8 research outputs found
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
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- Windebank S.
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- Wu Y. Q.
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- Zhai Z.
- Zhang F.
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- Zhao H.
- Zhao J.
- Zhao X. Y.
- Zheng R.
- Zhou F. C.
- Zhou S.
- Zhu B. H.
- Zhu W. H.
- Zincircioglu C.
- Zogheib E. H.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p<0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p<0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding
Development and characterization of <i>in situ </i>gelling system containing atorvastatin-loaded polycaprolactone nanoparticles for periodontal diseases
- Publication venue
- Publication date
- 01/01/2023
- Field of study
The periodontal pocket provides a suitable environment for bacterial accumulation and growth which results in ultimately tooth loss. The clinical efficacy of current therapy for periodontal pocket is low because the flushing actions within the mouth causes to rapid clearance of the solution. The antioxidant and anti-inflammatory effects of atorvastatin (ATV) can facilitate healing process of periodontal diseases. The aim of this study was to develop in situ gel formulation containing ATV-loaded polycaprolactone nanoparticles (PCL-NPs). PCL NPs were prepared by nanoprecipitation method. The NPs had spherical shape with a particle size range of 176-329 nm. They showed 59% encapsulation efficiency and prolonged release profile. In order to increase the mucoadhesive properties of the formulation and the residence time of the drug at the site of action, NPs were incorporated to in situ gel to provide a combination therapy. In situ gel formulation was prepared by cold method and characterized in terms of pH, gelation temperature and time, viscosity, syringeability, and rheological behaviours. In vitro release studies revealed that in situ gel formulation remarkably extend the release time of ATV and mathematical release kinetic modelling shows formulations can fit multiple models. The overall findings indicated that the combination therapy strategy of locally administration of in situ gel containing ATV-loaded polycaprolactone nanoparticles to periodontal pockets is a promising and innovative approach
How does a biopsy of endoscopically normal terminal ileum contribute to the diagnosis? Which patients should undergo biopsy?
- Author
- Ali Riza Koksal
- Byrne MF
- Cabrera-Abreu JC
- Canan Alkim
- Cuvelier C
- da Silva JG
- Damlanur Sakiz
- Dogan Y
- Douda T
- Engin Altinkaya
- Geboes K
- Huseyin Alkim
- Jeong SH
- Järemo P
- Kapsoritakis AN
- Kayahan H
- McHugh JB
- Mehmet Bayram
- Melo MM
- Meltem Ergun
- Melton SD
- Misra SP
- Morowitz DA
- Osman Ozdogan
- Polinska B
- Powell N
- Salih Boga
- Sayilir A
- Yoong KK
- Yusoff IF
- Zwas FR
- Publication venue
- 'Co-Action Publishing'
- Publication date
- Field of study
Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one
- Author
- A. Berman
- A. Cochino
- A. De Jesus
- A. Groll
- A. Insalaco
- A. Jansson
- A. Kazmirchyk
- A. Kozlova
- A. Lazar
- A. Martini
- A. Martini
- A. Martini
- A. Martini
- A. Martini
- A. Ombrello
- A. Pistorio
- A. Ravelli
- A. Simon
- A. Simon
- A. Simon
- A. Simon
- A. Speziale
- A. Speziale
- A. Speziale
- A. Speziale
- A. Speziale
- A. Zeft
- A. Zeft
- A. Zeft
- Abdullah Alsonbul
- Abdullah Calıskan
- Achille Marino
- Acute-JIA Study Group
- Adel Al-Wahadneh
- Adele Civino
- Adele D’Amico
- Adrian Liston
- Adriana Ivonne Cespedes-Cruz
- Adriana Rodriguez Vidal
- Adriana S. Díaz-Maldonado
- Agneza Marija Pasini
- Ahmet B. Cekgeloglu
- Ahmet Gul
- Aki Hanaya
- Akihiro Yachie
- Akihiro Yachie
- Akihiro Yachie
- Alain Fischer
- Alan Salama
- Alberto Garaventa
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Martini
- Alberto Tommasini
- Alberto Tommasini
- Alberto Tommasini
- Alberto Vieira
- Aleksandra Czajkowska
- Aleksandra Szabat
- Aleksandre Kajrishvili
- Aleksandre Kajrishvili
- Aleksey Kozhevnikov
- Alena Torbyak
- Alenka Gagro
- Alessandra Meneghel
- Alessandra Russo
- Alessandro Cafarotti
- Alessandro Consolaro
- Alessandro Consolaro
- Alessandro De Fanti
- Alessandro Ventura
- Alessia Omenetti
- Alessia Omenetti
- Alessia Omenetti
- Alexandre Belot
- Alexandre Belot
- Alexandre Belot
- Alexandre Belot
- Alexey Maschan
- Alfonso Ragnar Torres-Jimenez
- Alfred Mahr
- Alice Grossi
- Alice Grossi
- Alma Nunzia Olivieri
- Alma Olivieri
- Almira Ćosićkić
- Amanda Ombrello
- Amanda Radulescu
- Amanda Saracino
- Amit Rawat
- Amit Rawat
- Amit Rawat
- Amra Adrovic
- Amra Adrovic
- Amra Adrovic
- Amra Adrovic
- Amra Adrovic
- Amra Adrovic
- An Goris
- Ana F. Mourão
- Ana M. Marín Sánchez
- Ana V. Villarreal
- Ana V. Villarreal Treviño
- Ana V. Villarreal-Treviño
- Ana Vieira
- Ana Villarreal
- Anders Fasth
- Andrea Magnolato
- Andrea Pession
- Andrea Petretto
- Andrea Taddio
- Andrea Taddio
- Andrea Taddio
- Andressa G. Alves
- Andressa G. Alves
- Andrew Henrey
- Angel J. Flores-Pineda
- Angela Aquilani
- Angela C. Mosquera
- Angela C. Mosquera
- Angela Cox
- Angela Mauro
- Angela Mauro
- Angela Mauro
- Angela McArdle
- Angela Miniaci
- Angela Pistorio
- Angela Pistorio
- Angela Rösen-Wolff
- Angelika Thon
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Angelo Ravelli
- Anita Dhanrajani
- Anju Gupta
- Anju Gupta
- Anju Gupta
- Anju Gupta
- Anju Gupta
- Ankur Kumar
- Ankur Kumar
- Anna C. Schulz
- Anna Gruenpeter
- Anna Kozlova
- Anna Mondino
- Anna Pogodina
- Anna Rubartelli
- Anna Shcherbina
- Anna Simon
- Anna Vermé
- Annacarin Horne
- Annalisa Chiocchetti
- Annalisa Salis
- Anne Grethe Jurik
- Anne H. Spannow
- Anne Hinks
- Anne Hulin
- Anne Lohse
- Anne Pagnier
- Anne Thorwarth
- Anne-Laure Mathieu
- Anneleen Avau
- Annemarie van Nieuwenhuijze
- Annemieke S. Littooij
- Annette Jansson
- Annette Keylock
- Annette von Scheven-Gête
- Antje Nimtz-Talaska
- Anton Hospach
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Insalaco
- Antonella Petaccia
- Antonella Petaccia
- Antonella Petaccia
- Antonia Kienast
- Antonio Fernández-Nebro
- Antonio L. Urda Cardona
- Antonio L. Urda Cardona
- Antonio Novelli
- Antonio Urda-Cardona
- Ariane Klein
- Ariane Standing
- Arinna Bertoni
- Arinna Bertoni
- Arinna Bertoni
- Arne Hørlyck
- Aygen Yılmaz
- Aysenur Pac Kısaarslan
- Aysenur Pac Kisaarslan
- Ayşen Bingöl
- Ayşenur Kısaarslan
- B. Flato
- B. Lauwerys
- B. Lauwerys
- Bahar Muezzinoglu
- Balahan Makay
- Balahan Makay
- Balahan Makay
- Banu Acar
- Banu Orak
- Barbara Stanimirovic
- Belinda Hernandez
- Belkisa Čolić
- Berenice Sanchez-Jara
- Berent Prakken
- Berent Prakken
- Beril Talim
- Berit Flato
- Berna E. Fidanci
- Berna Eren Fidanci
- Berta Lopez Montesinos
- Betul Sozeri
- Betul Sozeri
- Betul Sozeri
- Betül Sozeri
- Betül Sözeri
- Beverley Almeida
- Biagio Castaldi
- Bianca Lattanzi
- BIKER collaborative group
- Bilade Cherqaoui
- Biljana Djurdjevic-Banjac
- Biman Saikia
- Biman Saikia
- Birgitte T. Mahler
- Bita Arabshahi
- Bo Magnusson
- Bo Magnusson
- Board of the Swedish Pediatric Rheumatology Registry
- Bogumiła Szponar
- Boris Huegle
- Boris Hugle
- Brenden Dufault
- Brent Adler
- Brian M. Feldman
- Brigitte Bader-Meunier
- Brigitte Bader-Meunier
- Brigitte Bader-Meunier
- Brigitte Bader-Meunier
- Brigitte Bader-Meunier
- Bruno Charbit
- Bruno Dallapiccola
- Butsabong Lerkvaleekul
- Butsabong Lerkvaleekul
- Bénédicte Neven
- Bénédicte Neven
- C H. Spencer
- C. C. Barbosa Sandoval de Souza
- C. H. Spencer
- C. Wang
- C. Wouters
- Cagla Kaymakamgil
- Calin Lazar
- Calin Lazar
- Calin Lazar
- Camilla Celani
- Camilo Vargas
- CAPS
- Carine H. Wouters
- Carine Wouters
- Carine Wouters
- Carine Wouters
- Carla Aguilar Blancafort
- Carla Maldini
- Carlos Eduardo Ramalho
- Carolin Pretzer
- Carolina Uggenti
- Carolina Uggenti
- Caroline Freychet
- Caroline M. Andreasen
- Carsten W. Heuck
- Casper Schoemaker
- Caterina Di Battista
- Caterina Pellecchia
- Catherine Adamsbaum
- Catherine Orzechowski
- Cathryn E. Harkness
- Cecilia Lazea
- Chack-Yung Yu
- Chantal Deslandre
- Chantal Job Deslandre
- Charalampia Papadopoulou
- Charlotte Eijkelboom
- Chiara Lavarello
- Chiara Marini
- Chiara Passarelli
- Chiara Passarelli
- Chiara Trentin
- Chloe M. Stephenson
- Chris Pruunsild
- Chris Wallace
- Chris Williams
- Christelle Sordet
- Christiaan Scott
- Christian Høst
- Christian Pagnoux
- Christina Boros
- Christina Boros
- Christina Boros
- Christina Boros
- Christina Peterson
- Christine Arango
- Christine Barnerias
- Christine Bodemer
- Christine Bodemer
- Christine Bodemer
- Christine Bodemer
- Christine Nirschl
- Christine Seib
- Christine Soler
- Christoph Kessel
- Christoph Kessel
- Christopher Piper
- Chung-Yung Yu
- Ciaran Duffy
- Claas Hinze
- Claas Hinze
- Claas Hinze
- Claas Hinze
- Claire Grimwood
- Claire Hoyoux
- Claire Murphy
- Claire T. Deakin
- Clara Gimenez Roca
- Clara Giménez Roca
- Clara Malagon
- Clara Malagon
- Clara Malattia
- Clara Malattia
- Clara Malattia
- Clare Pain
- Clarissa Pilkington
- Clarissa pilkington
- Clarissa Pilkington
- Claudia Bracaglia
- Claudia Mauri
- Claudia Pastorino
- Claudia Pastorino
- Claudia Pastorino
- Claudia Poloni
- Claudio Lavarello
- Claudio Lavarello
- Clotilde Alizzi
- Clotilde Alizzi
- Consuelo Modesto
- Consuelo Modesto Caballero
- Consuelo Modesto Caballero
- Consuelo Modesto Caballero
- Cosimo Giannini
- Coskun F. Ozkececi
- Coskun F. Ozkececi
- Craig Kinnear
- Cristina Battagliotti
- Cristina Battagliotti
- Cristina Battagliotti
- Cristina de Min
- Cyril Gitiaux
- Cécile Gaujoux-Viala
- D. A. Williams
- D. Arikan
- D. J. Lovell
- D. J. Lovell
- D. Lovell
- D. Lovell
- D. Rigante
- Daiva Gorczyca
- Damien Bentayou
- Damien Noone
- Dan Cosma
- Dan Vasilescu
- Dan Ø. Pradsgaard
- Dana Nemcova
- Dana Nemcova
- Dana Nemcova
- Dana Nemcova
- Dana Němcová
- Daniel J. Lovell
- Daniel Kelberman
- Daniel L. Kastner
- Daniel L. Kastner
- Daniel Lovell
- Daniel Windschall
- Daniel Álvarez de la Sierra
- Daniela Chroustová
- Daria Augustyniak
- Darragh Duffy
- Darragh Duffy
- David Isenberg
- David Jayne
- David Moreno Romo
- Davide Gatti
- Deborah Stone
- Deepthi R. Abraham
- Deepti Suri
- Deepti Suri
- Delphine Regnard
- Demet Kartal
- Denise Ferrera
- Denise Lasigliè
- Denise Pires Marafon
- Denise Pires Marafon
- Denise Pires Marafon
- Denise Pires Marafon
- Denise Pires Marafon
- Denise Pires-Marafón
- Deniz Dogru
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Eleftheriou
- Despina Moshous
- Despoina Maritsi
- Despoina Maritsi
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- on behalf of EUROFEVER PROJECT
- on behalf of Eurofever Registry
- on behalf of PRINTO and Eurofever registry
- on behalf of ReACCh-Out Investigators
- On Behalf of the British Society for Paediatric and Adolescent Rheumatology
- Onder Yavascan
- Orla G. Killeen
- Ornella Milanesi
- Osman Nidai Özdeş
- Otto Lelieveld
- Ozge Altug Gucenmez
- Ozgur Kasapcopur
- Ozgur Kasapcopur
- Ozgur Kasapcopur
- Ozgur Kasapcopur
- Ozgur Kasapcopur
- Ozgur Kasapçopur
- Ozgur Kasapçopur
- Ozgur Kasapçopur
- Ozlem Aydog
- Ozren Vrdoljak
- P. A. Brogan
- P. Brogan
- P. Dolezalova
- P. Dolezalova
- P. N. Hawkins
- P. Quartier
- P. Quartier
- P. Quartier
- Paivi M. Miettunen
- Pandiarajan Vignesh
- Pandiarajan Vignesh
- Pandiarajan Vignesh
- Paola B. Lara-Herrea
- Paola Caramaschi
- Paolo Cressoni
- Paolo Cressoni
- Paolo Picco
- Pascal N. Tyrrell
- Pascal Pillet
- Patricia Woo
- Patrick Hundsdoerfer
- Patrick Matthys
- Patrizia Barone
- Patrizia Castellani
- Paul Brogan
- Paul Brogan
- Paul Brogan
- Paul Brogan
- Paul Brogan
- Paula Forgeron
- Pauline Marteau
- Pauline Taggart
- Pavla Dolezalova
- Pavla Doležalová
- Pediatric Allergy and Immunology Unit PGIMER, Chandigarh
- Pekka Lahdenne
- Perrine Dusser
- Perrine Dusser
- Peter A. Nigrovic
- Peter Gowdie
- Peter Krawitz
- Petra Krol
- Philip Hawkins
- Philipp Schoof
- Philippe Reix
- Pier Luigi Meroni
- Piernicola Pelliccia
- Pierre Moens
- Pierre Quartier
- Pierre Quartier
- Pierre Quartier
- Pierre Quartier
- Pieter Dijkstra
- Pieter Sauer
- Pieter Van Dijkhuizen
- Pilar Guarnizo
- Pilar Perez
- Pio D’Adamo
- Pirjo Tynjala
- Polymnia Louka
- Praman Fuangfa
- Prasad T. Oommen
- Prasad T. Oommen
- PRINTO/PRCSG
- Priyankar Pal
- Qing Zhou
- Qiong Wu
- R. Cimaz
- R. Cuttica
- R. Gallizzi
- R. Goldbach-Mansky
- R. Joos
- R. Laxer
- R. Laxer
- R. Russo
- R. Schepp
- R. Schneider
- R. Tarzynski-Potempa
- R. Wong
- Rabheh Abdul Aziz
- Rabheh Abdul Aziz
- Rae S. M. Yeung
- Rae S. Yeung
- Raffaella Basilico
- Raffaella Carlomagno
- Rainer Berendes
- Ralf Felix Trauzeddel
- Ralf Trauzeddel
- Randy C. Cron
- Rangaraj Satyapal
- Ranjana Minz
- Ranjana W. Minz
- Raphaela Goldbach-Mansky
- Raquel Campanilho-Marques
- Rawiah shehata
- ReACCh-Out Investigators
- Rebecca Nicolai
- Rebecca Ten Cate
- Reem Abdwani
- Reha Artan
- Rezan Topaloglu
- Ricardo Pujol Borrell
- Ricardo Russo
- Ricardo Yepez
- Richard McClead
- Richard Vesely
- Rita Carsetti
- Rita Consolini
- Rita Consolini
- Rita Fonseca
- Robert Nelson
- Roberta Berard
- Roberta Caorsi
- Roberta Caorsi
- Roberta Caorsi
- Roberta Salvatore
- Roberto Marini
- Roberto Ravazzolo
- Roberto Rondelli
- Rocio Galindo Zavala
- Rocio Galindo Zavala
- Rocio Maldonado
- Rocio Maldonado
- Rocío Galindo-Zavala
- Rodica Manasia
- Roger C. Allen
- Rohit Aggarwal
- Rolando Cimaz
- Rolando Cimaz
- Rolando Cimaz
- Rolando Cimaz
- Rolando Cimaz
- Rolando Cimaz
- Rolando Cimaz
- Rolando Cimaz
- Rolando Cimaz
- Romain Gherardi
- Roman Jurencak
- Romiesa Hagoug
- Romina Gallizzi
- Romina Gallizzi
- Romina Gallizzi
- Ronald M. Laxer
- Rosa Bou
- Rosalba Monica Ferraro
- Rose-Marie Herbigneaux
- Ruben Burgos-Vargas
- Ruben Cuttica
- Ruhan Dusunsel
- Ruhan Dusunsel
- Ruhan Dusunsel
- Ryuta Nishikomori
- S. Al-Mayouf
- S. Banerjee
- S. Benseler
- S. de Roock
- S. Kamphuis
- S. Nielsen
- S. Nielsen
- S. Ozen
- S. Ozen
- S. Ozen
- S. Ozen
- S. Padeh
- Sabrina Chiesa
- Sabrina Chiesa
- Sae Lim von Stuckrad
- Safia Al-Abrawi
- Sagar Bhattad
- Sally Pino
- Salvatore Albani
- Samuel U. Aliejim
- Sanae El Hani
- Sandra Biscardi
- Sandra Enciso
- Sandra Gran
- Sanimir Suljendić
- Sara Ahola Kohut
- Sara Marsal Barril
- Sara Marsal Barril
- Sara Pieropan
- Sarah Tansley
- Sarbelio Moreno-Espinosa
- Satoru Nagata
- Satoshi Fujikawa
- Savita V. Attri
- Sebahat Tulpar
- Sebastiaan J. Vastert
- Sebastiaan J. Vastert
- Selim Demir
- Sema Akman
- Sema Misir
- Serap Arıcı
- Serena Pastore
- Serena Pastore
- Serena Pastore
- Serena Pastore
- Sergi Borlan Fernandez
- Sergi Borlan Fernández
- Sergio Davi
- Sergio Davì
- Serhan Sevgi
- Severine Guillaume Czitrom
- Seza Ozen
- Seza Ozen
- Seza Ozen
- Seza Ozen
- Seza Ozen
- Seza Ozen
- Seza Ozen
- Seza Ozen
- Seza Ozen
- Seza Ozen
- Seza Özen
- Sezgin Sahin
- Sezgin Sahin
- Sezgin Şahin
- Sezgin Şahin
- Sharon Bout-Tabaku
- Sharon Bout-Tabaku
- Shehla Sheikh
- Sheila K. Oliveira
- Shorena Tvalabeishvili
- Shorena Tvalabeishvili
- Sibel Yel
- Silvana B. Sacchetti
- Silvana B. Sacchetti
- Silvana Martino
- Silvana Martino
- Silvana Martino
- Silvana Martino
- Silvana Martino
- Silvana Martino
- Silvia Borghini
- Silvia Borghini
- Silvia Federici
- Silvia Federici
- Silvia Giliani
- Silvia Magni Manzoni
- Silvia Magni Manzoni
- Silvia Magni-Manzoni
- Silvia Magni-Manzoni
- Silvia Magni-Manzoni
- Silvia Scala
- Silvio Polizzi
- Simon W. Eng
- Simon Williams
- Simona Cascioli
- Simona Rednic
- Sinem Durmus
- Sira Nanthapisal
- Sira Nanthapisal
- Soamarat Vilaiyuk
- Soamarat Vilaiyuk
- Sofia Torreggiani
- Sofia Torreggiani
- Sonia Carta
- Sonia Melo Gomes
- Sonia Trope
- Sonia Trope
- Stefania Citiso
- Stefania Simou
- Stefania Simou
- Stefania Simou
- Stefanie Dowle
- Stefanie Zenker
- Stefano Lanni
- Stefano Lanni
- Stefano Stagi
- Stefano Stagi
- Stefano Volpi
- Stefano Volpi
- Stella Garay
- Stella Maris Garay
- Stephania Simou
- Stephanie J. W. Shoop
- Stephanie Pau
- Stephen R. Pennington
- Steven Welch
- Stéphane Blanche
- Suat Fitoz
- Sue Wyatt
- Sulaiman M. Al-Mayouf
- Sulaiman Mohammed Al-Mayouf
- Sulliman O. Omarjee
- Sunil Sampath
- Suphaneewan Jaovisidha
- Surjit Singh
- Surjit Singh
- Surjit Singh
- Surjit Singh
- Surjit Singh
- Surjit Singh
- Susan D. Thompson
- Susan Nielsen
- Susan Nielsen
- Susan Nielsen
- Susan Nielsen
- Susan Nielsen
- Susanne Benseler
- Susanne M. Benseler
- Susanne M. Benseler
- Susanne Schalm
- Suzanne M. M. Verstappen
- Suzanne Parsons
- Sylvain Breton
- Sylvain Breton
- Sylvie Fraitag
- Sytze de Roock
- T. Constantin
- T. Herlin
- T. Herlin
- T. Kallinich
- T. Kallinich
- T. van der Poll
- T. Wolfs
- Tadej Avcin
- Tadey Avcin
- Tadey Avcin
- Tadey Avcin
- Takako Miyamae
- Takuma Hara
- Talia Diaz
- Talia Diaz
- Talia Diaz
- Talia Diaz Prieto
- Talia Diaz-Prieto
- Tamara Mandzyak
- Tatiana Gonzalez
- Tatyana Belova
- Tatyana Golovko
- Tatyana Knyazeva
- Teresa Giani
- Teresa Giani
- Thierry Walzer
- Thierry Walzer
- Thirusha Lane
- Thomas Cullup
- Thomas Lehman
- Thomas Lehman
- Thomas Lehman
- Thomas Loughin
- Thomas Vogl
- Thumanoon Ruangchaijatuporn
- Tilmann Kallinich
- Tilmann Kallinich
- Tilmann Kallinich
- Tilmann Kallinich
- Tilmann Kallinich
- Tilmann Kallinich
- Tim Dierckx
- Tina Romeo
- Tomonobu Kikkawa
- Tomáš Dallos
- Toni Weinhage
- Toshihiko Yabuuchi
- Tracy A. Briggs
- Trang Duong
- Troels Herlin
- Troels Herlin
- Troels Herlin
- Tu Anh Tran
- Tuncay Hazirolan
- U. A. Walker
- Ugo Ramenghi
- Ugur Ozcelik
- Umberto Dianzani
- Umberto Garagiola
- Umberto Garagiola
- V. Chasnyk
- V. Hentgen
- V. Paes Leme Ferriani
- V. Panaviene
- V. Stanevicha
- Vahid Ziaee
- Valda Stanevicha
- Valda Stanevicha
- Valda Stanevicha
- Valda Stanevicha
- Valda Stanevicha
- Valentina Leone
- Valentina Litta Modignani
- Valentino Conter
- Valeria Gerloni
- Valeria Gerloni
- Valérie Devauchelle-Pensec
- Vanessa Smith
- Vanessa Smith
- Vanessa Smith
- Vasiliy Burlakov
- Vera Milic
- Veronique Hentgen
- Victoria Arthur
- Victoria B. Nikolayenko
- Vimal Prajapati
- Vincent Bondet
- Violetta Opoka-Winiarska
- Virginia Messia
- Virginia Messia
- Vitor A. Teixeira
- Vladimir Kenis
- Vladimír Tesař
- Véronique Hentgen
- W.-Alberto Sifuentes-Giraldo
- W.-Alberto Sifuentes-Giraldo
- W.-Alberto Sifuentes-Giraldo
- Wafa A. Madan
- Walter Ferlin
- Wanxia Tsai
- Wendy Costello
- Wendy Thomson
- Wendy Thomson
- Wendy Thomson
- Wendy Thomson
- Wilco de Jager
- William Fahy
- Wineke Armbrust
- Witaya Sungkarat
- Working Group of Behçet’s Disease Pediatric Rheumatology Association of Japan (PRAJ)
- Working Group “Juvenile Dermatomyositis” of the German Society for Paediatric and Adolescent Rheumatology (GKJR)
- Working Group “Juvenile Dermatomyositis” of the German Society for Paediatric and Adolescent Rheumatology (GKJR)
- X. Li
- X. Wei
- X. Xu
- Xiaomin Yu
- Y. Joubert
- Y. Joubert
- Y. Joubert
- Y. Joubert
- Y. Uziel
- Yanick Crow
- Yanick Crow
- Yanick Crow
- Yanick Crow
- Yanick J. Crow
- Yasar Karaaslan
- Yasin Bulut
- Yasuo Nakagishi
- Yasushi Kawaguchi
- Yavuz Tokgöz
- Yelda Bilginer
- Yelda Bilginer
- Yelda Bilginer
- Yelda Bilginer
- Yelda Bilginer
- Yiannis Ioannou
- Yiannis Ioannou
- Ying Hong
- Ying Hong
- Yoann Rose
- Yoann Rose
- Yonatan Butbul
- Yosef Uziel
- Yosef Uziel
- Yosef Uziel
- Yosef Uziel
- Yosuke Fujii
- Yukie Saito
- Yuksel Aliyazicioglu
- Yulia Kostina
- Yulia Kostina
- Yumi Tani
- Yunus Arıkan
- Yuridiana Ramirez
- Yuridiana Ramirez Loyola
- Yuridiana Ramírez
- Yvonne Kusche
- Z. Serap Arıcı
- Zehra Serap Arici
- Zelal Ekinci
- Zelal Ekinci
- Zelal Ekinci
- Zelal Ekinci Ekinci
- Zeno Sparchez
- Zeyad El-Habahbeh
- Zeynep Birsin Özçakar
- Zubeyde Gunduz
- Zubeyde Gunduz
- Zübeyde Gunduz
- Özge A. Gücenmez
- Özge Basaran
- Şebnem Sara Kılıc
- Publication venue
- place:236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
- Publication date
- 01/01/2017
- Field of study
Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis
- Author
- Aarts E
- Abbas Z
- Abburu S
- Abd Ghaffar Mk
- Abdelgalil R
- Abdelhadi M
- Abdikadir Hr
- Abdulmajid A
- Abdulrahman N
- Abid A
- Abid H
- Abrisqueta Carrion J
- Abuhussein N
- Abul Mh
- Acar S
- Acherman Yiz
- Acquaah F
- Acres M
- Adams R
- Adams Rd
- Adebayo Aa
- Adeleja I
- Adiyaman C
- Adjei H
- Adlan A
- Afzal Z
- Agalar C
- Agarwal V
- Agrawal M
- Ahern N
- Ahmad A
- Ahmad K
- Ahmad S
- Ahmed F
- Ahmed H
- Ahmed M
- Ahmed N
- Ahmed S
- Ahn Js
- Aidoo-Micah Ge
- Aildasani L
- Aithie Jm
- Akbulut F
- Akcaoglu T
- Akdogan A
- Akhtar S
- Akkaya E
- Akkucuk S
- Akpunarli B
- Aksoy K
- Aktas Mk
- Aktekin H
- Al-Mousawi A
- Al-Nasser A
- Al-Nasser Z
- Al-Obaedi O
- Al-Robeye A
- Albayrak D
- Alberdi San Roman I
- Alberti Delgado P
- Alcazar Montero Ja
- Alcocer Bp
- Alconchel-Gago F
- Aldrey I
- Ali A
- Ali B
- Ali H
- Ali M
- Ali S
- Alim Ye
- Aliseda-Jover D
- Alizadeh M
- Aljbour A
- Aljbour I
- Allan C
- Allen Jly
- Allot R
- Alonso Gonçalves S
- Alonso Hernandez N
- Altintas O
- Altomare Df
- Alvarez Reyes I
- Amajuoyi A
- Amarelo Garcia M
- Ambrona-Zafra D
- Amelung Fj
- Amin H
- Amin O
- Amphlett Ah
- Anabitarte O
- Anakwenze V
- Anandarajah C
- Anania G
- Anconelli D
- Anderson L
- Anderson Lb
- Anderson Rgj
- Anderson Sm
- Ang A
- Angelov S
- Anilkumar A
- Anim-Addo N
- Ankarali T
- Ansari N
- Antoniou I
- Anyan-Brown J
- Aonzo P
- Apicella M
- Aquilino F
- Aray E
- Archer Ch
- Archer M
- Arcudi C
- Arenal Jj
- Arezzo A
- Argenti F
- Arif T
- Arora E
- Arrigo A
- Arslan E
- Arslan U
- Arthurs B
- Arukan C
- Arun C
- Asbjoernsen Ca
- Ashfaq U
- Ashken L
- Ashraf S
- Ashraf Sf
- Ashton Aj
- Ashwood J
- Asik M
- Aslan L
- Aslanyan A
- Asma A
- Asmadi A
- Assadullah S
- Atalay H
- Atasoy H
- Atayi A
- Atesavci Sn
- Atif M
- Atraszkiewicz Ba
- Attalla M
- Austreng L
- Auyoung E
- Avery P
- Axelson T
- Ayaz B
- Aydar Seyi
- Aytekin A
- Aziz H
- Aziz N
- Babaoglu H
- Bach S
- Badia Jm
- Badii B
- Badran A
- Baeten Cim
- Bagaglini G
- Bagley J
- Bahcecioglu B
- Baixauli J
- Baker An
- Baker C
- Bakewell Zr
- Bakhsh A
- Baki Be
- Balagna P
- Balaji S
- Balci B
- Baldwin A
- Bali An
- Balian V
- Bamac E
- Bamgbose Fa
- Bandirmali O
- Barai I
- Barmayehvar B
- Barnes J
- Barone V
- Barrera Gomez M
- Barrow Tr
- Barthorpe Ae
- Bartlett J
- Bartlett Rd
- Barton Ec
- Bartoš M
- Bartrina Soler P
- Baskoy L
- Bassam N
- Bassett J
- Bassiony S
- Bastiaansen Ajnm
- Bath Mf
- Batho A
- Batt E
- Baykan B
- Bayoumy Ab
- Bayram S
- Bazeer Hz
- Beaver D
- Becerra Nieves M
- Beckett J
- Beecroft S
- Behar N
- Bektur G
- Belia F
- Belibagli Zo
- Bell A
- Bell L
- Bell N
- Bellinato M
- Bellio G
- Beltrán de Heredia J
- Bemand Tp
- Bemelman Wa
- Benevento A
- Benli S
- Berends F
- Bergara T
- Bernstein I
- Bertelli Puche Jl
- Besısık Hm
- Bethell Gs
- Beyatli S
- Bhanderi S
- Bhangu A
- Bhaskaran G
- Bhatt N
- Bhatti M
- Bhome R
- Bhudia R
- Bianchini S
- Bianco F
- Bilgin S
- Bilicen G
- Bilici O
- Binbuga M
- Bingham G
- Birgin Bz
- Blanco Antona F
- Blanco-Colino R
- Blege Hk
- Blessed R
- Blonk L
- Bloomer J
- Bloomfield T
- Blore Cd
- Bober Dn
- Bodur S
- Boersma Am
- Bokkerink G
- Bolat Ab
- Bolton L
- Bolton W
- Bonouvrie D
- Bonsu S
- Bookless Lr
- Boom Ms
- Borrellas A
- Bos K
- Boschetti Me
- Bose R
- Botchey S
- Botrugno Em
- Bottini C
- Boulton Aj
- Boxall N
- Boyle J
- Bozkurt Gk
- Bradley C
- Braganza L
- Brathwaite-Shirley C
- Bravo M
- Brecher J
- Bremner Rh
- Brennan C
- Brennan D
- Brennan E
- Brennan K
- Brent G
- Bresges K
- Brewer Cf
- Brewster O
- Bright M
- Britton F
- Brogan A
- Brown D
- Brown E
- Brown Ej
- Brown Fs
- Broyd A
- Brueren L
- Bruno M
- Brzyska K
- Buakuma P
- Buchan Am
- Buckle Rt
- Bucko Am
- Bulley F
- Bullman Lm
- Bullock Np
- Burger Bhcm
- Burgess A
- Burke D
- Burke E
- Burke J
- Burney Lj
- Buyukkarabacak Y
- Buyukkasap C
- Caballero Rodriguez E
- Caballero L
- Cakaloglu Hc
- Cakir E
- Cakir Sg
- Calar Sn
- Calcagno P
- Calisgan B
- Caliskan T
- Callan R
- Cammarota A
- Campbell J
- Campion A
- Can Tatar O
- Canbay Torun B
- Candilio G
- Cannavò M
- Canning E
- Canning N
- Cantelo J
- Cantimer E
- Cao Y
- Capozzolo A
- Cardwell Ae
- Carlson S
- Caro Gonzalez Mp
- Carr L
- Carr R
- Carroll Af
- Carter D
- Carthew L
- Cartwright E
- Casagranda B
- Castiglione F
- Catalano M
- Caudullo G
- Cautiero R
- Cazzola Fe
- Celen D
- Celik B
- Celik E
- Celik K
- Celik S
- Cengiz U
- Cetin Sk
- Cetinkaya M
- Ceylan C
- Chamberlain M
- Chan C
- Chan N
- Chandan N
- Chapman Sj
- Charalambos Ma
- Charalambous G
- Charania A
- Charavanamuttu V
- Chaudhary M
- Chaudhry Fi
- Chaudhry Ww
- Checa Guillen M
- Checcacci P
- Cheema H
- Cheema J
- Chen Jh
- Chen M
- Chen X
- Cheng K
- Chervenkoff J
- Cheskes L
- Chetta N
- Cheung F
- Chew L
- Chew Ls
- Chhabra A
- Chhina C
- Chilima Cp
- Chillarge G
- Chilvers Nj
- Chin H
- Chin R
- Chisholm Eg
- Chitnis Ar
- Chiu Sm
- Choi J
- Choi Pj
- Chong Bf
- Chong J
- Choo Kp
- Chrastek D
- Chua Ey
- Chung A
- Cianchi F
- Ciano P
- Ciccioli E
- Ciciliot M
- Ciftci E
- Cin S
- Cinar S
- Cise S
- Cisternino G
- Ciurleo C
- Claireaux Ha
- Claramonte Bellmunt O
- Clark Ij
- Clarke Ak
- Cleere J
- Clement Kd
- Clerico G
- Clesham K
- Clifford T
- Coates A
- Coco C
- Cody A
- Cody N
- Coffey Cj
- Coffey D
- Coffin J
- Cok H
- Cole Sj
- Collier H
- Collins A
- Collins D
- Collins P
- Collinson S
- Colombo Em
- Colombo F
- Consten Ecj
- Cooper D
- Cooper Ge
- Copley Hc
- Copley Pc
- Cornish E
- Corte M
- Coskun O
- Costa A
- Costa-Navarro D
- Cotton A
- Coughlan G
- Coulson R
- Cox Se
- Coyne P
- Craig Ar
- Craig E
- Craig-McQuaide A
- Craven K
- Cremers D
- Crewdson Ja
- Croall A
- Crozier L
- Cruciani C
- Cruz Reyes Ja
- Cuckow L
- Cullen C
- Cullen S
- Culleton G
- Cumber E
- Cumber Em
- Cumen Ec
- Cumming S
- Cundy Oj
- Cunha P
- Curletti G
- Curran A
- Cuthbert G
- Cymes W
- Córdoba-Díaz de Laspra E
- Dalci K
- Danalıoglu An
- Daoub A
- Darr S
- Das M
- Datta U
- Davies J
- Davies Je
- Davies K
- Davies N
- Davies Sc
- Davis-Hall M
- Dawar R
- Dawson Pm
- de Andres Olabarria U
- de Bernier Gl
- de Boer Dv
- De Boni D
- de Bruin M
- de Castro Smm
- de Gooyer Jm
- de Groof Ej
- de Groof J
- de Guerre Levm
- de Hingh I
- de Jesus Rodriguez Perdomo M
- de la Portilla de Juan F
- de la Rosa-Estadella M
- De la Torre Conde C
- De Luca E
- De Manzini N
- de Mees T
- De Nardi P
- de Roy van Zuidewijn D
- De Serra Tejada I
- de Vos Tot Nederveen Cappel Rj
- de Wilt H
- de Zeeuw S
- Deall C
- Dean R
- Dean S
- Dean W
- Dear K
- Deas G
- Debenham R
- Decorato A
- Deekonda P
- Del Coco F
- Del Mar López-Cuevas M
- Delf J
- Delgado At
- Deliktas Ts
- Delport A
- Demetri Am
- Demir F
- Demirci A
- Demirci K
- Demirci Zs
- Demirtas B
- Dennis R
- Dennis Yf
- Derbyshire L
- Detmers Blom Fpn
- Devabalan Y
- Devlin E
- Dewdney Cj
- Dhanji A
- Dhar M
- Dhutia Aj
- Di Benedetto L
- Di Girolami L
- Diaper C
- Diaz-Jover P
- Dickson J
- Din W
- Dindyal S
- Dinsmore L
- Doan L
- Dobson J
- Dogan H
- Dogra T
- Doherty C
- Dolaghan M
- Dolbec Ks
- Dominguez Jimenez M
- Dominguez Rodriguez Lm
- Dominguez Sanchez Jm
- Dominguez-Prieto V
- Dorman C
- Dosa T
- Doshi A
- Doyle J
- Drake Tm
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- Yilmaz S
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- Zuhair M
- Örhalmi J
- Özkan Bb
- Šimáčková B
- Široká M
- Žebrák R
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2018
- Field of study
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien\u2013Dindo Grades III\u2013V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49\u20132.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46\u20130.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease
Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta-analysis.
- Author
- 6rhalmi J
- 6zkan Bb
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- Mirdavoudi V
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- Wong C
- Wong E
- Wong V
- Wood Ad
- Woodcock N
- Woodward H
- Woon E
- Wright A
- Wright Ev
- Wye J
- Wylam D
- Wylie J
- Wynell-Mayow Wm
- Xiao C
- Xu Gx
- Xylas D
- Y\u131gman S
- Yalcin Y
- Yaman S
- Yan A
- Yang T
- Yasar C
- Yates Ja
- Yauw S
- Yavuz G
- Yazkan Z
- Yekenkurul E
- Yener A
- Yeoh Tsl
- Yetiskin E
- Yildirim N
- Yildirim R
- Yildiz S
- Yildiz Ss
- Yildiz T
- Yilmaz I
- Yilmaz M
- Yilmaz S
- Yilmaz T
- Yim N
- Yoganathan S
- Yong Cs
- Yong N
- Yoruk I
- Yousif A
- Yow L
- Yuen R
- Yuksek B
- Yuksek Ma
- Yuksel A
- Yurdaor Ss
- Yurekli Am
- Zaidi R
- Zegeye Mi
- Zengin T
- Zhang Aa
- Zhao J
- Ziff O
- Zigiotto D
- Zijlmans Jl
- Zimmerman D
- Ziprin P
- Zope S
- Zuhair M
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2018
- Field of study
AIM:
Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.
METHODS:
This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results.
RESULTS:
This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46-0.75, P < 0.001) compared to normal weight patients.
CONCLUSIONS:
In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Aage Christiansen
- Aaradhana Adhikari
- Aaron Venti
- Aayesha Qadeer
- Abdellatif Benslama
- Abigail Beane
- Abu Hena Mostafa Kamal
- Abul Faiz
- Adam B Schlichting
- Adam Bell Bell
- Adenilton M R Ampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Aftab Akhtar
- Agreta Gecaj-Gashi
- Ahmed Farooq
- Ahmed S Al Jabbary
- Ahmet Dilek
- Ahmet Sukru Denker
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Akm Shamsul Alam
- Akut Aytulun
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alastair Rose
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Bacuzzi
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandra Siqueira Colombo
- Alexandre Biasi Cavalcanti
- Alexandre Biasi Cavalcanti
- Alexandre Chan
- Alexandre Demoule
- Alexandre Guilherme Ribeiro de Carvalho
- Alexandre Molin
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alison Ghosh
- Alistair Nichol
- Alistair Roy Roy
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amadeu Martinez
- Amanda Cowton
- Amanda Krstevski
- Amanda Maria R R de Oliveira
- Amanda Skinner
- Amanda Whileman
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Amy McInerney
- Ana Carolina P Antônio
- Ana Carolina Peçanha
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anand Dongre
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Andre Japiassu
- Andre Luiz Baptiston Nunes
- Andre Luiz Baptiston Nunes
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andrej Sribar
- Andrew Bentley
- Andrew Corner
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- André Peretti Torelly
- Angela Delsing
- Angela Pinder
- Aniko D Frigyik
- Anil Hormis
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna Walker
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Annop Piriyapatsom
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio Carlos Nogueira
- Antonio G Jimenez
- Antonio Jorge Pereira
- Antonio L Ruiz-Aguilar
- Antonio P Nassar Jr
- Antonio Paulo Nassar Junior
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areef Ahsan
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arshad Taqi
- Arvind K Baronia
- Ary Serpa Neto
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Asma Navasakulpong
- Asoka Gunaratne
- Atta Ur Rehman
- Aurelia M Martinho
- Aylin Seven
- Bao H Zhu
- Barbara Brunettini
- Barbara do Cs Martins
- Barrett T Kitch
- Barry Dixon
- Barry Kennedy
- Basak Ceyda Meco
- Batoul Khoundabi
- Beatriz C Tan
- Behzad Nadjm
- Ben Creagh-Brown
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bhuvana Krishna
- Bimal Kudavidanage
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brenno Cardoso Gomes
- Brigit L Roberts
- Brit Å Sjøbø
- Bruno Franco Mazza
- Bruno Gelée
- Bruno S Oliveira
- Candelaria De Haro
- Carlo A Volta
- Carlo Alberto Volta
- Carlos A Pellegrini
- Carlos Eduardo Barboza
- Carlos Munhoz
- Carlos S Pereira
- Carly Brown
- Carmen Scott
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- Caroline Berghe
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- Cassia Righy
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- Catherine Plowright
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- Cesar Milstein
- Cesar P Pere
- Chamila Pilimatalawwe
- Charlene Bigot
- Charlene Le Moal
- Charlotte Downes
- Chathurani Sigera
- Chern Min Voon
- Cheryl Padilla-Harris
- Chinni Krishna Kasi
- Chloe Hughes
- Christian C Rylander
- Christian Dellera
- Christian Frey
- Christian M Ramirez-Alfaro
- Christian Schlegel
- Christina Whitehead
- Christine Boyd
- Christine Brown
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- Christoph Muench
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- Chunting Wang
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- Colette Seasman
- Colette Seasman
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- Corinne Leemann-Refondini
- Cristiane Ritter
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- Cristina Santos
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- Damien Roux
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- Daniel Prado
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- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
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- Daniele M Combaux
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- Ed Bajwa
- Eddy Fan
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- Eimhin S Dunne
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- Elaine Ferreira
- Eldar Søreide
- Electra E Stamou
- Elena Frati
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- Eleni K Mouloudi
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- Eliane Bernadete Caser
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- Eliezer Silva
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- Eoin Young
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- Fernando José da Silva Ramos
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- Finn H Andersen
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- Flavia Ribeiro Machado
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- Frank Van Haren
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- Fumihito Ito
- Fábio Poianas Giannini
- Gabriel Démpaire
- Gabriele Sales
- Gabrielle C Hanlon
- Gaetan Béduneau
- Galen Henderson
- Garcia M Elisabet
- Gareth P Sellors
- Gary H Mills
- Gautier Buzancais
- Gayle Clifford
- Ged Dempsey
- Gemma Rialp
- Gerard Curley
- Ghaleb Almekhlafi
- Ghanem M Mustafa
- Ghassan Kamel
- Giacomo Bellani
- Giacomo Monti
- Gianluca Zani
- Giannis A Zacharas
- Gilda Cinnella
- Giorgio A Iotti
- Giovana Colozza Mecatti
- Giovanna Occhipinti
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- Giulia Crapelli
- Giuseppe Foti
- Giuseppe Melchionda
- Gonzalo Navarro
- Greet Hermans
- Guilherme Schettino
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
- Guillermo M Albaiceta
- Gulay Eren
- Gustavo A Plotnikow
- Gustavo Affonso de Oliveira
- Gustavo M Montanha
- Gustavo Pittini
- Guy M Francois
- Gyan Kayashta
- Gyorgy Frendl
- Güldem Turan
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- Haibo Qiu
- Haibo Qiu
- Haitao Liu
- Hamidreza Jamaati
- Hanane Ezzouine
- Hannah Crowther
- Hans Kedelv
- Hans-Bernd F Hopf
- Hasan M Al Dorzi
- Hazel Spencer
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- Helen Rodgers
- Helen S Wong
- Helen Talbot
- Helen Wong
- Helena Barcraft-Barnes
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- Helga Ceunen
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- Henrik Appelberg
- Henrik Reschreiter
- Henrik Reschreiter
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- Hermann Wrigge
- Hernan Aguirre-Bermeo
- Hernan Gianinetto
- Herve Dupont
- Herve Lebbinck
- Hervé O Zender
- Hicham Balkhi
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- Hiroyuki Honda
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- Hiroyuki Tanaka
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- Jorge Salluh
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- Juan Alfonso Soler
- Juan B López-Messa
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- Luca Brazzi
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- Lucas Oliveira
- Lucia L Rodriguez
- Lucia Mirabella
- Luciana Coelho Sanches
- Luciano C Azevedo
- Luciano Cesar Azevedo
- Lucy Cooper
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- Ma X Hua
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- Mohamad M Albarrak
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- Mohammad Salim
- Mohammed Abdur Rahman Chowdhury
- Mohammed Ghazi
- Mohammedfaruk Memon
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- Mohd Basri Mat Nor
- Mohd Shahnaz Hasan
- Monica Magret
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- Mozaffer Hossain
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- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- Werner Schmid
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Y A Hasitha Dilhani
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yavuz Orak
- Yen Lam Minh
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zerrin Demirtürk
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Álvaro Réa-Neto
- Ángela Algaba
- Ángela González-Salamanca
- Çiler Zincircioglu
- Érica Aranha Suzumura
- Ênio Rego
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies.
Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality.
Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001).
Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status
Mycotoxins in Foodstuffs
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- M Mably
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- S Díaz
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- S Döll
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- S El-Dessouki
- S El-Dessouki
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- S Fujii
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- S Ghidini
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- S Horii
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- S Imwidthaya
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- S Jakšić
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- S Krivobok
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- S Kumagai
- S Kumagai
- S Kumar
- S Kumar
- S Lappalainen
- S Lappalainen
- S Lasram
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- S Lindroth
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- S Lipigorngoson
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- S Lipigorngoson
- S Lipigorngoson
- S Lo Margo
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- S MacDonald
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- T Alves Dos Reis
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- T Bertuzzi
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- T Cirillo
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- T Delgado
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- T Delgado
- T Fujisawa
- T Fujisawa
- T Fujisawa
- T Fujisawa
- T Goto
- T Goto
- T Gumus
- T Gumus
- T Gutema
- T Gutema
- T Holmberg
- T Holmberg
- T Lee
- T Lee
- T Möller
- T Möller
- T Petkova-Bocharova
- T Petkova-Bocharova
- T Romer
- T Romer
- T Singh
- T Singh
- T Sugimoto
- T Sugimoto
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Tanaka
- T Toscani
- T Toscani
- T Urano
- T Urano
- T Vrabcheva
- T Vrabcheva
- T Vrabcheva
- T Vrabcheva
- T Vrabcheva
- T Vrabcheva
- T Vrabcheva
- T Vrabcheva
- T Yaroglu
- T Yaroglu
- T Yoshizawa
- T Yoshizawa
- T Yoshizawa
- T Yoshizawa
- T Yoshizawa
- T Yoshizawa
- T Yoshizawa
- T Yoshizawa
- T Yurdun
- T Yurdun
- T Yurdun
- T Yurdun
- T-C Tseng
- T-C Tseng
- T-C Tseng
- T-C Tseng
- T-C Tseng
- T-C Tseng
- T-C Tseng
- T-C Tseng
- TA Gbodi
- TA Gbodi
- TA Reis
- TA Reis
- TA Reis Dos
- TA Reis Dos
- TB Karki
- TB Karki
- TC Alozie
- TC Alozie
- TC Campbell
- TC Campbell
- TC Hewitt
- TC Hewitt
- TC Tseng
- TC Tseng
- TC Tseng
- TC Tseng
- TC Tseng
- TC Tseng
- TC Tung
- TC Tung
- TE Möller
- TE Möller
- TE Möller
- TE Möller
- TH Çelik
- TH Çelik
- TM Legarda
- TM Legarda
- TN Bhavanishankar
- TN Bhavanishankar
- TN Gopinandhan
- TN Gopinandhan
- TN Gopinandhan
- TN Gopinandhan
- TO Adejumo
- TO Adejumo
- TO Adejumo
- TO Adejumo
- TS Trung
- TS Trung
- TS Trung
- TS Trung
- TV Milanez
- TV Milanez
- TY Rusanova
- TY Rusanova
- U Aksoy
- U Aksoy
- U Baumann
- U Baumann
- U Gündinç
- U Gündinç
- U Kamber
- U Kamber
- U Lauber
- U Lauber
- U Meister
- U Meister
- U Samarajeewa
- U Samarajeewa
- U-S Lee
- U-S Lee
- U-S Lee
- U-S Lee
- V Awashati
- V Awashati
- V Gökmen
- V Gökmen
- V Gökmen
- V Gökmen
- V Hietaniemi
- V Hietaniemi
- V Hietaniemi
- V Hietaniemi
- V Meucci
- V Meucci
- V Meucci
- V Meucci
- V Ostry
- V Ostry
- V Ostrý
- V Ostrý
- V Roscoe
- V Roscoe
- V Roussi
- V Roussi
- V Sanchis
- V Sanchis
- V Sanchis
- V Sanchis
- V Seidel
- V Seidel
- V Sewram
- V Sewram
- V Sewram
- V Sewram
- V Sewram
- V Sewram
- V Tiwari
- V Tiwari
- VA Alonso
- VA Alonso
- VA Tutelyan
- VA Tutelyan
- VA Tutelyan
- VA Tutelyan
- VA Tutelyan
- VA Tutelyan
- VE Fernandez Pinto
- VE Fernandez Pinto
- VEF Pinto
- VEF Pinto
- VF Pinto
- VF Pinto
- VG Curtui
- VG Curtui
- VH Tournas
- VH Tournas
- VK Nakai
- VK Nakai
- VMT Lattanzio
- VMT Lattanzio
- VP Srivastava
- VP Srivastava
- VPS Freitas
- VPS Freitas
- W Blaas
- W Blaas
- W Fritz
- W Fritz
- W Kandler
- W Kandler
- W Kong
- W Kong
- W Langseth
- W Langseth
- W Langseth
- W Langseth
- W Langseth
- W Langseth
- W Langseth
- W Langseth
- W Ng
- W Ng
- W Ng
- W Ng
- W Seefelder
- W Seefelder
- W Seefelder
- W Seefelder
- W Steiner
- W Steiner
- W Tassaneeyakul
- W Tassaneeyakul
- W Wei
- W Wei
- W Winterlin
- W Winterlin
- W Zhi-Gang
- W Zhi-Gang
- W-B Shim
- W-B Shim
- W-B Shim
- W-B Shim
- W-J Kong
- W-J Kong
- W-J Kong
- W-J Kong
- WC Brumley
- WC Brumley
- WCA Gelderblom
- WCA Gelderblom
- WCA Gelderblom
- WCA Gelderblom
- WF El-Tras
- WF El-Tras
- WH Hunt
- WH Hunt
- WK Rumbeiha
- WK Rumbeiha
- WM Hagler Jr
- WM Hagler Jr
- WT Corbett
- WT Corbett
- WW McMillian
- WW McMillian
- X Ding
- X Ding
- X Wu
- X Wu
- X Wu
- X Wu
- XC Wang
- XC Wang
- Y Ackermann
- Y Ackermann
- Y Adachi
- Y Hayashi
- Y Hayashi
- Y Keskin
- Y Keskin
- Y Li
- Y Li
- Y Luo
- Y Luo
- Y Luo
- Y Luo
- Y Nakatani
- Y Nakatani
- Y Nonaka
- Y Nonaka
- Y Ramakrishna
- Y Ramakrishna
- Y Rodríguez-Carrasco
- Y Rodríguez-Carrasco
- Y Rodríguez-Carrasco
- Y Rodríguez-Carrasco
- Y Sugiura
- Y Sugiura
- Y Ueno
- Y Ueno
- Y Ueno
- Y Ueno
- Y Ueno
- Y Ueno
- Y-H Leong
- Y-H Leong
- Y-W Lee
- Y-W Lee
- Y. Adachi
- YH Chong
- YH Chong
- YM Abdulrazzaq
- YM Abdulrazzaq
- YMA Idris
- YMA Idris
- YMH Younis
- YMH Younis
- YP Sharma
- YP Sharma
- YP Sharma
- YP Sharma
- YZ Feng
- YZ Feng
- Z Atanassov
- Z Atanassov
- Z Bilgrami
- Z Bilgrami
- Z Han
- Z Han
- Z Han
- Z Han
- Z Han
- Z Han
- Z Jurjevic
- Z Jurjevic
- Z Liu
- Z Liu
- Z Ngoko
- Z Ngoko
- Z Weber
- Z Weber
- Z Zheng
- Z Zheng
- Z Zheng
- Z Zheng
- Z Zou
- Z Zou
- Z-H Liu
- Z-H Liu
- ZA Shamsuddin
- ZA Shamsuddin
- ZSC Okoye
- ZSC Okoye
- ZSC Okoye
- ZSC Okoye
- Á Ambrus
- Á Ambrus
- Á Medina
- Á Medina
- Á Medina
- Á Medina
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study