7 research outputs found
Systems biology of endothelial mechano-activated pathways
- Author
- Publication venue
- Massachusetts Institute of Technology
- Publication date
- 01/01/2013
- Field of study
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, February 2013"December 2012." Cataloged from PDF version of thesis.Includes bibliographical references.Multiple signaling pathways are employed by endothelial cells to differentially respond to distinct hemodynamic environments and acquire functional phenotypes, including regulation of inflammation, angiogenesis, blood coagulation, and the vascular tone. In order to understand how these pathways interact, this thesis applies a systems biology approach through a two-step process. First, we constructed an integrated mathematical model for shear-stress-induced nitric oxide (NO) production to assemble the current understanding of this signaling system. Second, we conducted experiments to define how shear stress dynamically modulates the expression of components of the endothelial glycocalyx, a mechanosensor that regulates shear-stressdependent NO production. Nitric oxide produced by vascular endothelial cells is an anti-inflammatory mediator and a potent vasodilator. In order to understand the rich diversity of responses observed experimentally in endothelial cells exposed to shear stress, we assembled four quantitative molecular pathways previously defined for shear-stress-induced NO production. In these pathways, endothelial nitric oxide synthase (eNOS) is activated (a) via calcium release, (b) via phosphorylation reactions, and (c) via enhanced protein expression. To these pathways we added (d) an additional pathway describing the actual NO production from the interactions of eNOS with its various protein partners. These pathways were then combined and simulated. The integrated model is able to describe the experimentally observed change in NO production with time following the application of fluid shear stress, and to predict the specific effects to the system following interventional pharmacological or genetic changes. Importantly, this model reflects the up-to-date understanding of the NO system and provides a platform to aggregate information in an additive way. The endothelial glycocalyx is a glycosaminoglycan layer located on the apical surface of vascular endothelial cells. Previous studies have documented a strong correlation between the glycocalyx expression, local hemodynamic environment, and atheroprotection. Based on these observations, we hypothesized that the expression of components of the endothelial glycocalyx is differentially regulated by distinct hemodynamic environments. In order to test this hypothesis, human endothelial cells were exposed to shear stress waveforms characteristic of atherosclerosis-resistant or atherosclerosis-susceptible regions of the human carotid, and the expression of several components of the glycocalyx was then assessed. Interestingly, we found that heparan sulfate expression is higher and evenly distributed on the apical surface of endothelial cells exposed to the atheroprotective waveform, and is irregularly present in cells exposed to the atheroprone waveform. Furthermore, the expression of a heparan sulfate proteoglycan, syndecan-1, is also differentially regulated by the two waveforms, and its suppression mutes the atheroprotective-flow-induced cell surface expression of heparan sulfate. Collectively, these data links distinct hemodynamic environments to the differential expression of critical components of the endothelial glycocalyx. Taken together, these projects present in this doctoral thesis increase our understanding of endothelial mechano-activated pathways, and have demonstrated how we could use systems biology approach to unravel complex biological problems.by Andrew Jia-An Koo.Ph.D
In Silico Modeling of Shear-Stress-Induced Nitric Oxide Production in Endothelial Cells through Systems Biology
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2012
- Field of study
Nitric oxide (NO) produced by vascular endothelial cells is a potent vasodilator and an antiinflammatory mediator. Regulating production of endothelial-derived NO is a complex undertaking, involving multiple signaling and genetic pathways that are activated by diverse humoral and biomechanical stimuli. To gain a thorough understanding of the rich diversity of responses observed experimentally, it is necessary to account for an ensemble of these pathways acting simultaneously. In this article, we have assembled four quantitative molecular pathways previously proposed for shear-stress-induced NO production. In these pathways, endothelial NO synthase is activated 1), via calcium release, 2), via phosphorylation reactions, and 3), via enhanced protein expression. To these activation pathways, we have added a fourth, a pathway describing actual NO production from endothelial NO synthase and its various protein partners. These pathways were combined and simulated using CytoSolve, a computational environment for combining independent pathway calculations. The integrated model is able to describe the experimentally observed change in NO production with time after the application of fluid shear stress. This model can also be used to predict the specific effects on the system after interventional pharmacological or genetic changes. Importantly, this model reflects the up-to-date understanding of the NO system, providing a platform upon which information can be aggregated in an additive way.National Institutes of Health (U.S.) (Grant R01HL090856)Singapore-MIT Alliance Computational and Systems Biology Progra
Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation
- Author
- A Koo
- A Remuzzi
- AB Baker
- AG Khan
- Andrew Jia-An Koo
- AW Gross
- AW Mulivor
- AW Mulivor
- BM Berg van den
- C. Forbes Dewey
- CK Payne
- D Chappell
- DR Potter
- EC Kennett
- EE Ebong
- G Dai
- G Rao
- G. Villarreal
- Guillermo Garcia-Cardena
- HH Lipowsky
- I Shafat
- I Vlodavsky
- I Vlodavsky
- IV Fuki
- JA Florian
- Jagadish Sankaran
- JD Esko
- Jennifer H. Shin
- Jiro Sakai
- KM Ainslie
- KM Parmar
- Kristina M. Giantsos-Adams
- L Gao
- M Nikmanesh
- M Yanagishita
- M. Gouverneur
- ML Ballinger
- MY Pahakis
- NM Carter
- P Zimmermann
- R. O. Dull
- RH Adamson
- S Sarrazin
- S. Reitsma
- Sukhyun Song
- T Arisaka
- TR Rudd
- V Ferro
- X Bai
- Y Takeuchi
- Y Yao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/11/2012
- Field of study
The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation suggests that the glycocalyx may have a central role in determining atherosclerotic plaque formation. However, the kinetics for the cells’ ability to adapt its glycocalyx to the environment have not been quantitatively resolved. Here we report that the heparan sulfate component of the glycocalyx of HUVECs increases by 1.4-fold following the onset of high shear stress, compared to static cultured cells, with a time constant of 19 h. Cell morphology experiments show that 12 h are required for the cells to elongate, but only after 36 h have the cells reached maximal alignment to the flow vector. Our findings demonstrate that following enzymatic degradation, heparan sulfate is restored to the cell surface within 12 h under flow whereas the time required is 20 h under static conditions. We also propose a model describing the contribution of endocytosis and exocytosis to apical heparan sulfate expression. The change in HS regrowth kinetics from static to high-shear EC phenotype implies a differential in the rate of endocytic and exocytic membrane turnover.National Heart, Lung, and Blood Institute (Grant HL090856-01)Singapore-MIT Allianc
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
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- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19
- Author
- Aalap Chokshi
- Abdelkader Medjahedi
- Abhishek Gupta
- Adam Bernheim
- Adel Allam
- Adelina Sanches
- Adolfo Facello
- Adriana Puente
- Adwait Trivedi
- Afroza Akhter
- Agha Haider
- Ahmad Amro
- Ahmad Ozair
- Ahmed Aljizeeri
- Ahmed Ibrahim
- Ahmed Kandeel
- Ahmed Suliman
- Ajay Vyas
- Albert Flotats
- Alberto Cadena
- Alberto Clemente
- Alberto Cuocolo
- Alberto Gerali
- Alejandro Maldonado
- Alejandro Radzinschi
- Alejandro Zuluaga Santamaria
- Alessandra Scatteia
- Alessia Gimelli
- Alexander Kokov
- Alexandre Volney Villa
- Alexey Ansheles
- Alfredo Rodrigues
- Alia Abdelfattah
- Alicia Camarero
- Alireza Emami-Ardekani
- Aloha Meave
- Alvin Quinon
- Amalia Peix
- Ambedhkar Shantaram Naojee
- Amee Shah
- Amelia Jimenez-Heffernan
- Amit Pursnani
- Amit Sharma
- Amjed Albadr
- Amparo Martinez Monzonis
- Ana Manovel-Sánchez
- Ana Teresa Timoteo
- Anastasia Oikonomou
- Anatoliy Karalkin
- Anda Bularga
- Anders Tjellaug Bråten
- Andor Glaudemans
- Andrea Bruno
- Andrea de Lorenzo
- Andrea Paccagnella
- Andrea Vilela
- Andres Preciado-Anaya
- Andressa Borges
- Andrew Choi
- Andrew Choi
- Andrew J Einstein
- Andrew Tauro
- Andrew Taylor
- Angela Byrne
- Angela Gaudiano
- Animesh Mishra
- Anita Liiver
- Anjali Chelliah
- Anna Baritussio
- Anna Teresinska
- Annette Johnstone
- Anthon Fuisz
- Anthony Samuel
- Anthony Upton
- Antonella Stefanelli
- Antonio Calderón
- Apurva Shrigiriwar
- Apurva Sinha
- Arati Lalchandani
- Aristóteles Ramírez Salazar
- Arjun Ghosh
- Arpakorn Kositwattanarerk
- Artan Goda
- Arturo Romero Acuña
- Arve Jørgensen
- Arvind Sethi
- Aryeh Shalev
- Asela Bustos-Barroso
- Ashwani Sood
- Attila Kovács
- Atul Verma
- Augusto Almeida
- Awadhesh Kumar Sharma
- Azeem Sheikh
- Azita Moalemi
- Barbara Gužic Salobir
- Barry Elison
- Bawinile Hadebe
- Bálint Szilveszter
- Belinda San Juan
- Benjamin Hudson
- Benjapa Khiewvan
- Bernadette Lisske
- Bernard Koch
- Bernardo Spiro
- Bernd Klaeser
- Berry Allen
- Bianca Patrut
- Bin Lu
- Binh Duong Duc
- Bjarne L Nørgaard
- Brenda Mccullough
- Brian Morrissey
- Caiying Li
- Calum Young
- Cameron Foster
- Camila Flores
- Candace Candela
- Carla Gonzalez
- Carla Sousa
- Carlo Joe San Juan
- Carlo Liguori
- Carlo Tedeschi
- Carlos Anselmi
- Carlos Caicedo Zamudio
- Carlos Cruz
- Carlos Eduardo Soares
- Carlos Eduardo Suaide Silva
- Carlos Salvador Navarro Quiroz
- Carmen Concha
- Carole Dennie
- Caroline M Van De Heyning
- Ceferino Gutierrez Mendiguchia
- Cesar Higa Nomura
- Cesar Rene Alducin Tellez
- Chae Moon Hong
- Chanan Moffitt
- Chen Sheng Low
- Chetan Patel
- Chongfu Jia
- Chris Rofe
- Christel Kamani
- Christian Llontop
- Christina Fragkaki
- Christoph Gräni
- Christopher Eduarte
- Chrysoula Fragkiadaki
- Chunxiang Tang
- Cibele Gontijo
- Clare Mckenzie
- Claudia Jaimes
- Claudia T Gutierrez Villamil
- Claudio Marcassa
- Claudio Mesquita
- Claudio Pereyra Sueldo
- Claudiu Stan
- Clothilde Berger
- Cole B Hirschfeld
- Connor Saunders
- Corrado Cittanti
- Cristina Gavina
- Cristina Sebastião Matushita
- Cuba Juan Felipe Batista
- D'Arne Downie
- Dainia Baugh
- Daisuke Sato
- Damayanthi Nanayakkara
- Damiana Vergel
- Daniel Berman
- Daniel Calderón
- Daniel Schere
- Danilo Naves
- Darach O H-Ici
- Daria Ryzhkova
- Dario Pellegrini
- David Cusack
- David German
- David Kassop
- David Kerins
- David Mccreavy
- David Prior
- David Wolinsky
- David Wong
- Dee Nandurkar
- Deepak Subedi
- Denis Agostini
- Derk Verschure
- Diana Paez
- Dianbo Cao
- Diego Alasia
- Diego Bromfman Pianta
- Diego Buchara
- Diego Echazarreta
- Diego Perez de Arenaza
- Dietrich Beitzke
- Dilip Na
- Dilip Patel
- Dinesh Kalra
- Domenico Albano
- Dominique Dabreo
- Donatas Vajauskas
- Donato Mele
- Dora Lenturut-Katal
- Dr Pradosh Kumar Sarangi
- Dragana Sobic Saranovic
- Dustin Thomas
- Edgardo Mastrovito
- Edison Bun
- Edith Chavez
- Edward Nicol
- Edward O'Rourke
- Edward Passen
- Ekaterina Migunova
- Elaine Lui
- Elena Busnardo
- Elena Califaretti
- Elena Kyrozi
- Eli Malkovskiy
- Elia García
- Elisa Mcalindon
- Elisa Milan
- Ellen Ostenfeld
- Elshaymaa Hussein
- Emmy Okello
- Enrique Vallejo
- Erdenechimeg Sereegotov
- Erick Alexánderson-Rosas
- Erik Bieging
- Erika Barragan
- Ernest Madu
- Ervina Shirka
- Erwin Affandi Soeriadi
- Estevan Cabeda
- Estrella Aguilera Hernandez
- Eva Alina Wegner
- Evelina Faragasso
- F Aaysha Cader
- Fabien Hyafil
- Fabio Fernandes
- Fabrizia Gelardi
- Fabrizio Ricci
- Fadi Hage
- Faisal Haque
- Faria Nasreen
- Farouk Mansouri
- Farshad Emami
- Febby Hutomo
- Federica Padovano
- Felix Keng
- Felix Solis
- Fernanda Erthal
- Fernando de Amorim Fernandes
- Fernando Faccio
- Fernando Mut
- Filip Homans
- Filipe Macedo
- Filipe Penna
- Franca Chierichetti
- Francesco Bianco
- Francesco Bovenzi
- Franco Gabriel Busso
- Gabriel Grossman
- Gabriela Melendez
- Gad Abikhzer
- Ganesan Karthikeyan
- Gary Small
- Gaspare Arnone
- Gaurav Sharma
- George Angelidis
- George Kinzfogl
- George Pandos
- Gerd Hinterleitner
- Gi Jeong Cheon
- Giampiero Longo
- Gianluca Spidalieri
- Gianmario Sambuceti
- Giedre Kviecinskiene
- Giovanni Matassa
- Girish Dwivedi
- Giuseppe De Vincentis
- Giuseppe Rubini
- Goleat Gutierrez
- Graham Cole
- Gudrun Feuchtner
- Guido Ventroni
- Guilherme S A Azevedo
- Guilherme Urpia Monte
- Gulnora Rozikhodjaeva
- Gulya Marina
- Gustavo Parisi
- Gustavo Vazquez
- Guzaliya Sayfullina
- Haluk Burcak Sayman
- Hamed Zuhairy
- Hamid Amer
- Hamid Naseer
- Hamza Regaieg
- Hanne Sondergaard
- Hanne-Elin Vassbotn
- Harold Arturo
- Harold Ayetey
- Harpreet Singh
- Hatem Alkadhi
- Hayato Ishimura
- Henrik Engblom
- Henry Bom
- Herwin Speckter
- Hesham Hamdy
- Heshui Shi
- Hideki Otsuka
- Hilman Syawaluddin
- Hiroki Teragawa
- Hiroshi Asano
- Hirotaka Maruno
- Ho-Chun Song
- Hoosen Lakhi
- Horacio Del Riego
- Horacio Glait
- Horacio Rojas
- Htin Zar
- Hugo Campanelli
- Hugo Gallegos
- Hugo Humberto Marçal Filho
- Hui Liu
- Humoud Al Dhuhli
- Ibraim Pinto
- Idan Roifman
- Idrissa Adamou Soli
- Igor Coelho
- Ikenna Erinne
- Ilan Gottlieb
- Ioannis Ntalas
- Ioannis Ntalas
- Irena Mitevska
- Irene Casáns-Tormo
- Irina Itskovich
- Irina Shurupova
- Iryna Noverko
- Isabel Blanco
- Isabel Carvajal-Juarez
- Isabella Bruno
- Ivo Andrade
- Jacqueline Henkel
- James Theuerle
- James White
- Jamie Kitt
- Jan Rasmussen
- Jana Polakova Mistinova
- Jane Cao
- Jason See
- Javier De Haro
- Javier Lopez Diaz
- Jawdat Abdulla
- Jay Layer
- Jeffrey Geske
- Jens Hove
- Jeremy Markowitz
- Jerry Obaldo
- Jesu Krupa
- Jesus Gregorio Medina Verdugo
- Ji-In Bang
- Ji-Young Kim
- Jiang Wu
- Jim Streeter
- Jina Chung
- Jinkang Liu
- Joanne Meaker
- Joao V Vitola
- Joao Vitola
- Johann Christopher
- Johanne Neill
- John Edmond
- John Kennedy
- John Lesser
- John Prior
- John Younger
- John-Paul Carpenter
- Jolanta Kunikowska
- Jonathan Hack
- Jonathan Rodrigues
- Jonathan Tow
- Jonathan Weir-Mccall
- Jordi Broncano
- Jorge Camilletti
- Jose Antonio Serna Macias
- Jose Javier Bustos Rivadero
- Jose Lotti
- Joseph Krepp
- Joseph Lee
- Joseph Weinstein
- José Esparza
- José Ortellado
- Juan Carlos Tirado Alderete
- Juan Erriest
- Juan L Londono
- Juan Lopez-Mattei
- Juan Lopez-Mattei
- Juan Montanez
- Juliana Leal Rocha
- Juliano Fernandes
- Julie Hephzibah
- Julie O'Brien
- Julio Manuel Lewkowicz
- Junichi Sato
- Kae Fukuyama
- Karen Hassen
- Karolina Zareba
- Katarina Milos
- Katarina Nelson
- Kate Hanneman
- Katherine Tweed
- Katherine Zukotynski
- Kathleen Magurany
- Katia Hiromoto Koga
- Kazuya Takehana
- Kelley Branch
- Kelly Anzola
- Kenichi Nakajima
- Kenneth Lee
- Kentaro Takanami
- Kevin Prigent
- Khaled Alfakih
- Khalid Makhdomi
- Khanyisile Hlongwa
- Kim Jasper
- Kim Taubman
- Kimiteru Ito
- Kirill Zhuravlev
- Kirsten Worthington
- Koichiro Fujise
- Konrad Weiss
- Konstantin Zavadovsky
- Kristian Hay Kragholm
- Kristian Øvrehus
- Kyoko Umeji
- Kyoung Sook Won
- Lara Carreira
- Lara Faggi
- Lars C Gormsen
- Lars Thorbjoern Jensen
- Laura Dragonetti
- Laura Evangelista
- Laure Sarda-Mantel
- Lazaro Omar Cabrera
- Leah Strickland
- Leena Robinson Vimala
- Leila Salioni
- Leonardo Sara Da Silva
- Leonie Scholtz
- Leslee J Shaw
- Li Yuan
- Lianggeng Gong
- Lilia M Sierra-Galan
- Lilia Sierra-Galan
- Lino Gonçalves
- Longjiang Zhang
- Lorenzo Sewanan
- Lu Chen
- Luca Mircoli
- Luca Pugliese
- Lucia Alberghina
- Lucia Leccisotti
- Lucia Rampin
- Luigia Florimonte
- Luis Benitez
- Luis Lumbreras Vega
- Luis Manuel Rochela Vázquez
- Luis Quintana
- Luisa Vera
- Luise Reichmuth
- Luiz Mastrocola
- Lydia Chelghoum
- Lynne Koweek
- Madhu Neupane
- Mady Doucoure
- Magdalena Kostkiewicz
- Magnus Simonsson
- Magnus T Jensen
- Mahmoud Al Heidous
- Mahmoud Sani
- Mahmoud Shaaban
- Mahmud Mossa-Basha
- Mahmut Yüksel
- Maja Franceschi
- Maja Hrabak Paar
- Majid Assadi
- Mallory Balmer-Swain
- Mamoru Nanasato
- Manish Motwani
- Manlio Gerardo Gama-Moreno
- Manuel Barreiro-Perez
- Manuel Cabada
- Manuel Castillo
- Manuel Valencia
- Manuja Premaratne
- Marc Faraggi
- Marcela Redruello
- Marcello Chiocchi
- Marcello Zapparoli
- Marcelo Santos
- Marcelo Silva
- Marcio Sommer Bittencourt
- Marco Gatti
- Marco Guglielmo
- Marcos Montecinos
- Marcus Chen
- Margarita Vakhromeeva
- Margherita Maffione
- Mari Sakanyan
- Maria Eduarda Menezes de Siqueira
- Maria Fernanda Merani
- Maria Helena Albernaz Siqueira
- Maria João Vidigal
- Maria Koutelou
- Maria Luisa De Rimini
- Maria Medus
- Marian Pop
- Marian Vandyck-Acquah
- Mariana Daicz
- Marie Rhiamar Sauler-Gomez
- Marija Vavlukis
- Marika Kalnina
- Marina Garcheva-Tsacheva
- Marina Leitman
- Marina Prpic
- Marina Rodríguez
- Marina Vlajkovic
- Mario Beretta
- Mario Ornelas
- Mark Hamilton
- Mark Hyun
- Mark Rabbat
- Maros Ferencik
- Martin Busk
- Martti Larikka
- Mary Carmen Herrera-Zarza
- Mary Schemmer
- Maryam Tajik
- Maryna Satyr
- Masaki Saito
- Masamichi Imai
- Masanao Naya
- Masao Miyagawa
- Masao Moroi
- Masayoshi Sarai
- Masoud Garashi
- Matteo Bauckneht
- Matthew Budoff
- Matthias Friedrich
- Matthieu Dietz
- Maurizio Dondi
- Mayra Sanchez Velez
- Michael Cahill
- Michael Cheezum
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- Michael Crowley
- Michael Dilorenzo
- Michael Gannon
- Michael Randazzo
- Michael Sobczak
- Michael Spartalis
- Michael Zgaljardic
- Michele Duldulao-Ogbac
- Michelle C Williams
- Mickaël Ohana
- Miguel Kapitan
- Miju Cheon
- Mike Kay
- Mila Uy
- Milan Kaminek
- Ming-Yen Ng
- Mirvat Alasnag
- Mitchell Kaplan
- Mohamad Haidar
- Mohamed Lemine Dieng
- Mohamed Mandour Ali
- Mohammad Ali Khan
- Mohammad Rawashdeh
- Mohammad Saadullah
- Mohan Ashok Kumar
- Mohmmed Nassoh Hafez
- Mokhtar Ridouh
- Mona Bhatia
- Mona Hassan
- Mona Kinkhabwala
- Monika Štalc
- Monvadi Srichai
- Morten Bøttcher
- Moshe Modiselle
- Mostafa Abass
- Mouaz Al-Mallah
- Mrinali Shetty
- Mugisha Julius Sebikali
- Muhammad Babar Imran
- Muhammad Numair Younis
- Murilo Foppa
- Mustafa Murtadha
- Myron Gerson
- Nadia Ismaili Alaoui
- Nadine Kawel-Böhm
- Naghmeh Tebyanian
- Nahla Zeidan
- Nailia Valiullina
- Naima Tag
- Nancy Quachang
- Naoya Matsumoto
- Naresh Kumar Goyal
- Natale Quartuccio
- Natalia Aramayo
- Natalie Rutherford
- Natallia Maroz-Vadalazhskaya
- Nathan Better
- Neiva Maciel
- Nelson Amores
- Nelson Lopez
- Nelsy Coromoto Gonzalez
- Nerisha Govender
- Nicolaj Hansson
- Niels Peter Rønnow Sand
- Niels Van Pelt
- Niki Lama
- Nilesh Banthia
- Nina Gagarina
- Nishant Shah
- Nita Ray Chaudhuri
- Nobuo Iguchi
- Nobuo Tomizawa
- Noor Khairiah A Karim
- Noriko Oyama-Manabe
- Nouzha Ben Rais
- Ntanganedzeni Muambadzi
- Nuno Bettencourt
- Nuno Moreno
- Olga Dariy
- Olga Morozova
- Oliver Sommer
- Omar Farouque
- Omoa Djuraev
- Osama Smettei
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- Osayande Evbuomwan
- Oscar Ulises Preciado-Gutiérrez
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- Prashant Nagpal
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- Punit Sharma
- Purvi Parwani
- Purvi Parwani
- Qais Naili
- Qaisar Siraj
- Rachele Bonfiglioli
- Raef Boktor
- Rafael Humberto Morales Murguia
- Rafael Lopes
- Rafael Torres
- Raihan Hussain
- Rajesh Janardhanan
- Ram Ghimire
- Ramanathapuram Parameswaran
- Ramezan Jafari
- Rami Abazid
- Rami Doukky
- Ramon Murgieitio-Cabrera
- Randall Thompson
- Raúl Araujo
- Rebecca Schofield
- Rebecca Seifried
- Reiko Ideguchi
- Renata Komiagiene
- Renée Bullock-Palmer
- Reyhaneh Manafi-Farid
- Ricardo Belisario Castro
- Ricardo Fontes-Carvalho
- Ricardo Geronazzo
- Ricardo Ruano Perez
- Riccardo Liga
- Riemer Slart
- Ripen Kumar Gupta
- Rita Alay
- Rob Beanlands
- Robert Biederman
- Robert Hendel
- Robert Manka
- Robert Miller
- Robert Skotnicki
- Roberta Assante
- Roberta Casoni
- Roberta Delgado
- Roberto Sciagrà
- Roberto Waltrick
- Rodolfo Ferrando
- Rodrigo Cerci
- Rodrigo Cerci
- Ronaldo Lima
- Ronen Goldkorn
- Ronny Ralf Buechel
- Rosanna Morales
- Roxana Campisi
- Ruben Leta
- Rupal O'Quinn
- Ryan Yudistiro
- Ryo Nakazato
- Sabha Bhatti
- Saeed Farzanehfar
- Said Aytani
- Saidur Rahman Khan
- Salah Bouyoucef
- Sameh Elkaffas
- Samer Arnous
- Sandra Abramson
- Sandra Graciela Rosales Uvera
- Sandra Rosales-Uvera
- Sang-Geon Cho
- Santo Dellegrottaglie
- Santosh Singh
- Sara Pacella
- Sarameth Thou
- Sarojini David
- Satoshi Isobe
- Saurav Chatterjee
- Scott Beuzeville
- Scott Bingham
- Scott Jerome
- Sean Blue
- Seth Uretsky
- Shady Abohashem
- Shamil Morayati
- Shankar Vamadevan
- Shantanu Sengupta
- Sharmila Dorbala
- Shashank Jain
- Shazia Fatima
- Shehu Kana
- Sherif Abd Elsamad
- Shigeki Nagamachi
- Shigeru Kiryu
- Shinichiro Fujimoto
- Shinichiro Kumita
- Shinichiro Yamada
- Shinya Shiraishi
- Shinya Yamazaki
- Shivani Pandey
- Shivani Patel
- Shmuel Fuchs
- Sinisa Stankovic
- Sirianong Namwongprom
- So Won Oh
- Soe Myat Win
- Sofia Haider
- Soley Varoeun
- Sonia Merlano-Gaitan
- Sonia Traverso
- Soo Woong Yoo
- Sorin Danciu
- Srikanth Vallurupalli
- Stephen Bloom
- Stephen Horgan
- Stephen Richard Underwood
- Steve Leung
- Stuart More
- Stuart Tie
- Su Thet Oo
- Subodh Joshi
- Subramaniyan Ramanathan
- Sujata Shanbhag
- Sujatha Buddhe
- Sukriti Kumar
- Suliman Suliman
- Susan Buckingham
- Susana Molteni
- Susana Zeffiro
- Søren Hess
- Tadao Aikawa
- Tadhg Gleeson
- Taghreed Abd Alrahman
- Tahir Ahmad
- Taimur Abbasi
- Tairkhan Dautov
- Takao Kato
- Takashi Kawamoto
- Takashi Norikane
- Tanyaluck Thientunyakit
- Tao Li
- Tapan Patel
- Tapati Mandal
- Tatsuya Yoneyama
- Tawika Kaewchur
- Teresa Massardo
- Themissa Voss
- Theodora Benedek
- Theodora Zaglavara
- Thércio Rocha
- Thiago Ferreira de Souza
- Thiri Kyiphyu
- Thomas N B Pascual
- Thomas Semple
- Tiago Senra
- Tiémégna Florence Ouattara
- Tiffany Chen
- Timothy Fairbairn
- Todd C Villines
- Todd Villines
- Tokuo Kasai
- Tomas Zaremba
- Tomasz Urbanik
- Tonci Batinic
- Tong Zhang
- Toral Patel
- Toshiaki Kadokami
- Turki Al Garni
- Tushar Garg
- Uchenna Onubogu
- Uka Geisler
- Uladzimir Tserakhau
- V J Karthikeyan
- Valentin Sinitsyn
- Valentina Soldat-Stankovic
- Valeria Pergola
- Valtteri Uusitalo
- Vassilis Prassopoulos
- Venkatesh Murthy
- Veronica Della Tommasina
- Verónica Vanesa Gómez Leiva
- Victor Hasbani
- Victor Jäger
- Victor Wayne
- Vijay Sai Chowdekar
- Vikas Tandon
- Vikas Verma
- Viktor Pospelov
- Vincent Sorrell
- Vincenzo Russo
- Virginia Garcia Quinto
- Virginia Pubul
- Vittorio Censullo
- Vivaswan Dutt Mishra
- Vivek Bhat
- Viviana Frantellizzi
- Vladimir Kincl
- Vladimir Sergienko
- Wanda Acampa
- Warren Moore
- Wenya Liu
- William DeSisto
- William Duvall
- William Topping
- Wilson Furlan Matos Alves
- Won Jun Kang
- Ximing Wang
- Xuan Canh Nguyen
- Yamilé Peña
- Yan Yi
- Yang Hou
- Yao Lu
- Yariela Herrera Malo
- Yaroslav Pynda
- Yasmin Hamirani
- Yassine Martinez
- Yasushi Wakabayashi
- Yasutaka Ichikawa
- Yasutoshi Ohta
- Yasuyo Taniguchi
- Yeon-Koo Kang
- Yiannis Chatzizisis
- Yining Wang
- Yoav Arnson
- Yoichi Otomi
- Yong Hyu Jeong
- Yosef Cohen
- Yoshimitsu Fukushima
- Young So
- Younghoon Kwon
- Yu Izawa
- Yunqiang An
- Zabah Jawa
- Zhaoqian Wang
- Zhuoran Xu
- Zorana Mrsic
- Zuzana Berecova
- Publication venue
- Publication date
- 01/01/2022
- Field of study
BACKGROUND The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown.OBJECTIVES The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care providers worldwide.METHODS The International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular diagnostic care at the pandemic's onset and 1 year later. Multivariable regression was used to determine factors associated with procedure volume recovery.RESULTS Surveys were submitted from 669 centers in 107 countries. Worldwide reduction in cardiac procedure volumes of 64% from March 2019 to April 2020 recovered by April 2021 in high- and upper middle-income countries (recovery rates of 108% and 99%) but remained depressed in lower middle- and low-income countries (46% and 30% recovery). Although stress testing was used 12% less frequently in 2021 than in 2019, coronary computed tomographic angiography was used 14% more, a trend also seen for other advanced cardiac imaging modalities (positron emission tomography and magnetic resonance; 22%-25% increases). Pandemic-related psychological stress was estimated to have affected nearly 40% of staff, impacting patient care at 78% of sites. In multivariable regression, only lower-income status and physicians' psychological stress were significant in predicting recovery of cardiac testing.CONCLUSIONS Cardiac diagnostic testing has yet to recover to prepandemic levels in lower-income countries. Worldwide, the decrease in standard stress testing is offset by greater use of advanced cardiac imaging modalities. Pandemic-related psychological stress among providers is widespread and associated with poor recovery of cardiac testing. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation
Kuluttajabarometri maakunnittain 2000, 2. neljännes
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- Zamudio D
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- Zapata DDM
- Zbitnew G
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- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- Tilastokeskus
- Publication date
- 11/07/2000
- Field of study
Suomen virallinen tilasto (SVT
Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
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- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
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- Angermair S
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- Anillo V
- Antal O
- Antill P
- Antoniadou E
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- Apostolou K
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- Ardern D
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- Attwood C
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- Avila Sanchez FJ
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- Chicken D-W
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- Chin II
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- Chisbert Cuenca V
- Chlorou D
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- Chronis C
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- Chung CKE
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- Ciobotaru OR
- Cirstea E
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- Clarkson R
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- Cloro LM
- Clyde A
- Cobzaru I
- Codita A
- Colangelo A
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- Comptaer N
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- Costelloe H
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- Smitz C
- Smolen S
- Soares MDC
- Sobol J
- Socorro Artiles T
- Sofjan I
- Sojod G
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- Song X
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- Sonnemann S
- Soon WC
- Soro M
- Sottosanti V
- Souri F
- Sousana A
- Souvatzis X
- Souza D
- Spadaro S
- Spagnesi L
- Spanjersberg R
- Spartinou A
- Spencer-Jones R
- Sperber J
- Spickett H
- Spowart E
- Sprakel J
- Spring A
- Spurdle K
- Squire R
- Ssettabi EM
- Stafylaraki M
- Stamatiou K
- Stamoulis K
- Stancombe L
- Stanescu D
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- Steele N
- Steen J
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- Steingrimsdottir GE
- Stella O
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- Stephenson L
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- Stewart K
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- Steyaert A
- Steynor M
- Stocker A
- Stoica R
- Stoltz D
- Stone L
- Streanga L
- Struck R
- Strydom M
- Stundner O
- Su L
- Suarez L
- Suarez-de-la-Rica A
- Subramaniam K
- Suen A
- Sukawi I
- Sulaiman HA
- Sule UM
- Sumner M
- Sun C
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- Sun Y
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- Sundayi S
- Sung W
- Susanti A
- Swain A
- Swarbrick G
- Swift D
- Sylvan A
- Synekidou E
- Syrogianni P
- Szabo C
- Szafranski J
- Szakmany T
- Tabajara FB
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- Tameem A
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- Tao F
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- Tayeh S
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- Tayo A
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- Tchekulaev A
- Tebar Soto MT
- Teixeira Jesus JS
- Templer P
- ten Bokkel-Andela J
- Terblanche N
- Tesniere A
- Tessera G
- Testa V
- Theodorakopoulou M
- Theodosopoulos T
- Thiessen B
- Thilen S
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- Thomas C
- Thomas C
- Thomas M
- Thomas M
- Thomas R
- Thomas S
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- Thorpe K
- Thunder J
- Tincu E
- Tinti C
- Tinuoye E
- Tolenaar N
- Tolmasov A
- Tom CO
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- Tomescu D
- Tong Y
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- Towse K
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- Travi ME
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- Trybus C
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- Tsakiridou I-S
- Tsakok M
- Tsampalas S
- Tsang MS
- Tsang MSC
- Tsaousi G
- Tsigou E
- Tsigris C
- Tsiligiannis S
- Tsimpoukas F
- Tsioka A
- Tsirogianni A
- Tsui A
- Tudor C
- Tulupova V
- Turner A
- Turton EW
- Tutunaru V
- Twohey L
- Tyrell B
- Ugolini G
- Ugwu I
- Ullah S
- Umeh F
- Ungureanu LL
- Urias E
- Ursache E
- Ursu I
- Usher H
- Utara UH
- Utkin I
- Uwubamwen N
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- Vahedi A
- Vaida C
- Vakalos A
- Valle Beltran A
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- van den Berg B
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- van Duivenvoorde Y
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- Vanluchene A
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- Wan X
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- Wijeysundera D
- Wikner M
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- Winstone U
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- Woolsey A
- Woon YL
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- Wylie K
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- Xiao W
- Xiao W
- Xie G
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- Xifara A
- Xiong X
- Xiong Y
- Xouplidis K
- Xu G-J
- Xu L
- Xu L
- Xu Q
- Xu S
- Xue R
- Yagnik A
- Yan Y
- Yang J
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- Yang Y
- Yao S
- Yao Y
- Yap HL
- Yarwood J
- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
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- Yuan J
- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
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- Zhang J
- Zhang K
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- Zhang Q
- Zhang R
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2017
- Field of study
This was an investigator-initiated study funded by Nestle Health Sciences through an unrestricted research grant and by a National Institute for Health Research (UK) Professorship held by R.P. The study was sponsored by Queen Mary University of London