658 research outputs found
Experimental and Simulation Study of a High Current 1D Silicon Nanowire Transistor Using Heavily Doped Channels
Silicon nanowires have numerous potential applications, including transistors, memories, photovoltaics, biosensors and qubits [1]. Fabricating a nanowire with the required characteristics for a specific application, however, poses some challenges. For example, a major challenge is that, as the transistors dimensions are reduced, it is difficult to maintain a low off-current (Ioff) whilst simultaneously maintaining a high on-current (Ion). Some sources of this parasitic leakage current include quantum mechanical tunnelling, short channel effects and statistical variability [2, 3]. A variety of new architectures, including ultra-thin silicon-on-insulator (SOI), double gate, FinFETs, tri-gate, junctionless and gate all-around (GAA) nanowire transistors, have therefore been developed to improve the electrostatic control of the conducting channel. This is essential since a low Ioff implies low static power dissipation and it will therefore improve power management in the multi-billion transistors circuits employed globally in microprocessors, sensors and memories
Experimental and simulation study of 1D silicon nanowire transistors using heavily doped channels
The experimental results from 8 nm diameter silicon nanowire junctionless field effect transistors with gate lengths of 150 nm are presented that demonstrate on-currents up to 1.15 mA/m for 1.0 V and 2.52 mA/m for 1.8 V gate overdrive with an off-current set at 100 nA/m. On- to off-current ratios above 108 with a subthreshold slope of 66 mV/dec are demonstrated at 25 oC. Simulations using drift-diffusion which include densitygradient quantum corrections provide excellent agreement with the experimental results. The simulations demonstrate that the present silicon-dioxide gate dielectric only allows the gate to be scaled to 25 nm length before short-channel effects significantly reduce the performance. If high-K dielectrics replace some parts of the silicon dioxide then the technology can be scaled to at least 10 nm gatelength
Application of latent semantic analysis for open-ended responses in a large, epidemiologic study
Nivolumab and brentuximab vedotin with or without bendamustine for R/R Hodgkin lymphoma in children, adolescents, and young adults
Children, adolescents, and young adults (CAYA) with relapsed/refractory (R/R) classic Hodgkin lymphoma (cHL) without complete metabolic response (CMR) before autologous hematopoietic cell transplantation (auto-HCT) have poor survival outcomes. CheckMate 744, a phase 2 study for CAYA (aged 5-30 years) with R/R cHL, evaluated a risk-stratified, response-adapted approach with nivolumab plus brentuximab vedotin (BV) followed by BV plus bendamustine for patients with suboptimal response. Risk stratification was primarily based on time to relapse, prior treatment, and presence of B symptoms. We present the primary analysis of the standard-risk cohort. Data from the low-risk cohort are reported separately. Patients received 4 induction cycles with nivolumab plus BV; those without CMR (Deauville score >3, Lugano 2014) received BV plus bendamustine intensification. Patients with CMR after induction or intensification proceeded to consolidation (high-dose chemotherapy/auto-HCT per protocol). Primary end point was CMR any time before consolidation. Forty-four patients were treated. Median age was 16 years. At a minimum follow-up of 15.6 months, 43 patients received 4 induction cycles (1 discontinued), 11 of whom received intensification; 32 proceeded to consolidation. CMR rate was 59% after induction with nivolumab plus BV and 94% any time before consolidation (nivolumab plus BV ± BV plus bendamustine). One-year progression-free survival rate was 91%. During induction, 18% of patients experienced grade 3/4 treatment-related adverse events. This risk-stratified, response-adapted salvage strategy had high CMR rates with limited toxicities in CAYA with R/R cHL. Most patients did not require additional chemotherapy (bendamustine intensification). Additional follow-up is needed to confirm durability of disease control. This trial was registered at www.clinicaltrials.gov as #NCT02927769.</p
Nivolumab and brentuximab vedotin with or without bendamustine for R/R Hodgkin lymphoma in children, adolescents, and young adults
Children, adolescents, and young adults (CAYA) with relapsed/refractory (R/R) classic Hodgkin lymphoma (cHL) without complete metabolic response (CMR) before autologous hematopoietic cell transplantation (auto-HCT) have poor survival outcomes. CheckMate 744, a phase 2 study for CAYA (aged 5-30 years) with R/R cHL, evaluated a risk-stratified, response-adapted approach with nivolumab plus brentuximab vedotin (BV) followed by BV plus bendamustine for patients with suboptimal response. Risk stratification was primarily based on time to relapse, prior treatment, and presence of B symptoms. We present the primary analysis of the standard-risk cohort. Data from the low-risk cohort are reported separately. Patients received 4 induction cycles with nivolumab plus BV; those without CMR (Deauville score >3, Lugano 2014) received BV plus bendamustine intensification. Patients with CMR after induction or intensification proceeded to consolidation (high-dose chemotherapy/auto-HCT per protocol). Primary end point was CMR any time before consolidation. Forty-four patients were treated. Median age was 16 years. At a minimum follow-up of 15.6 months, 43 patients received 4 induction cycles (1 discontinued), 11 of whom received intensification; 32 proceeded to consolidation. CMR rate was 59% after induction with nivolumab plus BV and 94% any time before consolidation (nivolumab plus BV ± BV plus bendamustine). One-year progression-free survival rate was 91%. During induction, 18% of patients experienced grade 3/4 treatment-related adverse events. This risk-stratified, response-adapted salvage strategy had high CMR rates with limited toxicities in CAYA with R/R cHL. Most patients did not require additional chemotherapy (bendamustine intensification). Additional follow-up is needed to confirm durability of disease control. This trial was registered at www.clinicaltrials.gov as #NCT02927769.</p
Longitudinal double spin asymmetries in single hadron quasi-real photoproduction at high
We measured the longitudinal double spin asymmetries for single
hadron muo-production off protons and deuterons at photon virtuality <
1(GeV/) for transverse hadron momenta in the range 0.7
GeV/ to 4 GeV/ . They were determined using COMPASS data taken
with a polarised muon beam of 160 GeV/ or 200 GeV/ impinging on
polarised or targets. The experimental
asymmetries are compared to next-to-leading order pQCD calculations, and are
sensitive to the gluon polarisation inside the nucleon in the range
of the nucleon momentum fraction carried by gluons
Interplay among transversity induced asymmetries in hadron leptoproduction
In the fragmentation of a transversely polarized quark several left-right
asymmetries are possible for the hadrons in the jet. When only one unpolarized
hadron is selected, it exhibits an azimuthal modulation known as Collins
effect. When a pair of oppositely charged hadrons is observed, three
asymmetries can be considered, a di-hadron asymmetry and two single hadron
asymmetries. In lepton deep inelastic scattering on transversely polarized
nucleons all these asymmetries are coupled with the transversity distribution.
From the high statistics COMPASS data on oppositely charged hadron-pair
production we have investigated for the first time the dependence of these
three asymmetries on the difference of the azimuthal angles of the two hadrons.
The similarity of transversity induced single and di-hadron asymmetries is
discussed. A new analysis of the data allows to establish quantitative
relationships among them, providing for the first time strong experimental
indication that the underlying fragmentation mechanisms are all driven by a
common physical process.Comment: 6 figure
Interplay among transversity induced asymmetries in hadron leptoproduction
In the fragmentation of a transversely polarized quark several left-right
asymmetries are possible for the hadrons in the jet. When only one unpolarized
hadron is selected, it exhibits an azimuthal modulation known as Collins
effect. When a pair of oppositely charged hadrons is observed, three
asymmetries can be considered, a di-hadron asymmetry and two single hadron
asymmetries. In lepton deep inelastic scattering on transversely polarized
nucleons all these asymmetries are coupled with the transversity distribution.
From the high statistics COMPASS data on oppositely charged hadron-pair
production we have investigated for the first time the dependence of these
three asymmetries on the difference of the azimuthal angles of the two hadrons.
The similarity of transversity induced single and di-hadron asymmetries is
discussed. A new analysis of the data allows to establish quantitative
relationships among them, providing for the first time strong experimental
indication that the underlying fragmentation mechanisms are all driven by a
common physical process.Comment: 6 figure
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