Stability of twin circular tunnels in cohesive-frictional soil using the node-based smoothed finite element method (NS-FEM)

This paper presents an upper bound limit analysis procedure using the node-based smoothed finite element method (NS-FEM) and second order cone programming (SOCP) to evaluate the stability of twin circular tunnels in cohesive-frictional soils subjected to surcharge loading. At first stage, kinematically admissible displacement fields of the tunnel problems are approximated by NS-FEM using triangular elements (NS-FEM-T3). Next, commercial software Mosek is employed to deal with the optimization problems, which are formulated as second order cone. Collapse loads as well as failure mechanisms of plane strain tunnels are obtained directly by solving the optimization problems. For twin circular tunnels, the distance between centers of two parallel tunnels is the major parameter used to determine the stability. In this study, the effects of mechanical soil properties and the ratio of tunnel diameter and the depth to the tunnel stability are investigated. Numerical results are verified with those available to demonstrate the accuracy of the proposed method

Impact of a case-management intervention for reducing emergency attendance on primary care: randomised control trial

BACKGROUND: The impact on primary care workload of case-management interventions to reduce emergency department (ED) attendances is unknown. AIM: To examine the impact of a telephone-based case-management intervention targeting people with high ED attendance on primary care use. DESIGN AND SETTING: A single-site data extract from a larger randomised control trial, using the patient-level data from primary care electronic health records (2015–2020), was undertaken. METHOD: A total of 363 patients at high risk of ED usage were randomised to receive a 6-month case-management intervention (253 patients) or standard care (110 patients). Poisson regression models were used to calculate monthly rates of primary care use over time for the 2 years post-randomisation, comparing both arms. Usage was subclassified into face-to-face, telephone, letter, and community and secondary care referrals, stratified by patient demographics. RESULTS: No significant difference was found in the mean annual rate of primary care events between the intervention and control arms (P = 0.70). Secondary care referrals saw a 26% reduction in the mean annual referral rate (incident rate ratio [IRR] 0.74, 95% confidence interval [CI] = 0.64 to 0.86, P<0.001) and letters sent increased by 6% in the intervention arm compared with the control arm (IRR 1.06, 95% CI = 1.01 to 1.11, P = 0.01). In the case-managed arm, in patients aged ≥80 years there was a 33% increase in primary care usage (IRR 1.33, 95% CI = 1.28 to 1.40, P<0.001); with a corresponding 10% decrease in patients aged <80 years when compared with controls (IRR 0.90, 95% CI = 0.87 to 0.92, P<0.001). CONCLUSION: A targeted case-management intervention to reduce ED attendances did not increase overall primary care use. Redistribution of usage is seen among some patient groups, particularly older people, which may have important implications for primary healthcare planning

Engaging Audiences With Local News: Can Solutions Journalism Be a Solution to Local Media Crisis?

This article explores whether the increasingly touted power of solutions-oriented news serves as a potential measure for local media to attract and engage audiences. We take one local outlet in a London district (Chiswick) as a case study and investigate the audience’s evaluation of and engagement with two local solutions news stories during the pandemic to explore whether or not this type of journalism helps local media overcome the problem of disengagement with audiences. The findings, from in-depth interviews with 21 local news users, indicate that audiences judge local news based on their community experience and prior knowledge of local news outlets. In doing so, they may express a degree of skepticism about the positive tone of the solutions-oriented news in question. Their concerns can be explained in light of audience expectations of what Silverstone calls the “proper distance” between local journalists and their sponsors and sources. The general demand is that local news should stress its monitorial role, not a promotional one, even in small community contexts

Cerebral pressure passivity in newborns with encephalopathy undergoing therapeutic hypothermia

We extended our recent modification of the power spectral estimation approach to quantify spectral coherence. We tested both the standard and the modified approaches on simulated data, which showed that the modified approach was highly specific and sensitive to the coupling introduced in the simulation while the standard approach lacked these features. We also applied the modified and standard approaches to quantify the pressure passivity in 4 infants receiving therapeutic hypothermia. This was done by measuring the coupling between continuous cerebral hemoglobin differences and mean arterial blood pressure. Our results showed that the modified approach identified a lower pressure passivity index (PPI, percent time the coherence was above a predefined threshold) than the standard approach (P = 0.0027)

Remote Sensing Approach for Monitoring Coastal Wetland in the Mekong Delta, Vietnam: Change Trends and Their Driving Forces

Coastal wetlands in the Mekong Delta (MD), Vietnam, provide various vital ecosystem services for the region. These wetlands have experienced critical changes due to the increase in regional anthropogenic activities, global climate change, and the associated sea level rise (SLR). However, documented information and research on the dynamics and drivers of these important wetland areas remain limited for the region. The present study aims to determine the long-term dynamics of wetlands in the south-west coast of the MD using remote sensing approaches, and analyse the potential factors driving these dynamics. Wetland maps from the years 1995, 2002, 2013, and 2020 at a 15 m spatial resolution were derived from Landsat images with the aid of a hybrid classification approach. The accuracy of the wetland maps was relatively high, with overall accuracies ranging from 86–93%. The findings showed that the critical changes over the period 1995/2020 included the expansion of marine water into coastal lands, showing 129% shoreline erosion" a remarkable increase of 345% in aquaculture ponds" and a reduction of forested wetlands and rice fields/other crops by 32% and 73%, respectively. Although mangrove forests slightly increased for the period 2013/2020, the overall trend was also a reduction of 5%. Our findings show that the substantial increase in aquaculture ponds is at the expense of mangroves, forested wetlands, and rice fields/other crops, while shoreline erosion significantly affected coastal lands, especially mangrove forests. The interaction of a set of environmental and socioeconomic factors were responsible for the dynamics. In particular, SLR was identified as one of the main underlying drivers" however, the rapid changes were directly driven by policies on land-use for economic development in the region. The trends of wetland changes and SLR implicate their significant effects on environment, natural resources, food security, and likelihood of communities in the region sustaining for the long-term. These findings can assist in developing and planning appropriate management strategies and policies for wetland protection and conservation, and for sustainable development in the region

Rapid hepatic clearance of full length CCN-2/CTGF: a putative role for LRP1-mediated endocytosis

This is the final version. Available on open access from Springer via the DOI in this record.CCN-2 (connective tissue growth factor; CTGF) is a key factor in fibrosis. Plasma CCN-2 has biomarker potential in numerous fibrotic disorders, but it is unknown which pathophysiological factors determine plasma CCN-2 levels. The proteolytic amino-terminal fragment of CCN-2 is primarily eliminated by the kidney. Here, we investigated elimination and distribution profiles of full length CCN-2 by intravenous administration of recombinant CCN-2 to rodents. After bolus injection in mice, we observed a large initial distribution volume (454 mL/kg) and a fast initial clearance (120 mL/kg/min). Immunosorbent assay and immunostaining showed that CCN-2 distributed mainly to the liver and was taken up by hepatocytes. Steady state clearance in rats, determined by continuous infusion of CCN-2, was fast (45 mL/kg/min). Renal CCN-2 clearance, determined by arterial and renal vein sampling, accounted for only 12 % of total clearance. Co-infusion of CCN-2 with receptor-associated protein (RAP), an antagonist of LDL-receptor family proteins, showed that RAP prolonged CCN-2 half-life and completely prevented CCN-2 internalization by hepatocytes. This suggests that hepatic uptake of CCN-2 is mediated by a RAP-sensitive mechanism most likely involving LRP1, a member of the LDL-receptor family involved in hepatic clearance of various plasma proteins. Surface plasmon resonance binding studies confirmed that CCN-2 is an LRP1 ligand. Co-infusion of CCN-2 with an excess of the heparan sulphate-binding protamine lowered the large initial distribution volume of CCN-2 by 88 % and reduced interstitial staining of CCN-2, suggesting binding of CCN-2 to heparan sulphate proteoglycans (HSPGs). Protamine did not affect clearance rate, indicating that RAP-sensitive clearance of CCN-2 is HSPG independent. In conclusion, unlike its amino-terminal fragment which is cleared by the kidney, full length CCN-2 is primarily eliminated by the liver via a fast RAP-sensitive, probably LRP1-dependent pathway.FibroGen, Inc

Mapping for engagement: setting up a community based participatory research project to reach underserved communities at risk for Hepatitis C in Ho Chi Minh City, Vietnam

Background: Approximately 1. 07 million people in Vietnam are infected with hepatitis C virus (HCV). To address this epidemic, the South East Asian Research Collaborative in Hepatitis (SEARCH) launched a 600-patient cohort study and two clinical trials, both investigating shortened treatment strategies for chronic HCV infection with direct-acting antiviral drugs. We conducted ethnographic research with a subset of trial participants and found that the majority were aware of HCV infection and its implications and were motivated to seek treatment. However, people who inject drugs (PWID), and other groups at risk for HCV were under-represented, although injecting drug use is associated with high rates of HCV. Material and Methods: We designed a community-based participatory research (CBPR) study to engage in dialogues surrounding HCV and other community-prioritized health issues with underserved groups at risk for HCV in Ho Chi Minh City. The project consists of three phases: situation analysis, CBPR implementation, and dissemination. In this paper, we describe the results of the first phase (i.e., the situation analysis) in which we conducted desk research and organized stakeholder mapping meetings with representatives from local non-government and community-based organizations where we used participatory research methods to identify and analyze key stakeholders working with underserved populations. Results: Twenty six institutions or groups working with the key underserved populations were identified. Insights about the challenges and dynamics of underserved communities were also gathered. Two working groups made up of representatives from the NGO and CBO level were formed. Discussion: Using the information provided by local key stakeholders to shape the project has helped us to build solid relationships, give the groups a sense of ownership from the early stages, and made the project more context specific. These steps are not only important preliminary steps for participatory studies but also for other research that takes place within the communities

Nonlinear thermoelectric response of quantum dots: renormalized dual fermions out of equilibrium

The thermoelectric transport properties of nanostructured devices continue to attract attention from theorists and experimentalist alike as the spatial confinement allows for a controlled approach to transport properties of correlated matter. Most of the existing work, however, focuses on thermoelectric transport in the linear regime despite the fact that the nonlinear conductance of correlated quantum dots has been studied in some detail throughout the last decade. Here, we review our recent work on the effect of particle-hole asymmetry on the nonlinear transport properties in the vicinity of the strong coupling limit of Kondo-correlated quantum dots and extend the underlying method, a renormalized superperturbation theory on the Keldysh contour, to the thermal conductance in the nonlinear regime. We determine the charge, energy, and heat current through the nanostructure and study the nonlinear transport coefficients, the entropy production, and the fate of the Wiedemann-Franz law in the non-thermal steady-state. Our approach is based on a renormalized perturbation theory in terms of dual fermions around the particle-hole symmetric strong-coupling limit.Comment: chapter contributed to 'New Materials for Thermoelectric Applications: Theory and Experiment' Springer Series: NATO Science for Peace and Security Series - B: Physics and Biophysics, Veljko Zlatic (Editor), Alex Hewson (Editor). ISBN: 978-9400749863 (2012

Experimental violation of a Bell's inequality in time with weak measurement

The violation of J. Bell's inequality with two entangled and spatially separated quantum two- level systems (TLS) is often considered as the most prominent demonstration that nature does not obey ?local realism?. Under different but related assumptions of "macrorealism", plausible for macroscopic systems, Leggett and Garg derived a similar inequality for a single degree of freedom undergoing coherent oscillations and being measured at successive times. Such a "Bell's inequality in time", which should be violated by a quantum TLS, is tested here. In this work, the TLS is a superconducting quantum circuit whose Rabi oscillations are continuously driven while it is continuously and weakly measured. The time correlations present at the detector output agree with quantum-mechanical predictions and violate the inequality by 5 standard deviations.Comment: 26 pages including 10 figures, preprint forma

Quantifying mangrove leaf area index from Sentinel-2 imagery using hybrid models and active learning

Environmental Biolog