Bis[4-amino-N-(pyrimidin-2-yl-κN)benzene­sulfonamidato-κN](4,4′-di­methyl-2,2′-bipyridine-κ2 N,N′)cadmium dimethyl­formamide disolvate

In the title compound, [Cd(C10H9N4O2S)2(C12H12N2)]·2C3H7NO, the CdII ion lies on a twofold rotation axis, is six-coordinated by N atoms, and displays a trigonal–prismatic geometry arising from the two sulfadiazinate ligands and one 4,4′-dimethyl-2,2′-bipyridine ligand. Both ligands are bidentate and coordinate via their N atoms. The O and carbonyl C atoms of the dimethyl­formamide mol­ecule show disorder and were modelled with two different orientations and with site occupancies of 0.584 (10):0.416 (10). The geometry around the sulfadiazine S atom is distorted tetra­hedral. The crystal structure involves N—H⋯O hydrogen bonds which link mol­ecules into a three-dimensional network. Weak C—H⋯O hydrogen bonds are also observed

Experimental and Simulation Study of a High Current 1D Silicon Nanowire Transistor Using Heavily Doped Channels

Silicon nanowires have numerous potential applications, including transistors, memories, photovoltaics, biosensors and qubits [1]. Fabricating a nanowire with the required characteristics for a specific application, however, poses some challenges. For example, a major challenge is that, as the transistors dimensions are reduced, it is difficult to maintain a low off-current (Ioff) whilst simultaneously maintaining a high on-current (Ion). Some sources of this parasitic leakage current include quantum mechanical tunnelling, short channel effects and statistical variability [2, 3]. A variety of new architectures, including ultra-thin silicon-on-insulator (SOI), double gate, FinFETs, tri-gate, junctionless and gate all-around (GAA) nanowire transistors, have therefore been developed to improve the electrostatic control of the conducting channel. This is essential since a low Ioff implies low static power dissipation and it will therefore improve power management in the multi-billion transistors circuits employed globally in microprocessors, sensors and memories

Experimental and simulation study of 1D silicon nanowire transistors using heavily doped channels

The experimental results from 8 nm diameter silicon nanowire junctionless field effect transistors with gate lengths of 150 nm are presented that demonstrate on-currents up to 1.15 mA/m for 1.0 V and 2.52 mA/m for 1.8 V gate overdrive with an off-current set at 100 nA/m. On- to off-current ratios above 108 with a subthreshold slope of 66 mV/dec are demonstrated at 25 oC. Simulations using drift-diffusion which include densitygradient quantum corrections provide excellent agreement with the experimental results. The simulations demonstrate that the present silicon-dioxide gate dielectric only allows the gate to be scaled to 25 nm length before short-channel effects significantly reduce the performance. If high-K dielectrics replace some parts of the silicon dioxide then the technology can be scaled to at least 10 nm gatelength

Topotecan-vincristine-doxorubicin in stage 4 high risk neuroblastoma patients failing to achieve a complete metastatic response to rapid COJEC : a SIOPEN study

Purpose : Metastatic response to induction therapy for high-risk neuroblastoma is a prognostic factor. In the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) HR-NBL-1 protocol, only patients with metastatic complete response (CR) or partial response (PR) with <= three abnormal skeletal areas on iodine 123-metaiodobenzylguanidine ([I-123] mIBG) scintigraphy and no bone marrow disease proceed to high dose therapy (HDT). In this study, topotecan-vincristine-doxorubicin (TVD) was evaluated in patients failing to achieve these criteria, with the aim of improving the metastatic response rate. Materials and Methods : Patients with metastatic high-risk neuroblastoma who had not achieved the SIOPEN criteria for HDT after induction received two courses of topotecan 1.5 mg/m(2)/day for 5 days, followed by a 48-hour infusion of vincristine, 2 mg/m(2), and doxorubicin, 45 mg/m(2). Results : Sixty-three patients were eligible and evaluable. Following two courses of TVD, four (6.4%) patients had an overall CR, while 28 (44.4%) had a PR with a combined response rate of 50.8% (95% confidence interval [CI], 37.9 to 63.6). Of these, 23 patients achieved a metastatic CR or a PR with <= 3 mIBG skeletal areas and no bone marrow disease (36.5%; 95% CI, 24.7 to 49.6) and were eligible to receive HDT. Toxicity was mostly haematological, affecting 106 of the 126 courses (84.1%; 95% CI, 76.5 to 90.0), and dose reduction was necessary in six patients. Stomatitis was the second most common nonhematological toxicity, occurring in 20 patients (31.7%). Conclusion : TVD was effective in improving the response rate of high-risk neuroblastoma patients after induction with COJEC enabling them to proceed to HDT. However, the long-term benefits of TVD needs to be determined in randomized clinical trials

Using lanthanide ions in molecular bioimaging

Trivalent lanthanide ions offer remarkable opportunities in the design of bioimaging agents: this review presents an accessible discussion of their application in both optical and magnetic resonance imaging. Aspects of molecular design, control over key physical properties and biological compatibility are discussed in this context, together with developments and opportunities as responsive probes and in multimodal imaging

Complex dynamics of elementary cellular automata emerging from chaotic rules

We show techniques of analyzing complex dynamics of cellular automata (CA) with chaotic behaviour. CA are well known computational substrates for studying emergent collective behaviour, complexity, randomness and interaction between order and chaotic systems. A number of attempts have been made to classify CA functions on their space-time dynamics and to predict behaviour of any given function. Examples include mechanical computation, \lambda{} and Z-parameters, mean field theory, differential equations and number conserving features. We aim to classify CA based on their behaviour when they act in a historical mode, i.e. as CA with memory. We demonstrate that cell-state transition rules enriched with memory quickly transform a chaotic system converging to a complex global behaviour from almost any initial condition. Thus just in few steps we can select chaotic rules without exhaustive computational experiments or recurring to additional parameters. We provide analysis of well-known chaotic functions in one-dimensional CA, and decompose dynamics of the automata using majority memory exploring glider dynamics and reactions

Physical, chemical and biological variability in the Dr. C. Gelsi reservoir(NW Argentine) : a temporal and spatial approach

With the purpose of understanding the phytoplankton dynamics in two vertical profiles of the Dr. C. Gelsi reservoir (Tucumán, Argentina, monthly samplings were conducted from October 1997 to March 1999 in the limnetic zone and at the intersection of the Salí and Tapia tributary. The reservoir was characterized as warm monomictic, with bicarbonate, chloride, sodium, calcium and/or magnesium waters. In both sites total nitrogen concentration was higher than 1 mg/l, whereas that of orthophosphate reached 0.2 mg/l. Out of the eleven organochlorine pesticides analyzed, the presence mainly of lindane and methoxychlor, with higher concentrations in the warm months was confirmed. Bacterial load values were compatible with water quality standards, and variations in the number of actinomycetes colonies in the sediments were correlated, among other parameters, with dissolved oxygen. In the two zones studied a total of 57 phytoplankton taxa, 49 % green algae, 37 % diatoms, 9 % Cyanobacteria and 5 % dinoflagelates, were identified. Central diatoms (Aulacoseira granulata and Cyclotella meneghiniana) prevailed in the phytoplankton and, in a lesser degree, the other groups, low values of specific diversity being obtained. A principal components analysis based on the absolute abundance of species and on some physico-chemical parameters ordinated the samples of the various levels, this abundance being more evident in the limnetic zone. There was also a tendency to the separation of stratifications from the two consecutive years and homogeneity in the samples from the mixing period was noticed. On the basis of the saprobic index, water quality was from β − α-mesosaprobic to α-mesosaprobic.Con el objeto de interpretar la dinámica del fitoplancton en dos perfiles verticales del embalse Dr. C. Gelsi (Tucumán, Argentina), se realizaron muestreos mensuales desde octubre de 1997 a marzo de 1999, en la zona limnética y en la intersección de los tributarios, ríos Salí y Tapia. El embalse fue caracterizado como monomíctico cálido, con aguas bicarbonatadas, cloruradas, sódicas, cálcicas y/o magnésicas. En ambos sitios, la concentración media de nitrógeno total fue superior a 1 mg/l, mientras que la de ortofosfato llegó a 0.2 mg/l. De los once plaguicidas organoclorados analizados se comprobó, principalmente, la presencia de lindano y metoxicloro, con concentraciones más elevadas en los meses cálidos. Los valores de carga bacteriana fueron compatibles con las normas de calidad de agua y las variaciones del número de colonias de actinomycetes en los sedimentos estuvieron correlacionadas entre otros parámetros con el oxígeno disuelto. En las dos zonas estudiadas se identificaron un total de 57 taxones: 49 % algas verdes, 37 % diatomeas, 9 % Cyanobacteria y 5 % dinoflagelados. Las diatomeas centrales (Aulacoseira granulata y Cyclotella meneghiniana) predominaron en el fitoplancton y en menor orden, los otros grupos, obteniéndose bajos valores de diversidad específica. Los análisis de componentes principales basados en la abundancia absoluta de las especies y en algunos parámetros fisicoquímicos, ordenaron las muestras de los distintos niveles, siendo ésta más evidente en la zona limnética. Asimismo, hubo una tendencia a la separación de las estratificaciones de los dos años consecutivos y se observó homogeneidad en las muestras provenientes del período de mezcla. Sobre la base del índice sapróbico, la calidad del agua fue β − α-mesosapróbicas a α-mesosapróbicas

Reabilitação bimaxilar implanto-suportada num paciente desdentado total : caso clínico

Poster apresentado no XXV Congresso da Ordem dos Médicos Dentistas. 10-12 Novembro 2016, Exponor, Matosinhos, PortugalN/