Effect of resistance and aerobic exercises on bone mineral density, muscle strength and functional ability in children with hemophilia

Background and purpose: Children with hemophilia are at risk for reduced bone mineral density (BMD), muscle strength and functional ability as a result of reduced leisure-time activity and less involvement in intense activities. So, the purpose of this study was to investigate the effect of resistance and aerobic exercise program on BMD, muscle strength and functional ability in children with hemophilia.Materials and methods: Thirty boys with hemophilia A ranging in age from 10 to 14 years had participated in this study. They were assigned randomly into two equal groups (control and study groups). Control group received a designed physical therapy program and aerobic exercise in the form of treadmill training, while the study group received the same program as the control group in addition to resistance training program in the form of bicycle ergometer training and weight resistance. Both groups received treatment sessions three times per week for three successive months. BMD, muscle strength of knee flexors and extensors and functional ability were evaluated before and after the 3 months of treatment program.Results: There was no significant difference between both groups in the pre-treatment mean values of all measured variables. Significant improvement was observed in BMD, knee extensors and flexors strength, and functional ability in the study group when comparing pre and post treatment measurements. There was a significant improvement in functional ability of the control group. Significant difference was also observed between both groups when comparing the post treatment measurements in favor of the study group.Conclusion: Based on obtained data, it can be concluded that, resistance and aerobic exercise training program is effective in increasing BMD, muscle strength and functional ability in children with hemophilia.Keywords: Hemophilia; Resistance; Aerobic exercise; Bone mineral density; Strength; Functional abilit

Operative strategy for fistula-in-ano without division of the anal sphincter

We would like to thank Mr ER MacDonald for his contribution in data collection during the early years of the study. The material in this paper was presented as a poster at the annual meeting of the American Society of Colon and Rectal Surgeons held in Vancouver, Canada, May 2011.Peer reviewedPublisher PD

Kesiapan Guru Terhadap Penerapan Kurikulum 2013 Pada Mata Pelajaran PAI (Bahasa Arab) Di SMK PPMI Assalaam Surakarta Kelas XI Tahun Pelajaran 2014/2015

Perubahan dan pembaharuan kurikulum harus difahami sebagai hal yang lazim, karena kurikulum memang harus selalu beradaptasi dengan zaman dan kebutuhan, dan kurikulum 2013 memang disusun untuk mengantisipasi perkembangan zaman tersebut. Lalu yang menjadi masalah sekarang adalah bagaimanakah kesiapan guru dalam menerapkan kurikulum 2013 itu untuk tahun ini. Apabila guru memiliki kesiapan yang memadai, siap dalam segi kualifikasi dan kompetensi serta siap dalam hal kesamaan pemahaman paradigma yang dijabarkan dalam kurikulum 2013 maka tidak akan bermasalah. Penulis tertarik meneliti tentang: kesiapan guru terhadap penerapan kurikulum 2013 pada mata pelajaran PAI (bahasa Arab). Dalam penelitian ini masalah yang penulis bahas adalah kesiapan guru terhadap penerapan kurikulum 2013 pada mata pelajaran PAI (bahasa Arab) di SMK PPMI Assalaam Surakarta. Serta apa yang menjadi faktor pendukung dan penghambat dalam penerapan Kurikulum 2013 pada mata pelajaran PAI (bahasa Arab) di SMK PPMI Assalaam Surakarta. Tujuan penelitan ini adalah untuk mendeskripsikan kesiapan guru terhadap penerapan kurikulum 2013 pada mata pelajaran PAI (bahasa Arab). Serta mendeskripsikan apa yang menjadi faktor pendukung dan penghambat dalam penerapan kurikulum 2013 pada mata pelajaran PAI (bahasa Arab) di SMK PPMI Assalaam Surakarta kelas XI tahun pelajaran 2014/2015. Manfaat penelitian diharapkan dapat menambah wawasan dan pengetahuan dalam meningkatkan kesiapan guru dalam menerapkan kurikulum 2013. Penelitian ini merupakan penelitian kualitatif yang mengambil objek di SMK PPMI Assalaam Surakarta dengan subjek guru PAI dan siswa kelas XI. Metode pengumpulan data yang digunakan adalah dokumentasi, observasi, dan wawancara. Sedangkan metode analisis data yang digunakan adalah teknik analisis deskriptif kualitatif dengan cara deduktif yaitu pengumpulan data, penyajian data, dan penarikan kesimpulan. Berdasarkan hasil penelitian dan analisis data, maka dapat disimpulkan bahwa: Guru belum sepenuhnya siap dalam menerapkan kurikulum 2013 dalam mata pelajaran PAI (bahasa Arab). Hal ini dapat dilihat dari ketidak sesuian rumusan kurikulum 2013 dan penerapan mata pelajaran bahasa Arab di SMK PPMI Assalaaam, yaitu: SKL belum dirumuskan sesuai dengan kurikulum 2013, standar isi belum diadaptasi dengan kurikulum pemerintah. Dalam standar proses KI 1, KI 2, KI 3, dan KI 4 belum diterapkan dalam KBM. Dan standar penilaian pada sikap sesama teman dan portofolio belum dilakukan. Faktor pendukung: Siswa diajak aktif mengkonstruk pemahamannya dalam mengikuti setiap pembelajaran. Pembelajaran tidak hanya dilakukan di ruang kelas. Siswa dibebaskan memanfaatkan media pembelajaran seperti laptop. Faktor penghambatnya: Buku PAI disusun menggunakan bahasa Arab sehingga kurang efektif jika diajarkan dengan menerapkan kurikulum 2013. Metode yang kurang variatif sehingga menimbulkan kebosanan pada siswa

A Study of the androgen receptor gene polymorphism and the level of expression of the androgen receptor in androgenetic alopecia among Egyptians

Background: Androgenetic alopecia (AGA) occurs in men and women. Thenature of the genetic predisposition to androgenetic alopecia is still unresolved. The aim of the work is to study the genotype of the androgen receptor gene (StuI polymorphism) and its relationship to AGA in a case control study and to determine the level of androgen receptor expression (AR) in the balding scalp relative to the non-balding scalp area.Subjects and Methods: This study was conducted on one hundred individuals; 60 cases with AGA (36 males and 24 females) and 40 age and sex matched control patients (20 males and 20 females). StuI restriction fragment length polymorphism(RFLP) of exon 1 was detected by PCR based assay using genomic DNA of subjects with AGA and controls. Immunohistochemical detection of the androgen receptor (AR) using antihuman AR antibody was implemented to compare its level in the balding scalp and in the non-balding area in individuals having AGA.Results: Analysis of StuI restriction fragment length polymorphism in exon 1 of the androgen receptor (AR) gene revealed a relatively commoner incidence of the cut allele in males with AGA relative to age and sex matched controls (the association was of border line signifi cance p=0.07. Interestingly, all persons who had maternal uncles suffering from AGA had the Stu1 cut variant of AR gene (p= 0.03 using Chi square test). Semiquantitative immunohistochemical analysis of AR in the bold scalp biopsies showed higher expression in the level of AR than the non bold bioposies within the same individual.Conclusion: To the best of our knowledge this is the fi rst study of AR gene polymorphism and AR expression in AGA amongst Egyptians. This study contributes in the understanding of the molecular pathogenesis of AGA which could help in fi nding better therapeutic alternatives for such trait in the future.Keywords: Androgenetic alopecia, androgen receptor, StuI polymorphism, immunohistochemical expression

Synthesis and Characterization of a Mixed Nanofertilizer Influencing the Nutrient Use Efficiency, Productivity, and Nutritive Value of Tomato Fruits

Due to the higher potential for enhancing nutrient use efficiency, nanofertilizer (NF) is crucial in sustainable crop production. Thus, foliar-applied mixed nanofertilizer (MNFf) and commercial fertilizer (CF) into the soil (CFs) were claimed together ([MNFf + CFs]) and comparative nutrient use efficiency (NUE), productivity, and nutritional properties of tomato fruits were investigated. The mixed nanofertilizer (MNF) was prepared in our laboratory and characterized using scanning electron microscopy, X-ray diffraction, and Fourier transform infrared. To avoid the interference of other factors, all the treatments were divided into three groups: (i) blank treatment (no fertilizer), (ii) CF treatment, and (iii) combined [MNFf + CFs] treatment. The vegetative growth and qualitative and quantitative attributes of tomatoes were recorded, and the NUE, total production, and benefit-cost ratio (BCR) were also calculated. In addition, comparative nutritional properties for all treatments were analyzed. The plant's height, stem diameter, root length, photosynthetic pigments, leaf minerals, and qualitative traits of tomato fruits were significantly (p < 0.05) increased by [MNFf + CFs] treatment compared to CFs. The protein, fiber, Fe, Zn, and K contents were significantly (p < 0.05) increased by 23.80, 38.10, 44.23, 60.01, and 2.39%, respectively, with the [MNFf + CFs] treatment as compared to CFs, while the ash and protein contents were both lower than the untreated tomato. Moreover, [MNFf + CFs] treatment has significantly (p < 0.05) increased the antioxidant properties. The NUE, total production, and BCR were also increased by 26.08, 26.04, and 25.38%, respectively, with the same treatment. Thus, [MNFf + CFs] treatment could be a potential alternative for reducing the excess use of CF. © 2021 The Authors. Published by American Chemical Society.1

Using visual lifelogs to automatically characterise everyday activities

Visual lifelogging is the term used to describe recording our everyday lives using wearable cameras, for applications which are personal to us and do not involve sharing our recorded data. Current applications of visual lifelogging are built around remembrance or searching for specific events from the past. The purpose of the work reported here is to extend this to allow us to characterise and measure the occurrence of everyday activities of the wearer and in so doing to gain insights into the wearer's everyday behaviour. The methods we use are to capture everyday activities using a wearable camera called SenseCam, and to use an algorithm we have developed which indexes lifelog images by the occurrence of basic semantic concepts. We then use data reduction techniques to automatically generate a profile of the wearer's everyday behaviour and activities. Our algorithm has been evaluated on a large set of concepts investigated from 13 users in a user experiment, and for a group of 16 popular everyday activities we achieve an average F-score of 0.90. Our conclusions are that the the technique we have presented for unobtrusively and ambiently characterising everyday behaviour and activities across individuals is of sufficient accuracy to be usable in a range of applications

Early Respiratory Management of Respiratory Distress Syndrome in Very Preterm Infants and Bronchopulmonary Dysplasia: A Case-Control Study

BACKGROUND: In the period immediately after birth, preterm infants are highly susceptible to lung injury. Early nasal continuous positive airway pressure (ENCPAP) is an attempt to avoid intubation and may minimize lung injury. In contrast, ENCPAP can fail, and at that time surfactant rescue can be less effective. OBJECTIVE: To compare the pulmonary clinical course and outcome of very preterm infants (gestational age 25–32 weeks) with respiratory distress syndrome (RDS) who started with ENCPAP and failed (ECF group), with a control group of infants matched for gestational age, who were directly intubated in the delivery room (DRI group). Primary outcome consisted of death during admission or bronchopulmonary dysplasia (BPD). RESULTS: 25 infants were included in the ECF group and 50 control infants matched for gestational age were included in the DRI group. Mean gestational age and birth weight in the ECF group were 29.7 weeks and 1,393 g and in the DRI group 29.1 weeks and 1,261 g (p = NS). The incidence of BPD was significantly lower in the ECF group than in the DRI group (4% vs. 35%; P<0.004; OR 12.6 (95% CI 1.6–101)). Neonatal mortality was similar in both groups (4%). The incidence of neonatal morbidities such as severe cerebral injury, patent ductus arteriosus, necrotizing enterocolitis and retinopathy of prematurity, was not significantly different between the two groups. CONCLUSION: A trial of ENCPAP at birth may reduce the incidence of BPD and does not seem to be detrimental in very preterm infants. Randomized controlled trials are needed to test whether early respiratory management of preterm infants with RDS plays an important role in the development of BPD

Perturbation and Variational Methods in Nonextensive Tsallis Statistics

A unified presentation of the perturbation and variational methods for the generalized statistical mechanics based on Tsallis entropy is given here. In the case of the variational method, the Bogoliubov inequality is generalized in a very natural way following the Feynman proof for the usual statistical mechanics. The inequality turns out to be form-invariant with respect to the entropic index $q$. The method is illustrated with a simple example in classical mechanics. The formalisms developed here are expected to be useful in the discussion of nonextensive systems.Comment: revte

Impact of Protracted War Crisis on Dental Students: A Comparative Multicountry Cross-sectional Study

BACKGROUND: The impact of conflict and war crisis on dental students is poorly understood. Given the prolonged conflicts and political instability in the Arabic-speaking countries, it is crucial to investigate the effect of these conditions on dental students. This study aimed to assess the impact of protracted war on dental students by comparing the personal, university, and wider context challenges they face across war-affected and unaffected countries. METHODS: A cross-sectional study was conducted including a convenience sample of dental students from 13 universities in 12 Arabic-speaking countries. Respondents were those at entry and exit points of their undergraduate dental training. A self-administered paper questionnaire collected anonymized data on sociodemographics, and personal, university, and wider context challenges that students were facing. Multivariable Poisson regression analyses were carried out. RESULTS: The overall response rate was 64.8%. The mean age was 21.2 (standard deviation = 2.1) years, with 68% of participants being female. After adjusting for age and sex, dental students in Arabic-speaking countries affected by protracted war crisis were significantly more likely to report wider context challenges compared to their counterparts in unaffected countries (n = 2448; beta = 1.12; 95% confidence interval: 1.10-1.13; P < 0.001). DISCUSSION: Dental students in Arabic-speaking countries affected by protracted war crisis were more likely to suffer from wider context challenges such as difficulties in attendance due to the deterioration of security and lack of flexibility of teaching time to accommodate the different circumstances induced by the war crisis. Supporting dental students in areas affected by protracted war crises is needed and may include developing online dental education programs

Persistent Staphylococcus aureus Colonization Is Not a Strongly Heritable Trait in Amish Families

About 20% of adults are persistently colonized with S. aureus in the anterior nares. Host genetic factors could contribute susceptibility to this phenotype. The objective of this study was to determine whether the phenotype of persistent S. aureus colonization aggregates in family members who live in different households. Healthy adults and their eligible same sex siblings who lived in different households were recruited from the Old Order Amish of Lancaster, Pennsylvania. All participants had two cultures of the anterior nares to determine if they were persistently colonized with S. aureus. Three hundred and ninety eight participants finished the study, of whom 166 were index cases and 232 were siblings of index cases. Eighteen per cent (71/398) of all participants and 17% (29/166) of index cases were persistently colonized with S. aureus. Twenty two per cent (8/36) of siblings of persistently colonized index cases were persistently colonized with S. aureus compared to 17% (34/196) of siblings of non-persistently colonized index cases, yielding a prevalence rate ratio of 1.28 (95% CI: 0.65–2.54, p = 0.64) and sibling relative risk of 1.25 (95% CI: 0.65–2.38, p = 0.51). The heritability of persistent colonization was 0.19±0.21 (p = 0.31). Persistent S. aureus colonization does not strongly aggregate in Amish family members in different households and heritability is low, suggesting that environmental factors or acquired host factors are more important than host genetic factors in determining persistent S. aureus colonization in this community