13 research outputs found

    Fostering pre-university student participation in OSGeo through the Google Code-in competition

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    The Open Source Geospatial Foundation (OSGeo) was founded in 2006 and the number of projects under its umbrella is steadily growing. The current projects cover content management systems, desktop applications, geospatial libraries, metadata catalogs, spatial databases, and web mapping. OSGeo’s vision is to empower everyone, from pre-university students to professionals, with open source geospatial applications, tools and resources (OSGeo 2017). In 2011, the GeoForAll initiative was established through a partnership between OSGeo and the International Cartographic Association (ICA) to focus on open education. Three years later, the International Society for Photogrammetry and Remote Sensing (ISPRS) joined this memorandum of understanding emphasizing the importance of educational outreach and open source for the larger geospatial community. At present, GeoForAll consists of 122 labs, mainly based at universities world-wide. Even though there are various outreach activities at the university level, and not only through OSGeo, the majority of open source developers are between 30-49 years (Choi and Pruett 2015). This suggests that more effort is required to understand why individuals between 18-29 are not (yet) actively involved. OSGeo is a veteran organization having participated in Google Summer of Code for 11 years, and in 2017 decided to participate for the first time in the Code-in contest as well. Google Code-in (GCI) is an annual online competition aimed at introducing pre-university students (13-17 years) to open source projects, development and communities, through short 3-5 hour tasks. Students qualify for different prizes (i.e. certificate, t-shirts, hoodies and the grand prize of visiting Google) depending on the number of tasks they complete. During GCI, participating organizations, such as OSGeo, have a unique opportunity to interact with pre-university students and to encourage them to become part of their respective organizations. In this paper, we present our experience participating in the 2017/18 GCI and the results from a survey completed by the GCI students after the competition. Overall the 2017/2018 GCI had 3,555 participating students from 78 countries completing 16,468 tasks with a record 25 open source participating organizations. OSGeo had 20 members (i.e. 4 admins and 16 mentors) that created 176 tasks for GeoForAll, OSGeo and 11 projects (i.e. FOSS4G, GeoServer, GeoTools, GRASS GIS, gvSIG, MapServer, OpenLayers, OSGeoLive, pgRouting, PostGIS, and QGIS). Over the 51 days of the contest, 279 students completed 649 OSGeo tasks. Students consistently communicated through the GCI dashboard, IRC, and mailing lists with the mentors to discuss submission and receive inputs from the wide community of developers too. During the GCI, the mentors reviewed the students’ work and provided suggestions and feedback. Generally, the submissions (i.e. documentation, coding and design tasks) were very good and some of them are now part of the projects. One example is related to GRASS GIS project, during GCI the documentation of 12 modules was improved with examples and/or figures. Moreover, tests for the test suite of 11 modules were added. However, we also encountered a number of non-desirable and difficult to deal with issues, such as plagiarism, a non-collaborative attitude of some students, and seeking immediate feedback. As this was our first time participating in GCI these issues are seen as lessons learned and strategies to improve the process will be implemented based on the mentors’ experience. It is key to encourage these students to continue to contribute to the OSGeo community (the winner of the contest asked for and submitted more work even after GCI has finished!), as they will bring new energy and ideas into the organisation; for many of these young students, this contest is a way to introduce them to the now 400 billion USD geospatial industry (2017). For the students, the exposure to coding and open source will be beneficial if they intend to enroll for tertiary education, especially in computing (Hagan and Markham 2000). Lastly, the results from the survey and the mentors’ experience during the 2017/2018 Google Code-in could contribute to the outreach plan of OSGeo and provide guidelines on how to encourage students and young professionals to get involved and contribute to OSGeo. References: Open Source Geospatial Foundation (OSGeo) website, available online at https://www.osgeo.org, accessed on 7 February 2018. Choi N and Pruett JA (2015) The characteristics and motivations of library open source software developers: An empirical study, Library and Information Science Research, 37(2), pp. 109-117. Hagan D and Markham S (2000) Does it help to have some programming experience before beginning a computing degree programme, Proceedings of the Innovation and Technology in Computer Science Education, Helsinki, Finland, 11-13 July 2000. AlphaBeta (2017) The Economic Impact of Geospatial Services, Value of the Web, available online at https://www.valueoftheweb.com/reports/the-economic-impact-of-geospatial-services/, accessed on 7 February 2018

    Antibothropic action of Casearia sylvestris Sw. (flacourtiaceae) extracts

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    Casearia sylvestris Sw., popularly known in Brazil as 'guacatonga', has been used as antitumor, antiseptic, antiulcer, local anaesthetic and healer in folk medicine. Snakebite envenomation by Bothrops jararacussu (Bjssu) constitutes a relevant public health hazard capable of inducing serious local damage in victims. This study examined the pharmacological action of apolar and polar C sylvestris leaf extracts in reverting the neuromuscular blockade and myonecrosis, which is induced by Bjssu venom and its major toxin bothropstoxin-I on the mouse phrenic nerve-diaphragm preparations. The polar methanol extract (ME) was by far the most efficacious. ME not only prevented myonecrosis and abolished the blockade, but also increased ACh release. Such facilitation in neuromuscular transmission was observed with ME alone, but was accentuated in preparations incubated with ME plus venom or toxin. This established synergy opens an interesting point of investigation because the venom or toxin in contact with ME changes from a blocking to a facilitating effect. It is suggested that rutin, known to have potent antioxidant properties, and one of the components present in the ME, could have a role in the observed effects. Since commercial rutin did not reproduce the ME effects, it is likely that a rutin-containing phytocomplex is neutralizing the bothropic envenoming effects22678479

    Antibothropic Action Of Casearia Sylvestris Sw. (flacourtiaceae) Extracts

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    Casearia sylvestris Sw., popularly known in Brazil as 'guaçatonga', has been used as antitumor, antiseptic, antiulcer, local anaesthetic and healer in folk medicine. Snakebite envenomation by Bothrops jararacussu (Bjssu) constitutes a relevant public health hazard capable of inducing serious local damage in victims. This study examined the pharmacological action of apolar and polar C. sylvestris leaf extracts in reverting the neuromuscular blockade and myonecrosis, which is induced by Bjssu venom and its major toxin bothropstoxin-I on the mouse phrenic nerve-diaphragm preparations. The polar methanol extract (ME) was by far the most efficacious. ME not only prevented myonecrosis and abolished the blockade, but also increased ACh release. Such facilitation in neuromuscular transmission was observed with ME alone, but was accentuated in preparations incubated with ME plus venom or toxin. This established synergy opens an interesting point of investigation because the venom or toxin in contact with ME changes from a blocking to a facilitating effect. It is suggested that rutin, known to have potent antioxidant properties, and one of the components present in the ME, could have a role in the observed effects. Since commercial rutin did not reproduce the ME effects, it is likely that a rutin-containing phytocomplex is neutralizing the bothropic envenoming effects. Copyright © 2008 John Wiley & Sons, Ltd.226784790Bjarnason, J.B., Fox, J.W., Hemorrhagic metalloproteinases from snake venoms (1994) Pharmacol Ther, 62, pp. 325-372Borges, M.H., Soares, A.M., Rodrigues, V.M., Effects of aqueous extract of Casearia sylvestris (Flacourtiaceae) on actions of snake and bee venoms and on activity of phospholipases A 2 (2000) Comp Biochem Physiol B Biochem Mol Biol, 127, pp. 21-30Borges, M.H., Soares, A.M., Rodrigues, V.M., Neutralization of proteases from Bothrops snake venoms by aqueous extract from Casearia sylvestris (Flacourtiaceae) (2001) Toxicon, 39, pp. 1863-1869Bülbring, E., Observation on the isolated phrenic nerve diaphragm preparation of the rat (1946) Br J Pharmacol, 1, pp. 38-61De Oliveira, M., Cavalcante, W.L., Arruda, E.A., Melo, P.A., Dal-Pai Silva, M., Gallaci, M., Antagonism of myotoxic and paralyzing activities of bothropstoxin-l by suramin (2003) Toxicon, 42, pp. 373-379Girish, K.S., Kemparaju, K., Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides (2005) Biochemistry (Moscow), 70, pp. 948-952Gutierrez, J.M., Romero, M., Díaz, C., Borkow, G., Ovadia, M., Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo) (1995) Toxicon, 33, pp. 19-29Harbone, J.B., (1998) Phytochemical Methods: A Guide to Modern Techniques of Plants Analysis, , 3rd edn, Chapman & Hall: LondonHavsteen, B., Flavonoids, a class of natural products of high pharmacological potency (1983) Biochem Pharmacol, 32, pp. 1141-1148Heluany, N.F., Homsi-Brandeburgo, M., Giglio, J.R., Prado-Franceschi, J., Rodrigues-Simioni, L., Effects induced by bothrop-stoxin, a component from Bothrops jararacussu snake venom, on mouse and chick muscle preparations (1992) Toxicon, 30, pp. 1203-1210Iwanaga, S., Suzuki, T., Enzymes in snake venoms (1979) Snake Venoms. Handbook of Experimental Pharmacology, pp. 61-158. , Lee CY ed, Springer: New YorkJin, G.Z., Yamagata, Y., Tomita, K., Structure of rutin pentamethanol (1990) Chem Pharm Bull, 38, pp. 297-300Khan, A.A., Ashfaq, A., Ali, M.N., (1979) Pharmacognostic Studies of Selected Indigenous Plants of Pakistan, , Pakistan Forest Institute. Spinezer Printers: PeshawarMahmood A, Ahmad M, Jabeen A, Zafar M, Nadeem S. 2005. Pharmacognostic studies of some indigenous medicinal plants of Pakistan. Available in http://www.siu.edu/∼ebl/leaflets/abid.htm. Access in 06/03/2005Maistro, E.L., Carvalho, J.C., Mantovani, M.S., Evaluation of the genotoxic potential of the Casearia sylvestris extract on HTC and V79 cells by the comet assay (2004) Toxicol In Vitro, 18, pp. 337-342Markland, F.S., Snake venoms and the hemostatic system (1998) Toxicon, 36, pp. 1749-1800Matrisian, L.M., The matrix-degrading metalloproteinases (1992) BioEssays, 14, pp. 455-463Milani Junior, R., Jorge, M.T., de Campos, F.P., Snake bites by the jararacuçu (Bothrops jararacussu): Clinicopatho-logical studies of 29 proven cases in Sao Paulo State, Brazil (1997) Q J Med, 90, pp. 323-334(2001) Manual de Diagnóstico e Tratamento de Acidentes por Animais Pegonhentos, , Ministério da Saúde do Brasil, 2nd edn. Fundação Nacional da Saúde: BrasíliaMors, W.B., Nascimento, M.C., Pereira, B.M., Pereira, N.A., Plant natural products active against snake bite - the molecular approach (2000) Phytochemistry, 55, pp. 627-642Oshima-Franco, Y., Alves, C.M.V., Andréo Filho, N., Neutralization of the neuromuscular activity of bothropstoxin-l, a myotoxin from Bothrops jararacussu snake venom, by a hydroalcoholic extract of Casearia sylvestris Sw. (guaçatonga) (2005) J Venom Anim Toxins Trop Dis, 11, pp. 465-478Oshima-Franco, Y., Hyslop, S., Cintra, A.C.O., Giglio, J.R., Cruz-Höfling, M.A., Rodrigues-Simioni, L., Neutralizing capacity of commercial bothropic antivenom against Bothrops jararacussu venom and bothropstoxin-l (2000) Muscle Nerve, 23, pp. 1832-1839Oshima-Franco, Y., Leite, G.B., Dal Belo, C.A., The presynaptic activity of bothropstoxin-l, a myotoxin from Bothrops jararacussu snake venom (2004) Basic Clin Pharmacol Toxicol, 95, pp. 175-182Oshima-Franco, Y., Leite, G.B., Silva, G.H., Neutralization of the pharmacological effects of bothropstoxin-l from Bothrops jararacussu (jararacuçu) venom by crotoxin antiserum and heparin (2001) Toxicon, 39, pp. 1477-1485Oshima-Franco, Y., Leite, G.B., Valério, A.A., Rabbit antivenom efficacy against myotoxic and neurotoxic activities of Bothrops jararacussu venom and bothropstoxin-l (2002) J Venom Anim Toxins, 8, pp. 226-243Pessini, A.C., Takao, T.T., Cavalheiro, E.C., A hyaluronidase from Tityus serrulatus scorpion venom: Isolation, characterization and inhibition by flavonoids (2001) Toxicon, 39, pp. 1495-1504Randazzo-Moura, P., Leite, G.B., Silva, G.H., Study of myotoxicity of bothropstoxin-l (BthTX-l) using manganese (Mn 2+) in mouse phrenic nerve-diaphragm (PND) and extensor digitorum longus (EDL) preparations (2006) Braz J Morphol Sci, 23, pp. 171-184Rates, S.M.K., Plants as source of drugs (2001) Toxicon, 39, pp. 603-613Rodrigues-Simioni, L., Borgese, N., Ceccarelli, B., The effects of Bothrops jararacussu venom and its components on frog nerve-muscle preparation (1983) Neuroscience, 10, pp. 475-489Rodrigues-Simioni, L., Prado-Franceschi, J., Cintra, A.C.O., Giglio, J.R., Jiang, M.S., Fletcher, J.E., No role for enzymatic activity or dantrolene-sensitive Ca 2+ stores in the muscular effects of bothropstoxin, a Lys49 phospholipase A 2 myotoxin (1995) Toxicon, 33, pp. 1479-1489Rosenfeld, G., Symptomatology, pathology and treatment of snakebites in South America (1971) Venomous Animals and their Venoms, pp. 345-384. , Bucherl W, Buckley E eds, Academic Press: New YorkRucavado, A., Escalante, T., Gutiérrez, J.M., Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: Understanding the role of metalloproteinases in envenomation (2004) Toxicon, 43, pp. 417-424Selistre, H.S., Queiroz, L.S., Cunha, O.A., De Souza, G.E., Giglio, J.R., Isolation and characterization of hemorrhagic, myonecrotic and edema-inducing toxins from Bothrops insularis (jararaca ilhoa) snake venom (1990) Toxicon, 28, pp. 261-273Simōes CMO, Schenkel EP, Gosmann G, Mello JCP, Mentz LA, Petrovick PR. 2004. 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    Potential Antiulcer Agents From Plants: A Comprehensive Review

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    The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revision of the Clinical and Pathologic Staging of Small Cell Lung Cancer in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer

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