A systematic review of qualitative studies capturing the subjective experiences of Gay and Lesbian individuals’ of faith or religious affiliation

Individuals identifying as religious tend to report better health and happiness regardless of affiliation, work and family social support or financial status. Evidence suggests that cultural factors are intertwined with these concepts. Exploration of sexual minorities’ experiences has been neglected in previous years. Recently, a body of evidence is developing concerning this population, with theoretical speculation for changes of ‘stressors’ for future generations and implications, particularly, on mental health outcomes. Lesbian and Gay individuals of faith (or spirituality), are susceptible to unique ‘stressors’, whilst others suggest religion can provide a support network providing protective health benefits. This review systematically explores the existing published evidence for the subjective experiences and accounts of LG people of faith. Sexual minority individuals who follow a religion or faith can experience good social support, reducing the risk of negative health outcomes, while for others, potentially serious, negative mental and physical health consequences are experienced (e.g., internalised homophobia, anxiety, rejection and suicidal ideation)

Review: The Journal of Dramaturgy, volume 19, issue 2

Contents include: For the Record; An Introduction; Recognition for City of Wine, Brian Quirt, recipient of the 2009 Elliott Hayes Award Introduced by LMDA President Shelley Orr; Brian Quirt\u27s Elliott Hayes Acceptance Speech Washington, D.C. Watergate Restaurant July 18, 2009; Being Dramaturgical, A Conversation about Geoff Proehl\u27s New Book Toward a Dramaturgical Sensibility; Beyond Hamlet: Three Theatre Developments in Denmark; The Alexandrinsky and Renaissancing the Cultural Theatre Medium; The Acting and Dramaturgy of Odin Teatret; A Production Dramaturg and an Installation Dramaturg Discuss Their Approaches to Making Art. Issue editors: D.J. Hopkins, Lauren Beckhttps://soundideas.pugetsound.edu/lmdareview/1039/thumbnail.jp

Review: The Journal of Dramaturgy, volume 21, issue 2

Contents include: Celebrating 25 Years of Review; On African American Dramaturgy One Professional\u27s Personal Response; The Revolution Will Not Be Televised, But Can It Theatricalized?; Tahrir Stories Excerpts From A Verbatim Theatre Project Composed and Performed During the 2011 Egyptian Revolution; Introduction to the review of Burning the House: On Directing and Dramaturgy, by Eugenio Barba; Eugenio Barba\u27s On Directing and Dramaturgy: Burning the House; A Servant of Two or Three or Four or More...Masters, Business Advice for Dramaturgs Working in Virgin Territory; Bryan Doerries\u27s Theater of War, A New Incarnation of an Ancient Ritual. Issue editors: D.J. Hopkins, Sydney Cheek O\u27Donnell, Lauren Beckhttps://soundideas.pugetsound.edu/lmdareview/1042/thumbnail.jp

Review: The Newsletter of the Literary Managers and Dramaturgs of the Americas, volume 16, issue 2

Contents include: Driving, LMDA Conference 2006: Think Dramaturgically, Act Locally, Words of Welcome from the Conference Committee, Developing a Sense of Community: Reflections on the Balance of a Community Engagement and Artistic Integrity while Creating a Dramaturg-Driven Documentary Play, In Print: The Seattle Public Library Introduction, The Seattle Public Library: A Conversation, Dramaturgy as Catalyst: A Rockies Dramaturg Driven Project, and American Playwrights and Playwriting. Issue editors: D.J. Hopkins, Shelley Orr, Madeleine Oldhamhttps://soundideas.pugetsound.edu/lmdareview/1033/thumbnail.jp

LMDA\u27s 20th Aniversary 1985-2005: Celebrating the First Twenty Years

Contents include: Introduction: Only the Beginning..., A Brief History of LMDA, LMDA Canada - A History, Being There: Chance Memories of a Kitchen Dog, Interviews with the Past Presidents of LMDA, The LMDA Lifetime Achievement Award: Portraits of the Lessing Award, The Elliott Hayes Award: A Thumbprint History, LMDA\u27s Residency Programs, LMDA: A Living Chronology, Afterward: Looking Forward to Looking Ahead

Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells

Treatment failure in pediatric acute lymphoblastic leukemia (ALL) is related to cellular resistance to glucocorticoids (eg, prednisolone). Recently, we demonstrated that genes associated with glucose metabolism are differentially expressed between prednisolone-sensitive and prednisolone-resistant precursor B-lineage leukemic patients. Here, we show that prednisolone resistance is associated with increased glucose consumption and that inhibition of glycolysis sensitizes prednisolone-resistant ALL cell lines to glucocorticoids. Treatment of prednisolone-resistant Jurkat and Molt4 cells with 2-deoxy-D-glucose (2-DG), lonidamine (LND), or3-bromopyruvate (3-BrPA) increased the in vitro sensitivity to glucocorticoids, while treatment of the prednisolone-sensitive cell lines Tom-1 and RS4; 11 did not influence drug cyto-toxicity. This sensitizing effect of the glycolysis inhibitors in glucocorticoid-resistant ALL cells was not found for other classes of antileukemic drugs (ie, vincris-tine and daunorubicin). Moreover, down-regulation of the expression of GAPDH by RNA interference also sensitized to prednisolone, comparable with treatment with glycolytic inhibitors. Importantly, the ability of 2-DG to reverse glucocorticoid resistance was not limited to cell lines, but was also observed in isolated primary ALL cells from patients. Together, these findings indicate the importance of the glycolytic pathway in glucocorticoid resistance in ALL and suggest that targeting glycolysis is a viable strategy for modulating prednisolone resistance in ALL

Review: The Newsletter of the Literary Managers and Dramaturgs of the Americas, volume 15, issue 2

Contents include: Shopping=Theatre: Re-Staging Retail in NYC, LMDA\u27s Prez On Our Upcoming Extravaganza in the Lone Star State, Confessions of an Early Career Dramaturg, Dramablog, Dramaturging Education, Educating Dramturgs, Henier Muller on 42nd Street, LMDA\u27s Dramaturg Driven Project Gets Under Way, LMDA Regional Updates Issue editors: D.J. Hopkins, Shelley Orr, Megan Monaghan, Madeleine Oldhamhttps://soundideas.pugetsound.edu/lmdareview/1031/thumbnail.jp

Crystal structure of dichlorido(4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane)iron(III) hexafluoridophosphate

The title compound, [FeCl₂(C₁₄H₃₀N₄)]PF₆, contains Fe³⁺ coordinated by the four nitro­gen atoms of an ethyl­ene cross-bridged cyclam macrocycle and two cis chloride ligands in a distorted octa­hedral environment. In contrast to other similar compounds this is a monomer. Inter­molecular C-H...Cl inter­actions exist in the structure between the complex ions. Comparison with the mononuclear Fe²⁺ complex of the same ligand shows that the smaller Fe³⁺ ion is more fully engulfed by the cavity of the bicyclic ligand. Comparison with the μ-oxido dinuclear complex of an unsubstituted ligand of the same size demonstrates that the methyl groups of 4,11-dimethyl-1,4,8,11-tetra­aza­bicyclo­[6.6.2]hexa­decane prevent dimerization upon oxidation

Optimizing colorectal cancer screening by race and sex

BACKGROUND: Colorectal cancer (CRC) risk varies by race and sex. This study, 1 of 2 microsimulation analyses to inform the 2018 American Cancer Society CRC screening guideline, explored the influence of race and sex on optimal CRC screening strategies. METHODS: Two Cancer Intervention and Surveillance Modeling Network microsimulation models, informed by US incidence data, were used to evaluate a variety of screening methods, ages to start and stop, and intervals for 4 demographic subgroups (black and white males and females) under 2 scenarios for the projected lifetime CRC risk for 40-year-olds: 1) assuming that risk had remained stable since the early screening era and 2) assuming that risk had increased proportionally to observed incidence trends under the age of 40 years. Model-based screening recommendations were based on the predicted level of benefit (life-years gained) and burden (required number of colonoscopies), the incremental burden-to-benefit ratio, and the relative efficiency in comparison with strategies with similar burdens. RESULTS: When lifetime CRC risk was assumed to be stable over time, the models differed in the recommended age to start screening for whites (45 vs 50 years) but consistently recommended screening from the age of 45 years for blacks. When CRC risk was assumed to be increased, the models recommended starting at the age of 45 years, regardless of race and sex. Strategies recommended under both scenarios included colonoscopy every 10 or 15 years, annual fecal immunochemical testing, and computed tomographic colonography every 5 years through the age of 75 years. CONCLUSIONS: Microsimulation modeling suggests that CRC screening should be considered from the age of 45 years for blacks and for whites if the lifetime risk has increased proportionally to the incidence for younger adults