Using SPICES for a better service consumption

In this poster we present SPICES (Semantic Platform for the Interaction and Consumption of Enriched Services), a Web based tool that automates the process of consuming a Web service by making use of the semantic annotations that describe them. SPICES supports both traditional WSDL services and RESTful ones and offers end-users the possibility of interacting with them in an easy yet personalised manner, without the need of advanced technical skills -which were traditionally required-, being the complexity that lies underneath hidden to them. SPICES is being developed within the European project SOA4All

BRITISH MEDICAL ASSOCIATION'S COHORT STUDY OF 2006 MEDICAL GRADUATES : LONGITUDINAL ANALYSIS OF CAREER TRAJECTORIES

https://www.bma.org.uk/news/2017/september/women-more-likely-to-switch-career https://www.bma.org.uk/collective-voice/policy-and-research/education-training-and-workforce/cohort-stud

Resiliencia de equipo en deportistas profesionales

El deporte de élite es un acontecimiento que trasciende más allá de lo estrictamente deportivo, llegándose a convertir en un fenómeno social. De esta forma, los deportistas profesionales están expuestos a situaciones de gran estrés como consecuencia de su desempeño competitivo. El objetivo del presente trabajo consiste en revisar las recientes investigaciones que estudian la resiliencia dentro de los equipos deportivos de élite, los procesos psicosociales que se producen y las características que los definen. Para la elaboración de esta revisión se consultaron dos bases de datos (SPORT DISCUS: EBSCO y SCOPUS), seleccionando finalmente un total de 18 artículos. Las investigaciones elegidas contaban con muestras compuestas por atletas profesionales en activo de diferentes disciplinas deportivas sin importar sexo o rango de edad. Los estudios mostraron que el desarrollo de la resiliencia de equipo no solo mejora el rendimiento deportivo sino también la salud mental de los atletas. Se identificaron procesos psicosociales cruciales que fomentan el desarrollo de la resiliencia entre los miembros, además de características resilientes que permiten al grupo mantener sus niveles normales de funcionamiento ante factores de estrés. Por tanto, sería conveniente implementar programas que sustenten el trabajo de la resiliencia en equipos de élite, así como la inclusión de un psicólogo dentro del organigrama deportivo de los clubes.Professional sport is an event that transcends strictly sporting, becoming a social phenomenon. Thus, professional athletes are exposed to situations of great stress as a consequence of their competitive performance. This paper aims to review recent research that studies resilience within elite sports teams, the psychosocial processes that occur, and the characteristics that define them. Two databases (SPORT DISCUS: EBSCO and SCOPUS) were consulted for the elaboration of this review, finally selecting a total of 18 articles. The chosen research had samples composed of active professional athletes from different sports disciplines regardless of sex or age range. The studies showed that the development of team resilience improves sports performance and the mental health of athletes. Crucial psychosocial processes that foster the development of resilience among members were identified and resilient characteristics that allow the group to maintain its regular levels of functioning in the face of stressors. Therefore, it would be convenient to implement programs that support the work of resilience in elite teams and the inclusion of a psychologist within the sports organization of the clubs

New Bounds for Topological Indices on Trees through Generalized Methods

This article belongs to the Special Issue Analytical and Computational Properties of Topological Indices.Topological indices are useful for predicting the physicochemical behavior of chemical compounds. A main problem in this topic is finding good bounds for the indices, usually when some parameters of the graph are known. The aim of this paper is to use a unified approach in order to obtain several new inequalities for a wide family of topological indices restricted to trees and to characterize the corresponding extremal trees. The main results give upper and lower bounds for a large class of topological indices on trees, fixing or not the maximum degree. This class includes the first variable Zagreb, the Narumi–Katayama, the modified Narumi–Katayama and the Wiener index.The first author was partially supported by a grant from Ministerio de Ciencia, Innovación y Universidades (PGC2018-098321-B-I00), Spain; the second author was partially supported by two grants from Ministerio de Economía y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) (MTM2016-78227-C2-1-P and MTM2017-90584-REDT), Spain

A unified approach to bounds for topological indices on trees and applications

The aim of this paper is to use a unified approach in order to obtain new inequalities for a large family of topological indices restricted to trees and to characterizethe set of extremal trees with respect to them. Our main results provide upperand lower bounds for a large class of topological indices on trees, fixing or not themaximum degree or the number of pendant vertices. This class includes the variablefirst Zagreb, the multiplicative second Zagreb, the Narumi-Katayama and the sumlordeg indices. In particular, our results on the sum lordeg index partially solve anopen problem on this index.The first author was partially supported by a grant from Ministerio de Ciencia, Innovación y Universidades (PGC2018-098321-B-I00), Spain; the second author was partially supported by two grants from Ministerio de Economía y Competitividad, Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) (MTM2016-78227-C2-1-P and MTM2017-90584-REDT), Spain

Hyperbolicity of direct products of graphs

It is well-known that the different products of graphs are some of the more symmetric classes of graphs. Since we are interested in hyperbolicity, it is interesting to study this property in products of graphs. Some previous works characterize the hyperbolicity of several types of product graphs (Cartesian, strong, join, corona and lexicographic products). However, the problem with the direct product is more complicated. The symmetry of this product allows us to prove that, if the direct product G(1) x G(2) is hyperbolic, then one factor is bounded and the other one is hyperbolic. Besides, we prove that this necessary condition is also sufficient in many cases. In other cases, we find (not so simple) characterizations of hyperbolic direct products. Furthermore, we obtain good bounds, and even formulas in many cases, for the hyperbolicity constant of the direct product of some important graphs (as products of path, cycle and even general bipartite graphs).This work was supported in part by four grants from Ministerio de Economía y Competititvidad (MTM2012-30719, MTM2013-46374-P, MTM2016-78227-C2-1-P and MTM2015-69323-REDT), Spain

CAR T cell therapy in B-cell acute lymphoblastic leukaemia: Insights from mathematical models

Immunotherapies use components of the patient immune system to selectively target cancer cells. The use of CAR T cells to treat B-cell malignancies --leukaemias and lymphomas-- is one of the most successful examples, with many patients experiencing long-lasting complete responses to this therapy. This treatment works by extracting the patient's T cells and adding them the CAR group, which enables them to recognize and target cells carrying the antigen CD19+, that is expressed in these haematological tumors. Here we put forward a mathematical model describing the time response of leukaemias to the injection of CAR T-cells. The model accounts for mature and progenitor B-cells, tumor cells, CAR T cells and side effects by incorporating the main biological processes involved. The model explains the early post-injection dynamics of the different compartments and the fact that the number of CAR T cells injected does not critically affect the treatment outcome. An explicit formula is found that provides the maximum CAR T cell expansion in-vivo and the severity of side effects. Our mathematical model captures other known features of the response to this immunotherapy. It also predicts that CD19+ tumor relapses could be the result of the competition between tumor and CAR T cells analogous to predator-prey dynamics. We discuss this fact on the light of available evidences and the possibility of controlling relapses by early re-challenging of the tumor with stored CAR T cells

Left Ventricular Dysfunction and Plasmatic NT-proBNP Are Associated with Adverse Evolution in Respiratory Syncytial Virus Bronchiolitis

Aim: To investigate whether the presence of left ventricular myocardial dysfunction (LVMD) assessed by Tei index (LVTX) impacts the outcomes of healthy infants with Respiratory Syncytial Virus Bronchiolitis (RSVB). To explore whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) increases the accuracy of traditional clinical markers in predicting the outcomes. Methods: A single-centre, prospective, cohort study including healthy infants aged 1–12 months old admitted for RSVB between 1 October 2016 and 1 April 2017. All patients underwent clinical, laboratory and echocardiographic evaluation within 24 h of admission. Paediatric intensive care unit (PICU) admission was defined as severe disease. Results: We enrolled 50 cases of RSVB (median age of 2 (1–6.5) months; 40% female) and 50 age-matched controls. We observed higher values of LVTX in infants with RSVB than in controls (0.42 vs. 0.36; p = 0.008). Up to nine (18%) children presented with LVMD (LVTX > 0.5), with a higher incidence of PICU admission (89% vs. 5%; p < 0.001). The diagnostic performance of NT-proBNP in predicting LVMD was high (area under the receiver operator characteristic curve (AUC) 0.95, CI 95% 0.90–1). The diagnostic yield of the predictive model for PICU admission that included NT-proBNP was excellent (AUC 0.945, CI 95% 0.880–1), and significantly higher than the model without NT-proBNP (p = 0.026). Conclusions: LVMD could be present in healthy infants with RSVB who develop severe disease. NT-proBNP seems to improve traditional clinical markers for outcomes