Choisir Paris : les grandes donations aux musées de la Ville de Paris

La Ville de Paris est l’un des premiers collectionneurs de France. Ses quatorze musées, réunis depuis 2013 au sein de l’établissement public Paris Musées, conservent une part importante de ce patrimoine. Nées de l’intérêt porté par la Ville à sa propre mémoire et à sa vie artistique, ces collections sont aussi le fruit du rapport passionné que de nombreux amateurs et collectionneurs ont entretenu avec la capitale, qu’ils ont choisie pour conserver leurs trésors patiemment assemblés. Ce « choix de Paris » répond à des motifs qui, pour divers qu’ils soient, font sens et écrivent une manière d’histoire de l’art. Hommage aux donateurs, le colloque dont sont issus ces actes s’est donné pour objectif de mieux faire connaître cette histoire, d’éclairer la genèse des collections des musées de la Ville de Paris et de témoigner de l’actualité de la recherche sur les grandes donations qui les ont enrichis. Ces essais témoignent aussi du souhait de Paris Musées de renforcer la recherche au sein de ses différentes activités

Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2)

BACKGROUND: Nutritional support is crucial to the management of patients receiving invasive mechanical ventilation (IMV) and the most commonly prescribed treatment in intensive care units (ICUs). International guidelines consistently indicate that enteral nutrition (EN) should be preferred over parenteral nutrition (PN) whenever possible and started as early as possible. However, no adequately designed study has evaluated whether a specific nutritional modality is associated with decreased mortality. The primary goal of this trial is to assess the hypothesis that early first-line EN, as compared to early first-line PN, decreases day 28 all-cause mortality in patients receiving IMV and vasoactive drugs for shock. METHODS/DESIGN: The NUTRIREA-2 study is a multicenter, open-label, parallel-group, randomized controlled trial comparing early PN versus early EN in critically ill patients requiring IMV for an expected duration of at least 48 hours, combined with vasoactive drugs, for shock. Patients will be allocated at random to first-line PN for at least 72 hours or to first-line EN. In both groups, nutritional support will be started within 24 hours after IMV initiation. Calorie targets will be 20 to 25 kcal/kg/day during the first week, then 25 to 30 kcal/kg/day thereafter. Patients receiving PN may be switched to EN after at least 72 hours in the event of shock resolution (no vasoactive drugs for 24 consecutive hours and arterial lactic acid level below 2 mmol/L). On day 7, all patients receiving PN and having no contraindications to EN will be switched to EN. In both groups, supplemental PN may be added to EN after day 7 in patients with persistent intolerance to EN and inadequate calorie intake. We plan to recruit 2,854 patients at 44 participating ICUs. DISCUSSION: The NUTRIREA-2 study is the first large randomized controlled trial designed to assess the hypothesis that early EN improves survival compared to early PN in ICU patients. Enrollment started on 22 March 2013 and is expected to end in November 2015. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01802099 (registered 27 February 2013)

Building a typology of cropping practices from comparison with a technical reference: first step for a relevant cropping system redesigning process – results for tropical citrus production

Introduction. Farm typologies and cropping practice typologies generally aim at seeking determinants of existing crop management strategies. They constitute the first step for setting improvement goals for cropping systems. Though there are a host of farm typology methods, few deal specifically with farmers’ practices, and even fewer investigate the correlations between practices. We propose here a framework for analysing the determinants of crop management, based on a vision of a crop management sequence condensed into logical combinations of cropping techniques. Materials and methods. This analytical framework was applied to the case of Guadeloupian citrus production, using a representative sample of 41 producers. Three stages were necessary to implement our analytical framework. At stage 1, logical and ordered combinations of cropping practices (CCPs), constitutive of observed as well as reference crop managements (RCMs), were identified through expert analysis. Based on measurements of deviations between farmers’ CCPs and RCMs’ CCPs, a typology of cropping practices was next built. At stage 2, the performances of farmers’ crop managements were evaluated using relevant indicators. Finally, at stage 3, constraints – either related to the environment or to the whole farm management – that determined producers’ cropping practices were identified for making, with the stakeholders, proposals for further technical improvements. Results. Crop management sequences were condensed into five CCPs. A technical profile was then determined for every producer, before a multiple correspondence factorial analysis was run. It identified two groups of producers with contrasting technical profiles. The collective analysis of these results pointed out “weed management” as a major constraint on the cropping systems, revealing that the RCM was inadequate in a context of impossible mechanisation. Discussion. Restructuring complex sequences of cropping techniques into five logical combinations of techniques enabled the comparison with a reference crop management. The cropping systems’ constraints and the objectives for further improvements were then set up collectively by the farmers and social stakeholders, along with the researchers. This analysis constitutes the first stage of a process of redesigning cropping systems, and its result provides a sound basis for a participatory approac

Phytoseiid mites (Acari) are bio-indicators of agricultural practice impact on the agroecosystem functioning

National audienc

Oviposition Preference of the Cabbage Root Fly towards Some Chinese Cabbage Cultivars: A Search for Future Trap Crop Candidates

International audienceThe development of integrated pest management strategies becomes more and more pressing in view of potential harmful effects of synthetic pesticides on the environment and human health. A promising alternative strategy against is the use of trap crops. Chinese cabbage ( subsp. and subsp. ) is a highly sensitive Brassicaceae species previously identified as a good candidate to attract the cabbage root fly away from other crops. Here, we carried out multi-choice experiments both in the laboratory and in field conditions to measure the oviposition susceptibilities of different subspecies and cultivars of Chinese cabbages as compared to a broccoli reference. We found large differences among subspecies and cultivars of the Chinese cabbage, which received three to eleven times more eggs than the broccoli reference in field conditions. In laboratory conditions, the subspecies did not receive more eggs than the broccoli reference. We conclude that largely prefers to lay eggs on the subspecies of Chinese cabbage compared to the subspecies or broccoli. Some cultivars, which received over ten times more eggs than broccoli in the field, appear especially promising candidates to further develop trap crop strategies against the cabbage root fly

Remission after CAR T‐cell therapy: Do lymphoma patients recover a normal life?

International audienceChimeric antigen receptor T cells (CAR T cells) can induce prolonged remission in a substantial subset of patients with relapse/refractory lymphoma. However, little is known about patients' life after CAR T‐cell therapy. We prospectively assessed the multidimensional recovery of lymphoma patients in remission, before leukapheresis, before CAR T‐cell infusion, and 3, 6, and 12 months thereafter. Validated tools were used to measure lymphoma‐related and global health‐related quality of life (HRQoL; Functional Assessment of Cancer Therapy‐Lymphoma [FACT‐Lym] and EQ‐5D‐5L), cognitive complaint (FACT‐Cognition), fatigue (FACIT‐Fatigue subscale), psychological status (Hospital Anxiety and Depression Scale, Post‐Traumatic Check List Scale), and sexuality (Relationship and Sexuality Scale). Beyond 12 months of remission, we also surveyed physical, professional, sexual, and general life status. At 3, 6, and 12 months, 53, 35, and 23 patients were evaluable, respectively. Improvement in lymphoma‐related HRQoL was clinically relevant at 3, 6, and 12 months with a mean change from baseline of 10.9 (95% confidence interval [CI]: 5.8; 16.1), 12.2 (95% CI: 4.2; 20.1), and 11.72 (95% CI: 2.06; 21.38), respectively. Improvement in global HRQoL, fatigue, and anxiety was clinically relevant, but 20%–40% of patients experienced persistent fatigue, psychological distress, and cognitive complaints over time. Beyond 12 months after CAR T cells, 81.8% of 22 evaluable patients were satisfied with their daily life. Physical activity, professional, sexual, and global well‐being had returned to prediagnosis levels in nearly half of the patients. We found an improvement in HRQoL after CAR T‐cell therapy including anxiety, depression, sexual satisfaction, and general well‐being. However, not all patients recover a “normal life.” Further research is needed to determine which patients are at risk of quality‐of‐life impairment to improve recovery after CAR T‐cell infusion