A Multi-Method Assessment Approach to the Detection of Malingered Pain: Association with the MMPI-2 Restructured Form

The present study investigated the utility of the MMPI-2-Restructured Form (MMPI-2-RF) over-reporting scales (F-r, Fp-r, Fs, and FBS-r) and the Response Bias Scale (RBS) to detect symptom exaggeration among litigants claiming chronic pain. Utilizing the Bianchini et al. (2005) multi-method criteria for Malingered Pain Related Disability (MPRD), patients were classified along a continuum ranging from incentive only to definite malingering. Malingering classification was found to have a significant effect on MMPI-2-RF over-reporting scales, particularly the RBS, Infrequent Symptoms Scale (F-r), and Infrequent Somatic Responses scale (Fs), which supports the use of the MMPI-2-RF in forensic disability evaluations

Educational administration as a disciplinary practice: Appropriating Foucault\u27s view of power, discourse, and method

This article discusses the relevance of Foucault\u27s work to the field of educational administration. It argues for Foucault\u27s concept of disciplinary practice as a powerful new generative metaphor for the field. A major implication of Foucault\u27s view of power is that educational practices that may appear more democratic, participatory, or progressive may in fact constitute forms of disciplinary power and thus result in more effective technologies of control. The authors argue that regardless of which techniques of administration are used, the effects of disciplinary power cannot be escaped. No educational practices are inherently more empowering than others. They further discuss how disciplinary power operates through discourse practices, which, according to Foucault, link knowledge and power Discourses shape administrative practices, and administrative practices produce discourses. Finally, the authors discuss how Foucault\u27s methodology (genealogy) can be used to determine why some discourses have prevailed over others in the field of educational administration

Evaluating the impact and use of Transparent Reporting of Evaluations with Non-randomised Designs (TREND) reporting guidelines.

notes: PMCID: PMC3533093Freely available Open Access paper. Cite published version at: doi:10.1136/bmjopen-2012-002073INTRODUCTION: Accurate and full reporting of evaluation of interventions in health research is needed for evidence synthesis and informed decision-making. Evidence suggests that biases and incomplete reporting affect the assessment of study validity and the ability to include this data in secondary research. The Transparent Reporting of Evaluations with Non-randomised Designs (TREND) reporting guideline was developed to improve the transparency and accuracy of the reporting of behavioural and public health evaluations with non-randomised designs. Evaluations of reporting guidelines have shown that they can be effective in improving reporting completeness. Although TREND occupies a niche within reporting guidelines, and despite it being 8 years since publication, no study yet has assessed its impact on reporting completeness or investigated what factors affect its use by authors and journal editors. This protocol describes two studies that aim to redress this. METHODS AND ANALYSIS: Study 1 will use an observational design to examine the uptake and use of TREND by authors, and by journals in their instructions to authors. A comparison of reporting completeness and study quality of papers that do and do not use TREND to inform reporting will be made. Study 2 will use a cross-sectional survey to investigate what factors inhibit or facilitate authors' and journal editors' use of TREND. Semistructured interviews will also be conducted with a subset of authors and editors to explore findings from study 1 and the surveys in greater depth. ETHICS AND DISSEMINATION: These studies will generate evidence of how implementation and dissemination of the TREND guideline has affected reporting completeness in studies with experimental, non-randomised designs within behavioural and public health research. The project has received ethics approval from the Research Ethics Committee of the Peninsula College of Medicine and Dentistry, Universities of Exeter and Plymouth

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer.

Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing. Tryptophan metabolism, which produces immunosuppressive metabolites, is enhanced in RCC. Here we show indolamine-2,3-dioxygenase-1 (IDO1) expression, a kynurenine pathway enzyme, is increased not only in tumor cells but also in the microenvironment of human RCC compared to normal kidney tissues. Neither kynurenine metabolites nor IDO inhibitors affected the survival or proliferation of human RCC or murine renal cell adenocarcinoma (RENCA) cells in vitro. However, interferon-gamma (IFNγ) induced high levels of IDO1 in both RCC and RENCA cells, concomitant with enhanced kynurenine levels in conditioned media. Induction of IDO1 by IFNα was weaker than by IFNγ. Neither the IDO1 inhibitor methyl-thiohydantoin-DL-tryptophan (MTH-trp) nor IFNα alone inhibited RENCA tumor growth, however the combination of MTH-trp and IFNα reduced tumor growth compared to IFNα. Thus, the failure of IFNα therapy for human RCC is likely due to its inability to overcome the immunosuppressive environment created by increased IDO1. Based on our data, and given that IDO inhibitors are already in clinical trials for other malignancies, IFNα therapy with an IDO inhibitor should be revisited for RCC

Magnetic-field-induced collapse of charge-ordered nanoclusters and the Colossal Magnetoresistance effect in Nd(0.3)Sr(0.3)MnO(3)

We report synchrotron x-ray scattering studies of charge/orbitally ordered (COO) nanoclusters in Nd$_{0.7}$Sr$_{0.3}$MnO$_3$. We find that the COO nanoclusters are strongly suppressed in an applied magnetic field, and that their decreasing concentration follows the field-induced decrease of the sample electrical resistivity. The COO nanoclusters, however, do not completely disappear in the conducting state, suggesting that this state is inhomogeneous and contains an admixture of an insulating phase. Similar results were also obtained for the zero-field insulator-metal transition that occurs as temperature is reduced. These observations suggest that these correlated lattice distortions play a key role in the Colossal Magnetoresistance effect in this prototypical manganite.Comment: 5 pages, 3 embedded eps figures; to appear in PRB Rapid Commumication

On the Convergence Between PSY-5 Domains and PID-5 Domains and Facets: Implications for Assessment of DSM-5 Personality Traits

The DSM-5 Personality and Personality Disorders workgroup and their consultants have developed the 220-item, self-report Personality Inventory for the DSM-5 (PID-5) for direct assessment of the proposed personality trait system for DSM-5; however, most p

Chronological control and centennial-scale climatic subdivisions of the Last Glacial Termination in the western Mediterranean region

The Last Glacial Termination is marked by changing environmental conditions affected by abrupt and rapid climate oscillations, such as Heinrich Stadial 1 (HS1), which is characterized by extremely low sea surface temperatures (SST) and significant changes in northern hemisphere terrestrial landscape (e.g., vegetation) and human dispersion. Previous studies show that overall cold/dry conditions occurred during HS1, but the lack of high-resolution records precludes whether climate was stable or instead characterized by instability. A high-resolution paleoclimatic record from the Padul wetland (southern Iberian Peninsula), supported by a high-resolution chronology and contrasted with other records from southern Europe and the Mediterranean region, shows 1) that the age boundaries of HS1 in this area occurred at similar to 18.0 kyr BP (median age = 17,970 cal yr BP; mean age = 18,030 +/- 330 cal yr BP) and similar to 15.2 kyr BP (median age = 15,210 cal yr BP; mean age = 15,200 +/- 420 cal yr BP) and 2) that climate during HS1 was non-stationary and centennial-scale variability in moisture is superimposed on this overall cold climatic period. In this study, we improve the pollen sampling resolution with respect to previous studies on the same Padul-15-05 sedimentary core and suggest a novel subdivision of HS1 in 7 sub-phases, including: i) 3 sub-phases (a.1-a.3) during an arid early phase (HS1a; similar to 18.4-17.2 kyr BP), ii) a relatively humid middle phase (HS1b; similar to 17.2-16.9 kyr BP), and iii) 3 sub-phases (c.1-c.3) during an arid late phase (HS1c; similar to 16.9-15.7 kyr BP). This climatic subdivision is regionally supported by SST oscillations from the Mediterranean Sea, suggesting a strong land-sea coupling. A cyclostratigraphic analysis of pollen data between 20 and 11 kyr BP indicates that the climate variability and the proposed subdivisions characterized by similar to 2000 and similar to 800-yr periodicities could be related to solar forcing controlling climate in this area. (C) 2021 Elsevier Ltd. All rights reserved.Peer reviewe

Temperature, ozone, and mortality in urban and non-urban counties in the northeastern United States

Background: Most health effects studies of ozone and temperature have been performed in urban areas, due to the available monitoring data. We used observed and interpolated data to examine temperature, ozone, and mortality in 91 urban and non-urban counties. Methods: Ozone measurements were extracted from the Environmental Protection Agency's Air Quality System. Meteorological data were supplied by the National Center for Atmospheric Research. Observed data were spatially interpolated to county centroids. Daily internal-cause mortality counts were obtained from the National Center for Health Statistics (1988-1999). A two-stage Bayesian hierarchical model was used to estimate each county's increase in mortality risk from temperature and ozone. We examined county-level associations according to population density and compared urban (⩾1,000 persons/mile2) to non-urban (<1,000 persons/mile2) counties. Finally, we examined county-level characteristics that could explain variation in associations by county. Results: A 10 ppb increase in ozone was associated with a 0.45% increase in mortality (95% PI: 0.08, 0.83) in urban counties, while this same increase in ozone was associated with a 0.73% increase (95% PI: 0.19, 1.26) in non-urban counties. An increase in temperature from 70°F to 90°F (21.2°C 32.2°C) was associated with a 8.88% increase in mortality (95% PI: 7.38, 10.41) in urban counties and a 8.08% increase (95% PI: 6.16, 10.05) in nonurban counties. County characteristics, such as population density, percentage of families living in poverty, and percentage of elderly residents, partially explained the variation in county-level associations. Conclusions: While most prior studies of ozone and temperature have been performed in urban areas, the impacts in non-urban areas are significant, and, for ozone, potentially greater. The health risks of increasing temperature and air pollution brought on by climate change are not limited to urban areas

Observation of two time scales in the ferromagnetic manganite La(1-x)Ca(x)MnO(3), x = 0.3

We report new zero-field muon spin relaxation and neutron spin echo measurements in ferromagnetic (FM) (La,Ca)MnO3 which taken together suggest two spatially separated regions in close proximity possessing very different Mn-ion spin dynamics. One region corresponds to an extended cluster which displays 'critical slowing down' near Tc and an increasing volume fraction below Tc. The second region possesses more slowly fluctuating spins and a decreasing volume fraction below Tc. These data are discussed in terms of the growth of small polarons into overlapping regions of correlated spins below Tc, resulting in a microscopically inhomogeneous FM transition.Comment: 10 pages, 3 figure

A palaeoecological approach to understanding the past and present of Sierra Nevada, a Southwestern European biodiversity hotspot

Mediterranean mountainous environments are biodiversity hotspots and priority areas in conservation agendas. Although they are fragile and threatened by forecasted global change scenarios, their sensitivity to long-term environmental variability is still understudied. The Sierra Nevada range, located in southern Spain on the north-western European flanks of the Mediterranean basin, is a biodiversity hotspot. Consequently, Sierra Nevada provides an excellent model system to apply a palaeoecological approach to detect vegetation changes, explore the drivers triggering those changes, and how vegetation changes link to the present landscape in such a paradigmatic mountain system. A multi-proxy strategy (magnetic susceptibility, grain size, loss-on-ignition, macroremains, charcoal and palynological analyses) is applied to an 8400-year long lacustrine environmental archive from the Laguna de la Mosca (2889 masl). The long-term ecological data show how the Early Holocene pine forests transitioned towards mixed Pinus-Quercus submediterranean forests as a response to a decrease in seasonality at ~7.3 cal. kyr BP. The mixed Pinus-Quercus submediterranean forests collapsed drastically giving way to open evergreen Quercus formations at ~4.2 cal. kyr BP after a well-known aridity crisis. Under the forecasted northward expansion of the Mediterranean area due to global change-related aridity increase, mountain forests inhabiting territories adjacent to the Mediterranean Region could experience analogous responses to those detected in the Sierra Nevada forests to the Mid to Late Holocene aridification, moving from temperate to submediterranean and then Mediterranean formations