304 research outputs found
Convergent Evolution of Brain Morphology and Communication Modalities in Lizards
- Publication venue
- Digital Commons @ Trinity
- Publication date
- 01/01/2015
- Field of study
Animals communicate information within their environments via visual, chemical, auditory, and/or tactile modalities. The use of each modality is generally linked to particular brain regions, but it is not yet known whether the cellular morphology of neurons in these regions has evolved in association with the relative use of a modality. We investigated relationships between the behavioral use of communication modalities and neural morphologies in six lizard species. Two of these species (Anolis carolinensis and Leiocephalus carinatus) primarily use visual signals to communicate with conspecifics and detect potential prey, and two (Aspidoscelis gularis and Scincella lateralis) communicate and forage primarily using chemical signals. Two other species (Hemidactylus turcicus and Sceloporus olivaceus) use both visual and chemical signals. For each species, we performed behavioral observations and quantified rates of visual and chemical behaviors. We then cryosectioned brain tissues from 9-10 males of each species and measured the soma size and density of neurons in two brain regions associated with visual behaviors (the lateral geniculate nucleus and the nucleus rotundus) and one region associated with chemical behaviors (the nucleus sphericus). With analyses conducted in a phylogenetic context, we found that species that performed higher rates of visual displays had a denser lateral geniculate nucleus, and species that used a higher proportion of chemical displays had larger somas in the nucleus sphericus. These relationships suggest that neural morphologies in the brain have evolved convergently in species with similar communication behaviors
Diving into the vertical dimension of elasmobranch movement ecology
- Author
- Abrantes Katya
- Afonso Andre S.
- Ajemian Matthew J.
- Anderson Brooke N.
- Anderson Scot D.
- Andrzejaczek Samantha
- Araujo Gonzalo
- Armstrong Amelia J.
- Armstrong Asia O.
- Bach Pascal
- Barnett Adam
- Bennett Mike B.
- Bezerra Natalia P. A.
- Block Barbara A.
- Bonfil Ramon
- Boustany Andre M.
- Bowlby Heather D.
- Branco Ilka
- Braun Carmin D.
- Brooks Edward J.
- Brown Judith
- Burke Patrick J.
- Butcher Paul
- Carlisle Aaron B
- Castleton Michael
- Chapple Taylor K
- Chateau Olivier
- Clarke Maurice
- Coelho Rui
- Coffey Daniel M.
- Cortes Enric
- Couturier Lydie I. E.
- Cowley Paul D.
- Croll Donald A.
- Cuevas Juan M.
- Curnick David J.
- Curtis Tobey H.
- Dagorn Laurent
- Dale Jonathan J.
- Daly Ryan
- Dewar Heidi
- Doherty Philip D.
- Domingo Andres
- Dove Alistair D. M.
- Drew Michael
- Dudgeon Christine L.
- Duffy Clinton A. J.
- Elliott Riley G.
- Ellis Jim R.
- Erdmann Mark V.
- Farrugia Thomas J.
- Ferreira Luciana C
- Ferretti Francesco
- Filmalter John D
- Finucci Brittany
- Fischer Chris
- Fitzpatrick Richard
- Forget Fabien
- Forsberg Kerstin
- Francis Malcolm P.
- Franks Bryan R.
- Gallagher Austin J.
- Galva-Magana Felipe
- Garcia Mirta L.
- Gaston Troy F.
- Gillanders Bronwyn M.
- Gleiss Adrian C.
- Gollock Matthew J
- Goodman Maurice C.
- Green Jonathan R.
- Green Sofia
- Griffiths Christopher A.
- Hammerschlag Neil
- Hasan Abdi
- Hawkes Lucy A.
- Hazin Fabio H.V.
- Heard Matthew
- Hearn Alex
- Henderson Suzanne M.
- Holdsworth John C
- Holland Kim N.
- Howey Lucy A.
- Hueter Robert E.
- Humphries Nicolas E.
- Hussey Nigel E
- Hutchinson Melanie
- Huveneers Charlie
- Jacoby David M. P.
- Jaine Fabrice R. A.
- Jorgensen Salvador J.
- Kanive Paul E.
- Labaja Jessica
- Lana Fernanda O.
- Lassauce Hugo
- Lipscombe Rebecca S.
- Llewellyn Fiona
- Lucas Tim C. D.
- Macena Bruno C. L.
- Mambrasar Ronald
- McAllister Jaime D
- McCully Phillips Sophy R.
- McGregor Frazer
- McMillan Matthew N.
- McNaughton Lianne M.
- Meekan Mark G
- Mendonça Sibele A.
- Meyer Carl G.
- Meyers Megan
- Mohan John A.
- Montgomery John C.
- Mourier Johann
- Mucientes Gonzalo
- Musyl Michael K.
- Nasby-Lucas Nicole
- Natanson Lisa
- O\u27Sullivan John B.
- Oliveira Paulo
- Papastamatiou Yannis P
- Patterson Toby A.
- Peel Lauren R.
- Pierce Simon J.
- Queiroz Nuno
- Radford Craig A.
- Richardson Andy J.
- Richardson Anthony J.
- Righton David
- Rohner Christoph A
- Royer Mark A.
- Saunders Ryan A.
- Schaber Matthias
- Schallert Robert J.
- Scholl Michael C.
- Seitz Andrew C.
- Semmens Jayson M
- Setyawan Edy
- Shea Brendan D.
- Shidqi Rafid A.
- Shillinger George
- Shipley Oliver N.
- Shivji Mahmood
- Sianipar Abraham B.
- Silva Joana F.
- Sims David W.
- Skomal Gregory B
- Sousa Lara L.
- Southall Emily J
- Spaet Julia L. Y.
- Stehfest Killian M.
- Stevens Guy
- Stewart Joshua D.
- Sulikowski James
- Syakurachman Ismail
- Thorrold Simon R
- Thums Michele
- Tickler David
- Tolloti Mariana T.
- Townsend Kathy A.
- Travassos Paulo
- Tyminski John P
- Vaudo Jeremy
- Veras Drausio
- Wantiez Laurent
- Weber Sam B.
- Wells R.J. David
- Weng Kevin C.
- Wetherbee Bradley M.
- Williamson Jane E.
- Witt Matthew J.
- Wright Serena
- Zilliacus Kelly
- Publication venue
- NSUWorks
- Publication date
- 19/08/2022
- Field of study
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
Diving into the vertical dimension of elasmobranch movement ecology
- Author
- Abrantes Katya
- Afonso Andre S.
- Ajemian Matthew J.
- Anderson Brooke N.
- Anderson Scot D.
- Andrzejaczek Samantha
- Araujo Gonzalo
- Armstrong Amelia J.
- Armstrong Asia O.
- Bach Pascal
- Barnett Adam
- Bennett Mike B.
- Bezerra Natalia A.
- Block Barbara A.
- Boustany Andre M.
- Bowlby Heather D.
- Branco Ilka
- Braun Camrin D.
- Brooks Edward J.
- Burke Patrick J.
- Butcher Paul
- Carlisle Aaron
- Castleton Michael
- Chapple Taylor K.
- Clarke Maurice
- Coelho Rui
- Cortes Enric
- Couturier Lydie I. E.
- Cowley Paul D.
- Croll Donald A.
- Cuevas Juan M.
- Curnick David J.
- Curtis Tobey H.
- Dagorn Laurent
- Dale Jonathan J.
- Daly Ryan
- Dewar Heidi
- Doherty Philip D.
- Domingo Andres
- Dove Alistair D. M.
- Drew Michael
- Dudgeon Christine L.
- Duffy Clinton A. J.
- Elliott Riley G.
- Ellis Jim R.
- Erdmann Mark
- Farrugia Thomas J.
- Ferreira Luciana C.
- Ferretti Francesco
- Filmalter John D.
- Finucci Brittany
- Fischer Chris
- Fitzpatrick Richard
- Forget Fabien
- Forsberg Kerstin
- Francis Malcolm P.
- Franks Bryan R.
- Gallagher Austin J.
- Galvan-Magana Felipe
- Garcia Mirta L.
- Gaston Troy F.
- Gillanders Bronwyn M.
- Gleiss Adrian C.
- Gollock Matthew J.
- Goodman Maurice C.
- Green Jonathan R.
- Green Sofia
- Griffiths Christopher
- Hammerschlag Neil
- Hasan Abdi
- Hawkes Lucy A.
- Hazin Fabio
- Heard Matthew
- Hearn Alex
- Hedges Kevin J.
- Henderson Suzanne M.
- Holdsworth John
- Holland Kim N.
- Howey Lucy A.
- Hueter Robert E.
- Humphries Nicholas E.
- Hussey Nigel E.
- Hutchinson Melanie
- Huveneers Charlie
- Jacoby David M. P.
- Jaine Fabrice R. A.
- Jorgensen Salvador J.
- Kanive Paul E.
- Labaja Jessica
- Lana Fernanda O.
- Lassauce Hugo
- Lipscombe Rebecca S.
- Llewellyn Fiona
- Lucas Tim C. D.
- Macena Bruno C. L.
- Mambrasar Ronald
- McAllister Jaime D.
- McGregor Frazer
- McMillan Matthew N.
- McNaughton Lianne M.
- Meekan Mark G.
- Mendonca Sibele A.
- Meyer Carl G.
- Meyers Megan
- Mohan John A.
- Montgomery John C.
- Mourier Johann
- Mucientes Gonzalo
- Musyl Michael K.
- Nasby-Lucas Nicole
- Natanson Lisa J.
- O'Sullivan John B.
- Oliveira Paulo
- Papastamtiou Yannis P.
- Patterson Toby A.
- Phillips Sophy R. McCully
- Pierce Simon J.
- Queiroz Nuno
- Radford Craig A.
- Richardson Anthony J.
- Righton David
- Rohner Christoph A.
- Royer Mark A.
- Saunders Ryan A.
- Schaber Matthias
- Schallert Robert J.
- Scholl Michael C.
- Seitz Andrew C.
- Semmens Jayson M.
- Setyawan Edy
- Shea Brendan D.
- Shidqi Rafid A.
- Shillinger George L.
- Shipley Oliver N.
- Shivji Mahmood S.
- Sianipar Abraham B.
- Silva Joana F.
- Sims David W.
- Skomal Gregory B.
- Sousa Lara L.
- Southall Emily J.
- Spaet Julia L. Y.
- Stehfest Kilian M.
- Stewart Joshua D.
- Sulikowski James A.
- Syakurachman Ismail
- Thorrold Simon R.
- Thums Michele
- Tickler David
- Tolloti Mariana T.
- Townsend Kathy A.
- Travassos Paulo
- Tyminski John P.
- Vaudo Jeremy J.
- Veras Drausio
- Wantiez Laurent
- Weber Sam B.
- Wells R. J. David
- Weng Kevin C.
- Wetherbee Bradley M.
- Williamson Jane E.
- Witt Matthew J.
- Wright Serena
- Zilliacus Kelly
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
Diving into the vertical dimension of elasmobranch movement ecology
- Author
- Afonso Andre S.
- Ajemian Matthew J.
- Anderson Brooke N.
- Anderson Scot D.
- Andrzejaczek Samantha
- Araujo Gonzalo
- Armstrong Amelia J.
- Armstrong Asia O.
- Bach Pascal
- Barnett Adam
- Bennett Mike B.
- Bezerra Natalia A.
- Block Barbara A.
- Bonfil Ramon
- Boustany Andre M.
- Bowlby Heather D.
- Branco Ilka
- Braun Camrin D.
- Brooks Edward J.
- Brown Judith
- Burke Patrick J.
- Butcher Paul
- Carlisle Aaron
- Castleton Michael
- Chapple Taylor K.
- Chateau Olivier
- Clarke Maurice
- Coelho Rui
- Coffey Daniel M.
- Cortes Enric
- Couturier Lydie I. E.
- Cowley Paul D.
- Croll Donald A.
- Cuevas Juan M.
- Curnick David J.
- Curtis Tobey H.
- Dagorn Laurent
- Dale Jonathan J.
- Daly Ryan
- Dewar Heidi
- Doherty Philip D.
- Domingo Andres
- dos Santos Abrantes Katya
- Dove Alistair D. M.
- Drew Michael
- Dudgeon Christine L.
- Duffy Clinton A. J.
- Elliott Riley G.
- Ellis Jim R.
- Erdmann Mark
- Farrugia Thomas J.
- Ferreira Luciana C.
- Ferretti Francesco
- Filmalter John D.
- Finucci Brittany
- Fischer Chris
- Fitzpatrick Richard
- Forget Fabien
- Forsberg Kerstin
- Francis Malcolm P.
- Franks Bryan R.
- Gallagher Austin J.
- Galvan-Magana Felipe
- Garcia Mirta L.
- Gaston Troy F.
- Gillanders Bronwyn M.
- Gleiss Adrian C.
- Gollock Matthew J.
- Goodman Maurice C.
- Green Jonathan R.
- Green Sofia
- Griffiths Christopher A.
- Hammerschlag Neil
- Hasan Abdi
- Hawkes Lucy A.
- Hazin Fabio
- Heard Matthew
- Hearn Alex
- Hedges Kevin J.
- Henderson Suzanne M.
- Holdsworth John
- Holland Kim N.
- Howey Lucy A.
- Hueter Robert E.
- Humphries Nicholas E.
- Hussey Nigel E.
- Hutchinson Melanie
- Huveneers Charlie
- Jacoby David M.P.
- Jaine Fabrice R. A.
- Jorgensen Salvador J.
- Kanive Paul E.
- Labaja Jessica
- Lana Fernanda O.
- Lassauce Hugo
- Lipscombe Rebecca S.
- Llewellyn Fiona
- Lucas Tim. C.D.
- Macena Bruno C. L.
- Mambrasar Ronald
- McAllister Jaime D.
- McGregor Frazer
- McMillan Matthew N.
- McNaughton Lianne M.
- Meekan Mark G.
- Mendonca Sibele A.
- Meyer Carl G.
- Meyers Megan
- Mohan John A.
- Montgomery John C.
- Mourier Johann
- Mucientes Gonzalo
- Musyl Michael K.
- Nasby-Lucas Nicole
- Natanson Lisa J.
- O'Sullivan John B.
- Oliveira Paulo
- Papastamtiou Yannis P.
- Patterson Toby A.
- Peel Lauren R.
- Phillips Sophy R. McCully
- Pierce Simon J.
- Queiroz Nuno
- Radford Craig A.
- Richardson Andy J.
- Richardson Anthony J.
- Righton David
- Rohner Christoph A.
- Royer Mark A.
- Saunders Ryan A.
- Schaber Matthias
- Schallert Robert J.
- Scholl Michael C.
- Seitz Andrew C.
- Semmens Jayson M.
- Setyawan Edy
- Shea Brendan D.
- Shidqi Rafid A.
- Shillinger George L.
- Shipley Oliver N.
- Shivji Mahmood S.
- Sianipar Abraham B.
- Silva Joana F.
- Sims David W.
- Skomal Gregory B.
- Sousa Lara L.
- Southall Emily J.
- Spaet Julia L. Y.
- Stehfest Kilian M.
- Stevens Guy
- Stewart Joshua D.
- Sulikowski James A.
- Syakurachman Ismail
- Thorrold Simon R.
- Thums Michele
- Tickler David
- Tolloti Mariana T.
- Townsend Kathy A.
- Travassos Paulo
- Tyminski John P.
- Vaudo Jeremy J.
- Veras Drausio
- Wantiez Laurent
- Weber Sam B.
- Wells R. J. David
- Weng Kevin C.
- Wetherbee Bradley M.
- Williamson Jane E.
- Witt Matthew J.
- Wright Serena
- Zilliacus Kelly
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2022
- Field of study
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
A first generation whole genome RH map of the river buffalo with comparison to domestic cattle
- Author
- Amaral M Elisabete J
- Brunner Ronald M
- Caetano Alexandre R
- Cai Zhipeng
- Filho Edson A Rodrigues
- Fornitano Larissa C
- Galvão Stephan R
- Goldammer Tom
- Grant Jason R
- Greco Anthony J
- Jeong Jooha
- Jones Brittany C
- Kochan Kelli J
- Kumar M Aravind
- Kumar Satish
- Kumar ST Bharani
- Lin Guohui
- Mariani Paola
- Mathew Boby
- Mishra Bina
- Miziara Melissa N
- Moore Stephen
- Pelai Vanderlei A
- Prasad Aparna
- Riggs Penny K
- Santana Andre M
- Saradhi G Pardha
- Stafuzza Nedenia B
- Stothard Paul
- Tantia Madhu S
- Tonhati Humberto
- Vijh Ramesh K
- Weikard Rosemarie
- Womack James E
- Publication venue
- BMC Genomics
- Publication date
- 01/01/2008
- Field of study
BACKGROUND: The recently constructed river buffalo whole-genome radiation hybrid panel (BBURH(5000)) has already been used to generate preliminary radiation hybrid (RH) maps for several chromosomes, and buffalo-bovine comparative chromosome maps have been constructed. Here, we present the first-generation whole genome RH map (WG-RH) of the river buffalo generated from cattle-derived markers. The RH maps aligned to bovine genome sequence assembly Btau_4.0, providing valuable comparative mapping information for both species. RESULTS: A total of 3990 markers were typed on the BBURH(5000 )panel, of which 3072 were cattle derived SNPs. The remaining 918 were classified as cattle sequence tagged site (STS), including coding genes, ESTs, and microsatellites. Average retention frequency per chromosome was 27.3% calculated with 3093 scorable markers distributed in 43 linkage groups covering all autosomes (24) and the X chromosomes at a LOD ≥ 8. The estimated total length of the WG-RH map is 36,933 cR(5000). Fewer than 15% of the markers (472) could not be placed within any linkage group at a LOD score ≥ 8. Linkage group order for each chromosome was determined by incorporation of markers previously assigned by FISH and by alignment with the bovine genome sequence assembly (Btau_4.0). CONCLUSION: We obtained radiation hybrid chromosome maps for the entire river buffalo genome based on cattle-derived markers. The alignments of our RH maps to the current bovine genome sequence assembly (Btau_4.0) indicate regions of possible rearrangements between the chromosomes of both species. The river buffalo represents an important agricultural species whose genetic improvement has lagged behind other species due to limited prior genomic characterization. We present the first-generation RH map which provides a more extensive resource for positional candidate cloning of genes associated with complex traits and also for large-scale physical mapping of the river buffalo genome
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
- Brown Andrew
- Brown Clive
- Brown Jacqui
- Brown Margaret
- Brown Mary
- Brown Mary J.
- Brown Michael
- Brown Nancy C.
- Bruce David D.
- Bruce Robert
- Bruno William J.
- Bruskiewich Richard
- Bryant Jackie
- Bryant Jennifer E.
- Bryant Nathaniel P.
- Brüls Thomas
- Buatsi Delali
- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
- Bulbul Kerem
- Buller Sarah
- Bunker Nathan
- Burberry Jill
- Burch Paula Ellen
- Burford Deborah
- Burgess Joanne
- Burgin Matt
- Burkett Carrie E.
- Burkhart-Schultz Karolyn
- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
- Butcher Phil
- Butler Adam
- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
- Cardenas Faviola
- Cardenas Lolo
- Cardenas Veronica
- Carder Carol
- Carder Paul
- Carpenter Kelly
- Carrano Anthony V.
- Carriere Jason
- Carter Jason
- Carter Kelvin
- Carter Nigel
- Caruso Lauren
- Casias Kristal
- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
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- Chi Cheng
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- Chillingworth Neil
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- Chung A
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- De Anda Claudia
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- Huckle Elizabeth
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- Jia Jia
- Jia Jia
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- Jones Steven
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- Kettleborough Ross
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- Kojima Kazuyasu
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- Kong Yi
- Korf Ian
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- Luo Chunqing
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- Mangum Brian
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- Manohar Chitra
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- Marinelli Lisa
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- Marquis-Homeyer Catherine
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- Mauceli Evan
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- Meng Shanshan
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- Mercado George
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- Mercer Simon
- Merritt Christina E.
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- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Robust estimation of bacterial cell count from optical density
- Author
- Aarnio Tiu
- Aaron Leow Chung Yong
- Abbas Anser
- Abduraimova Aiganym
- Abraham Doris
- Acar Beliz Leyla
- Acosta Joaquin
- Adler Nina
- Adulyanukosol Natthawut
- Agena Ejouan
- Agena Ethan
- Aggarwal Priya
- Aguirre Adriana Lizeth Rubio
- Ahlgren Christopher
- Ahuja Janvi
- Aizik Dror
- Akbary Mina
- Akinfenwa Akinwumi
- Akingbesote Ngozi D.
- Akova Umut
- Aldo Ferdinan
- Alexopoulos Ioannis
- Allen Lucy
- Alonso Alejandro
- Altarawneh Dina
- Alvarado Andres Benjamin Sanchez
- Ambre Sanika
- Ameziane Annissa
- Amheine Khadija
- Amin Ihya Fakhrurizal
- Amir Sayeda Sakina
- Amstel Chiel van
- An Yongyan
- Anand Nithishwer Mouroug
- Ananthakrishnan Sathvik
- Anderson Karl
- Angel Sagi
- Annem Vidhya
- Anson Chung Tsun Ho
- Anwar Mariam
- Appel Alana
- Araya Lucas
- Armstrong Alexander
- Arora Neha
- Arora Vasu
- Arruda Beck
- Ashwin F Amal Jude
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- Astles Ben
- Astorino Gabe
- Aubry Celine
- Avileli Rebecca
- Azad Mahnaz Sabeta
- Babar Rehmat
- Babu Priyanka
- Badalli Turan
- Badash Lior
- Baichman-Kass Amichai
- Baldwin Geoff S.
- Baltensperger Oliver Andreas
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- Bao Minyue
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- Barrington Seth
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- Shuan Yun
- Shulun [NO FIRST NAME IN SCOPUS]
- Shuyu Shi
- Sia Nympha Elisa M.
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- Smith Caroline
- Smith Ryan
- Smith Zion
- Snaith Eva
- So Kam Pang
- Solano Margarita Sofia Calixto
- Solvang Vanessa
- Somvanshi Tejas
- Son Tinh
- Song Guowei
- Song Haoyue
- Song Li
- Song Yiran
- Song Yong Rafael
- Soni Abhinav
- Sonnier Matt
- Spatharas Panagiotis
- Srinivasan Keerthana
- Standforth Kyle
- Starkel John
- Stewart Thomas
- Stocks Jon
- Strasser Dominik
- Street Morgan
- Stuhlweissenburg Fynn
- Stukenberg Daniel
- Sudarshan Bhuvana
- Suer Gun
- Sumner Kylie
- Sun Dongchang
- Sun Kai
- Sun Shiyu
- Sun Ting
- Suss Beatrix
- Swart Pim
- Sweet Bailey
- Tairan Li
- Takeyasu Reanna
- Tamayo Diana
- Tan Huishuang
- Tan Li Yang
- Tang Cassie
- Tang Christian
- Tang Erting
- Tang Jiaqi
- Tang Weiyi
- Tang Yu-Cheng
- Tang Yu-Hsin
- Tao Yibing
- Tapia Jennifer
- Tariq Ali
- Taskar Poorva
- Taylor Max
- Telesz Lauren
- ten Dam Marjolijn
- Tharp Darron
- Thokachichu Pranav
- Thomas Sophie
- Thormar Eirikur Andri
- Throsberg Christian
- Tian Hong
- Tian Qinghe
- Tian Ruonan
- Tianyi Chang
- Ting Weiyu
- Tirad Alice
- Toanen Marion
- Tobin David
- Toghani Dorsa
- Torell Agnes
- Toro Bibiana
- Torres Ares
- Totten Stephanie
- Trevizo Cynthia Lizeth Gonzalez
- Trivellin Cecilia
- Trujillo-Rodriguez Lidimarie
- Tsai Leona
- Tsai You-Yang
- Tsang Helen
- Tsitsilonis Ourania E.
- Tsui Jennifer
- Tunaj Brigit
- Turner Matthew
- Turton Kristi
- Tutuianu Anna
- Tuzov Vladislav
- Twisk Simone
- Ucan Kutay
- Uday Adwaith B.
- Ueding Elisa
- Unal Tunc
- Urban Julia
- Uslu Attila
- Vaidya Anjali
- Vaitkus Dovydas
- Vanini Nadine Vaz
- Varaljay Vanessa
- Vardi Omri
- Velasco Maria Antonia Luna
- Velikov Lukas
- Vella Toni
- Venclovas Tomas
- Venkatraghavan Sankalpa
- Verhagen Mick
- Verma Yashna
- Vignoni Alejandro
- Vincent Annette
- Vincent Sara
- Viswanathan Ashwin
- Vitkute Kornelija
- von Schoenberg Sophie
- Voort Gemma van der
- Vornholt Tobias
- Vries Philip Gorter de
- Waard Jazzy de
- Wadhams George
- Wagner Camille
- Wai Leung Chung
- Wan Chan Tsey
- Wan Leon
- Wan Mitchell
- Wang Cheng-Chieh
- Wang Chenxi
- Wang Choi Seong
- Wang Hao
- Wang Huichao
- Wang Kai
- Wang Kelsey
- Wang Kelsey
- Wang Ken
- Wang Li
- Wang Pengying
- Wang Ping
- Wang Qiupeng
- Wang Raven
- Wang Sibo
- Wang Sihan
- Wang Tian
- Wang Wei
- Wang Xiangxuan
- Wang Xin
- Wang Xinyue
- Wang Xuan
- Wang Xueyao
- Wang Yaling
- Wang Yi
- Wang Yifan
- Wang Yuefei
- Wang Yunyi
- Wang Yuyang
- Wang Yuyao
- Wang Zihao
- Wang Ziru
- Wang Ziyu
- Wanji Li
- Warzecha Heribert
- Watson Emily
- Wawrzyniak Dominika
- Weber Elisa
- Wei Zemeng
- Weile Carl
- Wenhao Xu
- Went Sam
- Whalen Kathleen
- Whiteside Jonny
- Whittle Michaella
- Wickiser Ken
- Windo Joe
- Wintermute Edwin
- Withanage Shamal
- Wolfbeisz Chiara
- Wong Angel
- Wong Hei Man
- Wong Joanne
- Woodward Noble
- Workman C. T.
- Wu Chenhai
- Wu Justin
- Wu Kangjie
- Wu Mengxuan
- Wu Michelle
- Wu Yaxuan
- Wu Yi
- Wu Yuxuan
- Wu Zishi
- Xi Yukun
- Xia Ruoyu
- Xiang Meredith
- Xiang Yuening
- Xiao Ziyang
- Xiaojin Li
- Xiaowen Mao
- Xilei Peng
- Xin Li
- Xin Tian
- Xing Jinming
- Xinguang Chen
- Xinlei Fang
- Xinyu Liu
- Xinyu Liu
- Xinyu Teng
- Xinyue Ma
- Xiong Xin
- Xiong Zhenyu
- Xirui Chen
- Xiu Yao
- Xiujing Hong
- Xu Guiyang
- Xu Hanning
- Xu Hao
- Xu Huandi
- Xu Sheng
- Xu Shirly
- Xu Xia
- Xu Xin
- Xu Yinsong
- Xuan Chen Zi
- Xue Fang
- Xue Han
- Xun Shu
- Yadav Ravineet
- Yadav Yash
- Yadi Liu
- Yan Calvin
- Yan Cathy
- Yan Han
- Yan Hongfa
- Yan Qingyan
- Yan Tsui Shing
- Yan Yeung Wing
- Yan Yining
- Yang Chao
- Yang Chenghao
- Yang Chuyi
- Yang Fan
- Yang Fuqiang
- Yang Hanyeol
- Yang Jake
- Yang Jianzhe
- Yang Jindian
- Yang Jinshu
- Yang Jun
- Yang Leyi
- Yang Ruofan
- Yang Shaobo
- Yang Shuting
- Yang Xilin
- Yang Yuchen
- Yang Zhuoyi
- Yang Zisang
- Yang Zon En
- Yao Andrew
- Yarbrough Hayden
- Yaxi Zhang
- Ye Yusheng
- Yee Chong Yuk
- Yeh Chan-yu
- Yehouessi Tamara
- Yeliseyeva Hanna
- Yesley Phillip
- Yeung Wong Tsz
- Yifan Li
- Yihang Qiu
- Yiming Quan
- Yin Jiacheng
- Yin Lee Ka
- Yin Xianqi
- Yong Nur Liyana Binte Ayub Ow
- Yong Zhangxiang
- Yongjie Lin
- Yoo Hojun
- Yoon Soohyun
- You Jaewon
- Young Cam
- Yu Haimeng
- Yu Jiacheng
- Yu Kai-Chiang
- Yu Liuhong
- Yu Tam Chi
- Yu Wenfei
- Yu Yuen Wai
- Yuan Hetian
- Yuan Long
- Yuan Xing
- Yuan Zhe
- Yuanxu Jiang
- Yucheng Chen
- Yue Qing
- Yueyi Li
- Yuhan Cheng
- Yujie Peng
- Yun Yejie
- Yung Jay
- Yutong Pan
- Zadeh Daniel
- Zamora Alejandro Robles
- Zanoni Paul
- Zanotti Violetta
- Zeng Chenxu
- Zeng Yuanhong
- Zepeng Xu
- Zerva Anastasia
- Zhan Yang
- Zhang Alice
- Zhang Bonan
- Zhang Jianxiang
- Zhang Jige
- Zhang Jinhan
- Zhang Kaida
- Zhang Kecheng
- Zhang Qian
- Zhang Shuyan
- Zhang Tianyi
- Zhang Wanli
- Zhang Xianyin
- Zhang Xinyu
- Zhang Yihao
- Zhang Yuanzhen
- Zhang Yunqian
- Zhang Zixuan
- Zhao Nannan
- Zhao Peng
- Zhao Tianyan
- Zhao Wenxue
- Zhao Yihang
- Zhaoting Li
- Zhecheng Huang
- Zheng Daniel
- Zheng Jiyang
- Zhiwei Song
- Zhong Yanling
- Zhou Hanmi
- Zhou Jiajie
- Zhou Jianan
- Zhou Rui
- Zhou Shuyao
- Zhou Xuanhao
- Zhou Yanjun
- Zhou Yi
- Zhou Yinchi
- Zhou Yineng
- Zhou Yuezhang
- Zhou Yuxin
- Zhou Zhiyu
- Zhu Chushu
- Zhu Ke
- Zhu Xueqian
- Zi Lihan
- Zilinskaite Nemira
- Zimmermann Andreas
- Zimmermann Jennifer
- Zirong Zeng
- Ziwei Zhou
- Ziyi Zhao
- Zorrilla Francisco
- Zou Jiahua
- Zukauskaite Kristina
- Zulueta Patricia
- Zvirblyte Justina
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo
- Author
- Aguilar Danielle
- Alencar Michelle
- Allen Nina O
- Andre M.
- Andre Thomas
- Antonio Jose
- Arent S. M
- Arent Shawn M
- Beck Darren T
- Bell Zachary
- Bello Marissa
- Ben-Ezra Victor
- Bennett Haley
- Bergstrom Haley
- Best Shiva
- Bishop Haley D
- Blue Malia M N
- Bove Daniel
- Bowen Clara R
- Broughton K. S
- Browne Rodrigo A V
- Buehn Richard
- Byrd M. T
- Byrd M. Travis
- Campbell Bill
- Campbell Bill I
- Capone Eddie
- Carney Christopher
- Chernesky Kyshia
- Cho M.
- Cholewa Jason M
- Colas Megan
- Cole Nathan
- Coles Katie
- Coletta A.
- Colletta A.
- Collins P. B
- Conlin Laurin
- Conway S.
- Conway Sean P
- Costa Eduardo C
- Couvillion Kaylee
- Dalton R.
- de Angelis Christian
- de Jesus Ferreira Amanda M
- de Souza Daniel C
- Deemer Sarah E
- DiFiore Brittany
- DiPietro Loretta
- Dobbins Chris
- Dolan Jeff
- Donelson Seth
- dos Santos Victor O A
- Durkalec-Michalski Krzysztof
- Earnest C. P
- Eckerson Joan M
- Ellerbroek Anya
- Endito Marvin R
- Escalante Guillermo
- Escobar Kurt A
- Espinoza Victoria
- Fairman Ciaran M
- Fayh Ana P T
- Ferreira Victor A
- Fink-Irizarry Paola
- Fleming S.
- Forsse Jeffrey
- Foster Cliffa
- Fragala M. S
- Fragala Maren S
- Frith Emily
- Gai Chris
- Gallo Samantha
- Gieske B.
- Gills Joshua L
- Glenn Jordan
- Grandjean Peter
- Greenwood M.
- Grubic T.
- Guillory Joshua N
- Haddock Bryan
- Hannings Tara
- Harris Roger C
- Harvey Phil
- Haun Cody T
- Hewins Amy
- Hirsch Katie
- Hofacker M.
- Hofacker Morgan L
- Holland A. M
- Hoover Thomas H
- Hudson Geoffrey M
- Hwang Paul
- Hyde Parker N
- Jagim A.
- Jagim Andrew R
- Jeszka Jan
- Jimenez Rachel
- Johnson Kelly E
- Johnston Carol
- Jones M.
- Jones M. T
- Joy Jordan M
- Jung Y. P
- Jäger Ralf
- Kalman Doug
- Kendall Kristina L
- Kephart Wesley C
- Kerksick C.
- Kerksick Chad M
- Kisiolek J.
- Kisiolek Jacob
- Komorowski James
- Koozehchian M. S
- Kozehchain M.
- Krause Molly M
- Kreider R. B
- Kreutzer A.
- Kreutzer Andreas
- Lane Lauren M C
- Lane Michael T
- Lara Marissa
- Lavanger Kiley A
- Lenton Jack
- Liang Yishan
- Lieb Allison E
- Linden Melissa
- Lockwood Christopher M
- Lowery Lonnie
- Lowery Ryan P
- Lu Hocheng
- Mackowski Nick S
- Marshall Mallory R
- Martinez Nic
- Mathews Suresh T
- McCallum Ryley
- McFadden B.
- McFadden Bridget A
- McKinley Sarah
- Meers Grace M
- Meinking M.
- Mena Mauricio
- Mendel Ronald
- Mermier Christine M
- Micensky Ashley
- Miller Michael E
- Mobley C. B
- Mock Meredith G
- Monaco R.
- Monaco Robert M
- Monsalves-Alvarez Matias
- Moon Jordan R
- Morales Elisa
- Moriarty Terence
- Mullen Katie A
- Mumford Petey W
- Murano P.
- Murano P. S
- Newmire Daniel E
- Newton Annie
- Norton Layne
- Ochsenwald J.
- Ojalvo Sara P
- Okano Alexandre H
- Olivencia Alyssa
- Oliver J.
- Oliver J. M
- Oliver Jonathan M
- Ordway C.
- Ordway Chris E
- Oyharçabal Sebastian
- O’Connor A.
- Parker Kimberly
- Pascoe David D
- Patel Romil K
- Pawela Michael
- Peacock Corey
- Peacock Corey A
- Pellegrino J.
- Pellegrino Joseph K
- Perry Ross
- Petrella John K
- Peveler Willard
- Podgórski Tomasz
- Pollock Adam
- Poyssick Anthony J
- Purpura Martin
- Rabideau M.
- Rabideau Meaghan M
- Ramaswamy Lalitha
- Rasmussen C.
- Rector R. S
- Reyes A.
- Rivas Eric
- Roberts Michael D
- Rodriguez Winter
- Roelofs Erica J
- Rogers Rebecca R
- Romer Braden
- Romero Matthew A
- Rossi Fabricio
- Ruffner Kayla
- Sanchez B.
- Sanchez B. K
- Sanders Amey
- Sanders D.
- Sanders David J
- Sanders Gabriel J
- Sandler David
- Santos Emily
- Shin S. Y
- Silver Tobin
- Silver Tobin A
- Slack Grant
- Smith Bridget
- Smith C.
- Smith-Ryan Abbie
- Sowinski R.
- Spillane Mike
- Sprow Kyle
- Stecker R.
- Stepp Stephanie
- Stone Jason D
- Stratton Matthew
- Szymanski David
- Tamayo Armando
- Taylor Lem
- Tinsley Grant
- Tok Ozlem
- Toledo Andres D
- Trexler Eric
- Trussardi Fayh Ana P
- Urbina Stacie
- VanDusseldorp Trisha A
- Vansickle Andrea
- Vargas Andres
- Vargas Leo
- Velraja Supriya
- Villa Katelyn
- Vogel Roxanne M
- Walker A.
- Walker Alan J
- Wallace Brian
- Wallace Kelly
- Warning Brooke
- West Emily A
- Wilborn Colin
- Wildman Robert
- Willoughby Darryn
- Wilson Jacob M
- Witherbee K.
- Wright G.
- Wynn Matthew R
- Xing Dante
- Young Kaelin C
- Zavala P.
- Zawieja Bogna
- Zemek Kate
- Publication venue
- BioMed Central
- Publication date
- 12/09/2016
- Field of study
Meeting Abstracts: Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo Clearwater Beach, FL, USA. 9-11 June 201
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
- Bell Bryan
- Bell Charles J M
- Bell Peter
- Beltran Pedro
- Bender Lewis H
- Bender Steven
- Bennett Mark K
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S
- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
- Blake Zoe
- Blake Zoe
- Blakely Collin
- Blazar Bruce R
- Blogowski Wojciech
- Bloom Anja C
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
- Brech Dorothee
- Brenin David
- Broaddus V. C
- Brockstedt Dirk G
- Brockstedt Dirk G
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L
- Brown Sheila
- Bruce Jeffrey N
- Brunet Laura R
- Bruno Tullia C
- Bryan Jennifer
- Bryant Richard
- Buchbinder Elizabeth
- Bucsek Mark
- Budhu Sadna
- Budhu Sadna
- Budkowska Marta
- Bueno Raphael
- Buettner Florian
- Buettner Nico
- Bullock Kim
- Bullock Kim
- Burova Elena
- Burrill Joel
- Bussler Holm
- Butterfield Lisa H
- Butterfield Lisa H
- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K
- Campesato Luis F
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
- Carcaboso Angel M
- Carlino Matteo S
- Carpi Sara
- Carrasco Ruben
- Carrera Diego A
- Carrero Rosa M S
- Carson Dennis A
- Castellini Laura
- Cathomas Richard
- Cauvin Annick
- Cauwenberghs Sandra
- Caux Christophe
- Cebon Jonathan S
- Ceccarelli Michele
- Celis Esteban
- Cerignoli Fabio
- Cerullo Vincenzo
- Cerullo Vincenzo
- Cervera-Carrascón Víctor
- Cesareni Gianni
- Cha John
- Cha John
- Cha John
- Champion Brian
- Chan Anissa S H
- Chan Chanty
- Chan Chanty
- Chan Ivan
- Chan Leo
- Chan Timothy A
- Chang Alfred E
- Chang Alfred E
- Chang Joe
- Chang Nancy N
- Chang Thomas
- Chanuc Fabien
- Chapelin Fanny
- Chaplin Jenny
- Chappel Scott C
- Charych Deborah H
- Charych Deborah H
- Chaudhuri Amitabha
- Chaussabel Damien
- Chen Ada
- Chen Ada
- Chen Gang
- Chen Jason
- Chen Jason
- Chen Xiaomu
- Chen Xin
- Chen Xiufen
- Chen Yu
- Chen Yu
- Chenchik Alex
- Chheda Zinal
- Chiang Eugene
- Chikina Maria
- Chittenden Thomas
- Chiu Hsiling
- Cho Charles
- Chongyung Fang
- Chou Margaret
- Choueiri Toni K
- Choy Carmen
- Clark Joseph I
- Clavijo Paul E
- Clifton Guy T
- Clynes Raphael
- Cobbold Mark
- Cobbold Mark
- Cobbold Mark
- Coder Brandon
- Coffman Robert L
- Cohen Cyrille
- Cohen Ezra E W
- Cohen Roger
- Colen Rivka
- Colevas A. D
- Collins Natalie
- Colrain Jillian
- Coltharp Carla
- Concha-Benavente Fernando
- Connolly Eileen P
- Conwell Darwin
- Conwell Darwin
- Corrales Leticia P
- Corrales Leticia P
- Coukos George
- Coukos George
- Coussens Lisa M
- Coussens Lisa M
- Craggs Graham
- Craig Andrew
- Crittenden Marka
- Cron Kyle R
- Cronstein Bruce N
- Crooks James
- Crosby Andrea
- Crosignani Stefano
- Crowder Robert
- Cruickshank Scott
- Csuka Orsolya
- Curbishley Stuart
- Curiel Tyler
- Curran Emily
- Curran Michael
- Curti Brendan
- Curti Brendan
- Da Costa Andre
- Dai Fu
- Dai Jie
- Dai Peihong
- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A
- Daud Adil
- David Justin M
- Davies Bronwyn
- de Boisferon Marc H
- de Groot Patricia
- de Gruijl Tanja
- De Henau Olivier
- de Leon Laura
- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
- Deacon Donna H
- DeBenedette Mark
- DeBenedette Mark
- Declerck Paul
- Decock Julie
- Decock Julie
- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
- Delgoffe Greg M
- Delgoffe Greg M
- Delgoffe Greg M
- Delogu Lucia
- Delorenzi Mauro
- Demaria Sandra
- Demaria Sandra
- Deng Liang
- Deng Weiwen
- Deng Wentao
- Denies Sofie
- Denis Caroline
- Desbien Anthony L
- deVries Michele
- Dhupkar Pooja
- Diab Adi
- Diab Adi
- Diab Adi
- Diaz Luis
- DiCostanzo AriCeli
- Diede Scott J
- Dietz Allan B
- Dillhoff Mary
- Dillon Patrick
- Dilworth Ryan
- Dimberg Anna
- Ding Yueyun
- Doberstein Stephen K
- Dobkin Julie
- Doener Fatma
- Dolegowska Barbara
- Doleschall Zoltan
- Doman Thompson
- Dominguez George
- Donahue Renee
- Donahue Renee
- Dorsey Frank C
- Dovedi Simon
- Downs-Canner Stephanie
- Drake Charles
- Drake Charles G
- Drake Charles G
- Driessens Gregory
- Driscoll Kyla
- Druker Brian J
- Dubensky Thomas W
- Dubensky Thomas W
- Dudimah Duafalia
- Duff Susan
- Dumontet Charles
- Dunai Cordelia
- Dunai Cordelia
- Dutcher Janice P
- Duttagupta Priyanka
- Duvvuri Uma
- Dyson Mike
- D’Apuzzo Massimo
- Ebner Peggy
- Edwards Robert
- Edwards Robert P
- Edwards Robert P
- Eickhoff Jens
- Eisenhower Mary
- El Alaoui Meddy
- El Alaoui Said
- Eles Klara
- Ellies Lesley
- Elnaggar Omar
- Elvecrog James
- Emberley Ethan
- Emerling Daniel
- Eng Charis
- Engelhard Victor H
- English Jessie
- Enstrom Amanda
- Eremeev Artem
- Eriksson Emma
- Eriksson Emma
- Eriksson Emma
- Ertelt Kathleen
- Eswarappa Rajesh
- Evans Elizabeth
- Evans Kathy
- Facciabene Andrea
- Facciabene Andrea
- Facciabene Andrea
- Facciponte John
- Facciponte John
- Falchook Gerald
- Fantini Massimo
- Fantini Massimo
- Fantini Massimo
- Farkas Emil
- Farren Matthew
- Faustman Denise
- Fa’ak Faisal
- Fa’ak Faisal
- Femel Julia
- Feng JunLi
- Feng Yan
- Feng Zipei
- Feola Sara
- Fernandez Christian
- Fernando Ingrid
- Ferris Robert L
- Ferris Robert L
- Ferris Robert L
- Ferris Robert L
- Fesenkova Valentyna
- Field Jessica J
- Fisher Kerry
- Fisher Terry
- Fitzharris Bernie
- Flano Emilio
- Flechtner Jessica B
- Flies Dallas B
- Flynn Patrick
- Fogler William
- Fong Lawrence
- Formenti Silvia C
- Formenti Silvia C
- Foster Cathie
- Foster Rosemary
- Fotin-Mleczek Mariola
- Fox Bernard
- Francica Brian
- Francis Julie-Ann
- Frangou Costa
- Franklin Marilyn
- Franklin Wilbur
- Frascaro Federica
- Fraser Kathryn
- Frederix Kim
- Freimark Bruce
- Freimark Bruce
- Freimark Bruce
- Frey Alan
- Fridman Leticia
- Friedman Alan
- Friedman David
- Fromm George
- Früh Martin
- Fu Yang-Xin
- Fu Yichun
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- Uecker Darrin
- Uecker Darrin
- Uecker Darrin
- Ugel Stefano
- Ugel Stefano
- Uhlik Mark
- Ujhelyi Mihaly
- Ullenhag Gustav
- Unfricht Darryn
- Ungerleider Richard
- Urban Julie
- Urban Julie
- Valsesia-Wittmann Sandrine
- Valsesia-Wittmann Sandrine
- Van der Meijs Pien
- van Vugt Marianne
- van Zutphen Mariëlle
- Vanamee Eva
- Vanderslice Peter
- VanderVeen Laurie
- Vanpouille-Box Claire I
- VanVlasselaer Peter
- Varhegyi Nikole
- Vasilakos John P
- Vaske Charles
- Vassilev Lotta
- Velcheti Vamsidhar
- Velculescu Victor
- Verma Amita
- Verma Amita
- Vetto John
- Vianden Christina
- Vietsch Eveline E
- Vignali Dario
- Vignali Dario
- Vogel Katharina
- Volkmuth Wayne
- Volz Barbara
- vonEbyen Rie
- Vreeland Timothy J
- Vu Tuyen
- Wada Hiroshi
- Wagtmann Nicolai
- Waldman Michelle
- Waldman Scott A
- Waller John
- Wallraven Gladice
- Walsh Richard
- Walters Ian B
- Wang Ena
- Wang Ena
- Wang Hongjie
- Wang Ping
- Wang Shangzi
- Wang Weiyi
- Wang Ximi K
- Wang Yi
- Wang Ziming
- Ward Stephen T
- Waugh Katherine
- Weber Amy
- Wehler Thomas
- Wei Spencer
- Weichselbaum Ralph R
- Weiner David
- Weiner Louis M
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
- Welsh James
- Wennerberg Erik
- Wenthe Jessica
- Wenthe Jessica
- Werner Lauryn R
- West Brian
- West James
- West James
- Wheatley Courtney
- Whetstone Ryan
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C
- Whiting Chan C
- Wicha Max S
- Wicha Max S
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W
- Wilkinson Robert W
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Chihunt
- Wong Deborah J
- Wong Gabriel
- Wong Kenneth R
- Wong Kenneth R
- Wong Michael K
- Wood Laura
- Woodside Darren G
- Workman Creg
- Wu Bill X
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- Ylösmäki Erkko
- Ylösmäki Erkko
- Young Gregory
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W
- Young Steve W
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
alpha-Linolenic acid and exercise training independently, and additively, decrease blood pressure and prevent diastolic dysfunction in obese Zucker rats
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2017
- Field of study
Although α-linolenic acid (ALA) and endurance exercise training independently attenuate hyperlipidaemia-related cardiovascular derangements, there is a paucity of information pertaining to their mechanisms of action and efficacy when combined as a preventative therapeutic approach. Therefore, we used obese Zucker rats to investigate the independent and combined effects of these interventions on cardiovascular disease. Specifically, animals were randomly assigned to one of the following groups: control diet-sedentary, ALA supplemented-sedentary, control diet-exercise trained or ALA supplemented-exercise trained. Following a 4 week intervention, although the independent and combined effects of ALA and exercise reduced (P < 0.05) the serum free/esterified cholesterol ratio, only the ALA supplemented-exercise trained animals displayed a reduction in the content of both serum free and esterified cholesterol. Moreover, although ALA and endurance training individually increased cardiac output, stroke volume and end-diastolic volume, as well as reduced left ventricle fibrosis, mean blood pressure and total peripheral resistance, these responses were all greater following the combined intervention (ALA supplemented-exercise trained). These effects occurred independent of changes in oxidative phosphorylation proteins, markers of oxidative stress or endogenous anti-oxidant capacity. We propose that the beneficial effects of a combined intervention occur as a result of divergent mechanisms of action elicited by ALA and endurance exercise because only exercise training increased the capillary content in the left ventricle and skeletal muscle, and tended to decrease protein carbonylation in the left ventricle (P = 0.06). Taken together, our data indicate that combining ALA and endurance exercise provides additional improvements in cardiovascular disease risk reduction compared to singular interventions in the obese Zucker rat
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