Diferentes tipos e protocolos de esclerosantes vasculares no tratamento das má formações vasculares orais: revisão literária

Revisar a literatura mundial a fim de avaliar os diferentes protocolos de tipos diversos de esclerosantes vasculares utilizados no tratamento das malformações vasculares presentes na cavidade oral. E por fim apresentar as possibilidades encontradas e ilustrá-las de forma ordenada. Foi realizada uma revisão da literatura através da busca ativa na base de dados Medline, via PubMed. Como critérios de inclusão, foram selecionados artigos que tenham avaliado  o tratamento de malformações vasculares orais, publicados a partir do ano 2000, nas línguas portuguesa, inglesa, espanhola ou francês com pesquisas envolvendo exclusivamente seres humanos. Foram elencados em uma tabela 23 diferentes protocolos de tratamento com agentes esclerosantes para malformações na região de cabeça e pescoço, de modo que todos culminaram com resultados satisfatórios aos pacientes. Esclerosantes vasculares são opções de tratamento seguros e efetivos na regressão e remissão de malformações vasculares orais. O oleato de etanolamina é um fármaco esclerosante muito utilizado no território brasileiro e dispõe de diversos protocolos de uso com respaldo na literatura científica

Entomological impact and social participation in dengue control : a cluster randomized trial in Fortaleza, Brazil

Fortaleza is a hotspot for dengue, vulnerable to infestation by Aedes aegypti where the irregularity of water supply leads people to store water in various containers. Achieving a successful outcome of dengue vector management is related to the role of communities in eliminating domestic breeding sites. Embedding social participation and environmental management in Fortaleza resulted in significant reduction of vector densities. Interventions included: community workshops; community involvement in clean-up campaigns; covering the elevated containers and in-house rubbish disposal without larviciding; mobilization of schoolchildren and senior inhabitants; and distribution of information, education and communication materials in the community

Grapevine bioclimatic indices in relation to climate change: a case study in the Portuguese Douro Demarcated Region

Climate change is of major relevance to wine production as most of the wine-growing regions of the world, in particular the Douro region, are located within relatively narrow latitudinal bands with average growing season temperatures limited to 13-21ºC. This study focuses on the temporal variability of three grapevine bioclimatic indices, which are commonly used as part of the Geoviticulture Multicriteria Climatic Classification System (MCC) to classify the climate of wine producing regions worldwide. Dynamical downscaling of MPI-ESM-LR global data forced with RCP8.5 climatic scenario is performed with the Weather Research and Forecast (WRF) model to a regional scale including the Douro valley of Portugal for recent-past (1986-2005) and future periods (2046-2065; 2081-2100). Results indicate significant shifts towards warmer and dryer conditions during the growing season and higher night temperatures during the grape ripening period. An assessment on the statistical significance of the differences between the recent-past and the future scenarios and the potential impact on wine production in the study area is performed. These results will provide evidence for future strategies aimed to preserve the high-quality wines in the region and their typicality in a sustainable way.The authors wish to thank the financial support of the DOUROZONE project (PTDC/AAG-MAA/3335/2014; POCI- 01-0145-FEDER-016778) through the Project 3599 – Promoting the scientific production and the technological development, and thematic networks (3599-PPCDT) and through FEDER, and the national funds from FCT – Science and Technology Portuguese Foundation for the doc grant of C. Silveira (SFRH/BD/112343/2015).info:eu-repo/semantics/publishedVersio

Analysis of climate change indices in relation to wine production: a case study in the Douro region (Portugal)

Climate change is of major relevance to wine production as most of the wine-growing regions of the world, in particular the Douro region, are located within relatively narrow latitudinal bands with average growing season temperatures limited to 13–21◦C. This study focuses on the incidence of climate variables and indices that are relevant both for climate change detection and for grape production with particular emphasis on extreme events (e.g. cold waves, storms, heat waves). Dynamical downscaling ofMPI-ESM-LR global data forced with RCP8.5 climatic scenario is performed with the Weather Research and Forecast (WRF) model to a regional scale including the Douro valley of Portugal for recent-past (1986–2005) and future periods (2046– 2065; 2081–2100). The number, duration and intensity of events are superimposed over critical phenological phases of the vine (dormancy, bud burst, flowering, v´eraison, and maturity) in order to assess their positive or negative implications on wine production in the region. An assessment on the statistical significance of climatic indices, their differences between the recent-past and the future scenarios and the potential impact on wine production is performed. Preliminary results indicate increased climatic stress on the Douro region wine production and increased vulnerability of its vine varieties. These results will provide evidence for future strategies aimed to preserve the high-quality wines in the region and their typicality in a sustainable way.The authors wish to thank the financial support of the DOUROZONE project (PTDC/AAG-MAA/3335/2014; POCI- 01-0145-FEDER-016778) through the Project 3599 – Promoting the scientific production and the technological development, and thematic networks (3599-PPCDT) and through FEDER.info:eu-repo/semantics/publishedVersio

Climate change impact on a wine-producing region using a dynamical downscaling approach: Climate parameters, bioclimatic indices and extreme indices

Climate change is of major relevance to wine production as most of the winegrowing regions of the world are located within relatively narrow latitudinal bands with average growing-season temperatures (GSTs) limited to 13–21 C. This study focuses on the incidence of climate variables and indices that are relevant both for climate change assessment and for grape production, with emphasis on grapevine bioclimatic indices and extreme events (e.g., cold waves, storms, heatwaves). Dynamical downscaling of European Reanalysis-Interim and Max Planck Institute Earth System low-resolution global simulations forced with a Representative Concentration Pathway 8.5 (RCP8.5) greenhouse gas emission scenario was performed with the Weather Research and Forecast (WRF) model to a regional scale including the Douro Valley of Portugal for recent-past (1986–2005) and future periods (2046–2065, 2081–2100). The number, duration and intensity of events were superimposed over critical phenological phases estimated by using a specific local grapevine varietal phenological model in order to assess their positive or negative implications for wine production in the region. An assessment of the relevance of climate parameters and indices and their progression in recent-past and future climate scenarios with regard to the potential impact on wine production was performed. Results indicate a positive relation between higher growing-season heat accumulations and greater vintage yields. A moderate incidence of very hot days (daily maximum temperature above 35 C) and drought from pre-véraison phenological conditions have a positive association with vintage ratings. However, the mid- and long-term WRF-MPI RCP8.5 future climate scenarios reveal shifts to warmer and drier conditions, with the mean GST not remaining within range for quality wine production in the long-term future climate scenario. These results indicate potential impacts that suggest a range of strategies to maintain wine production and quality in the region.The authors wish to thank the DOUROZONE project (PTDC/AAG-MAA/3335/2014; POCI-01-0145-FEDER- 016778) for financial support through Project 3599 – Promoting the Scientific Production and the Technological Development, and Thematic Networks (3599-PPCDT) – and through FEDER, and the national funds from FCT-Science and Technology Portuguese Foundation for the doctoral grant of D. Blanco-Ward (SFRH/BD/139193/2018). Thanks are also due for the financial support to CESAM (UID/AMB/50017 - POCI-01-0145-FEDER-007638), to FCT/MEC through national funds, and the co-funding by FEDER within the PT2020 Partnership Agreement and Compete 2020.info:eu-repo/semantics/publishedVersio

Síndrome de Stevens Johnson e necrólise epidérmica tóxica – a importância do cirurgião dentista no diagnóstico / Stevens johnson syndrome and toxic epidermal necrolysis - the importance of the dental surgeon in the diagnosis

Objetivo: Realizar revisão de literatura com a finalidade de evidenciar individualmente o Eritema multiforme, Síndrome de Stevens Johnson e Necrólise Epidérmica Tóxica. Revisão: A síndrome de Stevens e Johnson foi reconhecida e nomeada em 1922 por Stevens e Johnson, é causada por graves manifestações medicamentosas, que inclui diversos grupos farmacológicos como: antibióticos, anticonvulsivantes, anti-inflamatórios não-esteroides e antirretrovirais. É uma síndrome rara e com etiologia desconhecida, relacionada sensibilidade a medicações ou a infecções por vírus como herpes simples e micoplasma.  A incidência da SSJ varia entre 1,5 e 2 casos por milhão de pessoas por ano, havendo relatos da doença em pessoas de todas as idades, porém acometendo mais adultos. A Necrólise Epidérmica Tóxica é a fase mais grave da SSJ, que atinge predominantemente pele e mucosas. Ela é caracterizada pela morte generalizada dos queratinócitos e destacamento da epiderme no nível da junção dermoepidérmica, acomete mais de 30% da superfície corporal total e possui uma baixa incidência e alta mortalidade. O EM secundário ou menor apresenta-se de forma benigna e as manifestações são principalmente em pele e sem comprometimento de mucosa. Podem haver lesões bolhosas que envolvam menos que 10% da superfície do corpo e com maior preferência em membros extensores

O uso de Fibrina Rica em Plaquetas na Odontologia / The Use of Fibrin-Rich Platelets in Dentistry

Objetivo: A fibrina rica em plaquetas, é uma bioengenharia tecidual, sintetizada através de uma matriz de fibrina, de uso autólogo, foi desenvolvida para as cirurgias bucais. Métodos: Esse trabalho foi elaborado através de pesquisas científicas a base do Scielo. Conclusão: Apesar de ser uma técnica relativamente nova, o uso do PRF vem apresentando resultados favoráveis na odontologia. Essa matriz desempenha uma bioengenharia tecidual, que vai gerar uma micro vascularização local, isso ocorre devido a migração de células epiteliais e leucócitos que irão facilitar desempenho da coagulação e gerar uma hemostasia após os procedimentos cirúrgicos, para se obter a indução da cicatrização

Performance da CO-oximetria de pulso para identificação do tabagismo na Atenção Básica

Resumo   Objetivo: Avaliar o desempenho de um CO-oxímetro para determinação do status do tabagismo em relação a um medidor de monóxido de carbono exalado em indivíduos atendidos na atenção básica. Métodos: Estudo transversal realizado em pacientes ambulatoriais atendidos nas unidades básicas de saúde de Anápolis-GO, submetidos à avaliação clínica, dosagem do monóxido de carbono exalado e medida do monóxido de carbono por CO-oximetria de pulso. Resultados: Foram incluídos 449 indivíduos, 106 tabagistas (23,6%), 89 ex-tabagistas (19,8%), 203 nunca fumantes (45,2%) e 51 fumantes passivos (11,4%). A CO-oximetria com ponto de corte de ≥4% mostrou uma especificidade de 77,3% (IC95% 72,5%-81,6%), uma sensibilidade de 52,8% (IC95% 42,9%-62,6%), valores preditivos positivo e negativo de 45,3% (IC95% 38,9%-51,9%), 82,1% (IC95% 78,8%-85%), respectivamente e a área sob a curva ROC de 0,73 (IC95% 0,67-0,78). A dosagem do monóxido de carbono exalado com ponto de corte de ≥5ppm mostrou uma especificidade de 96,2% (IC95% 93,6%-98%), sensibilidade de 79,2% (IC95% 70,3%-86,5%), valor preditivo positivo e negativo de 88,2% (IC95% 81,3%-92,8%), 92,9% (IC95% 89,9%-95%), respectivamente e a área sob a curva ROC de 0,91 (IC95% 0,87-0,95). COHb(%)≥4 demostrou OR:4,3; (IC 95% 2,7-7,1); p<0,0001. Conclusão: A CO-oximetria apresentou capacidade de identificação do tabagismo inferior à da dosagem do monóxido de carbono exalado, entretanto, quando COHb(%)≥4 há alta probabilidade de tabagismo

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio