773 research outputs found

    Conversion Condominium Development: An Issue of Tenants\u27 Rights

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    It is against the backdrop of burgeoning condominium conversion activity, rental housing shortages and diverse legislative controls that this Note will examine the issue of tenant protection as it has developed in Ohio. The consideration given to conversion condominium development in the 1978 amendments to the Ohio Condominium Property Act creates minimal, if any, protection for either tenants or the rental housing market. This Note will critically examine the pertinent provision of the Ohio Act, outline the municipal tenant protection laws which have subsequently been enacted in metropolitan Cleveland communities and consider the issue of whether these local conversion regulations are a valid exercise of Home Rule power. Finally, the relative merits of state versus local legislation will be discussed

    Archeological Survey Of Proposed VA Outpatient Clinic In The City Of Lubbock, Lubbock County, Texas

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    This report documents the results of an intensive archeological survey carried out in advance of construction of a proposed U.S. Veterans Affairs (VA) outpatient clinic on 14 acres owned by Texas Tech University Health Sciences Center in Lubbock, Texas. The survey was conducted in compliance with the Antiquities Code of Texas under Permit No. 8415. Archeologists from AmaTerra Environmental, Inc. (AmaTerra) visually inspected the entire Area of Potential Effects (APE) and excavated 7 shovel tests in support of the survey. No new archeological sites were discovered as a result of the survey and no artifacts were observed within the APE. No artifacts were collected during this survey, but a field records and photographs were made during investigations. These records and photographs are to be permanently housed at the Texas Archeological Research Laboratory (TARL) in Austin. AmaTerra recommends that no further archeological work is warranted prior to construction

    Archeological Investigations At The Old Pecos Cemetery (41RV127), Reeves County, Texas

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    This report summarizes the results of archeological and historical investigations for the Old Pecos Cemetery in Pecos City, Reeves County, Texas. Colgate Energy plans to purchase the area around the cemetery and construct oil and gas facilities on that property. The Old Pecos Cemetery contains graves interred from 1881 to around 1910. It occupies an area of about 0.33 acres and is known to contain many unmarked burials. Colgate Energy hired AmaTerra in August 2017 to investigate outside the fenced limits of the cemetery, to determine whether any unmarked graves are located outside it, and if so, determine the extent of the graves so that they can be avoided. The land is currently owned by Reeves County, a political subdivision of the State of Texas. Therefore, an Antiquities Permit was required under the Antiquities Code of Texas. Work was conducted under Permit No. 8138 and consisted of visual inspection, mechanical scraping using a road grader, and archival research. The survey documented 51 unmarked grave shafts and 10 surface features that likely represent graves within an area encompassing approximately 4.2 acres. AmaTerra documented the expanded cemetery as site 41RV127, and has recorded the new boundary at the Reeves County Clerk’s Office, as required under Chapter 711.011 of the Texas Health and Safety Code. This report recommends that the cemetery 41RV127 is of undetermined eligibility as a State Antiquities Landmark; and further recommends fencing the new cemetery boundary to avoid impacts to marked and unmarked graves within it. No artifacts were collected during the survey, but all notes and records from field investigation will be curated the Center for Archaeological Studies at Texas State University in San Marcos

    Applying Choosing Wisely: Antinuclear Antibody (ANA) and Sub-Serology Testing in a Safety Net Hospital System.

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    ObjectiveIn 2013, the American College of Rheumatology (ACR) participated in the Choosing Wisely campaign and devised a recommendation to avoid testing antinuclear antibody (ANA) subserologies without a positive ANA and clinical suspicion of disease. The goals of our study were to describe ANA and subserology ordering practices and predictors of ordering concurrent ANA and subserologies in a safety-net hospital.MethodsWe identified ANA and subserologies (dsDNA, Sm, RNP, SSA, SSB, Scl-70 and centromere) completed at Denver Health between 1/1/2005 and 12/31/2011. Variables included demographics, primary insurance, service, and setting from which the test was ordered. We performed multivariable logistic regression to determine predictors of concurrent ordering of ANA and subserologies.ResultsDuring seven years, 3221 ANA were performed in 2771 individuals and 211 (6.6%) were performed concurrently with at least one subserology. The most common concurrent subserologies were dsDNA (21.8%), SSA (20.8%), and SSB (19.7%). In the multivariable logistic analysis, significant predictors of concurrent ANA and subserologies were the labs being ordered from subspecialty care (OR 8.12, 95% CI 5.27-12.50, p-value <0.0001) or from urgent/inpatient care (OR 3.86, 95% CI 1.78-8.38, p-value 0.001). A significant predictor of decreased odds was male gender (OR 0.32, 95% CI 0.21-0.49, p-value <0.0001). Five individuals (2.2% of the negative ANA with subserologies ordered) had a negative ANA but positive subserologies.ConclusionOf 3221 ANA, 6.6% were performed concurrently with subserologies, and subspecialists were more likely to order concurrent tests. A negative ANA predicted negative subserologies with rare exceptions, which validates the ACR's recommendations

    Coarse-graining protein energetics in sequence variables

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    We show that cluster expansions (CE), previously used to model solid-state materials with binary or ternary configurational disorder, can be extended to the protein design problem. We present a generalized CE framework, in which properties such as energy can be unambiguously expanded in the amino-acid sequence space. The CE coarse grains over nonsequence degrees of freedom (e.g., side-chain conformations) and thereby simplifies the problem of designing proteins, or predicting the compatibility of a sequence with a given structure, by many orders of magnitude. The CE is physically transparent, and can be evaluated through linear regression on the energies of training sequences. We show, as example, that good prediction accuracy is obtained with up to pairwise interactions for a coiled-coil backbone, and that triplet interactions are important in the energetics of a more globular zinc-finger backbone.Comment: 10 pages, 3 figure

    A Search for High-Energy Counterparts to Fast Radio Bursts

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    We report on a search for high-energy counterparts to fast radio bursts (FRBs) with the Fermi Gamma-ray Burst Monitor (GBM), Fermi Large Area Telescope (LAT), and the Neil Gehrels Swift Observatory Burst Alert Telescope (BAT). We find no significant associations for any of the 23 FRBs in our sample, but report upper limits to the high-energy fluence for each on timescales of 0.1, 1, 10, and 100 s. We report lower limits on the ratio of the radio to high-energy fluence, frfÎł\frac{f_{r}}{f_{\gamma}}, for timescales of 0.1 and 100 s. We discuss the implications of our non-detections on various proposed progenitor models for FRBs, including analogs of giant pulses from the Crab pulsar and hyperflares from magnetars. This work demonstrates the utility of analyses of high-energy data for FRBs in tracking down the nature of these elusive sources

    DO the FERMI GAMMA-RAY BURST MONITOR and SWIFT BURST ALERT TELESCOPE SEE the SAME SHORT GAMMA-RAY BURSTS?

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    Compact binary system mergers are expected to generate gravitational radiation detectable by ground-based interferometers. A subset of these, the merger of a neutron star with another neutron star or a black hole, are also the most popular model for the production of short gamma-ray bursts (GRBs). The Swift Burst Alert Telescope (BAT) and the Fermi Gamma-ray Burst Monitor (GBM) trigger on short GRBs (SGRBs) at rates that reflect their relative sky exposures, with the BAT detecting 10 per year compared to about 45 for GBM. We examine the SGRB populations detected by Swift BAT and Fermi GBM. We find that the Swift BAT triggers on weaker SGRBs than Fermi GBM, providing they occur close to the center of the BAT field of view, and that the Fermi GBM SGRB detection threshold remains flatter across its field of view. Overall, these effects combine to give the instruments the same average sensitivity, and account for the SGRBs that trigger one instrument but not the other. We do not find any evidence that the BAT and GBM are detecting significantly different populations of SGRBs. Both instruments can detect untriggered SGRBs using ground searches seeded with time and position. The detection of SGRBs below the on-board triggering sensitivities of Swift BAT and Fermi GBM increases the possibility of detecting and localizing the electromagnetic counterparts of gravitational wave (GW) events seen by the new generation of GW detectors

    An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels

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    Slow inactivation of Kv1 channels involves conformational changes near the selectivity filter. We examine such changes in Shaker channels lacking fast inactivation by considering the consequences of mutating two residues, T449 just external to the selectivity filter and V438 in the pore helix near the bottom of the selectivity filter. Single mutant T449F channels with the native V438 inactivate very slowly, and the canonical foot-in-the-door effect of extracellular tetraethylammonium (TEA) is not only absent, but the time course of slow inactivation is accelerated by TEA. The V438A mutation dramatically speeds inactivation in T449F channels, and TEA slows inactivation exactly as predicted by the foot-in-the-door model. We propose that TEA has this effect on V438A/T449F channels because the V438A mutation produces allosteric consequences within the selectivity filter and may reorient the aromatic ring at position 449. We investigated the possibility that the blocker promotes the collapse of the outer vestibule (spring-in-the-door) in single mutant T449F channels by an electrostatic attraction between a cationic TEA and the quadrupole moments of the four aromatic rings. To test this idea, we used in vivo nonsense suppression to serially fluorinate the introduced aromatic ring at the 449 position, a manipulation that withdraws electrons from the aromatic face with little effect on the shape, net charge, or hydrophobicity of the aromatic ring. Progressive fluorination causes monotonically enhanced rates of inactivation. In further agreement with our working hypothesis, increasing fluorination of the aromatic gradually transforms the TEA effect from spring-in-the-door to foot-in-the-door. We further substantiate our electrostatic hypothesis by quantum mechanical calculations
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