1,934 research outputs found
Correction of Optical Aberrations in Elliptic Neutron Guides
Modern, nonlinear ballistic neutron guides are an attractive concept in
neutron beam delivery and instrumentation, because they offer increased
performance over straight or linearly tapered guides. However, like other
ballistic geometries they have the potential to create significantly
non-trivial instrumental resolution functions. We address the source of the
most prominent optical aberration, namely coma, and we show that for extended
sources the off-axis rays have a different focal length from on-axis rays,
leading to multiple reflections in the guide system. We illustrate how the
interplay between coma, sources of finite size, and mirrors with non-perfect
reflectivity can therefore conspire to produce uneven distributions in the
neutron beam divergence, the source of complicated resolution functions. To
solve these problems, we propose a hybrid elliptic-parabolic guide geometry.
Using this new kind of neutron guide shape, it is possible to condition the
neutron beam and remove almost all of the aberrations, whilst providing the
same performance in beam current as a standard elliptic neutron guide. We
highlight the positive implications for a number of neutron scattering
instrument types that this new shape can bring.Comment: Presented at NOP2010 Conference in Alpe d'Huez, France, in March 201
Variant Plasmodium ovale isolated from a patient infected in Ghana
Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes. This study presents a P. ovale isolate from a patient infected in Ghana together with an analysis of the small subunit RNA, cytochrome b, cytochrome c oxidase I, cysteine protease and lactate dehydrogenase genes, which show that the sample is a variant P. ovale and identical or highly similar to variant P. ovale isolated from humans in South-East Asia and Africa, and from a chimpanzee in Cameroon. The split between the variant and classic P. ovale is estimated to have occurred 1.7 million years ago
Modeling and Simulation as Boundary Objects to Facilitate Interdisciplinary Research
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150614/1/sres2564.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150614/2/sres2564_am.pd
Unusual Metabolism and Hypervariation in the Genome of a Gracilibacterium (BD1-5) from an Oil-Degrading Community.
The candidate phyla radiation (CPR) comprises a large monophyletic group of bacterial lineages known almost exclusively based on genomes obtained using cultivation-independent methods. Within the CPR, Gracilibacteria (BD1-5) are particularly poorly understood due to undersampling and the inherent fragmented nature of available genomes. Here, we report the first closed, curated genome of a gracilibacterium from an enrichment experiment inoculated from the Gulf of Mexico and designed to investigate hydrocarbon degradation. The gracilibacterium rose in abundance after the community switched to dominance by Colwellia Notably, we predict that this gracilibacterium completely lacks glycolysis, the pentose phosphate and Entner-Doudoroff pathways. It appears to acquire pyruvate, acetyl coenzyme A (acetyl-CoA), and oxaloacetate via degradation of externally derived citrate, malate, and amino acids and may use compound interconversion and oxidoreductases to generate and recycle reductive power. The initial genome assembly was fragmented in an unusual gene that is hypervariable within a repeat region. Such extreme local variation is rare but characteristic of genes that confer traits under pressure to diversify within a population. Notably, the four major repeated 9-mer nucleotide sequences all generate a proline-threonine-aspartic acid (PTD) repeat. The genome of an abundant Colwellia psychrerythraea population has a large extracellular protein that also contains the repeated PTD motif. Although we do not know the host for the BD1-5 cell, the high relative abundance of the C. psychrerythraea population and the shared surface protein repeat may indicate an association between these bacteria.IMPORTANCE CPR bacteria are generally predicted to be symbionts due to their extensive biosynthetic deficits. Although monophyletic, they are not monolithic in terms of their lifestyles. The organism described here appears to have evolved an unusual metabolic platform not reliant on glucose or pentose sugars. Its biology appears to be centered around bacterial host-derived compounds and/or cell detritus. Amino acids likely provide building blocks for nucleic acids, peptidoglycan, and protein synthesis. We resolved an unusual repeat region that would be invisible without genome curation. The nucleotide sequence is apparently under strong diversifying selection, but the amino acid sequence is under stabilizing selection. The amino acid repeat also occurs in a surface protein of a coexisting bacterium, suggesting colocation and possibly interdependence
Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate.
Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental cell fate. We found that NMD factors tend to be expressed at higher levels in human pluripotent cells than in differentiated cells, raising the possibility that NMD must be downregulated to permit differentiation. Loss- and gain-of-function experiments in human embryonic stem cells (hESCs) demonstrated that, indeed, NMD downregulation is essential for efficient generation of definitive endoderm. RNA-seq analysis identified NMD target transcripts induced when NMD is suppressed in hESCs, including many encoding signaling components. This led us to test the role of TGF-β and BMP signaling, which we found NMD acts through to influence definitive endoderm versus mesoderm fate. Our results suggest that selective RNA decay is critical for specifying the developmental fate of specific human embryonic cell lineages
Widespread erosion on high plateaus during recent glaciations in Scandinavia
Glaciers create some of Earth’s steepest topography; yet, many areas that were repeatedly overridden by ice sheets in the last few million years include extensive plateaus. The distinct geomorphic contrast between plateaus and the glacial troughs that dissect them has sustained two long-held hypotheses: first, that ice sheets perform insignificant erosion beyond glacial troughs, and, second, that the plateaus represent ancient pre-glacial landforms bearing information of tectonic and geomorphic history prior to Pliocene–Pleistocene global cooling (~3.5 Myr ago). Here we show that the Fennoscandian ice sheets drove widespread erosion across plateaus far beyond glacial troughs. We apply inverse modelling to 118 new cosmogenic 10Be and 26Al measurements to quantify ice sheet erosion on the plateaus fringing the Sognefjorden glacial trough in western Norway. Our findings demonstrate substantial modification of the pre-glacial landscape during the Quaternary, and that glacial erosion of plateaus is important when estimating the global sediment flux to the oceans
SparsePak: A Formatted Fiber Field-Unit for The WIYN Telescope Bench Spectrograph. II. On-Sky Performance
We present a performance analysis of SparsePak and the WIYN Bench
Spectrograph for precision studies of stellar and ionized gas kinematics of
external galaxies. We focus on spectrograph configurations with echelle and
low-order gratings yielding spectral resolutions of ~10000 between 500-900nm.
These configurations are of general relevance to the spectrograph performance.
Benchmarks include spectral resolution, sampling, vignetting, scattered light,
and an estimate of the system absolute throughput. Comparisons are made to
other, existing, fiber feeds on the WIYN Bench Spectrograph. Vignetting and
relative throughput are found to agree with a geometric model of the optical
system. An aperture-correction protocol for spectrophotometric standard-star
calibrations has been established using independent WIYN imaging data and the
unique capabilities of the SparsePak fiber array. The WIYN
point-spread-function is well-fit by a Moffat profile with a constant power-law
outer slope of index -4.4. We use SparsePak commissioning data to debunk a
long-standing myth concerning sky-subtraction with fibers: By properly treating
the multi-fiber data as a ``long-slit'' it is possible to achieve precision sky
subtraction with a signal-to-noise performance as good or better than
conventional long-slit spectroscopy. No beam-switching is required, and hence
the method is efficient. Finally, we give several examples of science
measurements which SparsePak now makes routine. These include H
velocity fields of low surface-brightness disks, gas and stellar
velocity-fields of nearly face-on disks, and stellar absorption-line profiles
of galaxy disks at spectral resolutions of ~24,000.Comment: To appear in ApJSupp (Feb 2005); 19 pages text; 7 tables; 27 figures
(embedded); high-resolution version at
http://www.astro.wisc.edu/~mab/publications/spkII_pre.pd
Full Information Product Pricing: An Information Strategy for Harnessing Consumer Choice to Create a More Sustainable World
Research and practice in the information systems (IS) field have been evolving over time, nourishing and promoting the development of applications that transform the relationships of individuals, corporations, and governments. Building on this evolution, we push forward a vision of the potential influence of the IS field into one of the most important problems of our times, an increasingly unsustainable world, which is traditionally considered the product of imperfect markets or market externalities. We describe our work in Full Information Product Pricing (FIPP) and our vision of a FIPP global socio-technical system, I-Choose, as a way to connect consumer choice and values with environmental, social, and economic effects of production and distribution practices. FIPP and I-Choose represent a vision about how information systems research can contribute to interdisciplinary research in supply chains, governance, and market economies to provide consumers with information packages that help them better understand how, where, and by whom the products they buy are produced. We believe that such a system will have important implications for international trade and agreements, for public policy, and for making a more sustainable world
Incidence of Free of Charge Physiotherapy in a Danish National Cohort of Stroke, Parkinson’s Disease, Multiple Sclerosis and Rheumatoid Arthritis Patients
Background: Denmark is a welfare state with a publically funded healthcare system that includes the right to free of charge physiotherapy (FCP) for patients with chronic or progressive disease who fulfill strict criteria. The aim of this study was to investigate the incidence of referral to FCP in patients with a hospital diagnosis of stroke, multiple sclerosis (MS), Parkinson’s disease (PD) and rheumatoid arthritis (RA) between 2007 and 2016.
Methods: The study was register-based and included data from The Danish National Patient Registry and The National Health Service Registry. The study population included the four largest disease groups receiving FCP in Denmark. The incidence of receiving FCP was reported as the cumulated incidence proportion (CIP).
Results: The study showed that FCP was mainly initiated within the first 2 years after diagnosis. The 2-year CIP was 8% for stroke patients, 53% for PD patients, 49% for MS patients, and 16% for RA patients. The proportion of patients referred to FCP generally increased over the period of the study due to more patients being referred from medical specialists in primary care.
Conclusion: This study found substantial differences in the incidence of referral to FCP in a Danish population of stroke, PD, MS and RA patients
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