity arises from differences in their conformations, not their manner of receptor binding, suggesting that a matrix protein that differentially binds them might determine their distinct activities

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P < 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.