Treatment-Resistant Hypertension: An Update in Device Therapy

Resistant hypertension (RH) is a clinical condition in which the hypertensive patient has become resistant to drug therapy and is often associated with increased cardiovascular morbidity and mortality. Several signaling pathways have been studied and related to the development and progression of RH: modulation of sympathetic activity by leptin and aldosterone, primary aldosteronism, arterial stiffness, endothelial dysfunction, and variations in the renin-angiotensin-aldosterone system (RAAS)

Decoding resistant hypertension signalling pathways

Resistant hypertension (RH) is a clinical condition in which the hypertensive patient has become resistant to drug therapy and is often associated with increased cardiovascular morbidity and mortality. Several signalling pathways have been studied and related to the development and progression of RH: modulation of sympathetic activity by leptin and aldosterone, primary aldosteronism, arterial stiffness, endothelial dysfunction and variations in the renin–angiotensin–aldosterone system (RAAS). miRNAs comprise a family of small non-coding RNAs that participate in the regulation of gene expression at post-transcriptional level. miRNAs are involved in the development of both cardiovascular damage and hypertension. Little is known of the molecular mechanisms that lead to development and progression of this condition. This review aims to cover the potential roles of miRNAs in the mechanisms associated with the development and consequences of RH, and explore the current state of the art of diagnostic and therapeutic tools based on miRNA approaches

ANÁLISE DO POTENCIAL BIOCATALÍTICO DE LIPASE DE CANDIDA RUGOSA IMOBILIZADA EM DIFERENTES SUPORTES: POTENCIAL BIOCATALÍTICO DE LIPASE DE CANDIDA RUGOSA

Neste trabalho é avaliado o potencial biocatalítico da lipase de Candida rugosa (LCR) imobilizada em diferentes suportes: carvão ativado, gesso comercial e sílica gel, visando a produção de biodiesel. O método de imobilização por adsorção foi utilizado na imobilização da LCR nos suportes. A eficiência de imobilização expressa em termos da razão entre a atividade do complexo suporte-LCR e atividade da enzima livre, foram estimados, fornecendo eficiência de 89% para o carvão ativado-LCR, 62% para a sílica gel-LCR e 48% para o gesso-LCR. O complexo carvão ativado-LCR forneceu o maior índice de acidez. A análise por cromatografia de camada delgada do biodiesel produzido por este complexo apresentou fatores de retenção e ordem de eluição dos acilgliceróis compatíveis com a literatura, indicando um potencial deste complexo para a produção de biodiesel