Molecular line study of the very young protostar IRAM 04191 in Taurus: Infall, rotation, and outflow

We present a detailed millimeter line study of the circumstellar environment of the low-luminosity Class 0 protostar IRAM 04191+1522 in the Taurus molecular cloud. New line observations demonstrate that the ~14000 AU radius protostellar envelope is undergoing both extended infall and fast, differential rotation. Radiative transfer modeling of multitransition CS and C34S maps indicate an infall velocity v_inf ~ 0.15 km/s at r ~ 1500 AU and v_inf ~ 0.1 km/s up to r ~ 11000 AU, as well as a rotational angular velocity Omega ~ 3.9 x 10^{-13} rad/s, strongly decreasing with radius beyond 3500 AU down to a value Omega ~ 1.5-3 x 10^{-14} rad/s at ~ 11000 AU. Two distinct regions, which differ in both their infall and their rotation properties, therefore seem to stand out: the inner part of the envelope (r ~< 2000-4000 AU) is rapidly collapsing and rotating, while the outer part undergoes only moderate infall/contraction and slower rotation. These contrasted features suggest that angular momentum is conserved in the collapsing inner region but efficiently dissipated due to magnetic braking in the slowly contracting outer region. We propose that the inner envelope is in the process of decoupling from the ambient cloud and corresponds to the effective mass reservoir (~0.5 M_sun) from which the central star is being built. Comparison with the rotational properties of other objects in Taurus suggests that IRAM 04191 is at a pivotal stage between a prestellar regime of constant angular velocity enforced by magnetic braking and a dynamical, protostellar regime of nearly conserved angular momentum. The rotation velocity profile we derive for the inner IRAM 04191 envelope should thus set some constraints on the distribution of angular momentum on the scale of the outer Solar system at the onset of protostar/disk formation.Comment: 23 pages, 16 figures, 1 table, Accepted by Astronomy & Astrophysic

Infall models of Class 0 protostars

We have carried out radiative transfer calculations of infalling, dusty envelopes surrounding embedded protostars to understand the observed properties of the recently identified ``Class 0'' sources. To match the far-infrared peaks in the spectral energy distributions of objects such as the prototype Class 0 source VLA 1623, pure collapse models require mass infall rates \sim10^{-4}\msunyr$^{-1}$. The radial intensity distributions predicted by such infall models are inconsistent with observations of VLA 1623 at sub-mm wavelengths, in agreement with the results of Andre et al. (1993) who found a density profile of $\rho \propto r^{-1/2}$ rather than the expected $\rho \propto r^{-3/2}$ gradient. To resolve this conflict, while still invoking infall to produce the outflow source at the center of VLA 1623, we suggest that the observed sub-mm intensity distribution is the sum of two components: an inner infall zone, plus an outer, more nearly constant-density region. This explanation of the observations requires that roughly half the total mass observed within 2000 AU radius of the source lies in a region external to the infall zone. The column densities for this external region are comparable to those found in the larger Oph A cloud within which VLA 1623 is embedded. The extreme environments of Class 0 sources lead us to suggest an alternative or additional interpretation of these objects: rather than simply concluding with Andre et al. that Class 0 objects only represent the earliest phases of protostellar collapse, and ultimately evolve into older ``Class I'' protostars, we suggest that many Class 0 sources could be the protostars of very dense regions. (Shortened)Comment: 22 pages, including 3 PostScript figures, accepted for publication in The Astrophysical Journa

A Spectrophotometric Method to Determine the Inclination of Class I Objects

A new method which enables us to estimate the inclination of Class I young stellar objects is proposed. Since Class I objects are not spherically symmetric, it is likely that the observed feature is sensitive to the inclination of the system. Thus, we construct a protostar model by carefully treating two-dimensional (2D) radiative transfer and radiative equilibrium. We show from the present 2D numerical simulations that the emergent luminosity L_SED,which is the frequency integration of spectral energy distribution (SED), depends strongly on the inclination of the system i, whereas the peak flux is insensitive to i. Based on this result, we introduce a novel indicator f_L, which is the ratio of L_SED to the peak flux, as a good measure for the inclination. By using f_L, we can determine the inclination regardless of the other physical parameters. The inclination would be determined by f_L within the accuracy of +- 5 degree, if the opening angle of bipolar outflows is specified by any other procedure. Since this spectrophotometric method is easier than a geometrical method or a full SED fitting method, this method could be a powerful tool to investigate the feature of protostars statistically with observational data which will be provided by future missions, such as SIRTF, ASTRO-F, and ALMA.Comment: 14 pages, 9 figures, accepted by Ap

Fabrication of free-standing ordered fluorescent polymer nanofibres by electrospinning

The authors are grateful to the Engineering and Physical Sciences Research Council for financial support.We demonstrate a static fabrication approach to make free-standing ordered arrays of fluorescent nanofibres through control of the transverse electrospinning field. The alignment and the density of the nanofibre arrays are optimised by careful design of both the source and collector electrode geometries which can control the transverse electric field over the full path of the jet. In doing so, we fabricate suspended fluorescent nanofibres with an aspect ratio of 10(4), and with a substantially increased density and order parameter (by a factor of similar to 10 compared to random deposition). Electrostatic modelling suggests that the field distribution of the component is the main contribution to the ordering between the plates. This method offers increased efficiency for the creation of ordered fibres collected over a small area and the characterisation of their photoluminescent properties.Publisher PDFPeer reviewe

LHC discovery potential for supersymmetry with \sqrt{s}=7 TeV and 5-30 fb^{-1}

We extend our earlier results delineating the supersymmetry (SUSY) reach of the CERN Large Hadron Collider operating at a centre-of-mass energy \sqrt{s}=7 TeV to integrated luminosities in the range 5 - 30 fb^{-1}. Our results are presented within the paradigm minimal supergravity model (mSUGRA or CMSSM). Using a 6-dimensional grid of cuts for the optimization of signal to background ratio -- including missing E_T-- we find for m(gluino) \sim m(squark) an LHC 5\sigma SUSY discovery reach of m(gluino) \sim 1.3,\ 1.4,\ 1.5 and 1.6 TeV for 5, 10, 20 and 30 fb^{-1}, respectively. For m(squark)>> m(gluino), the corresponding reach is instead m(gluino)\sim 0.8,\ 0.9,\ 1.0 and 1.05 TeV, for the same integrated luminosities.Comment: 7 pages with 2 .eps figure. In version 2, a new figure has been added along with associated discussio

Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer

Objective: To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers. Methods: Sections of paraffin-embedded histological material of 481 lungs from lung tumor patients following radical lung excision processed by a routine immunohistochemical method (avidin-biotin labeling, DAB chromogen). Specific antibodies against galectins-1 and - 3 and the heparin-binding lectin were tested. Staining by labeled galectins and hyaluronic acid was similarly visualized by a routine protocol. After semiquantitative assessment of staining, the results were compared with the pT and pN stages and the histological type. Survival was calculated by univariate and multivariate methods. Results: Binding of galectin-1 and its expression tended to increase, whereas the parameters for galectin-3 decreased in advanced pT and pN stages at a statistically significant level. The number of positive cases was considerably smaller among the cases with small cell lung cancer than in the group with non-small-cell lung cancer, among which adenocarcinomas figured prominently with the exception of galectin-1 expression. Kaplan-Meier computations revealed that the survival rate of patients with galectin-3-binding or galectin-1-expressing tumors was significantly poorer than that of the negative cases. In the multivariate calculations of survival lymph node metastases ( p < 0.0001), histological type ( p = 0.003), galectin-3-binding capacity ( p = 0.01), galectin-3 expression ( p = 0.03) and pT status ( p = 0.003) proved to be independent prognostic factors, not correlated with the pN stage. Conclusion: The expression and the capacity to bind the adhesion/growth regulatory galectin-3 is defined as an unfavorable prognostic factor not correlated with the pTN stage. Copyright (C) 2005 S. Karger AG, Basel

Understanding star formation in molecular clouds I. Effects of line-of-sight contamination on the column density structure

Column-density maps of molecular clouds are one of the most important observables in the context of molecular cloud- and star-formation (SF) studies. With the Herschel satellite it is now possible to determine the column density from dust emission. We use observations and simulations to demonstrate how LOS contamination affects the column density probability distribution function (PDF). We apply a first-order approximation (removing a constant level) to the molecular clouds of Auriga, Maddalena, Carina and NGC3603. In perfect agreement with the simulations, we find that the PDFs become broader, the peak shifts to lower column densities, and the power-law tail of the PDF flattens after correction. All PDFs have a lognormal part for low column densities with a peak at Av~2, a deviation point (DP) from the lognormal at Av(DP)~4-5, and a power-law tail for higher column densities. Assuming a density distribution rho~r^-alpha, the slopes of the power-law tails correspond to alpha(PDF)=1.8, 1.75, and 2.5 for Auriga, Carina, and NGC3603 (alpha~1.5-2 is consistent gravitational collapse). We find that low-mass and high-mass SF clouds display differences in the overall column density structure. Massive clouds assemble more gas in smaller cloud volumes than low-mass SF ones. However, for both cloud types, the transition of the PDF from lognormal shape into power-law tail is found at the same column density (at Av~4-5 mag). Low-mass and high-mass SF clouds then have the same low column density distribution, most likely dominated by supersonic turbulence. At higher column densities, collapse and external pressure can form the power-law tail. The relative importance of the two processes can vary between clouds and thus lead to the observed differences in PDF and column density structure.Comment: A&A accepted, 15.12. 201

Interaction of neuronal nitric oxide synthase with alpha(1)-adrenergic receptor subtypes in transfected HEK-293 cells

BACKGROUND: The C-terminal four amino acids (GEEV) of human α(1A)-adrenergic receptors (ARs) have been reported to interact with the PDZ domain of neuronal nitric oxide synthase (nNOS) in a yeast two-hybrid system. The other two α(1)-AR subtypes have no sequence homology in this region, raising the possibility of subtype-specific protein-protein interactions. RESULTS: We used co-immunoprecipitation and functional approaches with epitope-tagged α(1)-ARs to examine this interaction and the importance of the C-terminal tail. Following co-transfection of HEK-293 cells with hexahistidine/Flag (HF)-tagged α(1A)-ARs and nNOS, membranes were solubilized and immunoprecipitated with anti-FLAG affinity resin or anti-nNOS antibodies. Immunoprecipitation of HFα(1A)-ARs resulted in co-immunoprecipitation of nNOS and vice versa, confirming that these proteins interact. However, nNOS also co-immunoprecipitated with HFα(1B)- and HFα(1D)-ARs, suggesting that the interaction is not specific to the α(1A) subtype. In addition, nNOS co-immunoprecipitated with each of the three HFα(1)-AR subtypes which had been C-terminally truncated, suggesting that this interaction does not require the C-tails; and with Flag-tagged β(1)- and β(2)-ARs. Treatment of PC12 cells expressing HFα(1A)-ARs with an inhibitor of nitric oxide formation did not alter norepinephrine-mediated activation of mitogen activated protein kinases, suggesting nNOS is not involved in this response. CONCLUSIONS: These results show that nNOS does interact with full-length α(1A)-ARs, but that this interaction is not subtype-specific and does not require the C-terminal tail, raising questions about its functional significance

First Observations of the Magnetic Field Geometry in Pre-stellar Cores

We present the first published maps of magnetic fields in pre-stellar cores, to test theoretical ideas about the way in which the magnetic field geometry affects the star formation process. The observations are JCMT-SCUBA maps of 850 micron thermal emission from dust. Linear polarizations at typically ten or more independent positions in each of three objects, L1544, L183 and L43 were measured, and the geometries of the magnetic fields in the plane of the sky were mapped from the polarization directions. The observed polarizations in all three objects appear smooth and fairly uniform. In L1544 and L183 the mean magnetic fields are at an angle of around 30 degrees to the minor axes of the cores. The L43 B-field appears to have been influenced in its southern half, such that it is parallel to the wall of a cavity produced by a CO outflow from a nearby T Tauri star, whilst in the northern half the field appears less disturbed and has an angle of 44 degrees to the core minor axis. We briefly compare our results with published models of magnetized cloud cores and conclude that no current model can explain these observations simultaneously with previous ISOCAM data.Comment: 13 pages, 3 figs, to appear in ApJ Letter