Efficacy of three different pulpotomy agents in primary molars : a randomised control trial

AbstractHistological sectioning is a generally accepted in vitro validation method for caries detection techniques. However, it requires cumbersome sample preparation and induces irreversible sample destruction. Micro-Computer Tomography (micro-CT) allows non-destructive imaging of tooth structure. The aim of this study was to compare the performance of histological sectioning and micro-CT imaging in detecting approximal carious lesions. Unlike previous studies, evaluation is objectified by comparing visual appearance of exactly corresponding anatomical regions. Sixty extracted human teeth were scanned with a desktop micro CT system. Axial histological slices were prepared and photographed. Sample preparation, combined with dedicated image processing, ensured selection of identical anatomical regions on radiographic and histological images. Evaluation of the presence and extent of carious lesions was performed by four dentists using custom-designed software. Each section was scored independently (histo or micro CT). Scores of approximal surfaces were retained for further analysis. Spearman's correlation coefficients (0.738 to 0.829, p < 0.0001) showed a good agreement between signs of carious lesions in the identical region obtained with both methods. Bland-Altman plots showed that 90.76% of the data points were within the limits of agreement. Micro-CT imaging was shown to provide an interesting alternative to histological sectioning as detection method for carious lesions.Rajasekharan S, Martens LC, Vandenbulcke J, Jacquet W, Bottenberg P, Cauwels RGEC (2017) Efficacy of three different pulpotomy agents in primary molars: a randomized control trial. International Endodontic Journal 50, 215–28.An incorrect conflict of interest statement was published in the above paper. The correct statement is:Conflict of interestThe authors would like to report nonsupport (i.e. cement materials free of charge) from Septodont, France and Medcem, Switzerland during the conduct of the study. Outside of the submitted work, the authors received materials free of charge for educational courses and Dr. Martens and Dr. Cauwels report personal fees (honoraria/lecture fees). Furthermore, Dr. Martens reports research grants from Septodont, France negotiated with Ghent University. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.The authors apologize for this error.info:eu-repo/semantics/publishe