Estudio de marcadores tumorales citológicos e histológicos relacionados con las alteraciones cromosómicas de tumores sólidos.

Si bien hay diferencias en cuanto a la incidencia y la tasa de morbilidad y mortalidad de cada una de las formas de cáncer en los diversos países, se calcula que aproximadamente una de cada cinco personas en el mundo mueren de cáncer. Aunque ha habido considerables avances en el tratamiento, incluyendo procedimientos de alta precisión en cirugía y protocolos detallados para radio y quimioterapia, los tumores malignos siguen siendo una de las causas de muerte más prominentes de la sociedad moderna. Las estrategias para el tratamiento dependen de un diagnóstico preciso y temprano. Algunos tumores presentan dificultades para clasificarlos, lo que lleva consigo una incertidumbre en el pronóstico y tratamiento. Los tumores sólidos tanto de órganos como de tejidos blandos y óseo, son un grupo de neoplasias muy diverso, que ocurren en todas las edades. El diagnóstico/ pronóstico puede ser complicado y el dilema del diagnóstico diferencial depende frecuentemente de los métodos histopatológicos y radiológicos. El presente proyecto intenta correlacionar los parámetros histopatológicos e inmunohistoquímicos con las aberraciones cromosómicas que ellos presentan a los efectos de contribuir en el diagnóstico y tratamiento más eficientes. La detección de alteraciones cromosómicas como anillos, cromosomas dicéntricos, deleciones, traslocaciones, etc., que están asociadas con tipos específicos de tumores sólidos relacionándolos con su morfología permitirá contribuir a un mejor diagnóstico y por ende tratamientos más precisos, ya que ciertos tumores, a pesar de morfología similar pueden tener comportamiento diferente

Desafíos para la enseñanza de las producciones pecuarias en el marco de una carrera articulada

La educación superior en las Ciencias Agropecuarias ofrece un campo propicio para internalizar nuevos enfoques. La experiencia, con eje en las producciones de carne y leche, se desarrolla en una carrera articulada entre un ciclo terciario con orientación en Producción Agropecuaria integrado con un ciclo universitario. El título de Ingeniero Agrónomo se obtiene tras realizar un Trabajo Final de Graduación. En la enseñanza de las producciones pecuarias se enfatiza el logro de un encadenamiento dinámico, vertical y transversal, de los contenidos de todos los espacios curriculares relacionados con estas asignaturas en ambos ciclos de la carrera. Las asignaturas propedéuticas, de producción cárnica y lechera, ofrecen una plataforma propicia para consolidar el proceso formativo capitalizando conocimientos previos para un escalonamiento en jerarquía conceptual, profundización de contenidos y riqueza de interrelaciones. Finalizado el ciclo de complementación curricular, se espera que el alumno haya logrado afianzar e integrar con solvencia conocimientos y prácticas desarrollando competencias para su desempeño profesional. Del proceso conjunto participan producción de carne, producción de leche, forrajes y pasturas y nutrición animal del ciclo inicial, con los cursos de producción lechera, producción cárnica, selección del ganado, diagnóstico de explotaciones agropecuarias y manejo de rodeos de alta producción del tramo universitarioEje temático 1: Problemáticas y alternativas de mejora de la enseñanza e - Los enfoques y modalidades de integración curricularFacultad de Ciencias Agrarias y Forestale

Microplastics and anthropogenic debris in rainwater from Bahia Blanca, Argentina

Concern about atmospheric microplastic (MP) contamination has increased in recent years. This study assessed the abundance of airborne anthropogenic particles, including MPs, deposited in rainfall in Bahia Blanca, southwest Buenos Aires, Argentina. Rainwater samples were collected monthly from March to December 2021 using an active wet-only collector consisting of a glass funnel and a PVC pipe that is only open during rain events. Results obtained show that all rain samples contained anthropogenic debris. The term “anthropogenic debris” is used to refer to the total number of particles as not all the particles found could be determined as plastic. Among all the samples, an average deposition of 77 ± 29 items (anthropogenic debris) m⁻²d⁻¹ was found. The highest deposition was observed in November (148 items m⁻²d⁻¹) while the lowest was found in March (46 items m⁻²d⁻¹). Anthropogenic debris ranged in size from 0.1 mm to 3.87 mm with the most abundant particles being smaller than 1 mm (77.8%). The dominant form of particles found were fibers (95%), followed by fragments (3.1%). Blue color predominated (37.2%) in the total number of samples, followed by light blue (23.3%) and black (21.7%). Further, small particles (<2 mm), apparently composed of mineral material and plastic fibers, were recognized. The chemical composition of suspected MPs was examined by Raman microscopy. The analysis of μ-Raman spectra confirmed the presence of polystyrene, polyethylene terephthalate, and polyethylene vinyl acetate fibers and provided evidence of fibers containing industrial additives such as indigo dye. This is the first assessment of MP pollution in rain in Argentina.Centro de Química Inorgánic

Relationship between employee involvement and lean manufacturing and its effect on performance in a rigid continuous process industry

Relationship between employee involvement and lean manufacturing and its effect on performance in a rigid continuous process industry DOI: 10.1080/00207543.2014.975852 Juan A. Marin-Garciaa* & Tomas Bonaviab Received: 1 Aug 2013 Accepted: 30 Sep 2014 Published online: 04 Nov 2014 This research aims to empirically test the effect of employee involvement on lean manufacturing (LM), and the effect of LM on production outcomes. Employee involvement is operationalised through four related variables: empowerment, training, contingent remuneration and communication. The effects are tested by recording management perceptions in a different industrial sector from those usually studied in previous research ceramic manufacturers, a highly competitive and internationally successful sector. We obtained data from 101 ceramic tile plants (64% of response rate) in the Valencia region of Spain. This approach is developed using a statistical method called partial least squares. All paths are significant except for contingent remuneration; specifically, relationships were found between empowerment, training, communication and LM, and between LM and performance.This paper has been written with financial support from the Project "Path Dependence and decision-making for selecting LM tools and practices" (PAID-06-12-SP20120717) of the Universitat Politecnica de Valencia.Marín García, JA.; Bonavía Martín, T. (2015). Relationship between employee involvement and lean manufacturing and its effect on performance in a rigid continuous process industry. International Journal of Production Research. 53(11):3260-3275. https://doi.org/10.1080/00207543.2014.975852S32603275531

First joint observation by the underground gravitational-wave detector KAGRA with GEO 600

We report the results of the first joint observation of the KAGRA detector with GEO 600. KAGRA is a cryogenic and underground gravitational-wave detector consisting of a laser interferometer with 3 km arms, located in Kamioka, Gifu, Japan. GEO 600 is a British-German laser interferometer with 600 m arms, located near Hannover, Germany. GEO 600 and KAGRA performed a joint observing run from April 7 to 20, 2020. We present the results of the joint analysis of the GEO-KAGRA data for transient gravitational-wave signals, including the coalescence of neutron-star binaries and generic unmodeled transients. We also perform dedicated searches for binary coalescence signals and generic transients associated with gamma-ray burst events observed during the joint run. No gravitational-wave events were identified. We evaluate the minimum detectable amplitude for various types of transient signals and the spacetime volume for which the network is sensitive to binary neutron-star coalescences. We also place lower limits on the distances to the gamma-ray bursts analyzed based on the non-detection of an associated gravitational-wave signal for several signal models, including binary coalescences. These analyses demonstrate the feasibility and utility of KAGRA as a member of the global gravitational-wave detector network

Search for Eccentric Black Hole Coalescences during the Third Observing Run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass $M>70$ $M_\odot$) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities $0 < e \leq 0.3$ at $0.33$ Gpc$^{-3}$ yr$^{-1}$ at 90\% confidence level.Comment: 24 pages, 5 figure

All-sky search for continuous gravitational waves from isolated neutron stars using Advanced LIGO and Advanced Virgo O3 data

We present results of an all-sky search for continuous gravitational waves which can be produced by spinning neutron stars with an asymmetry around their rotation axis, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. Four different analysis methods are used to search in a gravitational-wave frequency band from 10 to 2048 Hz and a first frequency derivative from $-10^{-8}$ to $10^{-9}$ Hz/s. No statistically-significant periodic gravitational-wave signal is observed by any of the four searches. As a result, upper limits on the gravitational-wave strain amplitude $h_0$ are calculated. The best upper limits are obtained in the frequency range of 100 to 200 Hz and they are ${\sim}1.1\times10^{-25}$ at 95\% confidence-level. The minimum upper limit of $1.10\times10^{-25}$ is achieved at a frequency 111.5 Hz. We also place constraints on the rates and abundances of nearby planetary- and asteroid-mass primordial black holes that could give rise to continuous gravitational-wave signals

Open data from the third observing run of LIGO, Virgo, KAGRA and GEO

The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in April of 2019 and lasting six months, O3b starting in November of 2019 and lasting five months, and O3GK starting in April of 2020 and lasting 2 weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main dataset, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages.Comment: 27 pages, 3 figure

Search for subsolar-mass black hole binaries in the second part of Advanced LIGO’s and Advanced Virgo’s third observing run

We describe a search for gravitational waves from compact binaries with at least one component with mass 0.2 M⊙–1.0 M⊙ and mass ratio q ≥ 0.1 in Advanced LIGO and Advanced Virgo data collected between 1 November 2019, 15:00 UTC and 27 March 2020, 17:00 UTC. No signals were detected. The most significant candidate has a false alarm rate of 0.2yr−1 ⁠. We estimate the sensitivity of our search over the entirety of Advanced LIGO’s and Advanced Virgo’s third observing run, and present the most stringent limits to date on the merger rate of binary black holes with at least one subsolar-mass component. We use the upper limits to constrain two fiducial scenarios that could produce subsolar-mass black holes: primordial black holes (PBH) and a model of dissipative dark matter. The PBH model uses recent prescriptions for the merger rate of PBH binaries that include a rate suppression factor to effectively account for PBH early binary disruptions. If the PBHs are monochromatically distributed, we can exclude a dark matter fraction in PBHs fPBH ≳ 0.6 (at 90% confidence) in the probed subsolar-mass range. However, if we allow for broad PBH mass distributions we are unable to rule out fPBH = 1. For the dissipative model, where the dark matter has chemistry that allows a small fraction to cool and collapse into black holes, we find an upper bound fDBH &lt; 10−5 on the fraction of atomic dark matter collapsed into black holes