A PRODUÇÃO CAMPONESA EM FOCO: PASSOS METODOLÓGICOS PARA O CÁLCULO DE GRAVITAÇÃO ECONÔMICA

O artigo estuda a contribuição camponesa ao processo de desenvolvimento regional numa área amazônica, com especial ênfase ao chamado desenvolvimento endógeno e a teoria gravitacional econômica, relacionando diversos dados e indicadores socioeconômicos. Parte-se do pressuposto de que, apesar das possíveis interpretações de publicações oficiais e dos interesses envolvidos, a produção de origem camponesa apresenta uma participação relevante no espaço e no tempo, contribuindo positivamente para o processo de desenvolvimento socioeconômico da região estudada. O primeiro passo metodológico foi o de fazer um levantamento da mesorregião selecionada em números e relacionar estes dados de origem socioeconômica com a teoria gravitacional no processo de desenvolvimento regional. Em seguida foram encontrados os principais “pólos” (municípios de maior atratividade, a partir da análise das variáveis envolvidas). Os resultados obtidos foram agrupados em categorias de análise, construindo-se um perfil agregado dos municípios da mesorregião escolhida. As conclusões provisórias apontam para duas direções: a) “redescoberta” crítica do campesinato na Amazônia brasileira; b) necessidade de se reorganizar as políticas públicas na região estudada, com destaque para as atividades agropecuárias por conta de seu maior impacto econômico.----------------------The present work studies the peasant contribution to the process of regional development in an area of the State of Pará, with special emphasis to the call endogenous development and the theory economical gravitational, relating several data and socioeconomic indicators in Nordeste Paraense. There is presupposition that, in spite of the possible interpretations to the read texts, retired data of official publications and of the involved interests, origin farmer's production presents an important participation in the space and in the time, contributing positively to the process of socioeconomic development of the studied area. The temporary conclusions appear for two directions: the) to the “rediscovered” critic of the campesinato in the Amazonian Brazilian, in spite of the speech that looks for to condemn the activity farmer to the delay and the slow historical disappearance; b) to the need to reorganize the public politics in the studied area, with prominence for the agricultural activities due to your largest economical impact.Campesinato, Desenvolvimento Endógeno, Desenvolvimento Regional, Gravitação econômica, peasant, endogenous development, regional development, economical gravitational, Community/Rural/Urban Development,

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

Modelling human choices: MADeM and decision‑making

Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)