Understanding factors that enable and inhibit assessment of outcomes of competence development

© The Author(s) 2020. Employee participation in formal and informal learning is essential for the economic viability and competitive advantage of organizations. Therefore, assessing outcomes of competence development activities is important. However, this domain of human resources (HR) practice is often neglected because of factors that are not well understood. Accordingly, this article addresses the question: What factors enable and inhibit HR professionals in assessing outcomes of competence development activities and initiatives? To answer this question, we conducted a review of articles that examine assessment of outcomes of competence development activities. The primary purpose of the review was to identify and categorize enabling and inhibiting factors so that the factors can be better understood by researchers and HR professionals. We also call upon voices from the field, using quotations from HR professionals to illustrate enabling and inhibiting factors. Analysis and synthesis of the literature informed the development of propositions to guide future research

Беларусь в современном мире: материалы VII Международной научной конференции

Материалы VII Международной научной конференции студентов, магистрантов и аспирантов.Представлены доклады студентов, результаты диссертационных исследований аспирантов и молодых ученых по проблемам формирования государственности, исторической и социокультурной идентичности Беларуси, правовому обеспечению социально ориентированной экономики, внутреннего и внешнего туризма. Для преподавателей вузов, аспирантов и студентов, изучающих экономические и социально-гуманитарные дисциплины

The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment

Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. This can ultimately result in cancer immune evasion. The manipulation of chemokine and chemokine-receptor signaling can reshape the immunological phenotypes within the tumor microenvironment in order to increase the therapeutic efficacy of cancer immunotherapy. Here we discuss the three chemokine-chemokine receptor axes, CXCR1/2–CXCL1-3/5-8, CXCR3–CXCL9/10/11, and CXCR4-CXCL12 and their role on pro-tumorigenic immune cells and anti-tumorigenic effector cells in solid tumors. In particular, we summarize current strategies to target these axes and discuss their potential use in treatment approaches

A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells

The proteasome inhibitor bortezomib simultaneously renders tumor cells sensitive to killing by natural killer (NK) cells and resistant to killing by tumor-specific T cells. Here, we show that b-AP15, a novel inhibitor of proteasome deubiquitinating activity, sensitizes tumors to both NK and T cell-mediated killing. Exposure to b-AP15 significantly increased the susceptibility of tumor cell lines of various origins to NK (p<0.0002) and T cell (p=0.02) –mediated cytotoxicity. Treatment with b-AP15 resulted in increased TRAIL [tumor necrosis factor-related apoptosis-inducing ligand] receptor-2 expression (p=0.03) and decreased cFLIP expression in tumor cells in vitro. In tumor-bearing SCID/Beige mice, treatment with b-AP15 followed by infusion of either human NK cells or tumor-specific T cells resulted in a significantly delayed tumor progression compared with mice treated with NK cells (p=0.006), T cells (p<0.0001), or b-AP15 alone (p=0.003). Combined infusion of NK and T cells in tumor-bearing BALB/c mice following treatment with b-AP15 resulted in a significantly prolonged long-term survival compared with mice treated with b-AP15 and NK or T cells (p≤0.01). Our findings show that b-AP15-induced sensitization to TRAIL-mediated apoptosis could be used as a novel strategy to augment the anti-cancer effects of adoptively infused NK and T cells in patients with cancer.VetenskapsrådetEuropean Research CouncilAccepte

An Architecture-Based Verification Technique for AADL Specifications

Abstract. Quality assurance processes of software-intensive systems are an increasing challenge as the complexity of these systems dramatically increases. The use of Architecture Description Languages (ADLs) provide an important basis for evaluation. The Architecture Analysis and Design Language (AADL) is an ADL developed for designing softwareintensive systems. In this paper, we propose an architecture-based verification technique covering the entire development process by adapting a combination of model-checking and model-based testing approaches to AADL specifications. The technique reveals inconsistencies of early design decisions and ensures a system&apos;s conformity with its AADL specification. The objective and criteria (test-selection) of the verification technique is derived from traditional integration testing

Метод эмболизации маточных артерий в лечении миомы матки

МАТКИ НОВООБРАЗОВАНИЯМИОМАЭМБОЛИЗАЦИЯ ТЕРАПЕВТИЧЕСКАЯАРТЕРИ

Методика сравнения электромагнитных помеховых импульсов различного происхождения

Тез. докл. X Междунар. науч.-техн. конф. (науч. чтения, посвящ. П. О. Сухому), Гомель, 23-24 октября 2014 г