86 research outputs found
Doses cumulativas de iodo radioativo no tratamento do carcinoma diferenciado de tireoide: sabendo a hora de parar
OBJECTIVE: Evaluate the efficacy of cumulative doses (CDs) of 131I-iodide therapy (RIT) in differentiated thyroid cancer (DTC). SUBJECTS AND METHODS: The probability of progressive disease according to CDs was evaluated in patients < 45 years old and > 45 years old and correlated to tumor-node-metastasis (TNM), thyroglobulin values, histological types and variants, age, and zduration of the disease. RESULTS: At the end of a follow-up period of 69 ± 56 months, 85 out of 150 DTC patients submitted to fixed doses RIT had no evidence of disease, 47 had stable disease and 18 had progressive disease. Higher CDs were used in the more aggressive variants (p < 0.0001), higher TNM stages (p < 0.0001), and follicular carcinomas (p = 0.0034). Probability of disease progression was higher with CDs > 600 mCi in patients > 45 years old and with CDs > 800 mCi in patients < 45 years. CONCLUSION: Although some patients may still respond to high CDs, the impact of further RIT should be carefully evaluated and other treatment strategies may be warranted.OBJETIVO: Avaliar a eficĂĄcia de doses cumulativas (DCs) da terapia com iodeto-131I (RIT) no cĂąncer diferenciado de tiroide (CDT). SUJEITOS E MĂTODOS: A probabilidade de doença em progressĂŁo conforme a DC foi calculada em pacientes com idade < 45 e > 45 anos e correlacionada com o TNM, valores de tiroglobulina sĂ©rica, tipos histolĂłgicos e variantes, idade e tempo de doença. RESULTADOS: Ao final de um seguimento de 69 ± 56 meses, 85 dos 150 pacientes CDT submetidos a doses fixas de RIT nĂŁo tinham evidĂȘncia de doença, 47 tinham doença estĂĄvel e 18, doença progressiva. DCs mais elevadas foram usadas nas variantes agressivas (p < 0,0001), maior estĂĄgio TNM (p < 0,0001) e nos carcinomas foliculares (p = 0,0034). A probabilidade de doença em progressĂŁo foi maior com DCs > 600 mCi em pacientes > 45 anos e com DCs > 800 mCi em pacientes < 45 anos. CONCLUSĂO: Apesar de alguns pacientes ainda responderem a altas DCs, o impacto de RITs deve ser cuidadosamente avaliado e outras estratĂ©gias terapĂȘuticas devem ser consideradas.80781
Cumulative Doses Of Radioiodine In The Treatment Of Differentiated Thyroid Carcinoma: Knowing When To Stop.
Evaluate the efficacy of cumulative doses (CDs) of 131I-iodide therapy (RIT) in differentiated thyroid cancer (DTC). The probability of progressive disease according to CDs was evaluated in patients 45 years old and correlated to tumor-node-metastasis (TNM), thyroglobulin values, histological types and variants, age, and zduration of the disease. At the end of a follow-up period of 69 ± 56 months, 85 out of 150 DTC patients submitted to fixed doses RIT had no evidence of disease, 47 had stable disease and 18 had progressive disease. Higher CDs were used in the more aggressive variants (p 600 mCi in patients > 45 years old and with CDs > 800 mCi in patients < 45 years. Although some patients may still respond to high CDs, the impact of further RIT should be carefully evaluated and other treatment strategies may be warranted.54807-1
Screening of the odour-activity and bioactivity of the essential oils of leaves and flowers of Hyptis Passerina Mart. from the Brazilian Cerrado
Role of iodine oxoacids in atmospheric aerosol nucleation
Iodic acid (HIOâ) is known to form aerosol particles in coastal marine regions, but predicted nucleation and growth rates are lacking. Using the CERN CLOUD (Cosmics Leaving Outdoor Droplets) chamber, we find that the nucleation rates of HIOâ particles are rapid, even exceeding sulfuric acidâammonia rates under similar conditions. We also find that ion-induced nucleation involves IOââ» and the sequential addition of HIOâ and that it proceeds at the kinetic limit below +10°C. In contrast, neutral nucleation involves the repeated sequential addition of iodous acid (HIOâ) followed by HIOâ, showing that HIOâ plays a key stabilizing role. Freshly formed particles are composed almost entirely of HIOâ, which drives rapid particle growth at the kinetic limit. Our measurements indicate that iodine oxoacid particle formation can compete with sulfuric acid in pristine regions of the atmosphere
HUMANIZAĂĂO DA SAĂDE E INCLUSĂO SOCIAL NO ATENDIMENTO DE PESSOAS COM DEFICIĂNCIA FĂSICA
Towards a Muon Collider
A muon collider would enable the big jump ahead in energy reach that is
needed for a fruitful exploration of fundamental interactions. The challenges
of producing muon collisions at high luminosity and 10 TeV centre of mass
energy are being investigated by the recently-formed International Muon
Collider Collaboration. This Review summarises the status and the recent
advances on muon colliders design, physics and detector studies. The aim is to
provide a global perspective of the field and to outline directions for future
work.Comment: 118 pages, 103 figure
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