The relationship between postpartum depression and maternal emotional availability

A depressão pós-parto é um transtorno de alta prevalência que pode comprometer a qualidade da relação mãe-criança. Este estudo pretende determinar a prevalência do referido transtorno, comparar a interação mãe-bebê nos grupos com e sem depressão e verificar a relação entre depressão, apoio social e estilos de relacionamento e disponibilidade emocional maternos. As participantes eram gestantes que pretendiam dar à luz no Hospital Universitário da Universidade de São Paulo entre dezembro de 2006 e dezembro de 2008. A prevalência de depressão pós-parto em nossa amostra foi 28%. Não houve diferença significativa na relação mãe-criança no grupo com e sem depressão. Encontrou-se correlação positiva entre sensibilidade materna e escolaridade e entre sensibilidade e certas dimensões de apoio social e estilo de relacionamento. Conclui-se que a prevalência de depressão pós-parto em nossa amostra é mais alta que a média mundial, mas a sintomatologia depressiva não interfere significativamente na qualidade da interação mãe-bebê. A sensibilidade materna é influenciada por fatores sócio-cognitivos e afetivos.Postpartum depression is a highly prevalent disorder that can interfere in the mother-infant relationship. This study aims to evaluate the prevalence of postpartum depression in our sample to compare mother-infant interaction in depressed and non-depressed mothers and to assess the relationship between maternal depression, social support, attachment style, and emotional availability. Participants were pregnant women who planned to deliver at the University of São Paulo Hospital between December 2006 and December 2008. Postpartum depression prevalence in our sample was 28%. No difference was found in emotional availability between depressed and non-depressed mothers. There was a positive correlation between maternal sensitivity and education, and between sensitivity and some dimensions of social support and attachment styles. We conclude that postpartum depression prevalence in our sample was higher than the average international rates, but that depressive symptoms do not impair mother-infant interaction. Maternal sensitivity is affected by socio-cognitive and emotional factors.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Otitis externa canina por Aspergillus niger patogénico: reporte de caso

This paper reports a clinical case of Aspergillus otomycosis in an 8-year-old male English Cocker Spaniel, with a previous diagnosis of immune-mediated hemolytic anemia. The patient was treated for pain and discomfort in both ears. Routine blood tests were performed, as well as cytology and microbiological culture of ear secretion. Aspergillus niger together with Malassezia pachydermatis were the isolated, the oral and topical antifungal therapy was established with favorable results after 30 days of treatment. The isolated mold exhibited some important virulence factors such as hemolytic, lipase and amylase activity, as well as in vitro susceptibility to azole antifungals. In the immunosuppressed patients with otitis externa, it is necessary to perform microbiological cultures for environmental fungi, in addition to evaluating the pathogenic characteristic at the phenotypic level. This may help to establish a proper therapeutic approach and monitoring of liver enzymes for possible adverse effects.El presente artículo reporta un caso clínico de otomicosis por Aspergillus en un Cocker Spaniel Inglés macho de 8 años, con diagnóstico previo de anemia hemolítica inmunomediada. El paciente fue atendido por presentar dolor e incomodidad en ambos oídos. Se realizaron análisis sanguíneos, además de citología y cultivo microbiológico de secreción ótica. El Aspergillus niger junto con Malassezia pachydermatis fueron los agentes aislados, para lo cual se instauró una terapia antifúngica oral y tópica con resultados favorables después de 30 días de tratamiento. El moho aislado presentó algunos factores de virulencia importantes como actividad hemolítica, lipasa y amilasa, además de susceptibilidad in vitro a antifúngicos del tipo azoles. En pacientes inmunosuprimidos que presenten otitis externa es necesario realizar cultivos microbiológicos para hongos ambientales, además de evaluar a nivel fenotípico la característica patógena, lo cual ayude a establecer un correcto abordaje terapéutico y monitoreo de enzimas hepáticas por posibles efectos adversos

Future projections of extreme cold events in southeastern southamerica as reproduced by HadCM3 model

Las simulaciones del modelo HadCM3 fueron de las primeras disponibles para el análisis de proyecciones futuras, reflejándose en la literatura que describe principalmente variables de temperatura y precipitación para Sudamérica. El objetivo de ese trabajo es investigar los cambios en la circulación atmosférica en el sudeste de Sudamérica asociada a eventos extremos fríos, en el escenario de emisiones futuras más crítico denominado A2, para el periodo 2081-2100 respecto a un periodo climatológico de referencia 1961-1990, considerando el modelo HadCM3 y los datos del reanálisis NCEP/NCAR. A partir de la temperatura media diaria en 850 hPa, se identifican los eventos de temperatura negativa para los meses de mayo a septiembre, componiéndose los cinco eventos más extremos para tres áreas que incluyen la Pampa Húmeda (área 1), Uruguay y sur de Brasil (área 2), la parte oriental de Paraguay, norte de Argentina y sur de Brasil (área 3).Los patrones de circulación son analizados tanto para el reanálisis como para las simulaciones en el clima presente y futuro. Los resultados muestran para el clima presente que el modelo simula la incursión de las isotermas de 0°C más al norte respecto del reanálisis, a excepción del área 3 que limita con los trópicos, con anomalías negativas de temperatura más intensas y más extensas en términos latitudinales. A pesar que las configuraciones de los campos de presión sean similaresal reanálisis, se aprecia una mayor penetración del anticiclón continental, a excepción del área 3, con una intensificación de las anomalías en las respectivas áreas. El modelo también tiende a simular una componente de viento del sur más intensa en 850 hPa y captura la profunda vaguada sobre el continente en niveles altos con el jet subtropical bien configurado, típico de estos eventos extremos. En el escenario futuro, el modelo no proyecta eventos extremos de temperatura por debajo de 0°C para el área 3, restringiendo la incursión de la isoterma de 0° C a latitudes más al sur en las otras dos áreas respecto a la simulación en el clima presente, en concordancia con el aumento de temperatura media que el modelo proyecta para Sudamérica.The simulations with the HadCM3 model were among the first available to analyze future projections. This is reflected in the literature, which mainly describes the variables temperature and precipitation for South America. The aim of this paper is to investigate the changes in the atmospheric circulation over southeastern South America associated to extreme cold events in the most critical future emission scenario A2 for the period 2081-2100, with respect to the climatological reference period 1961-1990. To do that the HadCM3 model is used as well as the NCEP/NCAR reanalysis. Were identified the five most extreme events of daily mean negative temperature in 850 hPa from May to September over three areas: Wet Pampa (area 1), Uruguay and southern Brazil (area 2), eastern Paraguay, northern Argentina and southern Brazil (area 3). The obtained circulation patterns are analyzed in both, the reanalysis and the HadCM3 simulations of the present and future climate. In the present climate, with the exception of the area 3 that borders the tropics, the model simulates a more extended northward incursion of the 0oC isotherm than the reanalysis. It also shows more intense negative temperature anomalies, which have more latitudinal extension. Despite the fact that the configurations of the pressure fields are similar to that of the reanalysis, except for the area 3, a further inland penetration of the continental anticyclone is appreciated, with an intensification of the anomalies over the respective areas. The model also tends to simulate a more intense 850 hPa southerly wind component, capturing the high level deep trough over the continent and displaying a properly configured subtropical jet, which is typical of these extreme events. In the future scenario, the model does not project extreme cold events of below 0oC temperatures for area 3. The model also restricts the incursion of the 0oC isotherm to more southerly latitudes in the other two areas with respect to the simulation of the present climate. These facts are consistent with the mean temperature increase projected by the model for South America.Fil: Müller, Gabriela V.. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; ArgentinaFil: Rabelo Da Rocha Repinaldo, Cintia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; ArgentinaFil: Andrade, Kelen M.. Centro de Previsao de Tempo e Estudos Climáticos. Instituto Nacional de Pesquisas Espaciais; BrasilFil: Cavalcanti, Iracema F. A.. Centro de Previsao de Tempo e Estudos Climáticos. Instituto Nacional de Pesquisas Espaciais; Brasi

Interpreting measures of tuberculosis transmission : a case study on the Portuguese population

Background: Tuberculosis remains a high burden for Human society despite considerable investments in its control. Unique features in the history of infection and transmission dynamics of tuberculosis pose serious limitations on the direct interpretation of surveillance data and call for models that incorporate latent processes and simulate specific interventions.Methods: A transmission model was adjusted to the dataset of active tuberculosis cases reported in Portugal between 2002 and 2009. We estimated key transmission parameters from the data (i.e. time to diagnosis, treatment length, default proportion, proportion of pulmonary TB cases). Using the adjusted model to the Portuguese case, we estimated the total burden of tuberculosis in Portugal. We further performed sensitivity analysis to heterogeneities in susceptibility to infection and exposure intensity.Results: We calculated a mean time to diagnose of 2.81 months and treatment length of 8.80 months in Portugal. The proportion defaulting treatment was calculated as 0.04 and the proportion of pulmonary cases as 0.75. Using these values, we estimated a TB burden of 1.6 million infected persons, corresponding to more than 15% of the Portuguese population. We further described the sensitivity of these estimates to heterogeneity.Conclusions: We showed that the model reproduces well the observed dynamics of the Portuguese data, thus demonstrating its adequacy for devising control strategies for TB and predicting the effects of interventions

Gaps between calcium recommendations to prevent pre-eclampsia and current intakes in one hospital in Argentina

Background: Hypertensive disorders are a major cause of maternal mortality. In Latin America and the Caribbean, pre-eclampsia accounts for approximately one in every four maternal deaths. The World Health Organization recommends calcium supplementation during pregnancy for the prevention and treatment of pre-eclampsia and eclampsia in locations where dietary calcium intake is low. Calcium intake in Argentina is reported to be below WHO recommended levels; however, calcium intake from supplements and water has not been fully evaluated.The objective of this study was to evaluate calcium intake from supplements and water in a group of pregnant women. Methods: This cross-sectional study was conducted at a maternity hospital in the city of Buenos Aires, Argentina. Questionnaires were verbally administered to women attending a routine antenatal care visit. Participants were 18 years of age or older and in their third trimester of pregnancy. Participants were first interviewed to evaluate nutritional supplement consumption and a subgroup was invited to undergo a 24-hour dietary recall. Results: 137 women meeting inclusion criteria consented to participate.The average participant age was 27 years (SD ± 5.9), and all resided in an urban setting. None of the subjects took calcium supplements specifically, although 24 (17%) recalled taking supplements or antacids which contributed to their calcium intake. Mean calcium intake was 663mg SD ±389 for those women completing the 24-hour dietary recall,. This value increased to 706 mg SD ±387 upon considering water intake and measuring chemical composition of water from the areas where women lived at the time of the interview and was further increased to 719 mg (SD ±392) when calcium from supplements was taken into consideration. Conclusions: None of the subjects were consuming calcium supplements. Taking into account the low calcium intake in this population, diverse strategies would be required to comply with recommendations.Facultad de Ciencias ExactasFacultad de Ingenierí

Comparison between circulation patterns associated to frost events in the humid pampa in climatic settings related with the experiments CMIP3 and CMIP5 of the GFDL model

El propósito de este estudio es investigar los cambios en la circulación atmosférica asociados a eventos de heladas en la Pampa Húmeda (PH) en el clima futuro para los escenarios más críticos proyectados por el modelo acoplado oceano-atmósfera GFDL. Se emplea el modelo GFDL en sus dos versiones (GFDL-CM2 para el CMIP3 y GFDL-CM3 para el CMIP5). Se analiza la capacidad del modelo para simular los cinco eventos extremos más fríos en el clima presente (1961-1990), respecto de los obtenidos en el reanálisis del NCEP/NCAR. Luego se comparan las simulaciones del clima futuro (2081-2100) con las del presente. En el experimento CMIP3 del clima presente el modelo muestra una mayor penetración de la isoterma de 0°C en 850 hPa, con anomalías de temperatura negativas más intensas que las del NCEP. El anticiclón pos frontal se observa más extendido meridionalmente sobre el continente, con valores de anomalías similares principalmente en la Pampa Húmeda. El gradiente de presión entre la alta y la baja corriente abajo, provoca un flujo de aire frio del sur más intenso en 850 hPa que en el reanálisis, propiciando heladas del tipo advectivas en la región de estudio. En el clima futuro el modelo proyecta una menor incursión de la isoterma de 0°C y con anomalías negativas de temperatura más pequeñas. El máximo del anticiclón en el futuro se localiza más al norte que en el presente, propiciando heladas del tipo radiativas. En el campo de altura, el jet subtropical se presenta más zonal y con intensidades ligeramente mayores que en las simulaciones del clima presente. Para el experimento CMIP5 en el clima presente el modelo logra simular la incursión de la isoterma de 0°C, pero la anomalía de temperatura es mayor que en el reanálisis. El campo de presión presenta similares características que en el experimento de CMIP3, pero con anomalías más intensas al sur del continente. En el escenario futuro el modelo proyecta la incursión de la isoterma de 0°C, así como la anomalía negativa de temperatura, similares al presente. El anticiclón pos frontal se localiza más al norte, sobrestimando tanto su valor así como su anomalía en la PH. El campo de viento no muestra diferencias respecto del presente. En suma, comparando los dos experimentos, el de CMIP3 en el futuro muestra importantes cambios respecto al presente, lo que no ocurre en el CMIP5. Esos cambios se ven principalmente en el campo de presión, donde para el CMIP3 (CMIP5) las heladas tipo radiativas (advectivas) serían las favorecidas en la Pampa Húmeda debido a la posición del anticiclón.The purpose of this study is to investigate the change in the atmospheric circulation associated with frost events in the Wet Pampa (WP) in the future climate for the most critical scenarios projected by the GFDL ocean-atmosphere coupled model. Two versions of the GFDL model are used, the GFDL-CM2 for CMIP3 and GFDL-CM3 for CMIP5. We analyze the model capability to simulate the five most extreme cold events in the present climate (1961-1990), with respect to those obtained with the NCEP/NCAR Reanalysis. Then, we compare the future climate simulations (2081-2100) with the model simulation for the present climate. For the present climate the CMIP3 experiment presents more penetration of the 0°C isotherm in 850 hPa, intensifying the negative temperature anomalies in comparison to the reanalysis. The postfrontal anticyclone is more meridionally extended over the continent, with similar anomalies to those of the reanalysis, mainly over WP. The gradient between the high pressure and the low pressure downwind creates a more intense southerly cold airflow at 850 hPa than the reanalysis, giving place to advective frosts in the studied region. For the future climate, the model projects less penetration of the 0°C isotherm and less intense negative temperature anomalies. The anticyclone maximum is located further north than in the present climate, propitiating radiative frosts. In the upper levels, the subtropical jet shows a more zonally layout and slightly higher intensity than in the present climate simulations. For the present climate the CMIP5 experiment simulates well the incursion of the 0°C isotherm, although with a more intense temperature anomaly in comparison to the reanalysis. The pressure field presents similar characteristics to those shown in the CMIP3 experiment, but with larger anomalies in the southern part of the continent. For the future scenario, the model projects the 0°C isotherm incursion as well as the negative temperature anomalies similar to the present. The post frontal anticyclone is located further north, overestimating its value and the anomaly over WP. The wind field is similar to the present simulation. Summarizing the results of both experiments, the future projections with CMIP3 show significant changes with respect to the present, which is not the case with the CMIP5 experiment. These changes are mainly reflected in the pressure field, in which the position of the anticyclone in CMIP3 (CMIP5) would favor radiative (advective) frosts over WP.Asociación Argentina de Geofísicos y Geodesta

Forage Intake and Nitrogen Retention in Wethers Fed Ryegrass Haylage Supplemented with Maize Silage

Many decision support tools have been developed to predict herbage intake with herbivore ruminants indoors (Faverdin 1992) or at grazing, both using short-term (Baumont et al. 2004) or daily scale input variables (Heard et al. 2004; Delagarde et al. 2011). However, the ingestive and digestive interactions when diets with more than one type of forage are used have not been sufficiently studied. The aim of this study was to assess the effects of maize silage supplementation to wethers receiving ryegrass haylage on OM intake, OM digestibility, microbial protein synthesis and N retention

Modeling Partial Monosomy for Human Chromosome 21q11.2-q21.1 Reveals Haploinsufficient Genes Influencing Behavior and Fat Deposition

Haploinsufficiency of part of human chromosome 21 results in a rare condition known as Monosomy 21. This disease displays a variety of clinical phenotypes, including intellectual disability, craniofacial dysmorphology, skeletal and cardiac abnormalities, and respiratory complications. To search for dosage-sensitive genes involved in this disorder, we used chromosome engineering to generate a mouse model carrying a deletion of the Lipi–Usp25 interval, syntenic with 21q11.2-q21.1 in humans. Haploinsufficiency for the 6 genes in this interval resulted in no gross morphological defects and behavioral analysis performed using an open field test, a test of anxiety, and tests for social interaction were normal in monosomic mice. Monosomic mice did, however, display impaired memory retention compared to control animals. Moreover, when fed a high-fat diet (HFD) monosomic mice exhibited a significant increase in fat mass/fat percentage estimate compared with controls, severe fatty changes in their livers, and thickened subcutaneous fat. Thus, genes within the Lipi–Usp25 interval may participate in memory retention and in the regulation of fat deposition

Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability

Erratum in - Corrigendum: Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability. Fagundes GE, Macan TP, Rohr P, Damiani AP, Da Rocha FR, Pereira M, Longaretti LM, Vilela TC, Ceretta LB, Mendes C, Silveira PCL, Teixeira JPF, de Andrade VM. Mutagenesis. 2019 May 29;34(2):215. doi: 10.1093/mutage/gez006.Type 2 diabetes mellitus has undergone a worldwide growth in incidence in the world and has now acquired epidemic status. There is a strong link between type 2 diabetes and vitamin D deficiency. Because vitamin D has beneficial effects on glucose homeostasis, the aim of this study was to evaluate the influence of vitamin D3 supplementation on the modulation of glycaemic control and other metabolic effects, as well as modulation of genomic instability in patients with type 2 diabetes. We evaluated 75 patients with type 2 diabetes, registered in the Integrated Clinics of the University of Southern Santa Catarina. Participants received 4000 IU of vitamin D3 (25(OH)D) supplementation daily for 8 weeks. Blood samples were collected at the beginning and at the end of the supplementation, and 4 weeks after the end of supplementation. The glycidic and lipid profiles [total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein and triglycerides], oxidative stress, DNA damage and 25(OH)D levels were evaluated. Vitamin D3 supplementation for 8 weeks showed enough to significantly increase blood levels of 25(OH)D. A significant difference in lipid profile was observed only in non-HDL cholesterol. Significant changes were observed in glucose homeostasis (fasting glucose and serum insulin) and, in addition, a reduction in the parameters of oxidative stress and DNA damage. There was a significant reduction in the values of 25(OH)D 4 weeks after the end of the supplementation, but levels still remained above baseline. Use of vitamin D supplementation can be an ally in the health modulation of patients with type 2 diabetes mellitusThis work was supported by grants from Conselho Nacional de Pesquisa e Desenvolvimento (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (FAPESC) and Programa de Pós-Graduação em Ciências da Saúde/ Universidade do Extremo Sul Catarinense.info:eu-repo/semantics/publishedVersio