Signature of Energy Losses on the Cosmic Ray Electron Spectrum

We show that the fine structure of the electron spectrum in cosmic rays, especially the excess claimed by AMS-02 at energies $\sim$42 GeV, is fully accounted for in terms of inverse Compton losses in the photon background dominated by ultraviolet, infrared and CMB photons, plus the standard synchrotron losses in the Galactic magnetic field. The transition to the Klein-Nishina regime on the ultraviolet background causes the feature. Hence, contrary to previous statements, observations do not require the overlap of different components. We stress that the feature observed by AMS-02 at energies $\sim$42 GeV is not related to the positron excess, which instead requires the existence of positron sources, such as pulsars. Because energy losses are the physical explanation of this feature, we indirectly confirm that the transport of leptons in the Galaxy is loss-dominated down to energies of the order of tens of GeV. This finding imposes strong constraints on the feasibility of alternative theories of cosmic transport in which the grammage is accumulated in cocoons concentrated around sources, requiring that electrons and positrons become loss dominated only at very high energies.Comment: 5 pages, 3 figures, minor updates in the text, fixed a typo in Eq.

Progettazione di una cassa d’espansione e determinazione della riduzione del rischio idraulico con modellazione 2D

Nell’articolo si studia l’effetto di una cassa d’espansione posta a monte di un’area fluviale soggetta a rischio idraulico. Lo strumento utilizzato è un software bidimensionale sviluppato per simulare la propagazione delle piene fluviali. Il dominio di calcolo è rappresentato da una mesh triangolare non strutturata con una maggiore densità di elementi all’interno dell’alveo e nelle zone immediatamente limitrofe. Per facilitare gli accumuli temporanei di parte dei volumi di piena, si ipotizza la costruzione di un restringimento dell’alveo per mezzo di due pareti verticali che avvicinano le sponde fluviali. Durante la piena, il passaggio per lo stato critico nel restringimento provoca un rigurgito a monte, e quindi un agevole riempimento della cassa d’espansione. La perimetrazione di tale cassa è definita con la costruzione di un rilevato arginale di adeguata altezza. Per meglio simulare il rigurgito a monte della strozzatura, si introduce una scabrezza equivalente negli elementi della strozzatura, per riprodurre le perdite di carico nel restringimento e nel successivo risalto idraulico, malgrado l’ipotesi diffusiva utilizzata nel software di calcolo. La conoscenza delle aree allagate in due eventi di piena storici e dei due relativi idrogrammi di piena, ha consentito la determinazione del coefficiente di Manning quale misura della scabrezza in alveo e fuori alveo. Mediante l’applicazione del modello proposto è possibile validare sia il posizionamento degli argini a monte del restringimento per il contenimento della piena, sia la riduzione delle aree di valle soggette a rischio idraulico

Galactic factories of cosmic-ray electrons and positrons

We present a novel calculation of the spectrum of electrons and positrons from random sources, supernova remnants and pulsars, distributed within the spiral arms of the Galaxy. The pulsar emissivity in terms of electron-positron pairs is considered as time dependent, following the magnetic dipole spin-down luminosity, and the temporal evolution of the potential drop is accounted for. Moreover each pulsar, with the magnetic field and initial spin period selected at random from the observed distribution, is considered as a source of pairs only after it leaves the parent supernova due to its birth kick velocity (also selected at random from the observed distribution). We show that (i) the spectrum of electrons is characterized by a feature at $\gtrsim 50$ GeV that proves that their transport is dominated by radiative losses. The flux reduction at $E\gtrsim 1$ TeV is explained as a result of lepton transport from sources in the spiral arms. (ii) The spectrum of positrons is very well described by the contribution of pulsars and the rising positron fraction originates naturally. The implications of pulsars as positron sources in terms of positron fraction at very high energies are also discussed. (iii) The role of fluctuations in the high-energy regime is thoroughly discussed and used to draw conclusions on the possibility to single out the contribution of local sources to the lepton spectrum with current and upcoming experiments

Stochastic nature of Galactic cosmic-ray sources

The precision measurements of the spectra of cosmic ray nuclei and leptons in recent years have revealed the existence of multiple features, such as the spectral break at $\sim 300$ GV rigidity seen by PAMELA and AMS-02 and more recently confirmed by DAMPE and CALET, the softening in the spectra of H and He nuclei at $\sim 10$ TV reported by DAMPE, confirming previous hints by NUCLEON and CREAM, a tiny change of slope at $\sim 40$ GeV in the electron spectrum, revealed by AMS-02, and the large spectral break at $\sim$ TeV reported by indirect (HESS, MAGIC and VERITAS) and direct (DAMPE, CALET) measurements of the total (electrons+positrons) lepton spectrum. In all these cases, the possibility has been suggested that these features might reflect the occasional presence of a local cosmic ray source, inducing a noticeable reshaping of the average expected spectra. All these proposals have to face the question of how likely it is for such a source to exist, a question that we address here in a quantitative way. We study the statistical properties of random distribution of sources in space and time, and the effect of the spiral structure of our Galaxy for both the spectra of light nuclei (p and He) and leptons (electrons and positrons) in different energy regions

Association of non-alcoholic fatty liver disease and cardiometabolic risk factors with early atherosclerosis in an adult population in Southern Italy

Aim. The prevalence of risk factors for cardiovascular and metabolic diseases was inves-tigated in an adult population of the city of Cittanova, Southern Italy. Methods. The study was conducted among 992 randomly selected adults aged 18-75 years, between April 2009 and January 2011.  Results. Prevalence rates of non-alcoholic fatty liver disease (NAFLD), overweight, obe-sity, and metabolic syndrome (MS) were 24.8%, 41.5%, 27.1%, and 34.4%, respectively. For the components of MS, prevalence of central obesity was 47.4%, impaired fasting glucose (IFG) 34.7%; hypertension 53.7%, low high-density lipoprotein (HDL) choles-terol 34.2%, and hypertriglyceridemia 27.2%.  Conclusions. Hypertension, central obesity, IFG, low HDL cholesterol, hypertriglyc-eridemia, MS, and increased carotid artery intima-media thickness (IMT) were sig-nificantly associated with NAFLD after adjustment for age and sex. With additional adjustment for body mass index (BMI), IMT and MS (depending on the prevalence ra-tio that was investigated), the positive association between the NAFLD and increased IMT lost statistical significance, while that with body mass index (BMI) and MS re-mained significant

Residual feed intake is related with metabolic and inflammatory response during the pre-weaning period in Italian Simmental calves

Residual Feed Intake (RFI) is defined as the difference between measured and predicted intake. Understanding its biological regulators could benefit farm profit margins. The most-efficient animals (M-Eff) have observed intake smaller than predicted resulting in negative RFI, whereas the least-efficient (L-Eff) animals have positive RFI. Hence, this observational study aimed at retrospectively comparing the blood immunometabolic profile in calves with divergent RFI during the preweaning period. Twenty-two Italian Simmental calves were monitored from birth through 60 d of age. Calves received 3 L of colostrum from their respective dams. From 2 to 53 d of age, calves were fed a milk replacer twice daily, whereas from 54 to 60 d (i.e., weaning) calves were stepped down to only one meal in the morning. Calves had ad libitum access to concentrate and intakes were recorded daily. The measurement of BW and blood samples were performed at 0, 1, 7, 14, 21, 28, 35, 45, 54, and 60 d of age. Calves were ranked and categorized as M-Eff or L-Eff according to the median RFI value. Median RFI was –0.06 and 0.04 kg of DMI/d for M-Eff and L-Eff, respectively. No evidence for group differences was noted for colostrum and plasma IgG concentrations. Although growth rate was not different, as expected, [0.67 kg/d (95% CI = 0.57 ‒ 0.76) for both L-Eff and M-Eff) throughout the entire pre-weaning period (0–60 d), starter intake was greater in L-Eff compared with M-Eff calves (+36%). Overall, M-Eff calves had a greater gain-to-feed ratio compared with L-Eff calves (+16%). Plasma ceruloplasmin, myeloperoxidase, and reactive oxygen metabolite concentrations were greater in L-Eff compared with M Eff calves. Compared with L-Eff, M-Eff calves had an overall greater plasma concentration of globulin, and γ-glutamyl transferase (indicating a better colostrum uptake) and Zn at 1 d. Retinol and urea were overall greater in L-Eff. The improved efficiency in nutrient utilization observed in M-Eff was paired with a lower grade of oxidative stress and systemic inflammation. L-Eff may have had greater energy expenditure to sup port the activation of the immune system. Keywords: Residual feed intake, Growth performance, Metabolic profile, Simmental calves.peer-reviewe

XIPE: the X-ray Imaging Polarimetry Explorer

X-ray polarimetry, sometimes alone, and sometimes coupled to spectral and temporal variability measurements and to imaging, allows a wealth of physical phenomena in astrophysics to be studied. X-ray polarimetry investigates the acceleration process, for example, including those typical of magnetic reconnection in solar flares, but also emission in the strong magnetic fields of neutron stars and white dwarfs. It detects scattering in asymmetric structures such as accretion disks and columns, and in the so-called molecular torus and ionization cones. In addition, it allows fundamental physics in regimes of gravity and of magnetic field intensity not accessible to experiments on the Earth to be probed. Finally, models that describe fundamental interactions (e.g. quantum gravity and the extension of the Standard Model) can be tested. We describe in this paper the X-ray Imaging Polarimetry Explorer (XIPE), proposed in June 2012 to the first ESA call for a small mission with a launch in 2017 but not selected. XIPE is composed of two out of the three existing JET-X telescopes with two Gas Pixel Detectors (GPD) filled with a He-DME mixture at their focus and two additional GPDs filled with pressurized Ar-DME facing the sun. The Minimum Detectable Polarization is 14 % at 1 mCrab in 10E5 s (2-10 keV) and 0.6 % for an X10 class flare. The Half Energy Width, measured at PANTER X-ray test facility (MPE, Germany) with JET-X optics is 24 arcsec. XIPE takes advantage of a low-earth equatorial orbit with Malindi as down-link station and of a Mission Operation Center (MOC) at INPE (Brazil).Comment: 49 pages, 14 figures, 6 tables. Paper published in Experimental Astronomy http://link.springer.com/journal/1068

Quantitative MRI Harmonization to Maximize Clinical Impact: The RIN-Neuroimaging Network

Neuroimaging studies often lack reproducibility, one of the cardinal features of the scientific method. Multisite collaboration initiatives increase sample size and limit methodological flexibility, therefore providing the foundation for increased statistical power and generalizable results. However, multisite collaborative initiatives are inherently limited by hardware, software, and pulse and sequence design heterogeneities of both clinical and preclinical MRI scanners and the lack of benchmark for acquisition protocols, data analysis, and data sharing. We present the overarching vision that yielded to the constitution of RIN-Neuroimaging Network, a national consortium dedicated to identifying disease and subject-specific in-vivo neuroimaging biomarkers of diverse neurological and neuropsychiatric conditions. This ambitious goal needs efforts toward increasing the diagnostic and prognostic power of advanced MRI data. To this aim, 23 Italian Scientific Institutes of Hospitalization and Care (IRCCS), with technological and clinical specialization in the neurological and neuroimaging field, have gathered together. Each IRCCS is equipped with high- or ultra-high field MRI scanners (i.e., ≥3T) for clinical or preclinical research or has established expertise in MRI data analysis and infrastructure. The actions of this Network were defined across several work packages (WP). A clinical work package (WP1) defined the guidelines for a minimum standard clinical qualitative MRI assessment for the main neurological diseases. Two neuroimaging technical work packages (WP2 and WP3, for clinical and preclinical scanners) established Standard Operative Procedures for quality controls on phantoms as well as advanced harmonized quantitative MRI protocols for studying the brain of healthy human participants and wild type mice. Under FAIR principles, a web-based e-infrastructure to store and share data across sites was also implemented (WP4). Finally, the RIN translated all these efforts into a large-scale multimodal data collection in patients and animal models with dementia (i.e., case study). The RIN-Neuroimaging Network can maximize the impact of public investments in research and clinical practice acquiring data across institutes and pathologies with high-quality and highly-consistent acquisition protocols, optimizing the analysis pipeline and data sharing procedures

Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

Biomarker-based differential diagnosis of the most common forms of dementia is becoming increasingly important. Machine learning (ML) may be able to address this challenge. The aim of this study was to develop and interpret a ML algorithm capable of differentiating Alzheimer's dementia, frontotemporal dementia, dementia with Lewy bodies and cognitively normal control subjects based on sociodemographic, clinical, and magnetic resonance imaging (MRI) variables. 506 subjects from 5 databases were included. MRI images were processed with FreeSurfer, LPA, and TRACULA to obtain brain volumes and thicknesses, white matter lesions and diffusion metrics. MRI metrics were used in conjunction with clinical and demographic data to perform differential diagnosis based on a Support Vector Machine model called MUQUBIA (Multimodal Quantification of Brain whIte matter biomArkers). Age, gender, Clinical Dementia Rating (CDR) Dementia Staging Instrument, and 19 imaging features formed the best set of discriminative features. The predictive model performed with an overall Area Under the Curve of 98%, high overall precision (88%), recall (88%), and F1 scores (88%) in the test group, and good Label Ranking Average Precision score (0.95) in a subset of neuropathologically assessed patients. The results of MUQUBIA were explained by the SHapley Additive exPlanations (SHAP) method. The MUQUBIA algorithm successfully classified various dementias with good performance using cost-effective clinical and MRI information, and with independent validation, has the potential to assist physicians in their clinical diagnosis

Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

IMPORTANCE Delays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis. OBJECTIVE To evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer. DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery. EXPOSURES Any type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections. MAIN OUTCOMES AND MEASURES The primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable. RESULTS A total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95%CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95%CI, 1.15-1.53; P < .001), and stenotic lesions (OR, 1.15; 95%CI, 1.01-1.31; P = .03). CONCLUSIONS AND RELEVANCE This cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients