Role of Pakistan poverty alleviation fund's micro credit in poverty alleviation: a case of Pakistan

Poverty alleviation has been one of the major agenda of all civilized societies throughout the history. Different strategies have been adopted in Pakistan for the purpose, which include special programs and short-term measures targeted towards improving the earning capacity of masses and provision of social safety nets for the really poor. With a view to enhance the access of the low-income communities to socio-economic services, the Government of Pakistan has set up an independent and professionally managed unit, the Pakistan Poverty Alleviation Fund (PPAF). The Fund is working through a network of partner organizations having strong community outreach programs. PPAF continuously monitors and analyzes effectiveness of its programs. This paper attempts to quantify the impact of PPAF micro credit on poverty alleviation.. Data collected in Gallup (2005) has been utilized for the purpose. Counter-factual ‘Combined approach’ has been employed in the analysis. The Paper concludes that Micro credit has reduced poverty by 3.05 percentage points in the period under stud

Analyzing Global and Local Media Representations of Malala Yousafzai

During the War on Terror, when high rates of violence were occurring and schools were being forcefully torn down in Swat Valley of Pakistan, Malala Yousafzai fought for girls’ education rights. At just 17 years old, Malala Yousafzai has inspired people around the world with her passion and determination to make sure girls everywhere can get an education. When the Taliban tried to silence her, Malala answered their brutality with strength and resolve. Soon in the international media, she was acclaimed as a brave hero and later honored with a Nobel Prize. She received a mixed response for her efforts in Pakistan. While some praised her, others thought her as an opportunist or believed that there was a Western conspiracy behind her promotion on an international level. This article explores the disparities in media representation of Malala Yousafzai on global and local levels. Employing ethnographic research methods, we bring to light the perceptions of people from her hometown and juxtapose it with those of international media outlets. The article will help understand the complex controversies surrounding Yousafzai’s struggle and legacy

Double Sawi Transform: Theory and Applications to Boundary Values Problems

Symmetry can play an important role in the study of boundary value problems, which are a type of problem in mathematics that involves finding the solutions to differential equations subject to given boundary conditions. Integral transforms play a crucial role in solving ordinary differential equations (ODEs), partial differential equations (PDEs), and integral equations. This article focuses on extending a single-valued Sawi transform to a double-valued ST, which we call the double Sawi (DS) transform. We derive some fundamental features and theorems for the proposed transform. Finally, we study the applications of the proposed transform by solving some boundary value problems such as the Fourier heat equation and the D’Alembert wave equation.The APC is supported by the Basque Government, Grant IT1555-22

Mathematical analysis of neurological disorder under fractional order derivative

Multiple sclerosis (MS) is a common neurological disorder that affects the central nervous system (CNS) and can cause lesions that spread over space and time. Our study proposes a mathematical model that illustrates the progression of the disease and its likelihood of recurrence. We use Caputo fractional-order (FO) derivative operators to represent non-negative solutions and to establish a steady-state point and basic reproductive number. We also employ functional analysis to prove the existence of unique solutions and use the Ulam-Hyres (UH) notion to demonstrate the stability of the solution for the proposed model. Furthermore, we conduct numerical simulations using an Euler-type numerical technique to validate our theoretical results. Our findings are presented through graphs that depict various behaviors of the model for different parameter values

Discriminatory dissolution testing for liquisolid compacts containing a poorly water-soluble drug (Hydrochlorothiazide)

Drug release from liquisolid compacts is dependent on several variables and changes in experimental parameters, like drug loading and the type and quantity of the carrier material, which affect the dissolution rate, significantly. Therefore, a dissolution method is needed that can discriminate among in vitro release profiles of liquisolid compacts of varying nature. The objective of this study was to develop and validate a discriminatory dissolution testing method for liquisolid compacts of hydrochlorothiazide (HCTZ) to evaluate the effect of formulation and process variables on dissolution rate. Various experimental conditions were optimized, and the method was validated according to USP and ICH guidelines for different parameters like linearity, specificity, accuracy, precision, and stability of solution. Analysis of dissolution samples was carried out by high-performance liquid chromatography (HPLC). The discriminatory nature of the method was confirmed by determining dissolution rates of liquisolid compacts of HCTZ prepared with different load factors. A model-independent approach was applied for comparison of different dissolution profiles. Based on a screening study, USP apparatus I (basket method) was selected. The best in vitro dissolution profile was obtained using purified water containing Tween-80 (0.5% v/v) as the dissolution medium (900 mL), stirred at 75 rpm. Complete dissolution (99.83 ± 1.03%) was achieved within 60 min and dissolution media had no interference with sample analysis. HCTZ exhibited a linear response (r2 = 0.9974) in the selected dissolution medium and showed accurate results (98%–100%) in the concentration rage of 80%–120% of the dose. All validation parameters were found in acceptable range (%RSD > 2), and drug samples prepared in dissolution medium were stable for the specified period. Comparison of dissolution profiles in the official and developed media showed significant differences in f1 and f2 values. The developed dissolution test exhibited higher discriminative capacity in differentiating release profiles of HCTZ and can be applied during formulation development and quality control analysis of liquisolid compacts

O efeito moderador da pressão do tempo sobre os elementos de embalagem e o comportamento de compra do consumidor: um caso da Nestlé Paquistão

The purpose of this study to measure whether three product packaging Elements Wrapper Design, Packaging Material and Printed Information Influences Consumer Buying Behavior or does Time Pressure shows a moderating relationship. This study determines the importance of these elements when they purchase Nestle products during short time period. In this research highlighted that companies cannot afford to ignore the importance of time constraints and packaging elements of the products on consumer Buying Behavior. The study was conduct in District Vehari, Punjab Pakistan. Data was collecting to the students of Higher Educational Institution in District Vehari. Structured Questionnaire was used that consist on five point Likert Scale. Multiple Regression Analysis, ANOVA, coefficient was used to test the variables.El propósito de este estudio es medir si el diseño de envoltorio de tres elementos, el material de empaque y la información impresa influyen en el comportamiento de compra del consumidor o si la presión del tiempo muestra una relación moderada. Este estudio determina la importancia de estos elementos cuando compran productos Nestle durante un período de tiempo corto. En esta investigación, se destacó que las empresas no pueden permitirse ignorar la importancia de las limitaciones de tiempo y los elementos de empaquetado de los productos en el comportamiento de compra del consumidor. El estudio fue realizado en el Distrito Vehari, Punjab Pakistán. Los datos fueron recolectados a los estudiantes de la Institución de Educación Superior en el Distrito Vehari. Se utilizó un cuestionario estructurado que consta de una escala Likert de cinco puntos. El análisis de regresión múltiple, ANOVA, coeficiente se utilizó para probar las variables.O objetivo deste estudo é medir se três elementos de embalagem, design de invólucro, material de embalagem e informações impressas influenciam o comportamento de compra do consumidor ou se a pressão no tempo apresenta uma relação de moderação. Este estudo determina a importância desses elementos quando eles compram produtos da Nestlé durante um curto período de tempo. Nesta pesquisa destacou que as empresas não podem ignorar a importância das restrições de tempo e elementos de embalagem dos produtos no comportamento de compra do consumidor. O estudo foi realizado no Distrito Vehari, Punjab Paquistão. Data estava coletando para os estudantes da Instituição de Ensino Superior no Distrito Vehari. Utilizou-se Questionário Estruturado que consiste na Escala Likert de cinco pontos. Utilizou-se o coeficiente de Análise de Regressão Múltipla, ANOVA, para testar as variáveis

SeDeM-ODT Expert System: A Solution to Challenges in Characterization of Pharmaceutical Powders and Powdered Material

In the field of pharmaceutical sciences, material characterization has been a focus of research as properties of the powder ingredients govern characteristics of the finished dosage form. It has been a tedious and time-consuming job to develop a correlation between the characteristics of powder material and final dosage form. Extensive experimentation is carried out at different stages of formulation development to optimize the final blend and produce a product fulfilling official requirements. Various approaches have been applied for the purpose with varying degree of applications. SeDeM-ODT expert system is a novel pre-formulation technique developed for characterization of powder material of varying nature. Experimental and quantitative determination of various parameters provides a basis for SeDeM-ODT expert system. The system predicts suitability of powder material (APIs and excipients) for tablet preparation by direct compression technology and disintegration behavior of the resultant dosage form. It provides a basis for selection of excipients, both quantitatively and qualitatively. The present study covers area of powder characterization at pre-formulation level of pharmaceutical product development. SeDeM-ODT expert system reduces lead time for pre-formulation studies and provides formulations with minimum number of excipients. SeDeM-ODT expert system has been successfully applied for material characterization (APIs and excipients) before processing and after processing

A new sensitive HPLC/UV method for simultaneous determination of paclitaxel, sorafenib and omeprazole in standard solutions and spiked plasma: Application to in-vitro and in-vivo evaluation of paclitaxel polymeric nanoformulations

Purpose: To develop a simple, novel, sensitive and rapid reverse phase high performance liquid chromatographic method for simultaneous determination of paclitaxel, sorafenib and omeprazole in standard solutions and spiked human plasma and its application to the in-vitro and in-vivo evaluation of paclitaxel polymeric nanoparticle formulations.Methods: The method was tested for the assessment of paclitaxel, omeprazole and sorafenib using tamoxifen citrate as internal standard. The analysis was performed at a wavelength of 235 nm using Thermo HS C18 column, 40 °C column oven temperature, acetonitrile and water (70:30 v/v, pH 3.37 adjusted with phosphoric acid) as a mobile phase and at a flow rate of 0.8 ml/min. All analytes were extracted by simple protein precipitation method using acetonitrile. The linearity was assessed in the concentration range of 1 - 2000 ng/mL for paclitaxel, omeprazole and sorafenib.Results: The developed chromatographic method effectively separated omeprazole, paclitaxel, sorafenib and IS with retention time of 3.93, 5.18, 6.43 and 9.93 min, respectively. The chromatograms of the three target compounds and IS showed good resolution and peak separation. The LOD of the method was 1, 5 and. 5 ng/mL while the LOQ was 2, 7.5 and 10 ng/mL, for paclitaxel, sorafenib and omeprazole, respectively.Conclusion: The proposed RP-HPLC–UV method for the assessment of paclitaxel, sorafenib and omeprazole in standard solutions and spiked plasma is simple, economical, sensitive and robust. The method is also suitable for the analysis of paclitaxel in nanoformulations and for its pharmacokinetic studies in an animal model

Fuzzy congruences on AG-group

In this paper, we establish the idea of fuzzy congruences on Abel-Grassmann's group (AG-group). We investigate different outcomes of fuzzy-congruences on AG-groups in detail and give some examples to illustrate the newly established results. We develop the relation between fuzzy congruence and fuzzy normal subgroup. In the end, we also provide some results of fuzzy homomorphism on AG-groups