Ritchey-Chretien Telescope

A Ritchey-Chretien telescope is described which was designed to respond to images located off the optical axis by using two transparent flat plates positioned in the ray path of the image. The flat plates have a tilt angle relative to the ray path to compensate for astigmatism introduced by the telescope. The tilt angle of the plates is directly proportional to the off axis angle of the image. The plates have opposite inclination angles relative to the ray paths. A detector which is responsive to the optical image as transmitted through the plates is positioned approximately on the sagittal focus of the telescope

Mode hopping strongly affects observability of dynamical instability in optical parametric oscillators

Theoretical investigations of dynamical behavior in optical parametric oscillators (OPO) have generally assumed that the cavity detunings of the interacting fields are controllable parameters. However, OPOs are known to experience mode hops, where the system jumps to the mode of lowest cavity detuning. We note that this phenomenon significantly limits the range of accessible detunings and thus may prevent instabilities predicted to occur above a minimum detuning from being evidenced experimentally. As a simple example among a number of instability mechanisms possibly affected by this limitation, we discuss the Hopf bifurcation leading to periodic behavior in the monomode mean-field model of a triply resonant OPO and show that it probably can be observed only in very specific setups.Comment: submitted to Phys. Rev.

Fine guidance for a spaceborne telescope

Two transparent plates are mounted at equal and opposite angles in secondary optical-system housing, angles being set for optimum astigmatism correction. Rotation of secondary housing assembly and translation of detector are proportional to angular position of secondary image. Combined movement of two retains image within sagittal foci of secondary system

Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast

Genetic instability is a hallmark of aneuploidy in budding and fission yeast. All aneuploid yeast strains analyzed to date harbor elevated levels of Rad52-GFP foci, a sign of DNA damage. Here we investigate how continuously elevated levels of DNA damage affect aneuploid cells. We show that Rad52-GFP foci form during S phase, consistent with the observation that DNA replication initiation and elongation are impaired in some aneuploid yeast strains. We furthermore find that although DNA damage is low in aneuploid cells, it nevertheless has dramatic consequences. Many aneuploid yeast strains adapt to DNA damage and undergo mitosis despite the presence of unrepaired DNA leading to cell death. Wild-type cells exposed to low levels of DNA damage exhibit a similar phenotype, indicating that adaptation to low levels of unrepaired DNA is a general property of the cell's response to DNA damage. Our results indicate that by causing low levels of DNA damage, whole-chromosome aneuploidies lead to DNA breaks that persist into mitosis. Such breaks provide the substrate for translocations and deletions that are a hallmark of cancer

The Third International Symposium on Tilapia in Aquaculture

Tilapias, because of the low cost and relative ease of their production, are a potential food fish staple for many people ini tropical countries and a globally traded commodity. This volume of symposium proceedings shows a strong interest in production systems research and a dawning interest in socioeconomic research. Both of these fields of research are expected to receive much greater attention in the future as the economic and market importance of tilapia increases and as we seek to understand better the distribution of benefits of the different production technologies.Tilapia culture Tilapia, Oreochromis, Sarotherodon

Neutrino Oscillations in a Supersymmetric SO(10) Model with Type-III See-Saw Mechanism

The neutrino oscillations are studied in the framework of the minimal supersymmetric SO(10) model with Type-III see-saw mechanism by additionally introducing a number of SO(10) singlet neutrinos. The light Majorana neutrino mass matrix is given by a combination of those of the singlet neutrinos and the $SU(2)_L$ active neutrinos. The minimal SO(10) model gives an unambiguous Dirac neutrino mass matrix, which enables us to predict the masses and the other parameters for the singlet neutrinos. These predicted masses take the values accessible and testable by near future collider experiments under the reasonable assumptions. More comprehensive calculations on these parameters are also given.Comment: 14 pages, 5 figures; the version to appear in JHE

Anaerobic digestion of whole-crop winter wheat silage for renewable energy production

With biogas production expanding across Europe in response to renewable energy incentives, a wider variety of crops need to be considered as feedstock. Maize, the most commonly used crop at present, is not ideal in cooler, wetter regions, where higher energy yields per hectare might be achieved with other cereals. Winter wheat is a possible candidate because, under these conditions, it has a good biomass yield, can be ensiled, and can be used as a whole crop material. The results showed that, when harvested at the medium milk stage, the specific methane yield was 0.32 m3 CH4 kg–1 volatile solids added, equal to 73% of the measured calorific value. Using crop yield values for the north of England, a net energy yield of 146–155 GJ ha–1 year–1 could be achieved after taking into account both direct and indirect energy consumption in cultivation, processing through anaerobic digestion, and spreading digestate back to the land. The process showed some limitations, however: the relatively low density of the substrate made it difficult to mix the digester, and there was a buildup of soluble chemical oxygen demand, which represented a loss in methane potential and may also have led to biofoaming. The high nitrogen content of the wheat initially caused problems, but these could be overcome by acclimatization. A combination of these factors is likely to limit the loading that can be applied to the digester when using winter wheat as a substrat

Social Cognitive Determinants of HIV Voluntary Counselling and Testing Uptake among Married Individuals in Dar es Salaam Tanzania: Theory of Planned Behaviour (TPB)

Cumulative evidence indicates increasing HIV infection among married individuals. Voluntary Counselling and Testing for HIV (HCT) is known to be an effective intervention to induce safer sex behaviour and access to early treatment, care and support among married individuals, which are important for HIV prevention. In this context, knowledge of factors associated with HCT uptake among married individuals is critical in promoting the use of the services. This study therefore intended to identify the social cognitive factors associated with acceptance of HCT among married individuals. In a cross-sectional analytical study face to face questionnaires were administered among 200 randomly selected married individuals in Kinondoni district, Dar es Salaam Tanzania. The questionnaire included self-reported HCT, socio-demographic variables and social cognitive variables (attitude, subjective norms, perceived control and perceived risk). Logistic regression was used to identify the independent association of social cognitive predictors of HCT among married individuals. Nearly half (42%) of the respondents had never had HCT. Of the social cognitive constructs, the strongest predictor of HCT uptake was attitude (OR per additional score point = 1.07, 95% CI 1.04-1.10) followed by perceived behavioural control (OR = 1.04, 95% CI 1.02-1.06). Subjective norm and perceived risk were not associated with HCT uptake. Public health interventions targeting married individuals should be designed to enhance their positive attitude towards HCT and empower them to overcome barriers to the use of the services

Angiogenesis in tissue engineering : Breathing life into constructed tissue substitutes

Long-term function of three-dimensional (3D) tissue constructs depends on adequate vascularization after implantation. Accordingly, research in tissue engineering has focused on the analysis of angiogenesis. For this purpose, 2 sophisticated in vivo models (the chorioallantoic membrane and the dorsal skinfold chamber) have recently been introduced in tissue engineering research, allowing a more detailed analysis of angiogenic dysfunction and engraftment failure. To achieve vascularization of tissue constructs, several approaches are currently under investigation. These include the modification of biomaterial properties of scaffolds and the stimulation of blood vessel development and maturation by different growth factors using slow-release devices through pre-encapsulated microspheres. Moreover, new microvascular networks in tissue substitutes can be engineered by using endothelial cells and stem cells or by creating arteriovenous shunt loops. Nonetheless, the currently used techniques are not sufficient to induce the rapid vascularization necessary for an adequate cellular oxygen supply. Thus, future directions of research should focus on the creation of microvascular networks within 3D tissue constructs in vitro before implantation or by co-stimulation of angiogenesis and parenchymal cell proliferation to engineer the vascularized tissue substitute in situ