14 research outputs found
Interferon Therapy for Hypertrophic Scars and Keloids
Get PDFInterferons (IFNs) belong to the family of cytokines are widely used to treat keloids owing to their ability to increase collagenase activity thereby reducing the production of collagen and other extracellular matrix (ECM). Intralesional injection of IFN-α – 2b increases the collagenase level by inhibiting the secretion of metalloproteinases, an inhibitor of collagenase. Moreover, the anti-fibrotic activity of IFNs, interfere with fibroblast mediated collagen synthesis. On the other hand, combinatorial therapy has been preferred recently along with IFN due to its side effects observed in various clinical trials conducted only with IFN. Triamcinolone acetonide (TAC) and CO2 lasers along with IFNs are found to be the potential therapy for the treatment of scars and keloids. In this chapter, IFN mediated therapy for the treatment of scars and keloids, its benefits and limitations and the advantages of combinatorial therapy with the appropriate literature support are discussed
Centrifugal spun ultrafine fibrous web as a potential drug delivery vehicle
No full text10.3144/expresspolymlett.2013.22Express Polymer Letters73238-24
Nanoporous hollow fibers as a phantom material for the validation of diffusion magnetic resonance imaging
No full textDevelopment and characterization of an electrospun mat from Eri silk fibroin and PLA blends for wound dressing application
No full textOsteoinductive 3D scaffolds prepared by blend centrifugal spinning for long-term delivery of osteogenic supplements
No full textSpinning solution flow model in the nozzle and experimental study of nanofibers fabrication via high speed centrifugal spinning
No full textA comparison of high throughput core–shell 2D electrospinning and 3D centrifugal spinning techniques to produce platelet lyophilisate-loaded fibrous scaffolds and their effects on skin cells
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